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Journal Articles

Abstract 4314: Chromatin state alterations during melanoma progression

Kunal Rai, Christopher Terranova, Mayinuer Maitituoheti, Ming Tang, Kadir Akdemir, Elias Orouji, Lynda Chin, Petko Fiziev, Mayura Dhamdhere, Neha S. Samant, Amikhsha Shah, Sneha Sharma, Jason Ernst
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4314.
https://doi.org/10.1158/1538-7445.AM2018-4314
Published: 01 July 2018
View article titled, Abstract 4314: Chromatin state alterations during melanoma progression
Journal Articles

Abstract 71: Cas9 protein engineering for cell cycle-specific genome editing to enhance homology directed repair

Tony Gutschner, Monika Hämmerle, Giannicola Genovese, Giulio F. Draetta, Lynda Chin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 71.
https://doi.org/10.1158/1538-7445.AM2016-71
Published: 15 July 2016
View article titled, Abstract 71: Cas9 protein engineering for cell cycle-specific genome editing to enhance homology directed repair
Journal Articles

Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy

Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, John P. Miller, Xizeng Mao, Wei-Shen Chen, Hannah Cheung, Hong Jiang, Cara Haymaker, Mariana Petaccia De Macedo, Haven R. Garber, Pei-Ling Chen, Vancheswaran Gopalakrishnan, Jacob Austin-Breneman, Courtney W. Hudgens, Jason Roszik, Patrick Hwu, Scott E. Woodman, Lynda Chin, Michael A. Davies, Rodabe N. Amaria, Sapna P. Patel, Alexander J. Lazar, Michael T. Tetzlaff, Karen C. Dwyer, Ignacio I. Wistuba, Padmanee Sharma, James P. Allison, Jianhua Zhang, Andrew Futreal, Zachary A. Cooper, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2392.
https://doi.org/10.1158/1538-7445.AM2016-2392
Published: 15 July 2016
View article titled, Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy
Journal Articles

Abstract IA15: Functional diversity of the pancreas tumor stroma

Valerie S. LeBleu, Berna C. Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L. Carstens, Xiaofeng Zheng, Chin-Chia Wu, Tyler Simpson, Hanane Laklai, Hikaru Sugimoto, Christoph Kahlert, Sergey V. Novitskiy, Ana DeJesus Acosta, Padmanee Sharma, Pedram Heidari, Umar Mahmood, Lynda Chin, Harold Moses, Valerie Weaver, Anirban Maitra, James P. Allison, Raghu Kalluri
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): IA15.
https://doi.org/10.1158/1538-7445.FBCR15-IA15
Published: 07 April 2016
View article titled, Abstract IA15: Functional diversity of the pancreas tumor stroma
Journal Articles

Abstract 1301: Inter- and intra-tumoral immune and genomic heterogeneity in patients with metastatic melanoma

Alexandre Reuben, Zachary A. Cooper, Whijae Roh, Yu Cao, Jacob Austin-Breneman, Hong Jiang, Rodabe N. Amaria, Pei-Ling Chen, Michael T. Tetzlaff, Lynda Chin, Andrew Futreal, Michael A. Davies, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1301.
https://doi.org/10.1158/1538-7445.AM2015-1301
Published: 01 August 2015
View article titled, Abstract 1301: Inter- and intra-tumoral immune and genomic heterogeneity in patients with metastatic melanoma
Journal Articles

Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor

Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christophor Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos, Jay Theroff, Yuting Sun, Yuanqiang Wu, Melinda Smith, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4455.
https://doi.org/10.1158/1538-7445.AM2015-4455
Published: 01 August 2015
View article titled, Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor
Journal Articles

Abstract 2841: A co-clinical assessment of patterns of BRAF inhibitor resistance

Lawrence N. Kwong, Genevieve Boland, Dennie Frederick, Timothy Helms, Ahmad Akid, John Miller, Shan Jiang, Zachary Cooper, Xingzhi Song, Sahil Seth, Jennifer Kamara, Alexei Protopopov, Gordon Mills, Keith Flaherty, Jennifer Wargo, Lynda Chin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2841.
https://doi.org/10.1158/1538-7445.AM2015-2841
Published: 01 August 2015
View article titled, Abstract 2841: A co-clinical assessment of patterns of BRAF inhibitor resistance
Journal Articles

Abstract 2972: Genomic classification of cutaneous melanoma

Ian R. Watson, Chang-Jiun Wu, Lihua Zou, Jeffrey E. Gershenwald, Lynda Chin, on behalf of the Melanoma Analysis Working Group and The Cancer Genome Analysis Research Network
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2972.
https://doi.org/10.1158/1538-7445.AM2015-2972
Published: 01 August 2015
View article titled, Abstract 2972: Genomic classification of cutaneous melanoma
Journal Articles

Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities

Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos, Yuting Sun, Melinda Smith, Jay Theroff, Yuanqiang Wu, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4380.
https://doi.org/10.1158/1538-7445.AM2015-4380
Published: 01 August 2015
View article titled, Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities
Journal Articles

Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Avnish Kapoor, Wantong Yao, Haoqiang Ying, Sujun Hua, Alison Liewen, Anguraj Sadanandam, Ramsey Al-Khalil, Andrea Viale, Piergiorgio Pettazzoni, Nora Sanchez, Alexei Protopopov, Jianhua Zhang, Timothy Heffernan, Randy L. Johnson, Lynda Chin, Y. Alan Wang, Giulio Draetta, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A94.
https://doi.org/10.1158/1538-7445.PANCA2014-A94
Published: 30 June 2015
View article titled, Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
Journal Articles

Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma

Hoon Kim, Siyuan Zheng, Seyed S. Amini, Selene M. Virk, Tom Mikkelsen, Daniel J. Brat, Jonna Grimsby, Carrie Sougnez, Andrew E. Sloan, Mark L. Cohen, Erwin G. Van Meir, Lisa Scarpace, The Cancer Genome Research Network, Peter W. Laird, John N. Weinstein, Eric Lander, Stacey Gabriel, Gad Getz, Matthew Meyerson, Lynda Chin, Jill S. Barnholtz-Sloan, Roel G.w. Verhaak
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 984.
https://doi.org/10.1158/1538-7445.AM2014-984
Published: 01 October 2014
View article titled, Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma
Journal Articles

Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities

Joseph R. Marszalek, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Ninping Feng, Barbara Czako, Jason Gay, Mary Geck Do, Jennifer Greer, Ryan M. Johnson, Marina Konopleva, Zhijun Kang, Gang Liu, Timothy Lofton, Timothy McAfoos, Marina Protopopova, Alessia Petrocchi, Florian Muller, Jay Theroff, Yuanqing Wu, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, Emilia Di Francesco
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 949.
https://doi.org/10.1158/1538-7445.AM2014-949
Published: 01 October 2014
View article titled, Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities
Journal Articles

Abstract LB-214: The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF

Ian R. Watson, Liren Li, Peter K. Cabeceiras, Mozhdeh Mahdavi, Zhuangna Fang, Katherine Stemke-Hale, Gordon B. Mills, Lynda Chin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-214.
https://doi.org/10.1158/1538-7445.AM2014-LB-214
Published: 01 October 2014
View article titled, Abstract LB-214: The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF
Journal Articles

Abstract LB-134: The identification and characterization of MLL2, an epigenetic enzyme, as a novel tumor suppressor in melanoma

Emily Z. Keung, Kunal Rai, Kadir C. Akdemir, Liren Li, Sneha Sharma, Bryce Axelrad, Lynda Chin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-134.
https://doi.org/10.1158/1538-7445.AM2014-LB-134
Published: 01 October 2014
View article titled, Abstract LB-134: The identification and characterization of MLL2, an epigenetic enzyme, as a novel tumor suppressor in melanoma
Journal Articles

Abstract LB-315: Comprehensive genomic characterization of cutaneous melanoma

Ian R. Watson, Chang-Jiun Wu, Jeffrey E. Gershenwald, Lynda Chin, On Behalf of the Melanoma Analysis Working Group and The Cancer Genome Analysis Research Network
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-315.
https://doi.org/10.1158/1538-7445.AM2014-LB-315
Published: 01 October 2014
View article titled, Abstract LB-315: Comprehensive genomic characterization of cutaneous melanoma
Journal Articles

The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

Ian R. Watson, Liren Li, Peter K. Cabeceiras, Mozhdeh Mahdavi, Tony Gutschner, Giannicola Genovese, Guocan Wang, Zhuangna Fang, James M. Tepper, Katherine Stemke-Hale, Kenneth Y. Tsai, Michael A. Davies, Gordon B. Mills, Lynda Chin
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4845–4852.
https://doi.org/10.1158/0008-5472.CAN-14-1232-T
Published: 01 September 2014
View article titled, The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Open the PDF for The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF in another window
Includes: Supplementary data
Journal Articles

Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Haoqiang Ying, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Alec C. Kimmelman, Eric S. Martin, Jeffery Chang, Aram Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Costas A. Lyssiotis, Lynda Chin, Lewis C. Cantley, Ronald A. DePinho, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A101.
https://doi.org/10.1158/1538-7445.PANCA2012-A101
Published: 03 April 2014
View article titled, Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Journal Articles

Abstract A9: The pancreatic ductal adenocarcinoma project at the Ontario Institute for Cancer Research.

Kimberly N. Begley, Debabrata Mukhopadhyay, Gloria M. Petersen, Alexei Protopopov, Sarah Thayer, Lynda Chin, Emin Ibrahimov, Patricia Shaw, Thomas Hudson, Steve Gallinger, Ming-Sound Tsao, Lincoln Stein, John D. McPherson, Lakshmi Muthuswamy, Timothy Beck, Christina Yung, Michelle Sam, Lee Timms, Carson Holt
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A9.
https://doi.org/10.1158/1538-7445.PANCA2012-A9
Published: 03 April 2014
View article titled, Abstract A9: The pancreatic ductal adenocarcinoma project at the Ontario Institute for Cancer Research.
Journal Articles

Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions

Lawrence N. Kwong, Lynda Chin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (6): 1814–1821.
https://doi.org/10.1158/0008-5472.CAN-13-1446
Published: 13 March 2014
View article titled, Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Open the PDF for Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions in another window
Includes: Supplementary data
Journal Articles

Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons

J. Zachary Sanborn, Sofie R. Salama, Mia Grifford, Cameron W. Brennan, Tom Mikkelsen, Suresh Jhanwar, Sol Katzman, Lynda Chin, David Haussler
Journal: Cancer Research
Cancer Res (2013) 73 (19): 6036–6045.
https://doi.org/10.1158/0008-5472.CAN-13-0186
Published: 01 October 2013
View article titled, Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons
Open the PDF for Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons in another window
Includes: Supplementary data