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Marcia C. Haigis
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Journal Articles

Abstract 3169: Dependency-agnostic drug discovery: A dual-screening strategy to uncover novel cancer vulnerabilities

Free
Olasunkanmi Olaoye, Colleen Harrington, Kenneth N. Ross, Allen T. Basanthakumar, Jamie O. Brett, Shakchhi Joshi, Jonathan H. Shrimp, Min Shen, Lucy Merickel, Audrey Taillon, Silvi Salhotra, Bo Kyung A. Seong, Ji Seul Han, Yara R. Zabala, Ashleigh Meyer, Qi Liu, Luc de Waal, Jun Qi, Matthew D. Hall, Marcia C. Haigis, Jennifer Roth, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3169.
https://doi.org/10.1158/1538-7445.AM2025-3169
Published: 21 April 2025
View articletitled, Abstract 3169: Dependency-agnostic drug discovery: A dual-screening strategy to uncover novel cancer vulnerabilities
Journal Articles

Abstract 4449: SIRT5 promotes chemoresistance through metabolic rewiring for nucleotide replenishing in refractory triple negative breast cancer

Free
Zuen Ren, Kiran Kurmi, Tiziano Bernasocchi, Eric Zaniewski, Shakchhi Joshi, Garrett Lam, Chenxu (Vincent) Guo, Ilze Smidt, Preshita Dave, Agustina Maccio, Johannes Kreuzer, Gabrielle Elena Gioia, Veerle I. Bossuyt, Brian N. Dontchos, Gary X. Wang, Shinn-Huey S. Chou, Michael Lawrence, Esther Rheinbay, Laura M. Spring, Wilhelm Haas, Raul Mostoslavsky, Marcia C. Haigis, Leif W. Ellisen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4449.
https://doi.org/10.1158/1538-7445.AM2025-4449
Published: 21 April 2025
View articletitled, Abstract 4449: SIRT5 promotes chemoresistance through metabolic rewiring for nucleotide replenishing in refractory triple negative breast cancer
Journal Articles

Abstract 4425: Metabolic vulnerabilities of dedifferentiated liposarcoma

Free
Jamie O. Brett, Ji Seul Han, Choah Kim, Liam P. Kelley, SeongJun Han, Dylan Boone, Joseph Crowley, Shakchhi Joshi, Chandrajit P. Raut, Anna Greka, Marcia C. Haigis
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4425.
https://doi.org/10.1158/1538-7445.AM2024-4425
Published: 22 March 2024
View articletitled, Abstract 4425: Metabolic vulnerabilities of dedifferentiated liposarcoma
Journal Articles

Abstract 5850: Multiomics analysis unravels tumor metabolic reprogramming and potential resistance mechanism(s) to curative therapy in TNBC

Free
Zuen Ren, Kiran Kurmi, Robert Morris, Shakchhi Joshi, Eric Zaniewski, Johannes Kreuzer, Gabrielle Elena Gioia, Veerle I. Bossuyt, Brian N. Dontchos, Gary X. Wang, Shinn-Huey S. Chou, Laura M. Spring, Wilhelm Haas, Marcia C. Haigis, Leif W. Ellisen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5850.
https://doi.org/10.1158/1538-7445.AM2024-5850
Published: 22 March 2024
View articletitled, Abstract 5850: Multiomics analysis unravels tumor metabolic reprogramming and potential resistance mechanism(s) to curative therapy in TNBC
Journal Articles

Abstract 6592: Deciphering the effects of age on T cell immunity and immunotherapy

Free
SeongJun Han, Peter Georgiev, Jaime Schneider, Amy Huang, Zhanel Nugmanova, Thao H. Nguyen, Conghui Yao, Sheila Johnson, Shakchhi Joshi, Ishita Dhiman, Jefte M. Drijvers, Megan Fung, Jared H. Rowe, Brian C. Miller, Gordon J. Freeman, Alison E. Ringel, Marcia C. Haigis, Arlene H. Sharpe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6592.
https://doi.org/10.1158/1538-7445.AM2024-6592
Published: 22 March 2024
View articletitled, Abstract 6592: Deciphering the effects of age on T cell immunity and immunotherapy
Journal Articles

Abstract 3680: Multiomics analysis of triple negative breast cancer identifies potential metabolic vulnerability for overcoming the resistance of neoadjuvant therapy

Free
Zuen Ren, Kiran Kurmi, Robert Morris, Shakchhi Joshi, Eric Zaniewski, Johannes Kreuzer, Gabrielle Elena Gioia, Wilhelm Haas, Marcia C. Haigis, Leif W. Ellisen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3680.
https://doi.org/10.1158/1538-7445.AM2023-3680
Published: 04 April 2023
View articletitled, Abstract 3680: Multiomics analysis of triple negative breast cancer identifies potential metabolic vulnerability for overcoming the resistance of neoadjuvant therapy
Journal Articles

Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma

Available to Purchase
Elizabeth C. Randall, Begoña G.C. Lopez, Sen Peng, Michael S. Regan, Walid M. Abdelmoula, Sankha S. Basu, Sandro Santagata, Haejin Yoon, Marcia C. Haigis, Jeffrey N. Agar, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y.R. Agar
Journal: Cancer Research
Cancer Res (2020) 80 (6): 1258–1267.
https://doi.org/10.1158/0008-5472.CAN-19-0638
Published: 13 March 2020
View articletitled, Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma
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Includes: Supplementary data
Journal Articles

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

Free
Marcia C. Haigis, Chu-Xia Deng, Lydia W.S. Finley, Hyun-Seok Kim, David Gius
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2468–2472.
https://doi.org/10.1158/0008-5472.CAN-11-3633
Published: 14 May 2012
View articletitled, SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis
Open the PDF for SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis in another window