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Loredana Pellegrino
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Journal Articles

Abstract 6441: Discovery of ARID1A loss as a patient biomarker for NXP800 - A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer

Robert H. te Poele, Marissa Powers, Swee Sharp, Emmanuel de Billy, Maria Taskinen, Loredana Pellegrino, Sharon Gowan, Asadh Miah, Angela Hayes, Matthew Cheeseman, Keith Jones, Suzanne Eccles, Florence Raynaud, Paul Clarke, Paul Workman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6441.
https://doi.org/10.1158/1538-7445.AM2024-6441
Published: 22 March 2024
View article titled, Abstract 6441: Discovery of ARID1A loss as a patient biomarker for NXP800 - A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer
Journal Articles

Abstract PR-002: Activation of the integrated stress response by NXP800, an orally available, clinical-stage, investigational agent in ARID1A-mutated, platinum resistant ovarian cancer

Marissa V. Powers, Swee Y. Swap, Robert te Poele, Eirini-Maria Lampraki, Toby Roe, Loredana Pellegrino, Maria Taskinen, Suzenne Eccles, Florence Raynaud, Matthew Cheeseman, Keith Jones, Paul A. Clarke, Paul Workman
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): PR-002.
https://doi.org/10.1158/1538-7445.OVARIAN23-PR-002
Published: 04 March 2024
View article titled, Abstract PR-002: Activation of the integrated stress response by NXP800, an orally available, clinical-stage, investigational agent in ARID1A-mutated, platinum resistant ovarian cancer
Journal Articles

Abstract LB234: Activation of the integrated stress response by the developmental HSF1 pathway inhibitor NXP800

Marissa V. Powers, Swee Y. Sharp, Eirini-Maria Lampraki, Toby Roe, Loredana Pellegrino, Maria Taskinen, Robert te Poele, Florence Raynaud, Suzanne Eccles, Matthew Cheeseman, Keith Jones, Paul A. Clarke, Paul Workman
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB234.
https://doi.org/10.1158/1538-7445.AM2023-LB234
Published: 14 April 2023
View article titled, Abstract LB234: Activation of the integrated stress response by the developmental HSF1 pathway inhibitor NXP800
Journal Articles

Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen

Matthew D. Cheeseman, Nicola E. Chessum, Carl S. Rye, Elisa A. Pasqua, Michael J. Tucker, Birgit Wilding, Lindsay E. Evans, Susan Lepri, Meirion Richards, Swee Y. Sharp, Salyha Ali, Martin Rowlands, Lisa O'Fee, Asadh Miah, Angela Hayes, Alan T. Henley, Marissa Powers, Robert te Poele, Emmanuel De Billy, Loredana Pellegrino, Florence Raynaud, Rosemary Burke, Robert L. van Montfort, Suzanne A. Eccles, Keith Jones, Paul Workman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-304.
https://doi.org/10.1158/1538-7445.AM2017-LB-304
Published: 01 July 2017
View article titled, Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
Journal Articles

Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

Filipa G. Pinho, Adam E. Frampton, Joao Nunes, Jonathan Krell, Heba Alshaker, Jimmy Jacob, Loredana Pellegrino, Laura Roca-Alonso, Alexander de Giorgio, Victoria Harding, Jonathan Waxman, Justin Stebbing, Dmitry Pchejetski, Leandro Castellano
Journal: Cancer Research
Cancer Res (2013) 73 (19): 5936–5948.
https://doi.org/10.1158/0008-5472.CAN-13-0158
Published: 01 October 2013
View article titled, Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Open the PDF for Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation in another window
Includes: Supplementary data