1-13 of 13
Margaret C. Frame
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Carolin Temps, Daniel Lietha, Emily R. Webb, Xue-Feng Li, John C. Dawson, Morwenna Muir, Kenneth G. Macleod, Teresa Valero, Alison F. Munro, Rafael Contreras-Montoya, Juan R. Luque-Ortega, Craig Fraser, Henry Beetham, Christina Schoenherr, Maria Lopalco, Mark J. Arends, Margaret C. Frame, Bin-Zhi Qian, Valerie G. Brunton, Neil O. Carragher, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5438–5450.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0613
Published: 01 November 2021
View article
PDF
Includes: Supplementary data
Journal Articles

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

Marta Canel, Adam Byron, Andrew H. Sims, Jessy Cartier, Hitesh Patel, Margaret C. Frame, Valerie G. Brunton, Bryan Serrels, Alan Serrels
Journal: Cancer Research
Cancer Res (2017) 77 (19): 5301–5312.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-0418
Published: 01 October 2017
View article
PDF
Includes: Supplementary data
Journal Articles

Abstract PR13: The canonical Wnt pathway participates in anchorage-independent growth in a subset of heterogeneous tumor cells derived from a single murine pancreatic tumor

Man Yeung Heung, Bryan Serrels, Jennifer P. Morton, Owen J. Sansom, Valerie Brunton, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR13.
DOI: https://doi.org/10.1158/1538-7445.FBCR11-PR13
Published: 28 October 2014
View article
Journal Articles

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Max Nobis, Ewan J. McGhee, Jennifer P. Morton, Juliane P. Schwarz, Saadia A. Karim, Jean Quinn, Mike Edward, Andrew D. Campbell, Lynn C. McGarry, T.R. Jeffry Evans, Valerie G. Brunton, Margaret C. Frame, Neil O. Carragher, Yingxiao Wang, Owen J. Sansom, Paul Timpson, Kurt I. Anderson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (15): 4674–4686.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-4545
Published: 31 July 2013
View article
PDF
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 4307: The effect of ablating ADF/cofilin pathway during skin homeostasis and tumorigenesis

Jing Zhou, Hitesh Patel, Valerie G. Brunton, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4307.
DOI: https://doi.org/10.1158/1538-7445.AM2012-4307
Published: 15 April 2012
View article
Journal Articles

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Paul Timpson, Ewan J. McGhee, Jennifer P. Morton, Alex von Kriegsheim, Juliane P. Schwarz, Saadia A. Karim, Brendan Doyle, Jean A. Quinn, Neil O. Carragher, Mike Edward, Michael F. Olson, Margaret C. Frame, Valerie G. Brunton, Owen J. Sansom, Kurt I. Anderson
Journal: Cancer Research
Cancer Res (2011) 71 (3): 747–757.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-2267
Published: 01 February 2011
View article
PDF
Includes: Multimedia, Supplementary data
Journal Articles

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Marta Canel, Alan Serrels, Derek Miller, Paul Timpson, Bryan Serrels, Margaret C. Frame, Valerie G. Brunton
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9413–9422.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-1454
Published: 14 November 2010
View article
PDF
Includes: Multimedia, Supplementary data
Journal Articles

Real-time Study of E-Cadherin and Membrane Dynamics in Living Animals: Implications for Disease Modeling and Drug Development

Alan Serrels, Paul Timpson, Marta Canel, Juliane P. Schwarz, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, Kurt I. Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (7): 2714–2719.
DOI: https://doi.org/10.1158/0008-5472.CAN-08-4308
Published: 01 April 2009
View article
PDF
Includes: Multimedia, Supplementary data
Journal Articles

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4–Regulated Compartment via Effects on Phosphoinositide 3-Kinase

David G. McEwan, Valerie G. Brunton, George S. Baillie, Nicholas R. Leslie, Miles D. Houslay, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2007) 67 (11): 5248–5257.
DOI: https://doi.org/10.1158/0008-5472.CAN-07-0097
Published: 01 June 2007
View article
PDF
Journal Articles

Suppression of tumour formation and malignant conversion in a mouse model of skin carcinogenesis by the dual Src/Bcr-Abl tyrosine kinase inhibitor AZD0530

Bryan Serrels, Tim Green, Margaret C. Frame, Valerie G. Brunton
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 888.
Published: 15 April 2006
View article
Journal Articles

Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Valerie G. Brunton, Egle Avizienyte, Valerie J. Fincham, Bryan Serrels, Chester A. Metcalf, III, Tomi K. Sawyer, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1335–1342.
DOI: https://doi.org/10.1158/0008-5472.CAN-04-1949
Published: 25 February 2005
View article
PDF
Includes: Multimedia, Supplementary data
Journal Articles

Role of Src and FAK tyrosine kinase signalling in the progression of colon cancer

Valerie G. Brunton, Egle Avizienyte, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1136.
Published: 01 April 2004
View article
Journal Articles

Decreased Focal Adhesion Kinase Suppresses Papilloma Formation during Experimental Mouse Skin Carcinogenesis

Gordon W. McLean, Ken Brown, Margaret I. Arbuckle, Anne W. Wyke, Timo Pikkarainen, Erkki Ruoslahti, Margaret C. Frame
Journal: Cancer Research
Cancer Res (2001) 61 (23): 8385–8389.
Published: 01 December 2001
View article
PDF