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Marc Hummersone
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Journal Articles

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Sylvie M. Guichard, Zoe Howard, Dan Heathcote, Mark Roth, Gareth Hughes, Jon Curwen, James Yates, Armelle Logie, Sarah Holt, Christine M. Chresta, Barry R. Davies, Karine Malagu, Marc Hummersone, Sarah L. Pass, Stephen Green, Martin Pass
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 917.
DOI: https://doi.org/10.1158/1538-7445.AM2012-917
Published: 15 April 2012
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Journal Articles

Abstract 5780: Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)

Celine Cano, Chris Bailey, Julia Bardos, Nicola Curtin, Mark Frigerio, Bernard Golding, Ian Hardcastle, Marc Hummersone, Keith Menear, David Newell, Kappusamy Saravanan, K Shea, Graeme Smith, Roger Griffin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5780.
DOI: https://doi.org/10.1158/1538-7445.AM10-5780
Published: 15 April 2010
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Journal Articles

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

Christine M. Chresta, Barry R. Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E. Critchlow, John P. Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini, Dominic James, Zoe Howard, Phillippa Dudley, Gareth Hughes, Lisa Smith, Sharon Maguire, Marc Hummersone, Karine Malagu, Keith Menear, Richard Jenkins, Matt Jacobsen, Graeme C.M. Smith, Sylvie Guichard, Martin Pass
Journal: Cancer Research
Cancer Res (2010) 70 (1): 288–298.
DOI: https://doi.org/10.1158/0008-5472.CAN-09-1751
Published: 04 January 2010
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Includes: Supplementary data
Journal Articles

Abstract #4770: Characterization of AZD8055, a potent selective inhibitor of mTORC1 and mTORC2 kinase

Christine Chresta, Barry Davies, Tom Harding, Ian Hickson, Sabina Cosulich, Susan Critchlow, Patrizia Sini, Dominic James, Karine Malagu, Marc Hummersone, Graeme Smith, Martin Pass, Sylvie Guichard
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4770.
Published: 01 May 2009
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Journal Articles

Potent in vitro and in vivo radiosensitisation by the selective DNA-dependent protein kinase inhibitor KU-0060648

Mark Albertella, Andrew Slade, Kerry Shea, Julia Bardos, Caroline Richardson, Michael Batey, Marc Hummersone, Laurent Rigoreau, Yan Zhao, Helen Jenkins, Roger Griffin, Keith Menear, David Newell, Nicola Curtin, Graeme Smith
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 406.
Published: 01 May 2008
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Journal Articles

Characterisation of a novel and highly selective kinase inhibitor of the mammalian target of rapamycin (mTOR)

Ian Hickson, Lisa Smith, Sharon Maguire, Heather Duggan, Karine Malagu, Marc Hummersone, Keith Menear, Christine Chresta, Barry Davies, Martin Pass, Niall Martin, Graeme Smith
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1422.
Published: 01 May 2008
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Journal Articles

Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach

Kappusamy Saravanan, Mark Albertella, Celine Cano, Nicola Curtin, Mark Frigerio, Bernard Golding, Karen Haggerty, Ian Hardcastle, Marc Hummersone, Keith Menear, David Newell, Tommy Rennison, Caroline Richardson, Laurent Rigoreau, Sonsoles Rodriguez-Aristegui, Graeme Smith, Roger Griffin
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4156.
Published: 01 May 2008
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Journal Articles

Cellular differentiation of rapamycin, PI3 kinase and TOR kinase inhibitors

Christine Chresta, Sam Butterworth, Sabina Cosulich, Nicola Curtis, Sara Davenport, Barry Davies, Rebecca Ellston, Tom Harding, Eric Newboult, Donald Ogilvie, Paul Smith, Martin Pass, Ian Hickson, Karine Malagu, Marc Hummersone, Kurt Pike, Lisa Drew, Lihua Yu, David Brandon
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3564.
Published: 01 May 2008
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Journal Articles

Identification and in vitro characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Ian Hickson, Yan Zhao, Xiaoling Cockcroft, Nicola J. Curtin, Sharon J. Green, Marc Hummersone, Niall Martin, Ian Matthews, Keith Menear, Alisdair I. Orr, Caroline J. Richardson, Laurent Rigoreau, Graeme C. Smith
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1236.
Published: 01 April 2004
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