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Journal Articles

Editor’s Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma

Louis Chesler, Chris Schlieve, David D. Goldenberg, Anna Kenney, Grace Kim, Alex McMillan, Katherine K. Matthay, David Rowitch, William A. Weiss
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3311.
https://doi.org/10.1158/0008-5472.CAN-24-2888
Published: 01 October 2024
View article titled, Editor’s Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma
Open the PDF for Editor’s Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma in another window
Journal Articles

Abstract A036 The Stratified Medicine Paediatrics programme for cancers of childhood: Cell free DNA and serial tumour sequencing identifies subtype specific evolution and epigenetic states

Sally L. George, Claire Lynn, Reda Stankunaite, Debbie Hughes, Jane Chalker, Saira Waqar Ahmed, Minou Oostveen, Paula Proszek, Lina Yuan, Ridwan Shaikh, Sabri Jamal, Jennifer Tall, Janet Shipley, Deborah Tweddle, Lynley Marshall, Chris Jones, Susanne Gatz, Aditi Vedi, Paola Angelini, John Anderson, George Cresswell, Trevor A. Graham, Bissan Al-Lazikani, Pamela Kearns, J. Ciaran Hutchinson, Darren Hargrave, Thomas Jacques, Michael Hubank, Andrea Sottoriva, Louis Chesler
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A036.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A036
Published: 05 September 2024
View article titled, Abstract A036 The Stratified Medicine Paediatrics programme for cancers of childhood: Cell free DNA and serial tumour sequencing identifies subtype specific evolution and epigenetic states
Journal Articles

Abstract A066 Acquired resistance to temozolomide in the Th-MYCN mouse as a clinically-relevant platform to evaluate novel therapeutic strategies against high-risk neuroblastoma

Evon Poon, Tong Liang, Giuseppe Barone, Barbara M. Costa, Sara Heuss, Simon P. Robinson, Charles Lin, Paul Workman, Yann Jamin, Louis Chesler
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A066.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A066
Published: 05 September 2024
View article titled, Abstract A066 Acquired resistance to temozolomide in the Th-<em>MYCN</em> mouse as a clinically-relevant platform to evaluate novel therapeutic strategies against high-risk neuroblastoma
Journal Articles

Abstract B035: Stratified Medicine Paediatrics2 – advancing precision medicine in paediatric cancer

Aditi Vedi, Sally George, Thomas Jacques, Isidro Cortes-Ciriano, Michael Hubank, Andrew Beggs, Maggie Cheang, Nuria Porta, Ciaran Hutchinson, Louise Hopkins, Amina Bukhari, Regan Barfoot, Steve Clifford, David O'Connor, Timothy Ritzmann, Amos Burke, John Anderson, Darren Hargrave, Louis Chesler
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B035.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B035
Published: 05 September 2024
View article titled, Abstract B035: Stratified Medicine Paediatrics2 – advancing precision medicine in paediatric cancer
Journal Articles

Abstract B063: Unveiling the immune landscape of recurrent, MYC-driven medulloblastoma

Ben Draper, Dean Thompson, Alaide Morcavallo, Bethany Remeniuk, John Anderson, Louis Chesler, Steve Clifford, Frank Huang, Laura K. Donovan
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B063.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B063
Published: 05 September 2024
View article titled, Abstract B063: Unveiling the immune landscape of recurrent, MYC-driven medulloblastoma
Journal Articles

Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models

Emilie Indersie, Sophie Branchereau, Brice Fresneau, Christophe Chardot, Didier Surdez, Alexandra Saint-Charles, Maria Eugénia Marques da Costa, Ángel M. Carcaboso, Katia Scotlandi, Massimo Moro, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Louis Chesler, Chris Jones, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Christina Guttke, Maureen Hattersley, Frédéric Colland, Ashley Strougo, Dennis Gürgen, Jens Hoffmann, Julia Schueler, Pablo M. Aviles, María José Guillén, Aniello Federico, Apurva Gopisetty, Justyna Anna Wierzbinska, Andreas Schlicker, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Nicole Huebener, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Louis F. Stancato, Stefan M. Pfister, Gilles Vassal, Eva-Maria Rief, Olivier Déas
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5469.
https://doi.org/10.1158/1538-7445.AM2024-5469
Published: 22 March 2024
View article titled, Abstract 5469: ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models
Journal Articles

Abstract 4871: Dysregulation of MYC-family proteins sensitizes cancers to NMT inhibition: identification of NMTi sensitivity and mechanism

James Zhang, Gregor A. Lueg, Monica Faronato, Evon Poon, Andrii Gorelik, Andrea G. Grocin, Eva Caamano-Gutierrez, Francesco Falciani, Roberto Solari, Robin Carr, Andrew S. Bell, Edward Bartlett, Jennie Hutton, Miriam Llorian-Sopena, Probir Chakravarty, Bernadette Brzezicha, Martin Janz, Matther J. Garnett, Louis Chesler, Dinis P. Calado, Edward W. Tate
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4871.
https://doi.org/10.1158/1538-7445.AM2023-4871
Published: 04 April 2023
View article titled, Abstract 4871: Dysregulation of MYC-family proteins sensitizes cancers to NMT inhibition: identification of NMTi sensitivity and mechanism
Journal Articles

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 234.
https://doi.org/10.1158/1538-7445.AM2023-234
Published: 04 April 2023
View article titled, Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <em>in vivo</em> testing
Journal Articles

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis Chesler, Chris Jones, Maria Eugénia Marques da Costa, Katia Scotlandi, Massimo Moro, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Ángel Montero Carcaboso, Dennis Gürgen, Jens Hoffmann, Emilie Indersie, Stefano Cairo, Julia Schueler, Nicole Huebener, Johannes H. Schulte, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Gilles Vassal, Lou F. Stancato, Lou F. Stancato, Stefan M. Pfister, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3571.
https://doi.org/10.1158/1538-7445.AM2023-3571
Published: 04 April 2023
View article titled, Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models
Journal Articles

Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma

Konstantinos Zormpas-Petridis, Evon Poon, Matthew Clarke, Neil P. Jerome, Jessica K.R. Boult, Matthew D. Blackledge, Fernando Carceller, Alexander Koers, Giuseppe Barone, Andrew D.J. Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Louis Chesler, Yinyin Yuan, Simon P. Robinson, Yann Jamin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (16): 3424–3435.
https://doi.org/10.1158/0008-5472.CAN-20-0133
Published: 14 August 2020
View article titled, Noninvasive MRI Native T<sub>1</sub> Mapping Detects Response to <em>MYCN</em>-targeted Therapies in the Th-<em>MYCN</em> Model of Neuroblastoma
Open the PDF for Noninvasive MRI Native T<sub>1</sub> Mapping Detects Response to <em>MYCN</em>-targeted Therapies in the Th-<em>MYCN</em> Model of Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract IA11: Overcoming immune evasion in pediatric brain tumors

Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan, Meher B. Masihi, Jessica M. Rusert, Paula S. Norris, Florent Carrette, Megan M. Romero, Sorana A. Morrissy, Patryk Skowron, Florence M.G. Cavalli, Hamza Farooq, Vijay Ramaswamy, Alaide Morcavallo, Jacob J. Henderson, James M. Olson, Yoon-Jae Cho, Xiao-Nan Li, Louis Chesler, Marco A. Marra, Oren J. Becher, Linda M. Bradley, Carl F. Ware, Michael D. Taylor, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA11.
https://doi.org/10.1158/1538-7445.PEDCA19-IA11
Published: 15 July 2020
View article titled, Abstract IA11: Overcoming immune evasion in pediatric brain tumors
Journal Articles

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography

Jin Li, Konstantinos Zormpas-Petridis, Jessica K.R. Boult, Emma L. Reeves, Andreas Heindl, Maria Vinci, Filipa Lopes, Craig Cummings, Caroline J. Springer, Louis Chesler, Chris Jones, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (22): 5874–5883.
https://doi.org/10.1158/0008-5472.CAN-19-1595
Published: 15 November 2019
View article titled, Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography
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Includes: Supplementary data
Journal Articles

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

Orli Yogev, Gilberto S. Almeida, Karen T. Barker, Sally L. George, Colin Kwok, James Campbell, Magdalena Zarowiecki, Dimitrios Kleftogiannis, Laura M. Smith, Albert Hallsworth, Philip Berry, Till Möcklinghoff, Hannah T. Webber, Laura S. Danielson, Bliss Buttery, Elizabeth A. Calton, Barbara M. da Costa, Evon Poon, Yann Jamin, Stefano Lise, Gareth J. Veal, Neil Sebire, Simon P. Robinson, John Anderson, Louis Chesler
Journal: Cancer Research
Cancer Res (2019) 79 (20): 5382–5393.
https://doi.org/10.1158/0008-5472.CAN-18-2759
Published: 15 October 2019
View article titled, <em>In Vivo</em> Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis
Open the PDF for <em>In Vivo</em> Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis in another window
Includes: Supplementary data
Journal Articles

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

Konstantinos Zormpas-Petridis, Neil P. Jerome, Matthew D. Blackledge, Fernando Carceller, Evon Poon, Matthew Clarke, Ciara M. McErlean, Giuseppe Barone, Alexander Koers, Sucheta J. Vaidya, Lynley V. Marshall, Andrew D.J. Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Yinyin Yuan, Louis Chesler, Simon P. Robinson, Yann Jamin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (11): 2978–2991.
https://doi.org/10.1158/0008-5472.CAN-18-3412
Published: 03 June 2019
View article titled, MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment
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Includes: Supplementary data
Journal Articles

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Livingstone Fultang, Laura D. Gamble, Luciana Gneo, Andrea M. Berry, Sharon A. Egan, Fenna De Bie, Orli Yogev, Georgina L. Eden, Sarah Booth, Samantha Brownhill, Ashley Vardon, Carmel M. McConville, Paul N. Cheng, Murray D. Norris, Heather C. Etchevers, Jayne Murray, David S. Ziegler, Louis Chesler, Ronny Schmidt, Susan A. Burchill, Michelle Haber, Carmela De Santo, Francis Mussai
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (3): 611–624.
https://doi.org/10.1158/0008-5472.CAN-18-2139
Published: 01 February 2019
View article titled, Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
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Includes: Supplementary data
Journal Articles

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

Orli Yogev, Karen Barker, Arti Sikka, Gilberto S. Almeida, Albert Hallsworth, Laura M. Smith, Yann Jamin, Ruth Ruddle, Alexander Koers, Hannah T. Webber, Florence I. Raynaud, Sergey Popov, Chris Jones, Kevin Petrie, Simon P. Robinson, Hector C. Keun, Louis Chesler
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (10): 3025–3035.
https://doi.org/10.1158/0008-5472.CAN-15-1939
Published: 12 May 2016
View article titled, p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance
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Includes: Supplementary data
Journal Articles

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

Francis Mussai, Sharon Egan, Stuart Hunter, Hannah Webber, Jonathan Fisher, Rachel Wheat, Carmel McConville, Yordan Sbirkov, Kate Wheeler, Gavin Bendle, Kevin Petrie, John Anderson, Louis Chesler, Carmela De Santo
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (15): 3043–3053.
https://doi.org/10.1158/0008-5472.CAN-14-3443
Published: 02 August 2015
View article titled, Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity
Open the PDF for Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract 1488: In vivo magnetic resonance elastography in pediatric brain tumor models

Jin Li, Jessica K.R. Boult, Maria Vinci, Sergey Popov, Karen Barker, Zai Ahmad, Yann Jamin, Craig Cummings, Suzanne A. Eccles, Jeffrey C. Bamber, Ralph Sinkus, Louis Chesler, Chris Jones, Simon P. Robinson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1488.
https://doi.org/10.1158/1538-7445.AM2015-1488
Published: 01 August 2015
View article titled, Abstract 1488: <em>In vivo</em> magnetic resonance elastography in pediatric brain tumor models
Journal Articles

Abstract 491: Tumor response to cabozantinib in the TH-MYCN GEM model of neuroblastoma

Gilberto S. Almeida, Philippa King, Yann Jamin, Albert Hallsworth, Hannah Webber, Sergey Popov, Andrew D.J. Pearson, Louis Chesler, Simon P. Robinson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 491.
https://doi.org/10.1158/1538-7445.AM2015-491
Published: 01 August 2015
View article titled, Abstract 491: Tumor response to cabozantinib in the TH-MYCN GEM model of neuroblastoma
Journal Articles

Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic

Elizabeth R. Tucker, Laura S. Danielson, Paolo Innocenti, Louis Chesler
Journal: Cancer Research
Cancer Res (2015) 75 (14): 2770–2774.
https://doi.org/10.1158/0008-5472.CAN-14-3817
Published: 14 July 2015
View article titled, Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic
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