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Luke A. Selth
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Journal Articles

ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis

Available to Purchase
Raj K. Shrestha, Zeyad D. Nassar, Adrienne R. Hanson, Richard Iggo, Scott L. Townley, Jonas Dehairs, Chui Y. Mah, Madison Helm, Mohammadreza Alizadeh-Ghodsi, Marie Pickering, Bart Ghesquière, Matthew J. Watt, Lake-Ee Quek, Andrew J. Hoy, Wayne D. Tilley, Johannes V. Swinnen, Lisa M. Butler, Luke A. Selth
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2313–2332.
https://doi.org/10.1158/0008-5472.CAN-23-1489
Published: 15 July 2024
View articletitled, ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
Open the PDF for ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis in another window
Includes: Supplementary data
Journal Articles

Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition

Free
Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4981–4993.
https://doi.org/10.1158/0008-5472.CAN-20-3863
Published: 01 October 2021
View articletitled, Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition
Open the PDF for Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition in another window
Includes: Supplementary data
Journal Articles

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Free
Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1704–1718.
https://doi.org/10.1158/0008-5472.CAN-20-2511
Published: 01 April 2021
View articletitled, ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer
Open the PDF for ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO-036: ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress

Free
Raj Kumar Shrestha, Scott Townley, Adrienne Hanson, Marie Pickering, Zeyad D. Nassar, Chui Yan Mah, Mohammadreza A. Ghodsi, Andrew J. Hoy, Lake-Ee Quek, Wayne D. Tilley, Lisa M. Butler, Luke A. Selth
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-036.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-036
Published: 02 December 2020
View articletitled, Abstract PO-036: ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress
Journal Articles

Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer

Free
Elgene Lim, Theresa A Hickey, Luke A Selth, Kee Ming Chia, Heloisa H Milioli, Daniel Roden, Geraldine Laven-Law, Shalini Jindal, Mun Hui, Esmaeil Ebrahimie, Stephen N Birrell, Suzan Stelloo, C. Elizabeth Caldon, Jessica Finlay-Schultz, Tarek M Abdel-Fatah, Ian O Ellis, Willbert Zwart, Carlo Palmieri, Carol A Sartorius, Alex Swarbrick, Jason S Carroll, Wayne D Tilley
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS2-03.
https://doi.org/10.1158/1538-7445.SABCS19-GS2-03
Published: 15 February 2020
View articletitled, Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer
Journal Articles

Abstract 4433: Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro

Free
Jean M. Winter, Ebtihal H. Mustafa, Shudong Wang, Luke A. Selth, Theresa E. Hickey, Wayne D. Tilley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4433.
https://doi.org/10.1158/1538-7445.AM2019-4433
Published: 01 July 2019
View articletitled, Abstract 4433: Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro
Journal Articles

Abstract 3741: Deciphering the regulome of androgen receptor variants in prostate cancer

Free
Mark L. Daniel, Theresa E. Hickey, Jason S. Carroll, Wayne D. Tilley, Luke A. Selth, Scott M. Dehm
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3741.
https://doi.org/10.1158/1538-7445.AM2018-3741
Published: 01 July 2018
View articletitled, Abstract 3741: Deciphering the regulome of androgen receptor variants in prostate cancer
Journal Articles

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Available to Purchase
Suriyan Ponnusamy, Christopher C. Coss, Thirumagal Thiyagarajan, Kate Watts, Dong-Jin Hwang, Yali He, Luke A. Selth, Iain J. McEwan, Charles B. Duke, Jayaprakash Pagadala, Geetika Singh, Robert W. Wake, Christopher Ledbetter, Wayne D. Tilley, Tudor Moldoveanu, James T. Dalton, Duane D. Miller, Ramesh Narayanan
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6282–6298.
https://doi.org/10.1158/0008-5472.CAN-17-0976
Published: 14 November 2017
View articletitled, Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
Open the PDF for Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer

Free
Steve Paltoglou, Rajdeep Das, Scott L. Townley, Theresa E. Hickey, Gerard A. Tarulli, Isabel Coutinho, Rayzel Fernandes, Adrienne R. Hanson, Iza Denis, Jason S. Carroll, Scott M. Dehm, Ganesh V. Raj, Stephen R. Plymate, Wayne D. Tilley, Luke A. Selth
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3417–3430.
https://doi.org/10.1158/0008-5472.CAN-16-1616
Published: 02 July 2017
View articletitled, Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer
Open the PDF for Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer

Free
Zeyad D. Nassar, Margaret M. Centenera, Jelle Machiels, Samuel J. Polacek, Katarzyna Bloch, Wayne D. Tilley, Luke A. Selth, Johannes V. Swinnen, Lisa Butler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1152.
https://doi.org/10.1158/1538-7445.AM2017-1152
Published: 01 July 2017
View articletitled, Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer
Journal Articles

Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer

Free
Lu Miao, Lin Yang, Rui Li, Daniel N. Rodrigues, Mateus Crespo, Jer-Tsong Hsieh, Wayne D. Tilley, Johann de Bono, Luke A. Selth, Ganesh V. Raj
Journal: Cancer Research
Cancer Res (2017) 77 (11): 3101–3112.
https://doi.org/10.1158/0008-5472.CAN-16-2169
Published: 31 May 2017
View articletitled, Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Open the PDF for Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2

Free
Rajdeep Das, Philip A. Gregory, Rayzel C. Fernandes, Iza Denis, Qingqing Wang, Scott L. Townley, Shuang G. Zhao, Adrienne R. Hanson, Marie A. Pickering, Heather K. Armstrong, Noor A. Lokman, Esmaeil Ebrahimie, Elai Davicioni, Robert B. Jenkins, R. Jeffrey Karnes, Ashley E. Ross, Robert B. Den, Eric A. Klein, Kim N. Chi, Hayley S. Ramshaw, Elizabeth D. Williams, Amina Zoubeidi, Gregory J. Goodall, Felix Y. Feng, Lisa M. Butler, Wayne D. Tilley, Luke A. Selth
Journal: Cancer Research
Cancer Res (2017) 77 (4): 1021–1034.
https://doi.org/10.1158/0008-5472.CAN-16-2529
Published: 14 February 2017
View articletitled, MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2
Open the PDF for MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2 in another window
Includes: Supplementary data
Journal Articles

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17

Free
Dong G. Hu, Luke A. Selth, Gerard A. Tarulli, Robyn Meech, Dhilushi Wijayakumara, Apichaya Chanawong, Roslin Russell, Carlos Caldas, Jessica L.L. Robinson, Jason S. Carroll, Wayne D. Tilley, Peter I. Mackenzie, Theresa E. Hickey
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (19): 5881–5893.
https://doi.org/10.1158/0008-5472.CAN-15-3372
Published: 02 October 2016
View articletitled, Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17
Open the PDF for Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17 in another window
Includes: Supplementary data
Journal Articles

Abstract C6: Targeting Hsp90-dependent functional maturation of the androgen receptor in human prostate cancer

Free
Margaret M. Centenera, Sarah L. Carter, Joanna L. Gillis, Luke A. Selth, Peter D. Sutherland, Wayne D. Tilley, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C6.
https://doi.org/10.1158/1538-7445.PRCA2012-C6
Published: 09 May 2013
View articletitled, Abstract C6: Targeting Hsp90-dependent functional maturation of the androgen receptor in human prostate cancer