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Linda Z. Penn
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Journal Articles

Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

Peter Lin, Corey Lourenco, Jennifer Cruickshank, Luis Palomero, Jenna E. van Leeuwen, Amy H. Y. Tong, Katherine Chan, Samah El Ghamrasni, Miquel Angel Pujana, David W. Cescon, Jason Moffat, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4015–4029.
https://doi.org/10.1158/0008-5472.CAN-22-2948
Published: 15 December 2023
View article titled, Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
Open the PDF for Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality in another window
Includes: Supplementary data
Journal Articles

Abstract B073: Inhibiting prostate cancer by targeting the metabolic mevalonate pathway

Diandra Zipinotti dos Santos, Mohamad Elbaz, Emily Branchard, Wiebke Schormann, David W. Andrews, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B073.
https://doi.org/10.1158/1538-7445.PRCA2023-B073
Published: 02 June 2023
View article titled, Abstract B073: Inhibiting prostate cancer by targeting the metabolic mevalonate pathway
Journal Articles

Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity

Wail Ba-Alawi, Sisira Kadambat Nair, Bo Li, Anthony Mammoliti, Petr Smirnov, Arvind Singh Mer, Linda Z. Penn, Benjamin Haibe-Kains
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2378–2387.
https://doi.org/10.1158/0008-5472.CAN-21-2395
Published: 05 July 2022
View article titled, Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity
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Includes: Supplementary data
Journal Articles

Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching

Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Cunjie Zhang, Emily Branchard, Mohamad Elbaz, David W. Cescon, Richard R. Drake, James W. Dennis, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2625–2635.
https://doi.org/10.1158/0008-5472.CAN-20-2642
Published: 15 May 2021
View article titled, Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced <em>N</em>-glycosylation Abundance and Branching
Open the PDF for Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced <em>N</em>-glycosylation Abundance and Branching in another window
Includes: Supplementary data
Journal Articles

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Levens, John M. Maris, Ronen Marmorstein, Steven J. Metallo, Julie R. Park, Linda Z. Penn, Michael Rape, Martine F. Roussel, Kevan M. Shokat, William P. Tansey, Kliment A. Verba, Seychelle M. Vos, William A. Weiss, Elmar Wolf, Yaël P. Mossé
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1627–1632.
https://doi.org/10.1158/0008-5472.CAN-20-3108
Published: 01 April 2021
View article titled, Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
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Journal Articles

Abstract 5423: Lysine-52 stabilizes the MYC oncoprotein through a SCFFBXW7-independent mechanism

Jason De Melo, Sam S. Kim, Corey Lourenco, Diana Resetca, Maria Sunnerhagen, Brian Raught, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5423.
https://doi.org/10.1158/1538-7445.AM2018-5423
Published: 01 July 2018
View article titled, Abstract 5423: Lysine-52 stabilizes the MYC oncoprotein through a SCF<sup>FBXW7</sup>-independent mechanism
Journal Articles

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Peter J. Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2018) 78 (5): 1347–1357.
https://doi.org/10.1158/0008-5472.CAN-17-1231
Published: 28 February 2018
View article titled, Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins
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Includes: Supplementary data
Journal Articles

Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents

Jenna van Leeuwen, Aleksandra Pandyra, Carolyn Goard, Peter J. Mullen, Rosemary Yu, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3543.
https://doi.org/10.1158/1538-7445.AM2017-3543
Published: 01 July 2017
View article titled, Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents
Journal Articles

Abstract 2010: Charactering the interactomes of the Myc family of oncogenes

Diana Resetca, Dharmesh Dingar, Manpreet Kalkat, Brian Raught, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2010.
https://doi.org/10.1158/1538-7445.AM2016-2010
Published: 15 July 2016
View article titled, Abstract 2010: Charactering the interactomes of the Myc family of oncogenes
Journal Articles

Abstract 3410: A novel regulatory region of the MYC oncogene decreases Myc transcriptional activity

Manpreet Kalkat, Amanda Wasylishen, Pak-Kei Michael Chan, Aleksandra Pandyra, Sam Sulgi Kim, Christina Bros, Brian Raught, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3410.
https://doi.org/10.1158/1538-7445.AM2014-3410
Published: 01 October 2014
View article titled, Abstract 3410: A novel regulatory region of the MYC oncogene decreases Myc transcriptional activity
Journal Articles

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

Aleksandra Pandyra, Peter J. Mullen, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Zhihua Li, Suzanne Trudel, Karl S. Lang, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4772–4782.
https://doi.org/10.1158/0008-5472.CAN-14-0130
Published: 01 September 2014
View article titled, Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
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Includes: Supplementary data
Journal Articles

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Amanda R. Wasylishen, Michelle Chan-Seng-Yue, Christina Bros, Dharmendra Dingar, William B. Tu, Manpreet Kalkat, Pak-Kei Chan, Peter J. Mullen, Ling Huang, Natalie Meyer, Brian Raught, Paul C. Boutros, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2013) 73 (21): 6504–6515.
https://doi.org/10.1158/0008-5472.CAN-12-4063
Published: 31 October 2013
View article titled, MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
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Includes: Supplementary data
Journal Articles

Abstract LB-117: Myc phosphorylation suppresses transformation through novel regulatory regions.

Dharmendra Dingar, Amanda R. Wasylishen, Michelle Chan-Seng-Yue, Ling Huang, Christina Bros, William Tu, Natalie Meyer, Paul C. Boutros, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-117.
https://doi.org/10.1158/1538-7445.AM2013-LB-117
Published: 15 April 2013
View article titled, Abstract LB-117: Myc phosphorylation suppresses transformation through novel regulatory regions.
Journal Articles

Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair

Kaisa R. Luoto, Alice X. Meng, Amanda R. Wasylishen, Helen Zhao, Carla L. Coackley, Linda Z. Penn, Robert G. Bristow
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8748–8759.
https://doi.org/10.1158/0008-5472.CAN-10-0944
Published: 31 October 2010
View article titled, Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair
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Includes: Supplementary data
Journal Articles

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Reza Beheshti Zavareh, Ken S. Lau, Rose Hurren, Alessandro Datti, David J. Ashline, Marcela Gronda, Pam Cheung, Craig D. Simpson, Wei Liu, Amanda R. Wasylishen, Paul C. Boutros, Hui Shi, Amudha Vengopal, Igor Jurisica, Linda Z. Penn, Vern N. Reinhold, Shereen Ezzat, Jeff Wrana, David R. Rose, Harry Schachter, James W. Dennis, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2008) 68 (16): 6688–6697.
https://doi.org/10.1158/0008-5472.CAN-07-6833
Published: 12 August 2008
View article titled, Inhibition of the Sodium/Potassium ATPase Impairs <em>N</em>-Glycan Expression and Function
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Journal Articles

Development of a predictive microRNA signature for node-negative breast cancer

Wei Shi, Angela Hui, Paul C Boutros, Naomi Miller, Melania Pintilie, Derek Wong, Kate Gerster, Linda Z Penn, Igor Jurisica, David McCready, Tony Fyles, Fei-Fei Liu
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4427.
Published: 01 May 2008
View article titled, Development of a predictive microRNA signature for node-negative breast cancer
Journal Articles

CUL7 Is a Novel Antiapoptotic Oncogene

Sam S. Kim, Mary Shago, Lilia Kaustov, Paul C. Boutros, James W. Clendening, Yi Sheng, Grace A. Trentin, Dalia Barsyte-Lovejoy, Daniel Y.L. Mao, Robert Kay, Igor Jurisica, Cheryl H. Arrowsmith, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9616–9622.
https://doi.org/10.1158/0008-5472.CAN-07-0644
Published: 17 October 2007
View article titled, <em>CUL7</em> Is a Novel Antiapoptotic Oncogene
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Includes: Supplementary data
Journal Articles

The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis

Dalia Barsyte-Lovejoy, Suzanne K. Lau, Paul C. Boutros, Fereshteh Khosravi, Igor Jurisica, Irene L. Andrulis, Ming S. Tsao, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2006) 66 (10): 5330–5337.
https://doi.org/10.1158/0008-5472.CAN-06-0037
Published: 16 May 2006
View article titled, The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis
Open the PDF for The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

A six-gene prognostic classifier of early-stage non-small cell lung carcinoma

Suzanne K. Lau, Paul C. Boutros, Chang Qi Zhu, Melania Pintilie, Fiona Blackhall, Ni Liu, Linda Z. Penn, Frances A. Shepherd, Igor Jurisica, Sandy D. Der, Ming Sound Tsao
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 793.
Published: 15 April 2006
View article titled, A six-gene prognostic classifier of early-stage non-small cell lung carcinoma
Journal Articles

A modified steepest descent algorithm for enhanced prognostic marker identification

Paul C. Boutros, Suzanne K. Lau, Chang Qi Zhu, Melania Pintillie, Linda Z. Penn, Igor Jurisica, Ming S. Tsao
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 793–794.
Published: 15 April 2006
View article titled, A modified steepest descent algorithm for enhanced prognostic marker identification