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Journal Articles

Abstract 2668: Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment

Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Jens Luebeck, Huiying Tao, Yanfen Zhu, Xiaolong Sui, Yue Li, Shiqi Jiang, Qingqing Gao, Elias Rodriguez Fos, Gino Prasad, Yuanmei Wang, Run Zhou, Zhe Xu, Xiaoguang Pan, Linlin Chen, Xiang Xi, Huajing Teng, Chaoyang Sun, Tianyu Qin, Wei Dong, Yongwei Li, Xun Lan, Xuesong Li, Lin Lin, Lars Bolund, Huanming Yang, Roel G. Verhaak, Bishoy M. Faltas, Jacob B. Hansen, Sihan Wu, Paul S. Mischel, Anton G. Henssen, Vineet Bafna, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2668.
https://doi.org/10.1158/1538-7445.AM2025-2668
Published: 21 April 2025
View articletitled, Abstract 2668: Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment
Journal Articles

Abstract 3018: Discovery of SIGX1094R, a novel FAK inhibitor simultaneously blocking FAK and SRC signaling

Haisheng Zhang, Shu Zhuo, Lei Zhang, Lin Li, Wanfen Peng, Fengtao Jiang, Yufang Chen, Lin Lin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3018.
https://doi.org/10.1158/1538-7445.AM2025-3018
Published: 21 April 2025
View articletitled, Abstract 3018: Discovery of SIGX1094R, a novel FAK inhibitor simultaneously blocking FAK and SRC signaling
Journal Articles

Abstract PO1-04-05: Effectiveness and safety of inetetamab + pyrotinib + vinorelbine in ≥second-line treatment of HER2-positive metastatic breast cancer

Fan Wu, Mulan Chen, Weiwei Huang, Lili Wang, Nani Li, Xiufeng Wu, Xinhua Chen, Yi Hong, Lin Lin, Kan Chen, Jian liu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-04-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-04-05
Published: 02 May 2024
View articletitled, Abstract PO1-04-05: Effectiveness and safety of inetetamab + pyrotinib + vinorelbine in ≥second-line treatment of HER2-positive metastatic breast cancer
Journal Articles

Abstract LB193: Enhanced single cell DNA methylation analysis using combinatorial indexing

Sanika Khare, Dominic Skinner, Maggie Nakamoto, Hosu Sin, Ashley Woodfin, Eric Pu, Lin Lin, Jason Koth, Beth Walczak
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB193.
https://doi.org/10.1158/1538-7445.AM2024-LB193
Published: 05 April 2024
View articletitled, Abstract LB193: Enhanced single cell DNA methylation analysis using combinatorial indexing
Journal Articles

Abstract 3169: The role and mechanism of m6A methylation modification of LncRNA-ATB in regulating the invasion and metastasis of colorectal cancer

Yu Lang#, Jia-Lin Lin#, Jia-Peng Kang, Lu Yang, Dan Zhou, Can-Bin Fang*, Feng Ye*, Wei-wei Tang*
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3169.
https://doi.org/10.1158/1538-7445.AM2024-3169
Published: 22 March 2024
View articletitled, Abstract 3169: The role and mechanism of m6A methylation modification of LncRNA-ATB in regulating the invasion and metastasis of colorectal cancer
Journal Articles

Faecalibacterium prausnitzii Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade

Yaqi Gao, Pingping Xu, Danfeng Sun, Yi Jiang, Xiao-Lin Lin, Ting Han, Jun Yu, Chunquan Sheng, Haoyan Chen, Jie Hong, Yingxuan Chen, Xiu-Ying Xiao, Jing-Yuan Fang
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3710–3725.
https://doi.org/10.1158/0008-5472.CAN-23-0605
Published: 15 November 2023
View articletitled, Faecalibacterium prausnitzii Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade
Open the PDF for Faecalibacterium prausnitzii Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract 112: Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung

Wei Guo, Li Sun, Xiaoxi Chen, Haitao Zhou, Shi Yan, Gang Zhao, Haimeng Tang, Hua Bao, Xue Wu, Yang Shao, Lin Lin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 112.
https://doi.org/10.1158/1538-7445.AM2023-112
Published: 04 April 2023
View articletitled, Abstract 112: Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung
Journal Articles

Abstract 3870: TNF-MK2 signaling drives protective autophagy following MAPK pathway inhibition in pancreatic cancer

Iftikhar Ali Khawar, Qing Wei, Timothy Hung-Po Chen, Lin Lin, Patrick M. Grierson, Kian-Huat Lim
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3870.
https://doi.org/10.1158/1538-7445.AM2023-3870
Published: 04 April 2023
View articletitled, Abstract 3870: TNF-MK2 signaling drives protective autophagy following MAPK pathway inhibition in pancreatic cancer
Journal Articles

Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression

Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2520–2537.
https://doi.org/10.1158/0008-5472.CAN-22-0668
Published: 18 July 2022
View articletitled, Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression
Open the PDF for Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract PO-028: Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis

Min-Sik Lee, Insia Naqvi, Courtney Dennis, Lucas Dailey, Alireza Lorzadeh, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Unmesh Jadhav, Clary B. Clish, Nada Y. Kalaany
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-028.
https://doi.org/10.1158/1538-7445.PANCA21-PO-028
Published: 15 November 2021
View articletitled, Abstract PO-028: Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis
Journal Articles

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Pawel A. Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin, Chia-Nung Hung, Devalingam Mahalingam, Nameer B. Kirma, Chun-Liang Chen, Josephine A. Taverna, Michael A. Liss, Ian M. Thompson, Tim H.-M. Huang, Maria E. Gaczynska
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4110–4123.
https://doi.org/10.1158/0008-5472.CAN-20-3595
Published: 01 August 2021
View articletitled, Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer
Open the PDF for Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Josephine A. Taverna, Chia-Nung Hung, Daniel T. DeArmond, Meizhen Chen, Chun-Lin Lin, Pawel A. Osmulski, Maria E. Gaczynska, Chiou-Miin Wang, Nicholas D. Lucio, Chih-Wei Chou, Chun-Liang Chen, Alia Nazarullah, Shellye R. Lampkin, Lianqun Qiu, David J. Bearss, Steven Warner, Clifford J. Whatcott, Lars Mouritsen, Mark Wade, Steven Weitman, Ruben A. Mesa, Nameer B. Kirma, Wei-Ting Chao, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1551–1563.
https://doi.org/10.1158/0008-5472.CAN-19-3183
Published: 02 April 2020
View articletitled, Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
Open the PDF for Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract P4-05-17: ESR1 related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

Chun-Lin Lin
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-05-17.
https://doi.org/10.1158/1538-7445.SABCS19-P4-05-17
Published: 15 February 2020
View articletitled, Abstract P4-05-17: ESR1 related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer
Journal Articles

Abstract 5150: Adipose-derived stem cell disruption of gap junction intercellular communication in obesity-associated endometrial cancer

Li-Ling Lin, Srikanth Polusani, Guangcun Huang, Chun-Lin Lin, Chiou-Miin Wang, Nicholas Lucio, Mikhail Kolonin, Alexes Daquinag, Pawel Osmulski, Bruce Nicholson, Edward Kost, Tim Huang, Nameer B. Kirma
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5150.
https://doi.org/10.1158/1538-7445.AM2019-5150
Published: 01 July 2019
View articletitled, Abstract 5150: Adipose-derived stem cell disruption of gap junction intercellular communication in obesity-associated endometrial cancer
Journal Articles

Abstract SY43-03: Long-range epigenetic control of estrogen-responsive transcription

Chun-Lin Lin, Tim Hui-Ming Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY43-03.
https://doi.org/10.1158/1538-7445.AM2019-SY43-03
Published: 01 July 2019
View articletitled, Abstract SY43-03: Long-range epigenetic control of estrogen-responsive transcription
Journal Articles

Abstract 3943: Inhibition of ribosomal protein RPS6KB1 as a strategy to improve conventional therapy for prostate cancer

Alison D. Clark, Suleman S. Hussain, Shih-Bo Huang, Roble G. Bedolla, Mohammad A. Obeidat, Niko Papanikolaou, Chun Lin Lin, Tim H. Huang, Yogesh Gupta, Yidong Chen, Hiroshi Miyamoto, Rita Ghosh, Addanki P. Kumar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3943.
https://doi.org/10.1158/1538-7445.AM2019-3943
Published: 01 July 2019
View articletitled, Abstract 3943: Inhibition of ribosomal protein RPS6KB1 as a strategy to improve conventional therapy for prostate cancer
Journal Articles

Abstract 4126: Inferring target occupancy from fitting nonlinear-PK data with mechanistic PKRO model for Pembrolizumab

Fei Hua, Lin Lin, Lore Gruenbaum, Bjorn L. Millard, John M. Burke, Joshua F. Apgar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4126.
https://doi.org/10.1158/1538-7445.AM2019-4126
Published: 01 July 2019
View articletitled, Abstract 4126: Inferring target occupancy from fitting nonlinear-PK data with mechanistic PKRO model for Pembrolizumab
Journal Articles

Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells

Chun-Lin Lin, Tan Xi, Chia-Nung Hung, Pawel A. Osmulski, Chih-Wei Chou, Meizhen Chen, Chiou-Miin Wang, Kohzoh Mitsuya, Nameer Kirma, Maria E. Gaczynska, Chun-Liang Chen, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2766.
https://doi.org/10.1158/1538-7445.AM2019-2766
Published: 01 July 2019
View articletitled, Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells
Journal Articles

Abstract 684: A semi-mechanistic platform model to capture individual animal responses to checkpoint inhibitors in a syngeneic mouse model

Alison M. Betts, Lin Lin, Carissa L. Young, Wenlian Qiao, Jatin Narula, Peter O'Brien, Derek Bartlett, Andrea Hooper, Jason Williams, John M. Burke, Joshua Apgar, Fei Hua, Lore Gruenbaum
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 684.
https://doi.org/10.1158/1538-7445.AM2019-684
Published: 01 July 2019
View articletitled, Abstract 684: A semi-mechanistic platform model to capture individual animal responses to checkpoint inhibitors in a syngeneic mouse model
Journal Articles

Abstract 685: Development of a multiscale QSP model to characterize the tumor suppressive effects of a cytokine mRNA immunotherapy in a preclinical melanoma mouse model

Kamau Pierre, Lin Lin, Lore Gruenbaum, Carissa Young, Joshua Apgar, Christian Hotz, Timothy Wagenaar, Spyros K. Stamatelos
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 685.
https://doi.org/10.1158/1538-7445.AM2019-685
Published: 01 July 2019
View articletitled, Abstract 685: Development of a multiscale QSP model to characterize the tumor suppressive effects of a cytokine mRNA immunotherapy in a preclinical melanoma mouse model