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Marcus M. Fischer
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Journal Articles

Abstract 1637: MAT2A inhibition in MTAP-/- tumors confers mechanistic vulnerabilities to multiple clinically actionable synthetic lethal drug combinations

Kimberline Y. Gerrick, Jenny Laraio, Kelsey Annen, Hoang Tran, Marcus M. Fischer, Yevgeniy Freyman, Geeta Sharma, Isaac Bishof, Stephen Federowicz, Divya Pankajakshan, Claire L. Neilan, Biju Mangatt, Anthony Mazurek, Mark R. Lackner, Michael White, Zineb Mounir
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1637.
https://doi.org/10.1158/1538-7445.AM2023-1637
Published: 04 April 2023
View article titled, Abstract 1637: MAT2A inhibition in <em>MTAP-/-</em> tumors confers mechanistic vulnerabilities to multiple clinically actionable synthetic lethal drug combinations
Journal Articles

Abstract 1644: Dual inhibition of MAT2A and PRMT5 delivers synergistic anti-tumor responses in preclinical models of MTAP-deleted cancer

Marcus M. Fischer, Kimberline Gerrick, Brian Belmontes, Katherine Slemmons, Yevgeniy Freyman, Jay Jain, Steve Federowicz, Isaac Bishof, Arjun A. Rao, Melissa Fleury, Zineb Mounir, Mark R. Lackner, Paul E. Hughes, Mike White, Claire L. Neilan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1644.
https://doi.org/10.1158/1538-7445.AM2023-1644
Published: 04 April 2023
View article titled, Abstract 1644: Dual inhibition of MAT2A and PRMT5 delivers synergistic anti-tumor responses in preclinical models of <em>MTAP</em>-deleted cancer
Journal Articles

Abstract 1278: MAT2A inhibitor, IDE397, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts

Marcus M. Fischer, Neil Bhola, John Faulhaber, Yevgeniy Freyman, Bing Yao, Zineb Mounir, Mark R. Lackner, Claire Neilan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1278.
https://doi.org/10.1158/1538-7445.AM2021-1278
Published: 01 July 2021
View article titled, Abstract 1278: MAT2A inhibitor, IDE397, displays broad anti-tumor activity across a panel of <em>MTAP</em>-deleted patient-derived xenografts
Journal Articles

Abstract 1911: R-SPONDIN3 antagonism sensitizes colorectal cancer to taxane treatment

Marcus M. Fischer, V. Pete Yeung, Fiore Cattaruzza, Christopher Murriel, James W. Evans, Gilbert O'Young, Alayne Brunner, Min Wang, Belinda Cancilla, Ann Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1911.
https://doi.org/10.1158/1538-7445.AM2017-1911
Published: 01 July 2017
View article titled, Abstract 1911: R-SPONDIN3 antagonism sensitizes colorectal cancer to taxane treatment
Journal Articles

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M. Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M. Kapoun, John Lewicki, Timothy Hoey, Austin Gurney
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (3): 713–723.
https://doi.org/10.1158/0008-5472.CAN-15-0561
Published: 31 January 2016
View article titled, Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Open the PDF for Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types in another window
Includes: Supplementary data
Journal Articles

Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models

Marcus M. Fischer, Wan-Ching Yen, Chun Zheng, Randall Henner, Fiore Cattaruzza, Tracy Tang, Pete Yeung, Tanuka Biswas, John Lewicki, Austin Gurney, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4233.
https://doi.org/10.1158/1538-7445.AM2015-4233
Published: 01 August 2015
View article titled, Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models
Journal Articles

Abstract 3048: OMP-59R5 (Anti-Notch2/3) inhibits tumor growth and reduces cancer stem cell frequency in patient derived SCLC xenografts

Marcus M. Fischer, Jalpa Shah, Jennifer Cain, Belinda Cancilla, James W. Evans, Christopher L. Murriel, Tracy Tang, Jie Wei, Wan-Ching Yen, Chun Zhang, Austin Gurney, John Lewicki, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3048.
https://doi.org/10.1158/1538-7445.AM2014-3048
Published: 01 October 2014
View article titled, Abstract 3048: OMP-59R5 (Anti-Notch2/3) inhibits tumor growth and reduces cancer stem cell frequency in patient derived SCLC xenografts
Journal Articles

Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models

Pete Yeung, Lucia Beviglia, Belinda Cancilla, Cristina Dee-Hoskins, James W. Evans, Marcus M. Fischer, Wan-Ching Yen, Austin Gurney, John Lewicki, Timothy Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1907.
https://doi.org/10.1158/1538-7445.AM2014-1907
Published: 01 October 2014
View article titled, Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models
Journal Articles

Abstract 4547: Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes

Wan-Ching Yen, Marcus M. Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4547.
https://doi.org/10.1158/1538-7445.AM2014-4547
Published: 01 October 2014
View article titled, Abstract 4547: Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes
Journal Articles

Abstract 910: NOTCH3 expression is predictive of efficacy in pancreas tumor models treated with OMP-59R5, a monoclonal antibody targeting the NOTCH2 and NOTCH3 receptors

Belinda Cancilla, Wan-Ching Yen, Chun Zhang, Marcus M. Fischer, May Ji, Tracy Tang, Yu-Wang Liu, Raymond S. Tam, Min Wang, Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 910.
https://doi.org/10.1158/1538-7445.AM2014-910
Published: 01 October 2014
View article titled, Abstract 910: NOTCH3 expression is predictive of efficacy in pancreas tumor models treated with OMP-59R5, a monoclonal antibody targeting the NOTCH2 and NOTCH3 receptors
Journal Articles

Abstract 3725: Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.

Wan-Ching Yen, Marcus M. Fischer, Jalpa Shah, Jie Wei, Jennifer Cain, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Ann Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3725.
https://doi.org/10.1158/1538-7445.AM2013-3725
Published: 15 April 2013
View article titled, Abstract 3725: Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.
Journal Articles

Abstract 1014: Targeting cancer stem cells by a Notch2/Notch3 cross-reactive antibody inhibits tumor growth and delays tumor recurrence in pancreatic cancer

Marcus M. Fischer, Wan-Ching Yen, Min Wang, Ann M. Kapoun, Aaron Sato, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1014.
https://doi.org/10.1158/1538-7445.AM2012-1014
Published: 15 April 2012
View article titled, Abstract 1014: Targeting cancer stem cells by a Notch2/Notch3 cross-reactive antibody inhibits tumor growth and delays tumor recurrence in pancreatic cancer