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Mahmoud Ghandi
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Journal Articles

Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer

Richard C. Centore, Mark Charles, Mansi Arora, Yiwen Chen, Matthew Watson, Charlotte Kelley, Magdalena Czekalska, Marius Rebmann, Mahmoud Ghandi, Jerome Cattin, Nagakumar Bharatham, Prathima Radhakrishnan, Alex Howarth, Gale Rudlaff, William E. Arter, Seema Qamar, Kadi Saar, Douglas Williamson, Andrew Seeber, Tuomas Knowles, Shilpi Arora
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3231.
https://doi.org/10.1158/1538-7445.AM2024-3231
Published: 22 March 2024
View article titled, Abstract 3231: Pharmacological inhibition of the m<sup>6</sup>A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
Journal Articles

Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools

Kadi L. Saar, Marius Rebmann, Mohammed Kanchwala, Seema Qamar, Prathima Radhakrishnan, Jasmine Cornish, Julia Doh, Jerome Cattin, Assaf Rotem, Mahmoud Ghandi, Andrew Seeber, Richard C. Centore, Sarah A. Teichmann, Tuomas Knowles, Shilpi Arora
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4891.
https://doi.org/10.1158/1538-7445.AM2024-4891
Published: 22 March 2024
View article titled, Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using <em>in silico</em> predictive tools
Journal Articles

Abstract ND10: Discovery of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for MYC-driven cancers

Owen B. Wallace, Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Maciej Cabanski, Lisa Cantagallo, Agustin Chicas, Qian Chen, Anna Diesslin, Christopher King, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Dave Peck, Carolina Perdomo Ortiz, Martin Schillo, Ambika Singh, Ralph Tiedt, Simone Tortoioli, Silvia Buonamici, Markus Warmuth, Filip Janku, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): ND10.
https://doi.org/10.1158/1538-7445.AM2023-ND10
Published: 29 May 2023
View article titled, Abstract ND10: Discovery of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for MYC-driven cancers
Journal Articles

Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction

Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Maciej Cabanski, Lisa Cantagallo, Agustin Chicas, Qian Chen, Anna Diesslin, Christopher King, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Dave Peck, Carolina Perdomo Ortiz, Martin Schillo, Ambika Singh, Ralph Tiedt, Simone Tortoioli, Silvia Buonamici, Filip Janku, Owen Wallace, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3449.
https://doi.org/10.1158/1538-7445.AM2023-3449
Published: 04 April 2023
View article titled, Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction
Journal Articles

Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction

Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Agustin Chicas, Frederic Delobel, Brad Demarco, Alexander Flohr, Christopher King, Anne-Laure Laine, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Giorgio Ottaviani, Dave Peck, Sarah Pessa, Nooreen Rubin, Thomas Ryckmans, Martin Schillo, Ambika Singh, Simone Tortoioli, Dominico Vigil, Vladislav Zarayskiy, John Castle, Filip Janku, Owen Wallace, Silvia Buonamici, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3929.
https://doi.org/10.1158/1538-7445.AM2022-3929
Published: 15 June 2022
View article titled, Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction
Journal Articles

Abstract 1555: Pan-cancer patterns of synthetic lethality: statistical modeling of gene dependency profiles

Huwate Yeerna, Ramya Rangan, Andrew Aguirre, William Kim, Francisca Vazquez, Barbara Weir, Mahmoud Ghandi, Aviad Tsherniak, Jesse Boehm, William Hahn, Jill Mesirov, Pablo Tamayo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1555.
https://doi.org/10.1158/1538-7445.AM2017-1555
Published: 01 July 2017
View article titled, Abstract 1555: Pan-cancer patterns of synthetic lethality: statistical modeling of gene dependency profiles
Journal Articles

ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors

Eva M. Goetz, Mahmoud Ghandi, Daniel J. Treacy, Nikhil Wagle, Levi A. Garraway
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7079–7089.
https://doi.org/10.1158/0008-5472.CAN-14-2073
Published: 30 November 2014
View article titled, ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
Open the PDF for ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers

Katherine Helming, Xiaofeng Wang, Boris Wilson, Francisca Vazquez, Jeffrey Haswell, Haley Manchester, Youngha Kim, Gregory V. Kryukov, Mahmoud Ghandi, Andrew J. Aguirre, Zainab Jagani, Zhong Wang, Levi Garraway, William Hahn, Charles Roberts
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-126.
https://doi.org/10.1158/1538-7445.AM2014-LB-126
Published: 01 October 2014
View article titled, Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers