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Journal Articles

Abstract 458: Precision systems medicine in acute myeloid leukemia: real-time translation of tailored therapeutic opportunities arising from ex-vivo drug sensitivity testing and molecular profiling

Free
Disha Malani, Ashwni Kumar, Bhagwan Yadav, Mika Kontro, Swapnil Potdar, Oscar Bruck, Säri Kytölä, Jani Saarela, Samuli Eldfors, Riikka Karjalainen, Muntasir M. Majumder, Imre Västrik, Pekka Ellonen, Matti Kankainen, Minna Suvela, Siv Knappila, Alun Parson, Aino Palva, Pirkko Mattila, Evgeny Kulesskiy, Laura Turunen, Karoliina Laamanen, Elina Lehtinen, Maria Nurmi, Katja Suomi, Astrid Muruimägi, Bjorn T. Gjertsen, Satu Mustjoki, Simon Anders, Maija Wolf, Tero Aittokallio, Krister Wennerberg, Caroline Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 458.
https://doi.org/10.1158/1538-7445.AM2019-458
Published: 01 July 2019
View articletitled, Abstract 458: Precision systems medicine in acute myeloid leukemia: real-time translation of tailored therapeutic opportunities arising from ex-vivo drug sensitivity testing and molecular profiling
Journal Articles

Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling

Free
Disha Malani, Ashwini Kumar, Bhagwan Yadav, Mika Kontro, Swapnil Potdar, Oscar Brück, Sari Kytölä, Jani Saarela, Samuli Eldfors, Poojitha Ojamies, Karjalainen Riikka, Muntasir Mamun Majumder, Imre Västrik, Pekka Ellonen, Matti Kankainen, Minna Suvela, Siv Knappila, Alun Parson, Aino Palva, Pirkko Mattila, Evgeny Kulesskiy1, Laura Turunen, Karoliina Laamanen, Elina Lehtinen, Piia Mikkonen, Maria Nurmi, Sanna Timonen, Astrid Murumägi, Bjorn Tore Gjersten, Satu Mustjoki, Tero Aittokallio, Krister Wennerberg, Simon Anders, Maija Wolf, Caroline Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3899.
https://doi.org/10.1158/1538-7445.AM2018-3899
Published: 01 July 2018
View articletitled, Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling
Journal Articles

Abstract 2378: Responses of AML patients to tailored drug regimens: monitoring cancer subclones by ultra-deep resequencing

Free
Poojitha N Ojamies, Mika Kontro, Henrik Edgren, Pekka Ellonen, Sonja Lagstrom, Henrikki Almusa, Timo Miettinen, Samuli Eldfors, David Tamborero, Krister Wennerberg, Caroline Heckman, Kimmo Porkka, Maija Wolf, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2378.
https://doi.org/10.1158/1538-7445.AM2016-2378
Published: 15 July 2016
View articletitled, Abstract 2378: Responses of AML patients to tailored drug regimens: monitoring cancer subclones by ultra-deep resequencing
Journal Articles

Abstract 4679: Acquisition of cytarabine resistance leads to increased glucocorticoid sensitivity in AML

Free
Disha Malani, Astrid Murumägi, Bhagwan Yadav, Mika Kontro, Samuli Eldfors, Ashwini Kumar, Krister Wennerberg, Caroline Heckman, Kimmo Porkka, Maija Wolf, Tero Aittokallio, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4679.
https://doi.org/10.1158/1538-7445.AM2016-4679
Published: 15 July 2016
View articletitled, Abstract 4679: Acquisition of cytarabine resistance leads to increased glucocorticoid sensitivity in AML
Journal Articles

Abstract 5220: Identifying AML-specific key targeted drugs using high-throughput drug sensitivity and resistance testing profiles of AML cells.

Free
Disha Malani, Astrid Murumägi, Tea Pemovska, Bhagwan Yadav, Evgeny Kulesskiy, Jing Tang, John Patrick Mpindi, Maija Wolf, Riikka Karjalainen, Tero Aittokallio, Caroline Heckman, Kimmo Porkka, Krister Wennerberg, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5220.
https://doi.org/10.1158/1538-7445.AM2013-5220
Published: 15 April 2013
View articletitled, Abstract 5220: Identifying AML-specific key targeted drugs using high-throughput drug sensitivity and resistance testing profiles of AML cells.
Journal Articles

Abstract 3188: Development of a cancer pharmacopeia-wide ex-vivo drug sensitivity and resistance testing (DSRT) platform for AML: Towards individually optimized therapy and improved understanding of drug resistance patterns

Free
Disha Malani, Tea Pemovska, Mika Kontro, Astrid Murumägi, Evgeny Kulesskiy, Bhagwan Yadav, Maxim Bespalov, Samuli Eldfors, Erkki Elonen, Riikka Karjalainen, Jonathan KC Knowles, Muntasir Mamun Majumder, John Patrick Mpindi, Henrik Edgren, Agnieszka Szwajda, Naga Poojitha Kota Venkata, Laura Turunen, Satu Mustjoki, Maija Wolf, Tero Aittokallio, Caroline A. Heckman, Kimmo Porkka, Krister Wennerberg, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3188.
https://doi.org/10.1158/1538-7445.AM2012-3188
Published: 15 April 2012
View articletitled, Abstract 3188: Development of a cancer pharmacopeia-wide ex-vivo drug sensitivity and resistance testing (DSRT) platform for AML: Towards individually optimized therapy and improved understanding of drug resistance patterns
Journal Articles

Abstract 3175: Genomic and transcriptomic data integration in chronic myelomonocytic leukemia reveals a novel fusion gene involving onco-miR-125b-2

Free
Muntasir M. Majumder, Mika Kontro, Henrik Edgren, Daniel Nicorici, Alun Parsons, Riikka Karjalainen, Samuli Eldfors, Pirkko Mattila, Maija Lepistö, Pekka Ellonen, Henrikki Almusa, Hannele Rintala, Jonathan K c Knowles, Janna Saarela, Krister Wennerberg, Satu Mustjoki, Maija Wolf, Olli Kallioniemi, Kimmo Porkka, Caroline A. Heckman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3175.
https://doi.org/10.1158/1538-7445.AM2012-3175
Published: 15 April 2012
View articletitled, Abstract 3175: Genomic and transcriptomic data integration in chronic myelomonocytic leukemia reveals a novel fusion gene involving onco-miR-125b-2
Journal Articles

Abstract 4580: Personalized treatment selection for therapy-resistant AML by integrating ex-vivo drug sensitivity and resistance testing (DSRT) as well as serial genomic, transcriptomic and phosphoproteomic profiling

Free
Naga Poojitha Kota Venkata, Mika Kontro, Henrik Edgren, Samuli Eldfors, Tea Pemovska, Evgeny Kulesskiy, Muntasir Mamun Majumder, Astrid Murumägi, Daniel Nicorici, Henrikki Almusa, Pirkko Mattila, Pekka Ellonen, Maija Lepistö, John Patrick Mpindi, Riikka Karjalainen, Alun Parsons, Jonathan K.C Knowles, Janna Saarela, Maija Wolf, Krister Wennerberg, Caroline A. Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4580.
https://doi.org/10.1158/1538-7445.AM2012-4580
Published: 15 April 2012
View articletitled, Abstract 4580: Personalized treatment selection for therapy-resistant AML by integrating ex-vivo drug sensitivity and resistance testing (DSRT) as well as serial genomic, transcriptomic and phosphoproteomic profiling
Journal Articles

Abstract 895: Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significance

Free
Tea Pemovska, Evgeny Kylesskiy, Mika Kontro, Agnieszka Szwajda, Riikka Karjalainen, Muntasir M. Majumder, Disha Malani, Maxim M. Bespalov, Samuli Eldfors, Erkki Elonen, Jonathan Knowles, Astrid Murumägi, John P. Mpindi, Henrik Edgren, Naga Poojitha Kota Venkata, Laura Turunen, Satu Mustjoki, Maija Wolf, Bhagwan Yadav, Tero Aittokallio, Caroline A. Heckman, Kimmo Porkka, Olli Kallioniemi, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 895.
https://doi.org/10.1158/1538-7445.AM2012-895
Published: 15 April 2012
View articletitled, Abstract 895: Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significance
Journal Articles

Abstract 5067: Exome sequencing reveals both DNA sequence and copy number changes in AML: Potential driver changes and mechanisms of drug resistance revealed from serial samples from the same patients

Free
Riikka Karjalainen, Samuli Eldfors, Henrik Edgren, Naga Poojitha Kota Venkata, Mika Kontro, Muntasir Mamun Majumder, Astrid Murumägi, Alun Parsons, Henrikki Almusa, Pekka Ellonen, Maija Lepistö, Pirkko Mattila, Sari Hannula, Sonja Lagström, Minna Suvela, Maija Wolf, Krister Wennerberg, Jonathan KC Knowles, Satu Mustjoki, Janna Saarela, Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5067.
https://doi.org/10.1158/1538-7445.AM2012-5067
Published: 15 April 2012
View articletitled, Abstract 5067: Exome sequencing reveals both DNA sequence and copy number changes in AML: Potential driver changes and mechanisms of drug resistance revealed from serial samples from the same patients
Journal Articles

Abstract 4850: Paired-end RNA-sequencing based identification of 24 novel fusion genes in breast cancer

Free
Henrik Edgren, Astrid Murumägi, Sara Kangaspeska, Daniel Nicorici, Vesa Hongisto, Kristine Kleivi, Inga Hansine Rye, Maija Wolf, Anne-Lise Børresen-Dale, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4850.
https://doi.org/10.1158/1538-7445.AM2011-4850
Published: 15 April 2011
View articletitled, Abstract 4850: Paired-end RNA-sequencing based identification of 24 novel fusion genes in breast cancer
Journal Articles

Rapid bioinformatic analysis of gene expression and predicted functions in over 14,000 healthy and cancer tissues: discovery of novel cancer associated kinases

Free
Sami Kilpinen, Reija Autio, Kalle Ojala, Kristiina Iljin, Elmar Bucher, Henri Sara, Tommi Pisto, Rolf Skotheim, Paula Vainio, Kristine Kleivi, Kimmo Jaakkola, Mari Bjorkman, Matti Saarela, Henrik Edgren, Maija Wolf, Jaakko Astola, Sampsa Hautaniemi, Matthias Nees, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 792.
Published: 01 May 2008
View articletitled, Rapid bioinformatic analysis of gene expression and predicted functions in over 14,000 healthy and cancer tissues: discovery of novel cancer associated kinases
Journal Articles

High-throughput RNAi and drug screening for the identification and inhibition of oncogenic processes activated by the TMPRSS2-ERG gene fusions in prostate cancer

Free
Kristiina Iljin, Paula Vainio, Mari Bjorkman, Sami Kilpinen, Henri Sara, Maija Wolf, Henrik Edgren, Pekka Kohonen, John Mpindi, Santosh Gupta, Pasi Halonen, Tao He, Merja Perala, Matthias Nees, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4129.
Published: 01 May 2008
View articletitled, High-throughput RNAi and drug screening for the identification and inhibition of oncogenic processes activated by the TMPRSS2-ERG gene fusions in prostate cancer
Journal Articles

High-throughput siRNA screening reveals candidate therapeutic targets for clinically aggressive breast cancers, including several genes in the HER-2 amplicon

Free
Kristine Kleivi, Kirsi Hellstrom, Henrik Edgren, Saija Haapa-Paananen, Maija Wolf, Sirkku Pollari, Suvi-Katri Leivonen, Pekka Kohonen, Niko Sahlberg, Rami Makela, Juha Rantala, Pekka Tiikkainen, Petri Saviranta, Anne-Lise Borresen-Dale, Matthias Nees, Merja Perala, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 918.
Published: 01 May 2008
View articletitled, High-throughput siRNA screening reveals candidate therapeutic targets for clinically aggressive breast cancers, including several genes in the HER-2 amplicon
Journal Articles

Genome-scale uHTP cell microarray siRNA screening: Identification of siRNAs impacting on prostate cancer cell function and maintenance

Free
Juha Rantala, Kristiina Iljin, Paula Ojala, Santosh Gupta, Henrik Edgren, Petri Saviranta, Matthias Nees, Maija Wolf, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 935.
Published: 01 May 2008
View articletitled, Genome-scale uHTP cell microarray siRNA screening: Identification of siRNAs impacting on prostate cancer cell function and maintenance
Journal Articles

Functional analysis of RIC8A, a candidate tumor suppressor, mutated or inactivated in a subset of breast carcinomas

Free
Chang-Dong Zhang, Aslaug Muggerud, Henrik Edgren, Kristine Kleivi, Maija Wolf, Therese Sorlie, Olli Kallioniemi, Marko Kallio
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3651.
Published: 01 May 2007
View articletitled, Functional analysis of RIC8A, a candidate tumor suppressor, mutated or inactivated in a subset of breast carcinomas
Journal Articles

Histone deacetylase inhibition as a potential therapeutic in ERG-positive prostate cancer

Free
Mari Peltola, Kristiina Iljin, Maija Wolf, Henrik Edgren, Santosh Gupta, Sami Kilpinen, Matthias Nees, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 685.
Published: 01 May 2007
View articletitled, Histone deacetylase inhibition as a potential therapeutic in ERG-positive prostate cancer
Journal Articles

High-throughput gene silencing in breast cancer by RNAi reveals functional taxonomies and identifies candidate drug targets overexpressed in highly proliferative clinical breast cancers

Free
Kristine Kleivi, Saija Haapa-Paananen, Henrik Edgren, Maija Wolf, Sirkku Pollari, Niko Salhberg, Antti Kulta, Pekka Kohonen, Rami Makela, Juha Rantala, Pekka Tiikkainen, Kirsi Hellstrom, Anne-Lise Borresen-Dale, Petri Saviranta, Matthias Nees, merja Perala, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4955.
Published: 01 May 2007
View articletitled, High-throughput gene silencing in breast cancer by RNAi reveals functional taxonomies and identifies candidate drug targets overexpressed in highly proliferative clinical breast cancers
Journal Articles

TMPRSS2 Fusions with Oncogenic ETS Factors in Prostate Cancer Involve Unbalanced Genomic Rearrangements and Are Associated with HDAC1 and Epigenetic Reprogramming

Free
Kristiina Iljin, Maija Wolf, Henrik Edgren, Santosh Gupta, Sami Kilpinen, Rolf I. Skotheim, Mari Peltola, Frank Smit, Gerald Verhaegh, Jack Schalken, Matthias Nees, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2006) 66 (21): 10242–10246.
https://doi.org/10.1158/0008-5472.CAN-06-1986
Published: 01 November 2006
View articletitled, TMPRSS2 Fusions with Oncogenic ETS Factors in Prostate Cancer Involve Unbalanced Genomic Rearrangements and Are Associated with HDAC1 and Epigenetic Reprogramming
Open the PDF for TMPRSS2 Fusions with Oncogenic ETS Factors in Prostate Cancer Involve Unbalanced Genomic Rearrangements and Are Associated with HDAC1 and Epigenetic Reprogramming in another window
Includes: Supplementary data
Journal Articles

RNA interference profiles, gene expression, and copy number changes in bone metastatic breast cancer cells: an integrated molecular and functional screening

Free
Sirkku Pollari, Merja Perälä, Saija Haapa-Paananen, Niko Sahlberg, Kirsi Ojala, Pekka Tiikkainen, Maija Wolf, Henrik Edgren, Jukka Rissanen, Jussi Halleen, Sanna-Maria Käkönen, Olli-P. Kallioniemi
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 978.
Published: 15 April 2006
View articletitled, RNA interference profiles, gene expression, and copy number changes in bone metastatic breast cancer cells: an integrated molecular and functional screening