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Abstract 931: The T790M mutation is acquired through 5-methylcytosine deamination after EGFR TKI treatment in lung cancer

Najwa El Kadi, Luo Wang, April Davis, Alexander Cooke, Varun Vadnala, Hasan Korkaya, Gregory P. Kalemkerian, Khaled A. Hassan

Cancer Res (2019) 79 (13_Supplement): 931.

https://doi.org/10.1158/1538-7445.AM2019-931

Published: 01 July 2019

View articletitled, Abstract 931: The T790M mutation is acquired through 5-methylcytosine deamination after EGFR TKI treatment in lung cancer

Journal Articles

The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer

Najwa El Kadi, Luo Wang, April Davis, Hasan Korkaya, Alexander Cooke, Varun Vadnala, Noah A. Brown, Bryan L. Betz, Marilia Cascalho, Gregory P. Kalemkerian, Khaled A. Hassan

Cancer Res (2018) 78 (24): 6728–6735.

https://doi.org/10.1158/0008-5472.CAN-17-3370

Published: 13 December 2018

View articletitled, The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer

Includes: Supplementary data

Journal Articles

Abstract 5836: Activation Induced Cytosine Deamination, AICDA, is induced after EGFR TKI exposure leading to secondary resistant mutations in lung adenocarcinoma

Najwa El Kadi, April Davis, Alexander Cooke, Luo Wang, Hasan Korkaya, Gregory Kalemkerian, Khaled Hassan

Cancer Res (2018) 78 (13_Supplement): 5836.

https://doi.org/10.1158/1538-7445.AM2018-5836

Published: 01 July 2018

View articletitled, Abstract 5836: Activation Induced Cytosine Deamination, AICDA, is induced after EGFR TKI exposure leading to secondary resistant mutations in lung adenocarcinoma

Journal Articles

Abstract 4119: The development of EGFR resistant mutation, T790M, in lung adenocarcinoma is acquired through a specific cytosine deamination mechanism

Khaled Hassan, Najwa El Kadi, April Davis, Gregory Kalemkerian, Luo Wang, Hasan Korkaya

Cancer Res (2017) 77 (13_Supplement): 4119.

https://doi.org/10.1158/1538-7445.AM2017-4119

Published: 01 July 2017

View articletitled, Abstract 4119: The development of EGFR resistant mutation, T790M, in lung adenocarcinoma is acquired through a specific cytosine deamination mechanism

Journal Articles

Abstract 960: Blocking the Notch pathway induces mesenchymal-to-epithelial transition in lung adenocarcinoma: A novel approach to overcoming chemoresistance.

Khaled Hassan, Luo Wang, Hasan Korkaya, Paige O'Dowd, Sarah Dubaisi, Rayyan Kadi, Rawad Nasr, Binghui Zhang, April Davis, Gregory Kalemkerian, Max Wicha

Cancer Res (2013) 73 (8_Supplement): 960.

https://doi.org/10.1158/1538-7445.AM2013-960

Published: 15 April 2013

View articletitled, Abstract 960: Blocking the Notch pathway induces mesenchymal-to-epithelial transition in lung adenocarcinoma: A novel approach to overcoming chemoresistance.

Journal Articles

Abstract 3309: Blocking the Notch pathway inhibits the epithelial-mesenchymal transition (EMT) status in lung cancer and alters chemoresistance

Khaled A. Hassan, Luo Wang, Paige O'Dowd, Gwangil Kim, Hasan Korkaya, April Davis, Suling Liu, Gregory P. Kalemkerian, Max Wicha

Cancer Res (2012) 72 (8_Supplement): 3309.

https://doi.org/10.1158/1538-7445.AM2012-3309

Published: 15 April 2012

View articletitled, Abstract 3309: Blocking the Notch pathway inhibits the epithelial-mesenchymal transition (EMT) status in lung cancer and alters chemoresistance

Journal Articles

Abstract 496: Notch pathway activity identifies functional lung cancer stem cells and correlates with worse survival in patients with lung adenocarcinoma

Khaled A. Hassan, Luo Wang, Hasan Korkaya, Guoan Chen, Ivan Maillard, David Beer, Gregory P. Kalemkerian, Max S. Wicha

Cancer Res (2011) 71 (8_Supplement): 496.

https://doi.org/10.1158/1538-7445.AM2011-496

Published: 15 April 2011

View articletitled, Abstract 496: Notch pathway activity identifies functional lung cancer stem cells and correlates with worse survival in patients with lung adenocarcinoma

Journal Articles

Polymorphisms and haplotypes of the NBS1 gene associated with risk of sporadic breast cancer in young women: A case-control study

Jiachun Lu, Qingyi Wei, Melissa L. Bondy, Luo Wang, Donghui Li, Abenaa Brewster, Tse-Kuan Yu, Aysegul Sahin, Funda Meric-Bernstam, Kelly K. Hunt, S. Eva Singletary, Merrick I. Ross, Li-E Wang

Cancer Res (2006) 66 (8_Supplement): 481.

Published: 15 April 2006

View articletitled, Polymorphisms and haplotypes of the NBS1 gene associated with risk of sporadic breast cancer in young women: A case-control study

Journal Articles

Single nucleotide polymorphisms in selected apoptotic genes and apoptotic capacity in normal lymphocytes: a genotype-phenotype correlation analysis

Zhibin Hu, Li-E Wang, Luo Wang, Zhensheng Liu, Erich M. Sturgis, Margaret R. Spitz, Qingyi Wei

Cancer Res (2006) 66 (8_Supplement): 478–479.

Published: 15 April 2006

View articletitled, Single nucleotide polymorphisms in selected apoptotic genes and apoptotic capacity in normal lymphocytes: a genotype-phenotype correlation analysis

Journal Articles

A novel assay to measure the capacity to repair N7-guanine site-specific DNA damage.

Luo Wang, Qiuling Shi, Zhaosheng Guo, Yawei Qiao, Margaret R. Spitz, Qingyi Wei

Cancer Res (2006) 66 (8_Supplement): 1330–1331.

Published: 15 April 2006

View articletitled, A novel assay to measure the capacity to repair N7-guanine site-specific DNA damage.

Journal Articles

Methylation and mRNA expression of the p15^INK4b, p16^INK4a, BRCA1 and hMLH1 genes in ovarian cancer

Zhensheng Liu, Li-E Wang, Luo Wang, Karen H. Lu, Melissa Bondy, Gordon B. Mills, Qingyi Wei

Cancer Res (2005) 65 (9_Supplement): 519.

Published: 01 May 2005

View articletitled, Methylation and mRNA expression of the p15INK4b, p16INK4a, BRCA1 and hMLH1 genes in ovarian cancer

Journal Articles

Genetic variants of the MGMT gene associated with lung cancer risk in nonsmokers

Luo Wang, Hongji Liu, Zhensheng Liu, Margaret R. Spitz, Qingyi Wei

Cancer Res (2005) 65 (9_Supplement): 521–522.

Published: 01 May 2005

View articletitled, Genetic variants of the MGMT gene associated with lung cancer risk in nonsmokers

Journal Articles

Correlation between expression of DNMT3B6s and promoter methylation of tumor suppressor genes P16^INK4a and RASSF1A in non-small cell lung cancer

Jie Wang, Luo Wang, Diane Liu, Jack J. Lee, You-Hong Fan, Charles Lu, Waun Ki Hong, Li Mao

Cancer Res (2004) 64 (7_Supplement): 365.

Published: 01 April 2004

View articletitled, Correlation between expression of DNMT3B6s and promoter methylation of tumor suppressor genes P16INK4a and RASSF1A in non-small cell lung cancer

Journal Articles

Alternative RNA processing of tumor suppressor gene CEACAM1 is correlated with over-expression of polypyrimidine tract-binding protein (PTB) in lung cancers

Liudi Yuan, Luo Wang, Wei Jin, Henning Ren, Ping Yue, Gilbert J. Cote, Li Mao

Cancer Res (2004) 64 (7_Supplement): 649–650.

Published: 01 April 2004

View articletitled, Alternative RNA processing of tumor suppressor gene CEACAM1 is correlated with over-expression of polypyrimidine tract-binding protein (PTB) in lung cancers

Journal Articles

Functional relevance of C46359T in the promoter region of human DNMT3B6

Luo Wang, Zhensheng Liu, Li Mao, Margaret R. Spitz, Qingyi Wei

Cancer Res (2004) 64 (7_Supplement): 672.

Published: 01 April 2004

View articletitled, Functional relevance of C46359T in the promoter region of human DNMT3B6

Journal Articles

A Novel Polymorphism in Human Cytosine DNA-Methyltransferase-3B Promoter Is Associated with an Increased Risk of Lung Cancer

Hongbing Shen, Luo Wang, Margaret R. Spitz, Waun K. Hong, Li Mao, Qingyi Wei

Cancer Res (2002) 62 (17): 4992–4995.

Published: 01 September 2002

View articletitled, A Novel Polymorphism in Human Cytosine DNA-Methyltransferase-3B Promoter Is Associated with an Increased Risk of Lung Cancer

Journal Articles

Activation of Melanoma Antigen Tumor Antigens Occurs Early in Lung Carcinogenesis

Se J. Jang, Jean-Charles Soria, Luo Wang, Khaled A. Hassan, Rodolfo C. Morice, Garrett L. Walsh, Waun Ki Hong, Li Mao

Cancer Res (2001) 61 (21): 7959–7963.

Published: 01 November 2001

View articletitled, Activation of Melanoma Antigen Tumor Antigens Occurs Early in Lung Carcinogenesis

Journal Articles

Human Rad17 Is Phosphorylated upon DNA Damage and also Overexpressed in Primary Non-Small Cell Lung Cancer Tissues

Xin Wang, Luo Wang, Matthew D. Callister, Joe B. Putnam, Li Mao, Lei Li

Cancer Res (2001) 61 (20): 7417–7421.

Published: 01 October 2001

View articletitled, Human Rad17 Is Phosphorylated upon DNA Damage and also Overexpressed in Primary Non-Small Cell Lung Cancer Tissues

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Abstract 931: The T790M mutation is acquired through 5-methylcytosine deamination after EGFR TKI treatment in lung cancer

The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer

Abstract 5836: Activation Induced Cytosine Deamination, AICDA, is induced after EGFR TKI exposure leading to secondary resistant mutations in lung adenocarcinoma

Abstract 4119: The development of EGFR resistant mutation, T790M, in lung adenocarcinoma is acquired through a specific cytosine deamination mechanism

Abstract 960: Blocking the Notch pathway induces mesenchymal-to-epithelial transition in lung adenocarcinoma: A novel approach to overcoming chemoresistance.

Abstract 3309: Blocking the Notch pathway inhibits the epithelial-mesenchymal transition (EMT) status in lung cancer and alters chemoresistance

Abstract 496: Notch pathway activity identifies functional lung cancer stem cells and correlates with worse survival in patients with lung adenocarcinoma

Polymorphisms and haplotypes of the NBS1 gene associated with risk of sporadic breast cancer in young women: A case-control study

Single nucleotide polymorphisms in selected apoptotic genes and apoptotic capacity in normal lymphocytes: a genotype-phenotype correlation analysis

A novel assay to measure the capacity to repair N7-guanine site-specific DNA damage.

Methylation and mRNA expression of the p15^INK4b, p16^INK4a, BRCA1 and hMLH1 genes in ovarian cancer

Genetic variants of the MGMT gene associated with lung cancer risk in nonsmokers

Correlation between expression of DNMT3B6s and promoter methylation of tumor suppressor genes P16^INK4a and RASSF1A in non-small cell lung cancer

Alternative RNA processing of tumor suppressor gene CEACAM1 is correlated with over-expression of polypyrimidine tract-binding protein (PTB) in lung cancers

Functional relevance of C46359T in the promoter region of human DNMT3B6

A Novel Polymorphism in Human Cytosine DNA-Methyltransferase-3B Promoter Is Associated with an Increased Risk of Lung Cancer

Activation of Melanoma Antigen Tumor Antigens Occurs Early in Lung Carcinogenesis

Human Rad17 Is Phosphorylated upon DNA Damage and also Overexpressed in Primary Non-Small Cell Lung Cancer Tissues

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