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Journal Articles

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2023) 83 (6): 922–938.
https://doi.org/10.1158/0008-5472.CAN-21-3052
Published: 15 March 2023
View articletitled, Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
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Includes: Supplementary data
Journal Articles

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (5): 1216–1229.
https://doi.org/10.1158/0008-5472.CAN-20-0652
Published: 01 March 2021
View articletitled, A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
Open the PDF for A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shaoyan Hu, Li-Yan Xu, En-Min Li, Yanbing Ding, Samuel J. Klempner, Simon A. Gayther, Benjamin P. Berman, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (13): 2722–2736.
https://doi.org/10.1158/0008-5472.CAN-20-0390
Published: 02 July 2020
View articletitled, Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
Open the PDF for Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling

Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding, Anand Mayakonda, Nachiyappan Venkatachalam, Mei-Shi Yeo, Tiago C. Silva, Jin-Fen Xiao, Ngan B. Doan, Jonathan W. Said, Xue-Bin Ran, Si-Qin Zhou, Pushkar Dakle, Pavithra Shyamsunder, Angele Pei-Fern Koh, Ruby Yun-Ju Huang, Benjamin P. Berman, Soo-Yong Tan, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2020) 80 (2): 219–233.
https://doi.org/10.1158/0008-5472.CAN-18-2796
Published: 15 January 2020
View articletitled, RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling
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Includes: Supplementary data
Journal Articles

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma

Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W. Tyner, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6614–6626.
https://doi.org/10.1158/0008-5472.CAN-17-1143
Published: 30 November 2017
View articletitled, Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
View articletitled, Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target
Journal Articles

Abstract 4494: Tumor suppressive role of ZFP36L1 by suppressing HIF1α and Cyclin D1 in bladder and breast cancer

Xin Yi Loh, Ling Wen Ding, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4494.
https://doi.org/10.1158/1538-7445.AM2017-4494
Published: 01 July 2017
View articletitled, Abstract 4494: Tumor suppressive role of ZFP36L1 by suppressing HIF1α and Cyclin D1 in bladder and breast cancer
Journal Articles

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma

De-Chen Lin, Anand Mayakonda, Huy Q. Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-wen Ding, Jie Wang, Benjamin P. Berman, Er-Wei Song, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2255–2265.
https://doi.org/10.1158/0008-5472.CAN-16-2822
Published: 30 April 2017
View articletitled, Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Ling-Wen Ding, Qiao-Yang Sun, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda Thippeswamy, Allen Eng Juh Yeoh, Norihiko Kawamata, Yasunobu Nagata, Jin-Fen Xiao, Xin-Yi Loh, De-Chen Lin, Manoj Garg, Yan-Yi Jiang, Liang Xu, Su-Lin Lim, Li-Zhen Liu, Vikas Madan, Masashi Sanada, Lucia Torres Fernández, Hema Preethi, Michael Lill, Hagop M. Kantarjian, Steven M. Kornblau, Satoru Miyano, Der-Cherng Liang, Seishi Ogawa, Lee-Yung Shih, Henry Yang, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (2): 390–400.
https://doi.org/10.1158/0008-5472.CAN-16-1303
Published: 16 January 2017
View articletitled, Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Abstract 3939: The genomic landscape of nasopharyngeal carcinoma

DECHEN LIN, Xuan Meng, Masaharu Hazawa, Yasunobu Nagata, Ana Maria Varela, Liang Xu, Yusuke Sato, Li-Zhen Liu, Ling-Wen Ding, Arjun Sharma, Boon Cher Goh, Soo Chin Lee, Bengt Fredrik Petersson, Feng Gang Yu, Paul Macary, Min Zin Oo, Soh Ha Chan, Henry Yang, Seishi Ogawa, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3939.
https://doi.org/10.1158/1538-7445.AM2015-3939
Published: 01 August 2015
View articletitled, Abstract 3939: The genomic landscape of nasopharyngeal carcinoma
Journal Articles

Abstract 138: Novel PAK4 allosteric modulators (PAMs) provide potential therapeutic options in human gastric cancer

Wenwen Chien, Jinfen Xiao, Ling-Wen Ding, Muhammad Ikhsan B. Muzakar, Qiao-Yang Sun, Sigal Gery, William Senapedis, Sharon Shacham, Erkan Baloglu, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 138.
https://doi.org/10.1158/1538-7445.AM2015-138
Published: 01 August 2015
View articletitled, Abstract 138: Novel PAK4 allosteric modulators (PAMs) provide potential therapeutic options in human gastric cancer
Journal Articles

Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma

Liang Xu, De-Chen Lin, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shi-zhu Yu, Michael Kahn, Dong Yin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 122.
https://doi.org/10.1158/1538-7445.AM2015-122
Published: 01 August 2015
View articletitled, Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma
Journal Articles

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

De-Chen Lin, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1815–1827.
https://doi.org/10.1158/0008-5472.CAN-14-1433
Published: 30 April 2015
View articletitled, Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma
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Includes: Supplementary data
Journal Articles

Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR

Manoj Garg, Deepika Kanojia, Ryoko Okamoto, Vikas Madan, Wenwen Chien, Abhishek Sampath, Ling-Wen Ding, Meng Xuan, Jonathan W Said, Ngan Doan, Li-Zhen Liu, Henry Yang, Sigal Gery, Gleen D Braunstein, H.Phillip Koeffler
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5570.
https://doi.org/10.1158/1538-7445.AM2014-5570
Published: 01 October 2014
View articletitled, Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR
Journal Articles

Abstract 586: Genomic and functional characterizations of phosphodiesterase 4Din human cancers.

Dechen Lin, Liang Xu, Ling-Wen Ding, Arjun Sharma, Li-Zhen Liu, Henry Yang, Patrick Tan, Jay Vadgama, Beth Karlan, Jenny Lester, Nicole Urban, Michèl Schummer, Ngan Doan, Jonathan Said, Martin Walsh, Paresma Patel, Craig Thomas, Daniel Chan, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 586.
https://doi.org/10.1158/1538-7445.AM2013-586
Published: 15 April 2013
View articletitled, Abstract 586: Genomic and functional characterizations of phosphodiesterase 4Din human cancers.