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Journal Articles

Abstract 3547: Therapeutic efficacy of genetically modified CD34-derived allogeneic dendritic cell cancer vaccine platform in a pancreatic tumor model

Jose Dominic Gonzalez, Sara Huerta-Yepez, Neha Sheik, Senay Beraki, Elango Kathirvel, Ariel Rodriguez Frandsen, Saleemulla Mahammad, Lu Chen, Francois Binette, David Weinstein, Anahid Jewett
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3547.
https://doi.org/10.1158/1538-7445.AM2025-3547
Published: 21 April 2025
View articletitled, Abstract 3547: Therapeutic efficacy of genetically modified CD34-derived allogeneic dendritic cell cancer vaccine platform in a pancreatic tumor model
Journal Articles

CRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance

Meixi Wang, Fangdi Zou, Shengxin Wang, Yichen Yang, Cong Xia, Lu Chen, Ben Liu, Lian Li, Mulin Jun Li, Haixin Li, Weijie Song, Ruifang Niu, Zhiyong Yuan, Jie Yang, Xiangchun Li, Kexin Chen, Zhiqiang Wu, Zeyun Mi
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3196
Published: 04 March 2025
View articletitled, CRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Open the PDF for CRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance in another window
Includes: Supplementary data
Journal Articles

The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression

Dandan Liu, Benliang Wei, Long Liang, Yue Sheng, Shengjie Sun, Xing Sun, Maohua Li, Haobo Li, Chaoying Yang, Yuanliang Peng, Yifang Xie, Chengcai Wen, Lu Chen, Xionghao Liu, Xiang Chen, Hong Liu, Jing Liu
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2265–2281.
https://doi.org/10.1158/0008-5472.CAN-23-3942
Published: 15 July 2024
View articletitled, The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression
Open the PDF for The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression in another window
Includes: Supplementary data
Journal Articles

Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Haotian Liao, Xing Chen, Haichuan Wang, Youpei Lin, Lu Chen, Kefei Yuan, Mingheng Liao, Hanyu Jiang, Jiajie Peng, Zhenru Wu, Jiwei Huang, Jiaxin Li, Yong Zeng
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1747–1763.
https://doi.org/10.1158/0008-5472.CAN-23-3298
Published: 04 June 2024
View articletitled, Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers
Open the PDF for Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers in another window
Includes: Supplementary data
Journal Articles

Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)

Chase Neumann, Harish Shankaran, Kiran Nadella, Kelly Biette, Shane Rowley, Ethan Gardner, Shadi Swaidani, Vamshi Manda, Lu Chen, Daria Beshnova, Ashraf Saeed, Christopher Bailey, Janet Paulsen, Paul Rearden, Carl Brooks, Ashish Bhandari, Chris Gibson, Laura Schaevitz, Imran Haque, Hayley Donnella, Michael Cuccarese, Marie Evangelista
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7133.
https://doi.org/10.1158/1538-7445.AM2024-7133
Published: 22 March 2024
View articletitled, Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)
Journal Articles

Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets

Jenny Rudnick, Kiran Nadella, Chase Neumann, Shane Rowley, Ethan Gardner, Shadi Swaidani, Aimee Iberg, Lu Chen, Daria Beshnova, Aurora Blucher, Rebecca Sarto Basso, Malini Rajan, Kevin Fales, Ashraf Saeed, Christopher Bailey, Weston Judd, Chrissy Egbert, Joel Ellis, John Ansede, Pouya Hadipour, Kevin Jessing, Janet Paulsen, Paul Rearden, Vamshi Manda, Sashi Kasimsetty, Sashi Kasimsetty, Michael Hancock, Harish Shankaran, Bryan Ellis, Meenakshy Iyer, Carl Brooks, Ashish Bhandari, Chris Gibson, Irit Rappley, Laura Schaevitz, Imran Haque, Hayley Donnella, Michael Cuccarese, Marie Evangelista
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB071.
https://doi.org/10.1158/1538-7445.AM2023-LB071
Published: 14 April 2023
View articletitled, Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets
Journal Articles

Abstract 2815: Exploring the role of telomerase in senescence and exhaustion in CAR T cell immunotherapy

Tara Murty, Maria C. Ramello, Elena Sotillo, Lu Chen, Steven A. Artandi, Crystal L. Mackall
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2815.
https://doi.org/10.1158/1538-7445.AM2022-2815
Published: 15 June 2022
View articletitled, Abstract 2815: Exploring the role of telomerase in senescence and exhaustion in CAR T cell immunotherapy
Journal Articles

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M. Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3067–3078.
https://doi.org/10.1158/0008-5472.CAN-20-2694
Published: 01 June 2021
View articletitled, SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243
Open the PDF for SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243 in another window
Includes: Supplementary data
Journal Articles

Abstract PS6-53: Higher clinical lymph node stage predicts worse survival in patients with breast cancer who achieve a pathologic complete response after neoadjuvant chemotherapy

Li-Yun Xie, Kun Wang, Yan-Xia Shi, Hai-Lu Chen, Jian-Hao Huang, Yang-Hang Fan, Si-Qi Qiu, Zhi-Yong Wu
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS6-53.
https://doi.org/10.1158/1538-7445.SABCS20-PS6-53
Published: 15 February 2021
View articletitled, Abstract PS6-53: Higher clinical lymph node stage predicts worse survival in patients with breast cancer who achieve a pathologic complete response after neoadjuvant chemotherapy
Journal Articles

Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor–Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer

Tzu-Ting Huang, Ethan Brill, Jayakumar R. Nair, Xiaohu Zhang, Kelli M. Wilson, Lu Chen, Craig J. Thomas, Jung-Min Lee
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5380–5392.
https://doi.org/10.1158/0008-5472.CAN-20-1439
Published: 02 December 2020
View articletitled, Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor–Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer
Open the PDF for Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor–Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 457: Discovery and characterization of GNF-7 as a preferentially cytotoxic compound for camptothecin-resistant Ewing sarcoma cells

Carly M. Sayers, Morgan B. Carter, Haiyan Lei, Steven Shema, Xiaohu Zhang, Kelli Wilson, Lu Chen, Craig J. Thomas, Jack F. Shern
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 457.
https://doi.org/10.1158/1538-7445.AM2020-457
Published: 15 August 2020
View articletitled, Abstract 457: Discovery and characterization of GNF-7 as a preferentially cytotoxic compound for camptothecin-resistant Ewing sarcoma cells
Journal Articles

Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

Ukhyun Jo, Yasuhisa Murai, Junko Murai, Shar‐yin N Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Yves Pommier
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-121.
https://doi.org/10.1158/1538-7445.AM2020-LB-121
Published: 15 August 2020
View articletitled, Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents
Journal Articles

Abstract 621: Combined inhibition of checkpoint kinase 1 (CHK1) and phosphoinositide 3-kinase (PI3K) pathways induces greater replication stress and DNA damage in high-grade serous ovarian cancer (HGSOC)

Tzu-Ting Huang, Jayakumar Nair, Ethan Brill, Xiaohu Zhang, Kelli Wilson, Lu Chen, Craig J. Thomas, Jung-Min Lee
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 621.
https://doi.org/10.1158/1538-7445.AM2020-621
Published: 15 August 2020
View articletitled, Abstract 621: Combined inhibition of checkpoint kinase 1 (CHK1) and phosphoinositide 3-kinase (PI3K) pathways induces greater replication stress and DNA damage in high-grade serous ovarian cancer (HGSOC)
Journal Articles

Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer

Yi Gao, Lu Chen, ZunGuo Du, WenChao Gao, ZhengMing Wu, XiuJuan Liu, Hai Huang, DanFeng Xu, QingQuan Li
Journal: Cancer Research
Cancer Res (2019) 79 (18): 4638–4649.
https://doi.org/10.1158/0008-5472.CAN-19-0700
Published: 13 September 2019
View articletitled, Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer
Open the PDF for Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma

Shi-Lu Chen, Chris Zhiyi Zhang, Li-Li Liu, Shi-Xun Lu, Ying-Hua Pan, Chun-Hua Wang, Yang-Fan He, Cen-Shan Lin, Xia Yang, Dan Xie, Jing-Ping Yun
Journal: Cancer Research
Cancer Res (2019) 79 (3): 534–545.
https://doi.org/10.1158/0008-5472.CAN-18-2357
Published: 01 February 2019
View articletitled, A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma
Open the PDF for A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma in another window
Journal Articles

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Min Shen, Lu Chen, Rajarshi Guha, Bethelihem Tebase, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-066.
https://doi.org/10.1158/1538-7445.AM2018-LB-066
Published: 01 July 2018
View articletitled, Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein
Journal Articles

Abstract LB-188: POH1 knockdown induces cancer cell apoptosis via p53 and Bim

Shi-Lu Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-188.
https://doi.org/10.1158/1538-7445.AM2018-LB-188
Published: 01 July 2018
View articletitled, Abstract LB-188: POH1 knockdown induces cancer cell apoptosis via p53 and Bim
Journal Articles

CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma

Chris Zhiyi Zhang, Shi-Lu Chen, Chun-Hua Wang, Yang-Fan He, Xia Yang, Dan Xie, Jing-Ping Yun
Journal: Cancer Research
Cancer Res (2018) 78 (1): 51–63.
https://doi.org/10.1158/0008-5472.CAN-17-0700
Published: 02 January 2018
View articletitled, CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma
Open the PDF for CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis

Lu Chen, Jessica Chubak, Denise M. Boudreau, William E. Barlow, Noel S. Weiss, Christopher I. Li
Journal: Cancer Research
Cancer Res (2017) 77 (21): 6033–6041.
https://doi.org/10.1158/0008-5472.CAN-17-0687
Published: 31 October 2017
View articletitled, Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis
Open the PDF for Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis in another window
Includes: Supplementary data
Journal Articles

An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma

Ariosto Silva, Maria C. Silva, Praneeth Sudalagunta, Allison Distler, Timothy Jacobson, Aunshka Collins, Tuan Nguyen, Jinming Song, Dung-Tsa Chen, Lu Chen, Christopher Cubitt, Rachid Baz, Lia Perez, Dmitri Rebatchouk, William Dalton, James Greene, Robert Gatenby, Robert Gillies, Eduardo Sontag, Mark B. Meads, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2017) 77 (12): 3336–3351.
https://doi.org/10.1158/0008-5472.CAN-17-0502
Published: 14 June 2017
View articletitled, An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma
Open the PDF for An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma in another window
Includes: Supplementary data