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Mélanie Desbois
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Journal Articles

Abstract 3438: Enhanced NK and CD8+ T cell proliferation, tumor cytotoxicity and reversal of T cell exhaustion with IGM-7354, an anti-PD-L1 IgM antibody and IL-15 cytokine fusion

Thierry Giffon, Melanie Desbois, Poonam Yakkundi, Keerthana Sekar, Marigold Manlusoc, Rodnie Rosete, Daniel Machado, Susan Calhoun, Tasnim Kothambawala, Dean Ng, Vu Tran, Avneesh Saini, Abhinav Jain, Beatrice Wang, Maya Kotturi, Bruce Keyt, Angus Sinclair
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3438.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3438
Published: 15 June 2022
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Journal Articles

Abstract 1068: Anti-DR5 agonist IgM antibody IGM-8444 combined with SMAC mimetic birinapant induces strong synergistic tumor cytotoxicity

Beatrice T. Wang, Melanie Desbois, Susan E. Calhoun, Thomas J. Matthew, Poonam Yakkundi, Ling Wang, Xingjie Chen, Tasnim Kothambawala, Miho Oyasu, Maya F. Kotturi, Genevive Hernandez, Xiaohan Liu, Marvin S. Peterson, Eric W. Humke, Bruce A. Keyt, Angus M. Sinclair
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1068.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1068
Published: 15 June 2022
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Journal Articles

Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity

Beatrice T. Wang, Tasnim Kothambawala, Kevin C. Hart, Xingjie Chen, Melanie Desbois, Susan E. Calhoun, Poonam Yakkundi, Rodnie A. Rosete, Yuan Cao, Katie Cha, Thomas J. Matthew, Ling Wang, Paul R. Hinton, Maya K. Leabman, Genevive Hernandez, Maya F. Kotturi, Eric W. Humke, Angus M. Sinclair, Bruce A. Keyt
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 52.
DOI: https://doi.org/10.1158/1538-7445.AM2021-52
Published: 01 July 2021
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Journal Articles

Abstract 463: Integrated digital pathology and transcriptome analysis identifies molecular mediators of T cell exclusion in ovarian cancer

Melanie Desbois, Akshata Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Amy Lo, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 463.
DOI: https://doi.org/10.1158/1538-7445.AM2019-463
Published: 01 July 2019
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Journal Articles

Abstract 2194: New oxazaphosphorine prodrugs for immunotherapy and nanomedicine against cancer

Charles Skarbek, Henri Gonde, Mélanie Desbois, Julia Delahousse, Nathalie Chaput-Gras, Jean-Pierre Benoit, Emilie Roger, Angelo Paci
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2194.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2194
Published: 15 July 2016
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Journal Articles

Abstract 2577: RLI, a sushi-IL-15Rα/IL-15 fusion protein, is a potent immunomodulatory agent on NK and CD8+ T cells and synergizes with anti-PD1 treatment in preclinical mouse tumor models

Mélanie Desbois, Coralie Beal, Clelia Coutzac, Magali Terme, Geraldine Teppaz, Sebastien Morisseau, David Bechard, Erwan Mortier, Nathalie Chaput
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2577.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2577
Published: 01 October 2014
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Journal Articles

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Sylvie Rusakiewicz, Michaela Semeraro, Matthieu Sarabi, Mélanie Desbois, Clara Locher, Rosa Mendez, Nadège Vimond, Angel Concha, Federico Garrido, Nicolas Isambert, Loic Chaigneau, Valérie Le Brun-Ly, Patrice Dubreuil, Isabelle Cremer, Anne Caignard, Vichnou Poirier-Colame, Kariman Chaba, Caroline Flament, Niels Halama, Dirk Jäger, Alexander Eggermont, Sylvie Bonvalot, Frédéric Commo, Philippe Terrier, Paule Opolon, Jean-François Emile, Jean-Michel Coindre, Guido Kroemer, Nathalie Chaput, Axel Le Cesne, Jean-Yves Blay, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3499–3510.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-0371
Published: 13 June 2013
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Includes: Supplementary data
Journal Articles

Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells

Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Jérôme D. Coudert, Mélanie Desbois, François Ghiringhelli, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Lieping Chen, Salaheddine Mécheri, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Mariapia Degli-Esposti, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2012) 72 (11): 2757–2767.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-3379
Published: 31 May 2012
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Includes: Supplementary data
Journal Articles

IL-18 Induces PD-1–Dependent Immunosuppression in Cancer

Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Mélanie Desbois, Nicolas Delahaye, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5393–5399.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-0993
Published: 11 August 2011
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Includes: Supplementary data