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Journal Articles

Abstract CT504: A phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics (PK) and efficacy of D-1553, a novel KRASG12C inhibitor, in patients with advanced or metastatic solid tumor harboring KRASG12C mutation

Timothy Price, Jaspreet Grewal, Afaf Abed, Melissa Moore, Yu-Min Yeh, Shirish Gadgeel, Gary Richardson, Craig Underhill, Vinod Ganju, Keun-Wook Lee, Seok Jae Huh, Sang-We Kim, Chih-Hsin Yang, Yuh-Min Chen, Ziyong Xiang, Zhe Shi, Yaolin Wang, Ling Zhang, Michael Millward
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT504.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT504
Published: 15 June 2022
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Abstract CT505: Phase I study of D-1553 to assess safety and efficacy in patients with non-small cell lung cancer (NSCLC) harboring KRASG12C mutation

Hong Jian, Zhenbo Song, Yiping Zhang, Kunyan Li, Nong Yang, Melissa Moore, Pingli Wang, Yanqiu Zhao, Yi Gong, Craig Underhill, Sang-We Kim, Cheng-Ta Yang, Ziyong Xiang, Zhe Shi, Ling Zhang, Yaolin Wang, Shun Lu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT505.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT505
Published: 15 June 2022
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Journal Articles

Abstract 932: Discovery of D-1553, a novel and selective KRas-G12C Inhibitor with potent anti-tumor activity in a broad spectrum of tumor cell lines and xenograft models

Zhe Shi, Jifang Weng, Xiaochong Fan, Emma Wang, Qingqing Zhu, Liangshan Tao, Zixing Han, Zhenwu Wang, Haotao Niu, Yueheng Jiang, Ling Zhang, Xing Dai, Yaolin Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 932.
DOI: https://doi.org/10.1158/1538-7445.AM2021-932
Published: 01 July 2021
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Journal Articles

Abstract 1056: Potent in vivo anti-tumor activity of D-1553 as a single agent and in combination with targeted therapeutics in a broad spectrum of patient-derived xenograft tumor models with KRas G12C mutation

Zhe Shi, Jifang Weng, Xiaochong Fan, Qingqing Zhu, Emily Robb, Alyssa Moriarty, Michael Wick, Yueheng Jiang, Ling Zhang, Xing Dai, Yaolin Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1056.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1056
Published: 01 July 2021
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Journal Articles

Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition

Laura Misiara Lincheta, Ling Zhang, Govindi Samaranayake, Nisha Sharma, Dao Nguyen, Yu-Ki Tahara, Eric Kool, Priyamvada Rai
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2076.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2076
Published: 01 July 2021
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Journal Articles

Abstract PS11-26: A phase 1 study of D-0502, an orally bioavailable SERD, for advanced or metastatic HR-positive and HER2-negative breast cancer

Cynthia Osborne, Donald A Richards, Sharon T Wilks, Sami Diab, Dejan Juric, Kate Lathrop, Andrea Silber, William Edenfield, Amardeep Aulakh, Ben Cho, Binghe Xu, Tao Sun, Quchang Ouyang, Yanxia Shi, Kathryn Stazzone, Zhe Shi, Ling Zhang, Yaolin Wang, Erika P Hamilton
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS11-26.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS11-26
Published: 15 February 2021
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Journal Articles

Abstract CT068: Phase Ib/II combination study of APR-246 and azacitidine (AZA) in patients with TP53 mutant myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)

David A. Sallman, Amy DeZern, Kendra Sweet, David P. Steensma, Thomas Cluzeau, Mikkael Sekeres, Guillermo Garcia-Manero, Gail Roboz, Amy McLemore, Kathy McGraw, John Puskas, Ling Zhang, Chirag Bhagat, Armin Graber, Najla H. Al Ali, Eric Padron, Roger Tell, Jeffrey E. Lancet, Pierre Fenaux, Alan F. List, Rami S. Komrokji
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT068.
DOI: https://doi.org/10.1158/1538-7445.AM2018-CT068
Published: 01 July 2018
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Journal Articles

Abstract 954: TGF-ß signaling inhibition counteracts myelofibrosis in MPN

Matthias Bartenstein, Lanzhu Yue, Wanke Zhao, Wanting Tina Ho, Cem Murdun, Adam W. Mailloux, Ling Zhang, Anjali Budhakoti, Kith Pradhan, Franck Rapaport, Huaquan Wang, Zonghong Shao, Ulrich Steidl, Ross L. Levine, Zhizhuang Joe Zhao, Amit K. Verma, Pearlie K. Epling-Burnette
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 954.
DOI: https://doi.org/10.1158/1538-7445.AM2017-954
Published: 01 July 2017
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Journal Articles

Abstract 2648: Chimeric antigen receptor T-cell therapy against anaplastic lymphoma kinase (ALK) is limited by target antigen density and CAR surface expression

Robbie G. Majzner, Alec J. Walker, Meera Murgai, Ling Zhang, Adrienne H. Long, Kelsey M. Wanhainen, Rimas J. Orentas, Crystal L. Mackall
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2648.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2648
Published: 15 July 2016
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Journal Articles

Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

Ashley A. Basiorka, Kathy L. McGraw, Leentje De Ceuninck, Lori N. Griner, Ling Zhang, Justine A. Clark, Gisela Caceres, Lubomir Sokol, Rami S. Komrokji, Gary W. Reuther, Sheng Wei, Jan Tavernier, Alan F. List
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3531–3540.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-1756
Published: 14 June 2016
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Journal Articles

Abstract 3140: Antigen-induced downmodulation is associated with diminished efficacy of a novel chimeric antigen receptor targeting anaplastic lymphoma kinase

Alec J. Walker, Ling Zhang, Adrienne H. Long, Rimas J. Orentas, Crystal L. Mackall
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3140.
DOI: https://doi.org/10.1158/1538-7445.AM2015-3140
Published: 01 August 2015
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Journal Articles

Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms

Stefan Klingler, Baofeng Guo, Jun Yao, Haiyan Yan, Ling Zhang, Angelina V. Vaseva, Sida Chen, Peter Canoll, James W. Horner, Y. Alan Wang, Ji-Hye Paik, Haoqiang Ying, Hongwu Zheng
Journal: Cancer Research
Cancer Res (2015) 75 (10): 2109–2119.
DOI: https://doi.org/10.1158/0008-5472.CAN-14-3122
Published: 13 May 2015
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Includes: Supplementary data
Journal Articles

Abstract 975: MicroRNA-155 In chronic lymphocytic leukemia influences B-cell receptor signaling

Liguang Chen, Bing Cui, Suping Zhang, Marek Mraz, Jessie-F. Fecteau, Jian Yu, Ling Zhang, Lei Bao, Laura Rassenti, Karen Messer, Carlo Croce, Thomas Kipps
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 975.
DOI: https://doi.org/10.1158/1538-7445.AM2014-975
Published: 01 October 2014
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Journal Articles

Abstract A38: A functional connection between the SWI/SNF-BAF ATPase BRG1 and the tumor suppressor BRCA1 in DNA damage response

Ling Zhang, Hua Chen, Feng Gong
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): A38.
DOI: https://doi.org/10.1158/1538-7445.CEC13-A38
Published: 13 May 2014
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Journal Articles

Inhibition of Tumor Cell Migration by LD22-4, an N-Terminal Fragment of 24-kDa FGF2, Is Mediated by Neuropilin 1

Ling Zhang, Graham C. Parry, Eugene G. Levin
Journal: Cancer Research
Cancer Res (2013) 73 (11): 3316–3325.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-3015
Published: 30 May 2013
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Includes: Supplementary data
Journal Articles

Abstract 4944: Combined treatment of BTK and PI3K inhibitors synergistically disrupts BCR-signaling, overcomes microenviroment-mediated survival and drug resistance in mantle cell lymphoma.

Jiangchuan Tao, Tint Lwin, Xiaohong Zhao, Bijal Shah, Ling Zhang, Lynn Moscinski, William Dalton, Eduardo M. Sotomayor, Jianguo Tao
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4944.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4944
Published: 15 April 2013
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Journal Articles

Abstract 5472: Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44.

Suping Zhang, Christina Wu, Jessie Farrah-Fecteau, Bing Cui, Liguang Chen, Ling Zhang, Rongrong Wu, Laura Rassenti, Fitzgerald S. Lao, Stefan Weigand, Thomas J. Kipps
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5472.
DOI: https://doi.org/10.1158/1538-7445.AM2013-5472
Published: 15 April 2013
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Journal Articles

Abstract 613: The chromatin remodeling protein BRG1 modulates BRCA1’s response to UV irradiation.

Ling Zhang, Hua Chen, Feng Gong
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 613.
DOI: https://doi.org/10.1158/1538-7445.AM2013-613
Published: 15 April 2013
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Journal Articles

Abstract 4378: Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma

Yun Cao, Zhi-Ling Zhang, Ming Zhou, Paul Elson, Brian Rini, Hakan Aydin, Kristin Feenstra, Min-Han Tan, Bree Berghuis, Rebeka Tabbey, James Resau, Fang-Jian Zhou, Bin Tean Teh, Chao-Nan Qian
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4378.
DOI: https://doi.org/10.1158/1538-7445.AM2012-4378
Published: 15 April 2012
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Journal Articles

Abstract 3425: Interleukin-27 inhibits epithelial mesenchymal transition in lung carcinogenesis

Jay M. Lee, Ling Zhang, Puja Kachroo, Xiaoyan Cui, Saswati Hazra, Tonya C. Walser, John D. Minna, Sherven Sharma, Steven M. Dubinett
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3425.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3425
Published: 15 April 2011
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