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Abstract LB029: TIGIT deletion rescues the antitumor activity of low avidity T cells by increasing TCR signal strength

Cancer Res (2025) 85 (8_Supplement_2): LB029.

https://doi.org/10.1158/1538-7445.AM2025-LB029

Published: 25 April 2025

View articletitled, Abstract LB029: TIGIT deletion rescues the antitumor activity of low avidity T cells by increasing TCR signal strength

Journal Articles

Abstract CT127: A macrophages-based immunotherapy of solid tumors microenvironment: Preliminary results of the TEM-GBM_01 study

Cancer Res (2024) 84 (7_Supplement): CT127.

https://doi.org/10.1158/1538-7445.AM2024-CT127

Published: 05 April 2024

View articletitled, Abstract CT127: A macrophages-based immunotherapy of solid tumors microenvironment: Preliminary results of the TEM-GBM_01 study

Journal Articles

Abstract 5: Cytosine base editor ameliorates the safety profile of TCR edited T cells for the adoptive cell therapy of gastrointestinal tumors

Martina Spiga, Alessia Potenza, Stefano Beretta, Alessia Airaghi, Chiara Iozzi, Martina Fiumara, Samuele Ferrari, Neda Mohammadi, Oronza Botrugno, Maximilian Reichert, Maria Pia Protti, Stefano Crippa, Massimo Falconi, Luigi Naldini, Eliana Ruggiero, Chiara Bonini

Cancer Res (2024) 84 (6_Supplement): 5.

https://doi.org/10.1158/1538-7445.AM2024-5

Published: 22 March 2024

View articletitled, Abstract 5: Cytosine base editor ameliorates the safety profile of TCR edited T cells for the adoptive cell therapy of gastrointestinal tumors

Journal Articles

Abstract 3297: IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy

Thomas Kerzel, Stefano Beretta, Eloise Scamardella, Chiara Balestrieri, Tamara Canu, Federica Pedica, Rossana Norata, Lucia Sergi Sergi, Marco Genua, Ostuni Renato, Anna Kajaste-Rudnitski, Antonio Esposito, Masanobu Oshima, Giovanni Tonon, Francesca Sanvito, Mario Leonardo Squadrito, Luigi Naldini

Cancer Res (2022) 82 (12_Supplement): 3297.

https://doi.org/10.1158/1538-7445.AM2022-3297

Published: 15 June 2022

View articletitled, Abstract 3297: IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy

Journal Articles

Abstract 5213: Genetically modified Tie-2 expressing monocytes target IFN-α2 to the glioblastoma tumor microenvironment (TME): Preliminary data from the TEM-GBM Phase 1/2a study

Cancer Res (2022) 82 (12_Supplement): 5213.

https://doi.org/10.1158/1538-7445.AM2022-5213

Published: 15 June 2022

View articletitled, Abstract 5213: Genetically modified Tie-2 expressing monocytes target IFN-α2 to the glioblastoma tumor microenvironment (TME): Preliminary data from the TEM-GBM Phase 1/2a study

Journal Articles

Abstract CT180: Changes in immunologic responses and in the tumor microenvironment in patients with glioblastoma multiforme treated with IFN-a immune cell and gene therapy (TEM-GBM_001 Study)

Cancer Res (2021) 81 (13_Supplement): CT180.

https://doi.org/10.1158/1538-7445.AM2021-CT180

Published: 01 July 2021

View articletitled, Abstract CT180: Changes in immunologic responses and in the tumor microenvironment in patients with glioblastoma multiforme treated with IFN-a immune cell and gene therapy (TEM-GBM_001 Study)

Journal Articles

Abstract 3169: Lentiviral vector-based insertional mutagenesis identifies new clinically relevant liver cancer genes.

Cancer Res (2013) 73 (8_Supplement): 3169.

https://doi.org/10.1158/1538-7445.AM2013-3169

Published: 15 April 2013

View articletitled, Abstract 3169: Lentiviral vector-based insertional mutagenesis identifies new clinically relevant liver cancer genes.

Journal Articles

Abstract 1013: Enriched miR-126 bioactivity marks the primitive compartment in human AML and regulates leukemia stem cell numbers

Eric R. Lechman, Bernhard Gentner, Peter van Galen, Kolja Eppert, Katsuto Takenaka, Mark Minden, Luigi Naldini, John E. Dick

Cancer Res (2012) 72 (8_Supplement): 1013.

https://doi.org/10.1158/1538-7445.AM2012-1013

Published: 15 April 2012

View articletitled, Abstract 1013: Enriched miR-126 bioactivity marks the primitive compartment in human AML and regulates leukemia stem cell numbers

Journal Articles

Abstract 104: New liver cancer genes identified by lentiviral vector-based insertional mutagenesis in mice are associated to differential survival in hepatocellular carcinoma patients

Marco Ranzani, Daniela Cesana, Cynthia C. Bartholomae, Francesca Sanvito, Mauro Pala, Fabrizio Benedicenti, Pierangela Gallina, Lucia Sergi Sergi, Stefania Merella, Alessandro Bulfone, Claudio Doglioni, Christof von Kalle, Yoon Jun Kim, Manfred Schmidt, Giovanni Tonon, Luigi Naldini, Eugenio Montini

Cancer Res (2012) 72 (8_Supplement): 104.

https://doi.org/10.1158/1538-7445.AM2012-104

Published: 15 April 2012

View articletitled, Abstract 104: New liver cancer genes identified by lentiviral vector-based insertional mutagenesis in mice are associated to differential survival in hepatocellular carcinoma patients

Journal Articles

Abstract 2849: Tie2-expressing macrophages (TEM) depletion may enhance the clinical efficacy of combretastatin A-4-phosphate (CA-4-P)

Welford F. Abigail, Daniela Biziato, Seth B. Coffelt, Silvia Nucera, Matthew Fisher, Ferdinando Pucci, Clelia Di Serio, Luigi Naldini, Michele De Palma, Gillian M. Tozer, Claire E. Lewis

Cancer Res (2011) 71 (8_Supplement): 2849.

https://doi.org/10.1158/1538-7445.AM2011-2849

Published: 15 April 2011

View articletitled, Abstract 2849: Tie2-expressing macrophages (TEM) depletion may enhance the clinical efficacy of combretastatin A-4-phosphate (CA-4-P)

Journal Articles

Abstract 4982: Identification of new human liver cancer genes by a novel lentiviral vector-based insertional mutagenesis approach in three mouse models of hepatocarcinogenesis

Marco Ranzani, Daniela Cesana, Cynthia Bartholomae, Francesca Sanvito, Mauro Pala, Fabrizio Benedicenti, Lucia Sergi Sergi, Alessandro Bulfone, Claudio Doglioni, Christof von Kalle, Manfred Schmidt, Giovanni Tonon, Luigi Naldini, Eugenio Montini

Cancer Res (2011) 71 (8_Supplement): 4982.

https://doi.org/10.1158/1538-7445.AM2011-4982

Published: 15 April 2011

View articletitled, Abstract 4982: Identification of new human liver cancer genes by a novel lentiviral vector-based insertional mutagenesis approach in three mouse models of hepatocarcinogenesis

Journal Articles

Abstract 2937: Editing central memory T lymphocyte specificity for safe and effective adoptive immunotherapy of leukemia

Pietro Genovese, Elena Provasi, Zulma Magnani, Angelo Lombardo, Oscar Muniz Pello, Jurgen Kuball, Attilio Bondanza, Philip D. Gregory, Claudio Bordignon, Michael C. Holmes, Philip D. Greenberg, Luigi Naldini, Chiara Bonini

Cancer Res (2010) 70 (8_Supplement): 2937.

https://doi.org/10.1158/1538-7445.AM10-2937

Published: 15 April 2010

View articletitled, Abstract 2937: Editing central memory T lymphocyte specificity for safe and effective adoptive immunotherapy of leukemia

Journal Articles

Abstract SY27-02: Heterogeneity of tumor-associated macrophages: Implications for antiangiogenic therapy

Michele De Palma, Luigi Naldini

Cancer Res (2010) 70 (8_Supplement): SY27-02.

https://doi.org/10.1158/1538-7445.AM10-SY27-02

Published: 15 April 2010

View articletitled, Abstract SY27-02: Heterogeneity of tumor-associated macrophages: Implications for antiangiogenic therapy

Journal Articles

Abstract 1366: Inhibition of Tie2+ macrophage infiltration into tumors in combination with CA-4-P therapy may enhance the clinical efficacy of this vascular disrupting agent

Abigail F. Welford, Mary A. Venneri, Daniele Biziato, Luigi Naldini, Michele De Palma, Claire E. Lewis, Gillian M. Tozer

Cancer Res (2010) 70 (8_Supplement): 1366.

https://doi.org/10.1158/1538-7445.AM10-1366

Published: 15 April 2010

View articletitled, Abstract 1366: Inhibition of Tie2+ macrophage infiltration into tumors in combination with CA-4-P therapy may enhance the clinical efficacy of this vascular disrupting agent

Journal Articles

Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Sara Bobisse, Maria Rondina, Anna Merlo, Veronica Tisato, Susanna Mandruzzato, Mario Amendola, Luigi Naldini, Ralph A. Willemsen, Reno Debets, Paola Zanovello, Antonio Rosato

Cancer Res (2009) 69 (24): 9385–9394.

https://doi.org/10.1158/0008-5472.CAN-09-0494

Published: 14 December 2009

View articletitled, Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Includes: Supplementary data

Journal Articles

Abstract #1421: Cancer gene discovery in mouse models of hepatocarcinogenesis by insertional mutagenesis with genotoxic lentiviral vectors

Marco Ranzani, Manfred Schmidt, Francesca Sanvito, Daniela Cesana, Fabrizio Benedicenti, Cynthia Bartholomä, Claudio Doglioni, Christof VonKalle, Luigi Naldini, Eugenio Montini

Cancer Res (2009) 69 (9_Supplement): 1421.

Published: 01 May 2009

View articletitled, Abstract #1421: Cancer gene discovery in mouse models of hepatocarcinogenesis by insertional mutagenesis with genotoxic lentiviral vectors

Journal Articles

Abstract #2076: Tie2-expressing monocytes: Relationship with tumor-associated macrophages and therapeutic opportunities

Michele De Palma, Ferdinando Pucci, Roberta Mazzieri, Erika Zonari, Luigi Naldini

Cancer Res (2009) 69 (9_Supplement): 2076.

Published: 01 May 2009

View articletitled, Abstract #2076: Tie2-expressing monocytes: Relationship with tumor-associated macrophages and therapeutic opportunities

Journal Articles

Discovery of cancer genes by high throughput lentiviral oncogene-tagging in hematopoietic and solid tissues

Eugenio Montini, Marco Ranzani, Daniela Cesana, Manfred Schmidt, Fabrizio Benedicenti, Lucia Sergi Sergi, Francesca Sanvito, Claudio Doglioni, Crhistof vonKalle, Luigi Naldini

Cancer Res (2008) 68 (9_Supplement): 1714.

Published: 01 May 2008

View articletitled, Discovery of cancer genes by high throughput lentiviral oncogene-tagging in hematopoietic and solid tissues

Journal Articles

Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2

Claire E. Lewis, Michele De Palma, Luigi Naldini

Cancer Res (2007) 67 (18): 8429–8432.

https://doi.org/10.1158/0008-5472.CAN-07-1684

Published: 17 September 2007

View articletitled, Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2

Journal Articles

MET Overexpression Turns Human Primary Osteoblasts into Osteosarcomas

Salvatore Patanè, Sofia Avnet, Nadia Coltella, Barbara Costa, Simone Sponza, Martina Olivero, Elisa Vigna, Luigi Naldini, Nicola Baldini, Riccardo Ferracini, Simona Corso, Silvia Giordano, Paolo M. Comoglio, Maria Flavia Di Renzo

Cancer Res (2006) 66 (9): 4750–4757.

https://doi.org/10.1158/0008-5472.CAN-05-4422

Published: 01 May 2006

View articletitled, MET Overexpression Turns Human Primary Osteoblasts into Osteosarcomas

Includes: Supplementary data

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Abstract LB029: TIGIT deletion rescues the antitumor activity of low avidity T cells by increasing TCR signal strength

Abstract CT127: A macrophages-based immunotherapy of solid tumors microenvironment: Preliminary results of the TEM-GBM_01 study

Abstract 5: Cytosine base editor ameliorates the safety profile of TCR edited T cells for the adoptive cell therapy of gastrointestinal tumors

Abstract 3297: IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy

Abstract 5213: Genetically modified Tie-2 expressing monocytes target IFN-α2 to the glioblastoma tumor microenvironment (TME): Preliminary data from the TEM-GBM Phase 1/2a study

Abstract CT180: Changes in immunologic responses and in the tumor microenvironment in patients with glioblastoma multiforme treated with IFN-a immune cell and gene therapy (TEM-GBM_001 Study)

Abstract 3169: Lentiviral vector-based insertional mutagenesis identifies new clinically relevant liver cancer genes.

Abstract 1013: Enriched miR-126 bioactivity marks the primitive compartment in human AML and regulates leukemia stem cell numbers

Abstract 104: New liver cancer genes identified by lentiviral vector-based insertional mutagenesis in mice are associated to differential survival in hepatocellular carcinoma patients

Abstract 2849: Tie2-expressing macrophages (TEM) depletion may enhance the clinical efficacy of combretastatin A-4-phosphate (CA-4-P)

Abstract 4982: Identification of new human liver cancer genes by a novel lentiviral vector-based insertional mutagenesis approach in three mouse models of hepatocarcinogenesis

Abstract 2937: Editing central memory T lymphocyte specificity for safe and effective adoptive immunotherapy of leukemia

Abstract SY27-02: Heterogeneity of tumor-associated macrophages: Implications for antiangiogenic therapy

Abstract 1366: Inhibition of Tie2+ macrophage infiltration into tumors in combination with CA-4-P therapy may enhance the clinical efficacy of this vascular disrupting agent

Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Abstract #1421: Cancer gene discovery in mouse models of hepatocarcinogenesis by insertional mutagenesis with genotoxic lentiviral vectors

Abstract #2076: Tie2-expressing monocytes: Relationship with tumor-associated macrophages and therapeutic opportunities

Discovery of cancer genes by high throughput lentiviral oncogene-tagging in hematopoietic and solid tissues

Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2

MET Overexpression Turns Human Primary Osteoblasts into Osteosarcomas

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