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Lukas Perkhofer
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Journal Articles

Abstract A055: Multiomics profiling reveals druggable tumor-stroma interactions in ATM-deficient pancreatic cancer

Free
Elodie Roger, Hannah M. Mummey, Eleni Zimmer, Julia Ragg, Yuna Lee, Kyle J. Gaulton, Alica K. Beutel, Christopher J. Halbrook, Lukas Perkhofer, Johann Gout, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A055.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A055
Published: 15 September 2024
View articletitled, Abstract A055: Multiomics profiling reveals druggable tumor-stroma interactions in ATM-deficient pancreatic cancer
Journal Articles

Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits

Free
Elodie Roger, Anna Härle, Lukas Perkhofer, Elisabeth Hessmann, Alexander Kleger, Johann Gout
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B088.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B088
Published: 15 September 2024
View articletitled, Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits
Journal Articles

Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution

Free
Johann Gout, Yazid J Resheq, Jessica Lindenmayer, Julian D Schwab, Elodie Roger, Johann M Kraus, Thomas Ettrich, Alica K Beutel, Lukas Perkhofer, Hans A Kestler, Thomas Seufferlein, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C053.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C053
Published: 15 September 2024
View articletitled, Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution
Journal Articles

Abstract A061: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Free
Dharini Srinivasan, Frank Arnold, Elodie Roger, Anna Härle, Michael K Melzer, Chantal Allgöwer, Patrick C Hermann, Lukas Perkhofer, Johann Gout, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A061.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A061
Published: 15 September 2024
View articletitled, Abstract A061: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword
Journal Articles

Abstract A077: The EZH2 epigenetic factor orchestrates oncogenic properties in ATM-deficient pancreatic cancer

Free
Elodie Roger, Anna Härle, Johann Gout, Lukas Perkhofer, Elisabeth Hessmann, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A077.
https://doi.org/10.1158/1538-7445.PANCA2023-A077
Published: 16 January 2024
View articletitled, Abstract A077: The EZH2 epigenetic factor orchestrates oncogenic properties in ATM-deficient pancreatic cancer
Journal Articles

Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids

Free
Johann Gout, Yazid J. Resheq, Jessica Lindenmayer, Thomas Ettrich, Lukas Perkhofer, Thomas Seufferlein, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C061.
https://doi.org/10.1158/1538-7445.PANCA2023-C061
Published: 16 January 2024
View articletitled, Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids
Journal Articles

Abstract C028: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Free
Dharini Srinivasan, Frank Arnold, Elodie Roger, Anna Härle, Michael Melzer, Patrick Hermann, Lukas Perkhofer, Johann Gout, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C028.
https://doi.org/10.1158/1538-7445.PANCA2023-C028
Published: 16 January 2024
View articletitled, Abstract C028: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword
Journal Articles

Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

Free
Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ouralidis, Michael Allgäuer, Michael Menzel, Eugen Rempel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 810.
https://doi.org/10.1158/1538-7445.AM2022-810
Published: 15 June 2022
View articletitled, Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types
Journal Articles

RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

Available to Purchase
Frank Arnold, Johann Gout, Heike Wiese, Stephanie E. Weissinger, Elodie Roger, Lukas Perkhofer, Karolin Walter, Jeanette Scheible, Caterina Prelli Bozzo, André Lechel, Thomas J. Ettrich, Ninel Azoitei, Li Hao, Axel Fürstberger, Ewa K. Kaminska, Konstantin M.J. Sparrer, Volker Rasche, Sebastian Wiese, Hans A. Kestler, Peter Möller, Thomas Seufferlein, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1758–1774.
https://doi.org/10.1158/0008-5472.CAN-20-2633
Published: 01 April 2021
View articletitled, RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer
Open the PDF for RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Free
Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, Michaela Ihle, Stephanie Hampp, Dietrich Alexander Ruess, Elisabeth Hessmann, Ronan Russell, André Lechel, Ninel Azoitei, Qiong Lin, Stefan Liebau, Meike Hohwieler, Hanibal Bohnenberger, Marina Lesina, Hana Algül, Laura Gieldon, Evelin Schröck, Jochen Gaedcke, Martin Wagner, Lisa Wiesmüller, Bence Sipos, Thomas Seufferlein, Hans Christian Reinhardt, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5576–5590.
https://doi.org/10.1158/0008-5472.CAN-17-0634
Published: 15 October 2017
View articletitled, ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Open the PDF for ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage in another window
Includes: Supplementary data