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Abstract 6815: CXCL12-loaded-hydrogel (CLG) in vivo modifies lung metastatic niche toward an immunoactive microenvironment reducing lung metastasis development

Giuseppe Guardascione, Luigi Portella, Dario Guido Di Febbraro, Giulia Bertolini, Giuseppina Rea, Caterina Ieranò, Crescenzo D'Alterio, Maria Napolitano, Sara Santagata, Anna Maria Trotta, Emilia Scarpa, Sabrina Chiara Cecere, Alessandro Ottaiano, Giuliano Palumbo, Alessandro Morabito, Teresa Somma, Roberto Pacelli, Sandro Pignata, Stefania Scala

Cancer Res (2024) 84 (6_Supplement): 6815.

https://doi.org/10.1158/1538-7445.AM2024-6815

Published: 22 March 2024

View articletitled, Abstract 6815: CXCL12-loaded-hydrogel (CLG) in vivo modifies lung metastatic niche toward an immunoactive microenvironment reducing lung metastasis development

Journal Articles

Abstract 2463: Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

Cancer Res (2024) 84 (6_Supplement): 2463.

https://doi.org/10.1158/1538-7445.AM2024-2463

Published: 22 March 2024

View articletitled, Abstract 2463: Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

Journal Articles

Abstract 7655: The CXCR4/CXCR7/CXCL12 axis and PBRM1 are involved in everolimus resistance in human renal cancer cell lines

Federica Auletta, Caterina Ieranò, Giuseppina Rea, Maria Napolitano, Francesca Galdiero, Anna Maria Bello, Pierfrancesco Tassone, Maria Teresa Di Martino, Stefania Scala

Cancer Res (2024) 84 (6_Supplement): 7655.

https://doi.org/10.1158/1538-7445.AM2024-7655

Published: 22 March 2024

View articletitled, Abstract 7655: The CXCR4/CXCR7/CXCL12 axis and PBRM1 are involved in everolimus resistance in human renal cancer cell lines

Journal Articles

Abstract 2550: Tumor microenvironment (TME) is more suppressive in hepatocellular carcinoma (HCC) than in colorectal cancer liver metastasis (CRLM): CXCR4 antagonism as strategy to revert T regulatory cells (Tregs) suppressive activity

Daniela Castaldo, Sara Santagata, Giuseppina Rea, Maria Napolitano, Crescenzo D'Alterio, Rita Guarino, Vittorio Albino, Andrea Belli, Carmen Cutolo, Francesco Izzo, Stefania Scala

Cancer Res (2022) 82 (12_Supplement): 2550.

https://doi.org/10.1158/1538-7445.AM2022-2550

Published: 15 June 2022

View articletitled, Abstract 2550: Tumor microenvironment (TME) is more suppressive in hepatocellular carcinoma (HCC) than in colorectal cancer liver metastasis (CRLM): CXCR4 antagonism as strategy to revert T regulatory cells (Tregs) suppressive activity

Journal Articles

Abstract 6675: Basal NK activity and early Tregs inhibition predicts nivolumab responsiveness in metastatic renal cancer patients (REVOLUTION) trial

Sara Santagata, Anna Maria Trotta, Giuseppina Rea, Maria Napolitano, Anna Capiluongo, Crescenzo D'Alterio, Marilena Di Napoli, Sabrina Rossetti, Sandro Pignata, Stefania Scala

Cancer Res (2020) 80 (16_Supplement): 6675.

https://doi.org/10.1158/1538-7445.AM2020-6675

Published: 15 August 2020

View articletitled, Abstract 6675: Basal NK activity and early Tregs inhibition predicts nivolumab responsiveness in metastatic renal cancer patients (REVOLUTION) trial

Journal Articles

Abstract 4103: Blockade of intrinsic PD-1 promotes human colon cancer cells survival, chemo resistance and in vivo tumor growth of human colon cancer cells

Caterina Ieranò, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Gelsomina Monaco, Piera Maiolino, Antonio Luciano, Antonio Barbieri, Giuseppe Palma, Claudio Arra, Roberto Pacelli, Stefania Scala

Cancer Res (2019) 79 (13_Supplement): 4103.

https://doi.org/10.1158/1538-7445.AM2019-4103

Published: 01 July 2019

View articletitled, Abstract 4103: Blockade of intrinsic PD-1 promotes human colon cancer cells survival, chemo resistance and in vivo tumor growth of human colon cancer cells

Journal Articles

Abstract 5194: In vivo capture of early metastatic cells through a CXCL12 loaded-dermal filler

Caterina Ieranò, Crescenzo D'Alterio, Simona Giarra, Maria Napolitano, Assunta Santagata, Antonio Barbieri, Virginia Campani, Antonio Luciano, Claudio Arra, Annamaria Anniciello, Gerardo Botti, Laura Mayol, Giuseppe De Rosa, Roberto Pacelli, Stefania Scala

Cancer Res (2018) 78 (13_Supplement): 5194.

https://doi.org/10.1158/1538-7445.AM2018-5194

Published: 01 July 2018

View articletitled, Abstract 5194: In vivo capture of early metastatic cells through a CXCL12 loaded-dermal filler

Journal Articles

Abstract 580: Nivolumab treatment of metastatic renal cancer patients impairs Tregs and potentiates NK function: The role of CXCR4 inhibition (“REVOLUTION Trial”)

Sara Santagata, Anna Maria Trotta, Maria Napolitano, Luigi Portella, Sabrina Rossetti, Sisto Perdona, Sandro Pignata, Stefania Scala

Cancer Res (2017) 77 (13_Supplement): 580.

https://doi.org/10.1158/1538-7445.AM2017-580

Published: 01 July 2017

View articletitled, Abstract 580: Nivolumab treatment of metastatic renal cancer patients impairs Tregs and potentiates NK function: The role of CXCR4 inhibition (“REVOLUTION Trial”)

Journal Articles

Abstract 742: A novel multidrug metronomic chemotherapy significantly delays tumor growth in mice

Maria Tagliamonte, Annacarmen Petrizzo, Maria Lina Tornesello, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Maria Napolitano, Gennaro Ciliberto, Franco M. Buonaguro, Luigi Buonaguro

Cancer Res (2016) 76 (14_Supplement): 742.

https://doi.org/10.1158/1538-7445.AM2016-742

Published: 15 July 2016

View articletitled, Abstract 742: A novel multidrug metronomic chemotherapy significantly delays tumor growth in mice

Journal Articles

Abstract 426: Targeting CXCR4 reduced T regulatory cells (Tregs) -mediated cell proliferation suppression in renal cell carcinoma (RCC) patients

Sara Santagata, Maria Napolitano, Crescenzo D'Alterio, Sabrina Cecere, Renato De Domenico, Carmela Cacciapuoti, Salvatore Dimaro, Luciana Marinelli, Nicola Longo, Sandro Pignata, Sisto Perdonà, Stefania Scala

Cancer Res (2015) 75 (15_Supplement): 426.

https://doi.org/10.1158/1538-7445.AM2015-426

Published: 01 August 2015

View articletitled, Abstract 426: Targeting CXCR4 reduced T regulatory cells (Tregs) -mediated cell proliferation suppression in renal cell carcinoma (RCC) patients

Journal Articles

Abstract 1656: CXCR4 antagonist-expressing liposomes reduce lung metastases and deliver drugs to CXCR4 expressing cells: a new drug-targeting device

Caterina Ierano, Sara Lusa, Crescenzo D'Alterio, Giuseppina Salzano, Maria Napolitano, Maria Buoncervello, Massimo Spada, Daniele Macchia, Antonio Barbieri, Antonio Luciano, Lucia Gabriele, Giuseppe D. Rosa, Stefania Scala

Cancer Res (2014) 74 (19_Supplement): 1656.

https://doi.org/10.1158/1538-7445.AM2014-1656

Published: 01 October 2014

View articletitled, Abstract 1656: CXCR4 antagonist-expressing liposomes reduce lung metastases and deliver drugs to CXCR4 expressing cells: a new drug-targeting device

Journal Articles

Abstract 2393: Fc gamma receptor IIIa polymorphisms correlated with antibody-dependent cell-mediated cytotoxicity (ADCC): anti-EGFR antibodies induced and clinical outcome in metastatic colorectal cancer patients.

Anna Maria Trotta, Alessandro Ottaiano, Serena Zannotta, Maria Napolitano, Guglielmo Nasti, Rosario Vincenzo Iaffaioli, Stefania Scala

Cancer Res (2013) 73 (8_Supplement): 2393.

https://doi.org/10.1158/1538-7445.AM2013-2393

Published: 15 April 2013

View articletitled, Abstract 2393: Fc gamma receptor IIIa polymorphisms correlated with antibody-dependent cell-mediated cytotoxicity (ADCC): anti-EGFR antibodies induced and clinical outcome in metastatic colorectal cancer patients.

Journal Articles

Abstract 891: The chemokine receptor CXCR7 transduces its signal through mTOR: the role of everolimus

Caterina Ieranò, Michele Caraglia, Francesca Bernile, Elena Antignani, Maria Napolitano, Anna Riccio, Luigi Portella, Mark E. Penfold, Stefania Scala

Cancer Res (2012) 72 (8_Supplement): 891.

https://doi.org/10.1158/1538-7445.AM2012-891

Published: 15 April 2012

View articletitled, Abstract 891: The chemokine receptor CXCR7 transduces its signal through mTOR: the role of everolimus

Journal Articles

Abstract 4645: Preclinical development of RFF-1, a novel rational designed CXCL12 mimetic drug

Luigi Portella, Crescenzo D'Alterio, Marianeve Polimeno, Caterina Ieranò, Maria Napolitano, Rosa Calemma, Antonio Barbieri, Domenica Rea, Giuseppe Palma, Mariana Gala, Antonio Luciano, Stefania De Luca, Rosa Maria Vitale, Pietro Amodeo, Claudio Arra, Giuseppe Castello, Stefania Scala

Cancer Res (2012) 72 (8_Supplement): 4645.

https://doi.org/10.1158/1538-7445.AM2012-4645

Published: 15 April 2012

View articletitled, Abstract 4645: Preclinical development of RFF-1, a novel rational designed CXCL12 mimetic drug

Journal Articles

Abstract 394: Rapid and persistant neutrophil mobilization by novel CXCR4 peptide antagonists

Luigi Portella, Maria Napolitano, Anna Riccio, Crescenzo D'Alterio, Marianeve Polimeno, Rosa Calemma, Elena Antignani, Annamaria Trotta, Antonio Barbieri, Marianna Gala, Antonio Luciano, Gianpaolo Marcacci, Pietro Amodeo, Rosa Maria Vitale, Stefania De Luca, Claudio Arra, Giuseppe Castello, Stefania Scala

Cancer Res (2011) 71 (8_Supplement): 394.

https://doi.org/10.1158/1538-7445.AM2011-394

Published: 15 April 2011

View articletitled, Abstract 394: Rapid and persistant neutrophil mobilization by novel CXCR4 peptide antagonists

Journal Articles

Abstract 5211: CXCR7 is a functional receptor in renal cancer cell lines

Claudia Consales, Luigi Portella, Maria Napolitano, Mark E.T. Penfold, Maria Neve Polimeno, Michele Cioffi, Crescenzo D'Alterio, Rosa Calemma, Giuseppe Castello, Stefania Scala

Cancer Res (2010) 70 (8_Supplement): 5211.

https://doi.org/10.1158/1538-7445.AM10-5211

Published: 15 April 2010

View articletitled, Abstract 5211: CXCR7 is a functional receptor in renal cancer cell lines

Journal Articles

Abstract 2270: Design, synthesis, and functional characterization of new cycle-peptides inhibitors for C-X-C chemokine receptor-4 (CXCR4)

Stefania Scala, Luigi Portella, Maria Napolitano, Claudia Consales, Maria Neve Polimeno, Crescenzo D'Alterio, Giuseppe Palma, Claudio Arra, Rosamaria Vitale, Pietro Amodeo, Stefania De Luca, Luca Monfrecola, Giuseppe Castello

Cancer Res (2010) 70 (8_Supplement): 2270.

https://doi.org/10.1158/1538-7445.AM10-2270

Published: 15 April 2010

View articletitled, Abstract 2270: Design, synthesis, and functional characterization of new cycle-peptides inhibitors for C-X-C chemokine receptor-4 (CXCR4)

Journal Articles

The combination of gefitinib and trastuzumab affects cell cycle distribution and expression of cell cycle regulatory proteins in breast cancer cells

Amelia D'Alessio, Antonella De Luca, Monica Maiello, Adele Carotenuto, Anna Maria Rachiglio, Marianna Gallo, Maria Napolitano, Nicola Normanno

Cancer Res (2007) 67 (9_Supplement): 648.

Published: 01 May 2007

View articletitled, The combination of gefitinib and trastuzumab affects cell cycle distribution and expression of cell cycle regulatory proteins in breast cancer cells

Journal Articles

Melanoma associated fibroblasts promote melanoma invasiveness: Possible cross talk between CXCR4 and VEGF receptor

Paola Giuliano, Jr., Caterina Ieranò, Paolo Antonio Ascierto, Maria Napolitano, Marisa Lombardi, Monica Liguori, Rosa Calemma, Ester Simeone, Francesca Mauro, Luigi Aloj, Alessandro Ottaiano, Giuseppe Castello, Stefania Scala, Sr.

Cancer Res (2006) 66 (8_Supplement): 42.

Published: 15 April 2006

View articletitled, Melanoma associated fibroblasts promote melanoma invasiveness: Possible cross talk between CXCR4 and VEGF receptor

Journal Articles

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

Monica R. Maiello, Antonella De Luca, Adele Carotenuto, Manuela Campiglio, Maria Napolitano, Amelia D’Alessio, Sylvie Menard, Nicola Normanno

Cancer Res (2006) 66 (8_Supplement): 1115.

Published: 15 April 2006

View articletitled, The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

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Abstract 6815: CXCL12-loaded-hydrogel (CLG) in vivo modifies lung metastatic niche toward an immunoactive microenvironment reducing lung metastasis development

Abstract 2463: Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

Abstract 7655: The CXCR4/CXCR7/CXCL12 axis and PBRM1 are involved in everolimus resistance in human renal cancer cell lines

Abstract 2550: Tumor microenvironment (TME) is more suppressive in hepatocellular carcinoma (HCC) than in colorectal cancer liver metastasis (CRLM): CXCR4 antagonism as strategy to revert T regulatory cells (Tregs) suppressive activity

Abstract 6675: Basal NK activity and early Tregs inhibition predicts nivolumab responsiveness in metastatic renal cancer patients (REVOLUTION) trial

Abstract 4103: Blockade of intrinsic PD-1 promotes human colon cancer cells survival, chemo resistance and in vivo tumor growth of human colon cancer cells

Abstract 5194: In vivo capture of early metastatic cells through a CXCL12 loaded-dermal filler

Abstract 580: Nivolumab treatment of metastatic renal cancer patients impairs Tregs and potentiates NK function: The role of CXCR4 inhibition (“REVOLUTION Trial”)

Abstract 742: A novel multidrug metronomic chemotherapy significantly delays tumor growth in mice

Abstract 426: Targeting CXCR4 reduced T regulatory cells (Tregs) -mediated cell proliferation suppression in renal cell carcinoma (RCC) patients

Abstract 1656: CXCR4 antagonist-expressing liposomes reduce lung metastases and deliver drugs to CXCR4 expressing cells: a new drug-targeting device

Abstract 2393: Fc gamma receptor IIIa polymorphisms correlated with antibody-dependent cell-mediated cytotoxicity (ADCC): anti-EGFR antibodies induced and clinical outcome in metastatic colorectal cancer patients.

Abstract 891: The chemokine receptor CXCR7 transduces its signal through mTOR: the role of everolimus

Abstract 4645: Preclinical development of RFF-1, a novel rational designed CXCL12 mimetic drug

Abstract 394: Rapid and persistant neutrophil mobilization by novel CXCR4 peptide antagonists

Abstract 5211: CXCR7 is a functional receptor in renal cancer cell lines

Abstract 2270: Design, synthesis, and functional characterization of new cycle-peptides inhibitors for C-X-C chemokine receptor-4 (CXCR4)

The combination of gefitinib and trastuzumab affects cell cycle distribution and expression of cell cycle regulatory proteins in breast cancer cells

Melanoma associated fibroblasts promote melanoma invasiveness: Possible cross talk between CXCR4 and VEGF receptor

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

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