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Journal Articles

Abstract 444: ASXL1 mutations in AML are associated with a distinct epigenetic state that results in vulnerabilities to epigenetic-targeted agents

Free
Christopher P. Mill, Warren C. Fiskus, Christine E. Birdwell, John A. Davis, Kaberia Das, Hanxi Hou, Surbhi Sharma, Koji Sasaki, Sanam Loghavi, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Lu Wang, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 444.
https://doi.org/10.1158/1538-7445.AM2025-444
Published: 21 April 2025
View articletitled, Abstract 444: ASXL1 mutations in AML are associated with a distinct epigenetic state that results in vulnerabilities to epigenetic-targeted agents
Journal Articles

Abstract 7178: Advancing WGS and WTS diagnostic testing for pediatric leukemia: fast-tracking CNV, ploidy, and fusion oncogene detection in 5 days

Free
Rebecca K. Voss, Maria Cardenas, Meiling Jin, Yen-Chun Liu, Alexa N. Siskar, Stephen V. Rice, Michael N. Edmonson, Jennifer L. Neary, Caleb Gallops, Jiali Gu, Jamie L. Maciaszek, Michael Rusch, Mark R. Wilkinson, David Rosenfeld, Priya Kumar, Jeffery M. Klco, Charles G. Mullighan, Jinghui Zhang, David A. Wheeler, Lu Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7178.
https://doi.org/10.1158/1538-7445.AM2025-7178
Published: 21 April 2025
View articletitled, Abstract 7178: Advancing WGS and WTS diagnostic testing for pediatric leukemia: fast-tracking CNV, ploidy, and fusion oncogene detection in 5 days
Journal Articles

TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis

Available to Purchase
Yinlam Li, Ren Ming, Tianyi Zhang, Zixu Gao, Lu Wang, Yang Yang, Kangjie Shen, Chenlu Wei, Yu Zhu, Jianrui Li, Shaoluan Zheng, Zucheng Luo, Yiteng Ding, Jiangying Xuan, Qianrong Hu, Yanwen Yang, Jianying Gu, Chuanyuan Wei
Journal: Cancer Research
Cancer Res (2025) 85 (1): 84–100.
https://doi.org/10.1158/0008-5472.CAN-24-0158
Published: 02 January 2025
View articletitled, TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis
Open the PDF for TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract B036: Integrating gene expression evaluation in molecular diagnostics for pediatric AML molecular classification

Free
Lu Wang, Rebecca Voss, Victor Pastor Loyola, Maria F. Cardenas, Jing Ma, Priya Kumar, Mark R. Wilkinson, David A. Wheeler, Jeffery M. Klco
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B036.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B036
Published: 05 September 2024
View articletitled, Abstract B036: Integrating gene expression evaluation in molecular diagnostics for pediatric AML molecular classification
Journal Articles

Abstract 3898: SJPedPanel: A pan-cancer gene panel for childhood malignancies

Free
Pandurang Kolekar, Vidya Balagopal, Li Dong, Yanling Liu, Scott Foy, Quang Tran, Heather Mulder, Anna LW Huskey, Emily Plyler, Zhikai Liang, Jingqun Ma, Joy Nakitandwe, Jiali Gu, Jamie Maciaszek, Debbie Payne-Turner, Saradhi Mallampati, Lu Wang, John Easton, Jeffery M. Klco, Xiaotu Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3898.
https://doi.org/10.1158/1538-7445.AM2024-3898
Published: 22 March 2024
View articletitled, Abstract 3898: SJPedPanel: A pan-cancer gene panel for childhood malignancies
Journal Articles

Abstract 4506: Discovery of potent, highly selective and orally efficacious SMARCA2 degraders

Free
Lingying Leng, Lin Yang, Wenbin Tu, Rohan Rej, Srinivasa Rao Allu, Liyue Huang, Wei Jiang, Yu Wang, Jeanne Stuckey, Farzad R Sarkari, Meilin Wang, Lu Wang, Bo Wen, Duxin Sun, Shaomeng Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4506.
https://doi.org/10.1158/1538-7445.AM2024-4506
Published: 22 March 2024
View articletitled, Abstract 4506: Discovery of potent, highly selective and orally efficacious SMARCA2 degraders
Journal Articles

Abstract 4504: Discovery of CBPD-409 and CBPD-268 as highly potent and orally efficacious CBP/p300 PROTAC degraders for the treatment of castration-resistant prostate cancer

Free
Zhixiang Chen, Mi Wang, Dimin Wu, Lijie Zhao, Tianfeng Xu, Hoda Metwally, Yu Wang, Donna McEachern, Wei Jiang, Longchuan Bai, Jie Luo, Meilin Wang, Ruiting Li, John Takyi-Williams, Lu Wang, Qiuxia Li, Bo Wen, Duxin Sun, Arul M. Chinnaiyan, Shaomeng Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4504.
https://doi.org/10.1158/1538-7445.AM2024-4504
Published: 22 March 2024
View articletitled, Abstract 4504: Discovery of CBPD-409 and CBPD-268 as highly potent and orally efficacious CBP/p300 PROTAC degraders for the treatment of castration-resistant prostate cancer
Journal Articles

Abstract 3359: HEY1::NCOA2 fusion disturbs the transcriptional program of chondrogenic differentiation and activates oncogenes in mesenchymal chondrosarcoma tumorigenesis

Free
Wenqing Qi, Wojciech Rosikiewicz, Beisi Xu, Lu Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3359.
https://doi.org/10.1158/1538-7445.AM2024-3359
Published: 22 March 2024
View articletitled, Abstract 3359: HEY1::NCOA2 fusion disturbs the transcriptional program of chondrogenic differentiation and activates oncogenes in mesenchymal chondrosarcoma tumorigenesis
Journal Articles

Abstract 4401: GATA6 is a novel regulator of gene expression and 3D genome in colorectal cancer

Free
Huijue Lyu, Xintong Chen, Yang Cheng, Te Zhang, Ping Wang, Josiah Hiu-yuen Wong, Juan Wang, Lena Stasiak, Leyu Sun, Guangyu Yang, Lu Wang, Feng Yue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4401.
https://doi.org/10.1158/1538-7445.AM2024-4401
Published: 22 March 2024
View articletitled, Abstract 4401: GATA6 is a novel regulator of gene expression and 3D genome in colorectal cancer
Journal Articles

Abstract 7419: Seq2Karyotype (S2K): A method for deconvoluting heterogeneity of copy number alterations using single-sample whole-genome sequencing data

Free
Limeng Pu, Karol Szlachta, Virginia Valentine, Xiaolong Chen, Jian Wang, Dennis Kennetz, Daniel Putnam, Sivaraman Natarajan, Li Dong, Thomas Look, Marcin Wlodarski, Lu Wang, Steven Burden, John Easton, Xiang Chen, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7419.
https://doi.org/10.1158/1538-7445.AM2024-7419
Published: 22 March 2024
View articletitled, Abstract 7419: Seq2Karyotype (S2K): A method for deconvoluting heterogeneity of copy number alterations using single-sample whole-genome sequencing data
Journal Articles

Abstract CT003: IMbrave050: Phase 3 study of adjuvant atezolizumab + bevacizumab versus active surveillance in patients with hepatocellular carcinoma (HCC) at high risk of disease recurrence following resection or ablation

Free
Pierce Chow, Minshan Chen, Ann-Lii Cheng, Ahmed O. Kaseb, Masatoshi Kudo, Han Chu Lee, Adam Yopp, Jian Zhou, Lu Wang, Xiaoyu Wen, Jeong Heo, Won Young Tak, Shinichiro Nakamura, Kazushi Numata, Thomas Uguen, David Hsiehchen, Edward Cha, Stephen P. Hack, Qinshu Lian, Jessica Spahn, Chun Wu, Shukui Qin
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT003.
https://doi.org/10.1158/1538-7445.AM2023-CT003
Published: 29 May 2023
View articletitled, Abstract CT003: IMbrave050: Phase 3 study of adjuvant atezolizumab + bevacizumab versus active surveillance in patients with hepatocellular carcinoma (HCC) at high risk of disease recurrence following resection or ablation
Journal Articles

Abstract 1470: ASCL1 dimerizes with TCF12 protein and activates BMP-SMAD1 pathway during subtype switching from mesenchymal towards adrenergic neuroblastoma

Free
Lu Wang, Tze King Tan, Hyoju Kim, Dennis Kappei, Shi Hao Tan, A. Thomas Look, Takaomi Sanda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1470.
https://doi.org/10.1158/1538-7445.AM2023-1470
Published: 04 April 2023
View articletitled, Abstract 1470: ASCL1 dimerizes with TCF12 protein and activates BMP-SMAD1 pathway during subtype switching from mesenchymal towards adrenergic neuroblastoma
Journal Articles

Abstract 1462: Oncogenic activation of FOXR2 driven by somatic acquisition of a LINE-1 promoter in pediatric high-grade glioma

Free
Xiaolong Chen, Diane A. Flasch, Bensheng Ju, Heather L. Mulder, John Easton, Lu Wang, Suzanne J. Baker, Jason Chiang, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1462.
https://doi.org/10.1158/1538-7445.AM2022-1462
Published: 15 June 2022
View articletitled, Abstract 1462: Oncogenic activation of FOXR2 driven by somatic acquisition of a LINE-1 promoter in pediatric high-grade glioma
Journal Articles

Abstract LB200: Pdgf/Pi3k/akt axis activation by hey1-ncoa2 fusion and potential target in the treatment of mesenchymal chondrosarcoma

Free
Wenqing Qi, Lu Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB200.
https://doi.org/10.1158/1538-7445.AM2022-LB200
Published: 15 June 2022
View articletitled, Abstract LB200: Pdgf/Pi3k/akt axis activation by hey1-ncoa2 fusion and potential target in the treatment of mesenchymal chondrosarcoma
Journal Articles

Abstract 4092: Fuzzion2: Fast, sensitive detection of known gene fusions by fuzzy pattern matching for clinical testing and large-scale data mining

Free
Stephen V. Rice, Michael N. Edmonson, Liqing Tian, Michael Rusch, David A. Wheeler, Jennifer L. Neary, Scott Newman, Lu Wang, Patrick R. Blackburn, Michael Macias, Andrew Thrasher, Jian Wang, Mark R. Wilkinson, Xin Zhou, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4092.
https://doi.org/10.1158/1538-7445.AM2022-4092
Published: 15 June 2022
View articletitled, Abstract 4092: Fuzzion2: Fast, sensitive detection of known gene fusions by fuzzy pattern matching for clinical testing and large-scale data mining
Journal Articles

Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk

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Jianbo Tian, Can Chen, Meilin Rao, Ming Zhang, Zequn Lu, Yimin Cai, Pingting Ying, Bin Li, Haoxue Wang, Lu Wang, Yao Li, Jinyu Huang, Linyun Fan, Xiaomin Cai, Caibo Ning, Yanmin Li, Fuwei Zhang, Wenzhuo Wang, Yuan Jiang, Yizhuo Liu, Min Wang, Heng Li, Chaoqun Huang, Zhiyong Yang, Jiang Chang, Ying Zhu, Xiaojun Yang, Xiaoping Miao
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2084–2096.
https://doi.org/10.1158/0008-5472.CAN-21-4367
Published: 06 June 2022
View articletitled, Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk
Open the PDF for Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk in another window
Includes: Supplementary data
Journal Articles

PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

Open Access
Zibo Zhao, Aileen P. Szczepanski, Natsumi Tsuboyama, Hiam Abdala-Valencia, Young Ah Goo, Benjamin D. Singer, Elizabeth T. Bartom, Feng Yue, Lu Wang
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4696–4708.
https://doi.org/10.1158/0008-5472.CAN-21-1114
Published: 15 September 2021
View articletitled, PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
Open the PDF for PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer

Free
David A. Wheeler, Scott Newman, Joy Nakitandwe, Chimene A. Kesserwan, Elizabeth M. Azzato, Michael C. Rusch, Sheila Shurtleff, Armita Bahrami, Brent Orr, Jeffery M. Klco, Dale J. Hedges, Kayla V. Hamilton, Scott G. Foy, Michael N. Edmonson, Andrew Thrasher, Jiali Gu, Lynn W. Harrison, Lu Wang, Roya Mostafavi, Manish Kubal, Jamie Maciaszek, Michael Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W. Brady, Xin Zhou, Mark Wilkinson, Delaram Rahbarinia, Jay Knight, Jian Wang, Charles G. Mullighan, Rose B. McGee, Emily A. Quinn, Elsie L. Gerhardt, Leslie M. Taylor, Regina Nuccio, Jessica M. Valdez, Stacy J. Hines-Dowell, Alberto Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W. Ellison, James R. Downing, Jinghui Zhang, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 642.
https://doi.org/10.1158/1538-7445.AM2021-642
Published: 01 July 2021
View articletitled, Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer
Journal Articles

Abstract 1194: Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions

Free
Sara Lindström, Siddhartha Kar, Lu Wang, Constance Turman, James MacDonald, Theo Bammler, BCAC, OCAC, PRACTICAL, Jeroen Huyghe, Stephanie Schmit, Tracy A. O'Mara, Deborah J. Thompson, Puya Gharahkhani, Stuart MacGregor, Paul Brennan, Richard S. Houlston, Beatrice S. Melin, Christopher I. Amos, James McKay, Mark M. Iles, Matthew H. Law, Alison Klein, Laufey Amundadottir, Bogdan Pasaniuc, Paul Pharoah, Rayjean J. Hung, Peter Kraft
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1194.
https://doi.org/10.1158/1538-7445.AM2020-1194
Published: 15 August 2020
View articletitled, Abstract 1194: Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions
Journal Articles

An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin

Available to Purchase
Yangjun Wu, Yiming Zhao, Lin Huan, Jingjing Zhao, Yuqiang Zhou, Linguo Xu, Zhixiang Hu, Yizhe Liu, Zhiao Chen, Lu Wang, Shenglin Huang, Xianghuo He, Linhui Liang
Journal: Cancer Research
Cancer Res (2020) 80 (5): 976–987.
https://doi.org/10.1158/0008-5472.CAN-19-2115
Published: 02 March 2020
View articletitled, An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin
Open the PDF for An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin in another window
Includes: Supplementary data