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Journal Articles

Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Cancer Res (2024) 84 (6_Supplement): 1646.

https://doi.org/10.1158/1538-7445.AM2024-1646

Published: 22 March 2024

View article titled, Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Journal Articles

Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Matthew Tcheng, Marcela Gronda, Rose Hurren, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Mark D. Minden, Aaron D. Schimmer

Cancer Res (2024) 84 (6_Supplement): 5898.

https://doi.org/10.1158/1538-7445.AM2024-5898

Published: 22 March 2024

View article titled, Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Journal Articles

Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D. Brown, Brian Raught, Andrea Arruda, Hong Chang, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadavecchio, Aaron D. Schimmer

Cancer Res (2023) 83 (7_Supplement): 333.

https://doi.org/10.1158/1538-7445.AM2023-333

Published: 04 April 2023

View article titled, Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Journal Articles

Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness

Cancer Res (2021) 81 (13_Supplement): 3099.

https://doi.org/10.1158/1538-7445.AM2021-3099

Published: 01 July 2021

View article titled, Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness

Journal Articles

Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2

Aaron D. Botham, Etienne Coyaud, Sanjit Nirmalanandhan, Marcela Gronda, Rose Hurren, Neil Maclean, Jonathan St. Germain, Sara Mirali, Estelle Laurent, Brian Raught, Aaron Schimmer

Cancer Res (2019) 79 (13_Supplement): 4529.

https://doi.org/10.1158/1538-7445.AM2019-4529

Published: 01 July 2019

View article titled, Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2

Journal Articles

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Cancer Res (2019) 79 (13_Supplement): 2720.

https://doi.org/10.1158/1538-7445.AM2019-2720

Published: 01 July 2019

View article titled, Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Journal Articles

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer

Cancer Res (2019) 79 (13_Supplement): 3003.

https://doi.org/10.1158/1538-7445.AM2019-3003

Published: 01 July 2019

View article titled, Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Journal Articles

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Cancer Res (2015) 75 (12): 2478–2488.

https://doi.org/10.1158/0008-5472.CAN-14-2676

Published: 14 June 2015

View article titled, Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Includes: Supplementary data

Journal Articles

Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death

Shrivani Sriskanthadevan, Marko Skrtic, Bozhena Jhas, Yulia Jitkova, Rose Hurren, Marcela Gronda, Xiaoming Wang, Mahadeo A. Sukhai, Mark Minden, Aaron Schimmer

Cancer Res (2012) 72 (8_Supplement): 1123.

https://doi.org/10.1158/1538-7445.AM2012-1123

Published: 15 April 2012

View article titled, Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death

Journal Articles

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Cancer Res (2011) 71 (24): 7628–7639.

https://doi.org/10.1158/0008-5472.CAN-11-2745

Published: 15 December 2011

View article titled, Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Includes: Supplementary data

Journal Articles

Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells

Reza Beheshti Zavareh, Rose Hurren, Marcela Gronda, Mahadeo A. Sukhai, Craig D. Simpson, Xiaoming Wang, Neil A. MacLean, Troy Ketela, Jason Moffat, David R. Rose, Harry Schachter, James W. Dennis, Aaron D. Schimmer

Cancer Res (2011) 71 (8_Supplement): 1484.

https://doi.org/10.1158/1538-7445.AM2011-1484

Published: 15 April 2011

View article titled, Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells

Journal Articles

Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Marko Skrtic, Paul Spagnuolo, Xiaoming Wang, Marcela Gronda, Rose Hurren, Craig D. Simpson, Sonali Fonseca, Alessandro Datti, Jean C Y Wang, John E. Dick, Jeffrey L. Wrana, Shana O. Kelley, Aaron D. Schimmer

Cancer Res (2010) 70 (8_Supplement): 4538.

https://doi.org/10.1158/1538-7445.AM10-4538

Published: 15 April 2010

View article titled, Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Journal Articles

Abstract 2529: The anti-malarial agent Mefloquine preferentially demonstrates pre-clinical activity in leukemia and myeloma cells through STAT1-induced reactive oxygen species production

Mahadeo A. Sukhai, Xiaoming Li, Xiaoming Wang, Rose Hurren, Marcela Gronda, Joyce Sun, Sue Chow, Rod Bremner, David Hedley, Aaron D. Schimmer

Cancer Res (2010) 70 (8_Supplement): 2529.

https://doi.org/10.1158/1538-7445.AM10-2529

Published: 15 April 2010

View article titled, Abstract 2529: The anti-malarial agent Mefloquine preferentially demonstrates pre-clinical activity in leukemia and myeloma cells through STAT1-induced reactive oxygen species production

Journal Articles

Abstract #5372: Chemical inhibition of the E1 ligase induces endoplasmic reticulum stress and displays preclinical activity in hematologic malignancies

G. Xu, Tabitha Wood, Mohsin Ali, Derek Wong, Rose Hurren, Marcela Gronda, Neil MacLean, Marko Skrtic, Xiaoming Wang, Xinliang Mao, Xiaoming Li, Meenakshi Venkatesan, Reza Zavareh, Troy Ketela, David Rose, Jason Moffatt, Robert Batey, Sirhano Dhe-Paganon, Aaron Schimmer

Cancer Res (2009) 69 (9_Supplement): 5372.

Published: 01 May 2009

View article titled, Abstract #5372: Chemical inhibition of the E1 ligase induces endoplasmic reticulum stress and displays preclinical activity in hematologic malignancies

Journal Articles

Abstract #1950: Inhibition of the Na⁺/K⁺ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Craig Simpson, Imtiaz Mawji, Kika Anyiwe, Moyo Williams, Xiaoming Wang, Amudha Venugopal, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey Wrana, Shereen Ezzat, Aaron Schimmer

Cancer Res (2009) 69 (9_Supplement): 1950.

Published: 01 May 2009

View article titled, Abstract #1950: Inhibition of the Na+/K+ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Journal Articles

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Craig D. Simpson, Imtiaz A. Mawji, Kika Anyiwe, Moyo A. Williams, Xiaoming Wang, Amudha L. Venugopal, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey L. Wrana, Shereen Ezzat, Aaron D. Schimmer

Cancer Res (2009) 69 (7): 2739–2747.

https://doi.org/10.1158/0008-5472.CAN-08-2530

Published: 01 April 2009

View article titled, Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Includes: Supplementary data

Journal Articles

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Cancer Res (2008) 68 (16): 6688–6697.

https://doi.org/10.1158/0008-5472.CAN-07-6833

Published: 12 August 2008

View article titled, Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Journal Articles

A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

Imtiaz A. Mawji, Craig D. Simpson, Marcela Gronda, Moyo A. Williams, Rose Hurren, Clare J. Henderson, Alessandro Datti, Jeffrey L. Wrana, Aaron D. Schimmer

Cancer Res (2007) 67 (17): 8307–8315.

https://doi.org/10.1158/0008-5472.CAN-07-1687

Published: 05 September 2007

View article titled, A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

Journal Articles

A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

Reza Beheshti Zavareh, Rose Hurren, Alessandro Datti, Marcela Gronda, Pam Cheung, Ken Lau, Amanda Wasylishen, Hui Shi, David Ashline, Vern Reinhold, David Rose, Harry Schachter, James Dennis, Aaron Schimmer

Cancer Res (2007) 67 (9_Supplement): 1413.

Published: 01 May 2007

View article titled, A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

Journal Articles

Inhibition of FLIP sensitizes resistant cells to anoikis and decreases their metastatic potential.

Craig Simpson, Imtiaz Mawji, Rose Hurren, Marcela Gronda, Moyo Williams, Jorge Filmus, James Jonkman, Ralph Da Costa, Brian Wilson, Michael Thomas, John Reed, Gennadi Glinsky, Aaron Schimmer

Cancer Res (2007) 67 (9_Supplement): 1603.

Published: 01 May 2007

View article titled, Inhibition of FLIP sensitizes resistant cells to anoikis and decreases their metastatic potential.

NARROW

Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness

Abstract 4529: Mapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells

Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Abstract 2529: The anti-malarial agent Mefloquine preferentially demonstrates pre-clinical activity in leukemia and myeloma cells through STAT1-induced reactive oxygen species production

Abstract #5372: Chemical inhibition of the E1 ligase induces endoplasmic reticulum stress and displays preclinical activity in hematologic malignancies

Abstract #1950: Inhibition of the Na⁺/K⁺ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

Inhibition of FLIP sensitizes resistant cells to anoikis and decreases their metastatic potential.

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