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Manikandan Periyasamy
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Journal Articles

Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer

Carolina Gemma, Chun-Fui Lai, Anup K. Singh, Antonino Belfiore, Neil Portman, Heloisa Z. Milioli, Manikandan Periyasamy, Sara Raafat, Alyssa J. Nicholls, Claire M. Davies, Naina R. Patel, Georgia M. Simmons, Hailing Fan, Van T.M. Nguyen, Luca Magnani, Emad Rakha, Lesley-Ann Martin, Elgene Lim, R. Charles Coombes, Giancarlo Pruneri, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4283–4297.
https://doi.org/10.1158/0008-5472.CAN-24-0013
Published: 16 December 2024
View article titled, Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer
Open the PDF for Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

Koen D. Flach, Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C. Siefert, Theresa E. Hickey, Mark Opdam, Hetal Patel, Sander Canisius, David M. Wilson, III, Maria Donaldson Collier, Stefan Prekovic, Marja Nieuwland, Roelof J.C. Kluin, Alexey V. Zakharov, Jelle Wesseling, Lodewyk F.A. Wessels, Sabine C. Linn, Wayne D. Tilley, Anton Simeonov, Simak Ali, Wilbert Zwart
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1914–1926.
https://doi.org/10.1158/0008-5472.CAN-19-2207
Published: 15 May 2020
View article titled, Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer
Open the PDF for Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2428: The cytidine deaminase APOBEC3B is a regulator of gene expression in breast cancer

Manikandan Periyasamy
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2428.
https://doi.org/10.1158/1538-7445.AM2017-2428
Published: 01 July 2017
View article titled, Abstract 2428: The cytidine deaminase APOBEC3B is a regulator of gene expression in breast cancer
Journal Articles

Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.

Hetal Patel, Silvia Ottaviani, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B Kroll, Sean Delaney, Zahida Zahoor, Matthew J. Fuchter, Anthony G.M Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 694.
https://doi.org/10.1158/1538-7445.AM2013-694
Published: 15 April 2013
View article titled, Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.
Journal Articles

Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.

Silvia Ottaviani, Sean Delaney, Hetal Patel, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B. Kroll, Matthew J. Fuchter, Anthony G.M. Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 700.
https://doi.org/10.1158/1538-7445.AM2013-700
Published: 15 April 2013
View article titled, Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.
Journal Articles

The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Simak Ali, Dean A. Heathcote, Sebastian H.B. Kroll, Ashutosh S. Jogalekar, Bodo Scheiper, Hetal Patel, Jan Brackow, Alekasandra Siwicka, Matthew J. Fuchter, Manikandan Periyasamy, Robert S. Tolhurst, Seshu K. Kanneganti, James P. Snyder, Dennis C. Liotta, Eric O. Aboagye, Anthony G.M. Barrett, R. Charles Coombes
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6208–6215.
https://doi.org/10.1158/0008-5472.CAN-09-0301
Published: 29 July 2009
View article titled, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Open the PDF for The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

Abstract #5172: Investigation of the regulation of DNA methylation by the estrogen receptor

Manikandan Periyasamy, Ross Thomas, Rob Tolhurst, Anna Maria Ochocka, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5172.
Published: 01 May 2009
View article titled, Abstract #5172: <em>Investigation of the regulation of DNA methylation by the estrogen receptor</em>
Journal Articles

Abstract #3311: The development of a selective CDK7 inhibitor with anti-tumor activity

Raoul Coombes, cheiper, Ashutosh S. Jogalekar, Jan Brackow Simak Ali, Dean Heathcote, Sebastian Kroll, Bodo S, Aleksandra Siwicka, Manikandan Periyasamy, Robert Tolhurst, Seshu Kanneganti, James Snyder, Dennis Liotta, Eric Aboagye, Anthony Barrett
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3311.
Published: 01 May 2009
View article titled, Abstract #3311: The development of a selective CDK7 inhibitor with anti-tumor activity
Journal Articles

Comparison of MCF-7 derived cell lines adapted to growth in low estrogen environments through transient over-expression of the estrogen receptor

Laki Buluwela, Robert Tolhurst, Paul Thiruchelvam, Andrew Photiou, Manikandan Periyasamy, Marwa Al-sabbagh, Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3041.
Published: 01 May 2008
View article titled, Comparison of MCF-7 derived cell lines adapted to growth in low estrogen environments through transient over-expression of the estrogen receptor
Journal Articles

Identification of new androgen-regulated genes in prostate cancer cells using microarray analysis combined with high-throughput real-time RT-PCR

Sarah Ngan, Danish Mazhar, Andrew Photiou, Manikandan Periyasamy, Jonathan Waxman, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4289.
Published: 01 May 2007
View article titled, Identification of new androgen-regulated genes in prostate cancer cells using microarray analysis combined with high-throughput real-time RT-PCR