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Journal Articles

Abstract 5525: VISTA/PSGL1 axis as a dominant immunomodulatory pathway in human non-small cell lung cancer

Alicia Ding, Franz Villarroel-Espindola, Adam Ducler, Brian S. Henick, Shruti Desai, Nicole Gianino, Jon Zugazagoitia, David L. Rimm, Alain Robert, Francisco Cruzalegui, Pierre Ferré, Roy Herbst, Miguel Sanmamed, Lieping Chen, Kurt A. Schalper
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5525.
https://doi.org/10.1158/1538-7445.AM2020-5525
Published: 15 August 2020
View article titled, Abstract 5525: VISTA/PSGL1 axis as a dominant immunomodulatory pathway in human non-small cell lung cancer
Journal Articles

Abstract 3151: Quantitative measurement of Siglec-15 expression in non-small cell lung cancer and its association with PD-L1, B7-H4 and tumor infiltrating lymphocytes

Maria Toki, Jon Zugazagoitia, Mehmet Altan, Linda Liu, Nikita Mani, Yuting Liu, Konstantinos Syrigos, Lieping Chen, Solomon Langermann, Roy Herbst, David Rimm
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3151.
https://doi.org/10.1158/1538-7445.AM2019-3151
Published: 01 July 2019
View article titled, Abstract 3151: Quantitative measurement of Siglec-15 expression in non-small cell lung cancer and its association with PD-L1, B7-H4 and tumor infiltrating lymphocytes
Journal Articles

Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration

Wing Lam, Xiaochen Yang, Zaoli Jiang, Xue han, Fulan Guan, Rong Hu, Chang-Hua Xu, Wei Cai, William Cheng, Shwu-Huey Liu, Yuping Cai, Nicholas Rattray, Caroline Johnson, Lieping Chen, Yung-chi Cheng
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2252.
https://doi.org/10.1158/1538-7445.AM2019-2252
Published: 01 July 2019
View article titled, Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration
Journal Articles

Abstract 1681: Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors

Micaela Morgado, Ila Datar, Jun Wang, Miguel F. Sanmamed, Kristen McEachern, David Jenkins, Lieping Chen, Daniel Carvajal-Hausdorf, David L. Rimm, Roy S. Herbst, Kurt A. Schalper
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1681.
https://doi.org/10.1158/1538-7445.AM2018-1681
Published: 01 July 2018
View article titled, Abstract 1681: Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors
Journal Articles

Abstract 2724: YIV906 (PHY906) enhanced the antitumor activity of immune checkpoint blockade therapy: Anti-PD1 against liver cancer

Wing Lam, XiaoChen Yang, Zaoli Jiang, Xue Han, Fulan Guan, William Cheng, Shwu-Huey Liu, Lieping Chen, Yung-Chi Cheng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2724.
https://doi.org/10.1158/1538-7445.AM2018-2724
Published: 01 July 2018
View article titled, Abstract 2724: YIV906 (PHY906) enhanced the antitumor activity of immune checkpoint blockade therapy: Anti-PD1 against liver cancer
Journal Articles

Abstract 5584: PHY906(YIV-906), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Immune checkpoint blockade therapy: anti-PDL1, anti-PD1, anti-PD1/CTLA4 against melanoma

Wing Lam, Zaoli jiang, Xue han, Shwu-Huey Liu, Lieping Chen, YungChi Cheng
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5584.
https://doi.org/10.1158/1538-7445.AM2017-5584
Published: 01 July 2017
View article titled, Abstract 5584: PHY906(YIV-906), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Immune checkpoint blockade therapy: anti-PDL1, anti-PD1, anti-PD1/CTLA4 against melanoma
Journal Articles

Abstract LB-193: Phase I study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors.

Patricia M. LoRusso, John Powderly, Howard A. Burris, Muaiad Kittaneh, Jessica Grice, James F. Smothers, Sara Brett, Margaret Fleming, Rena J. May, Shannon Marshall, Martin Devenport, Stanley Pillemer, Drew M. Pardoll, Lieping Chen, Solomon Langermann, Jeffrey Infante
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-193.
https://doi.org/10.1158/1538-7445.AM2013-LB-193
Published: 15 April 2013
View article titled, Abstract LB-193: Phase I study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors.
Journal Articles

Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma

Sofia Lyford-Pike, Shiwen Peng, Geoffrey D. Young, Janis M. Taube, William H. Westra, Belinda Akpeng, Tullia C. Bruno, Jeremy D. Richmon, Hao Wang, Justin A. Bishop, Lieping Chen, Charles G. Drake, Suzanne L. Topalian, Drew M. Pardoll, Sara I. Pai
Journal: Cancer Research
Cancer Res (2013) 73 (6): 1733–1741.
https://doi.org/10.1158/0008-5472.CAN-12-2384
Published: 14 March 2013
View article titled, Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells

Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Jérôme D. Coudert, Mélanie Desbois, François Ghiringhelli, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Lieping Chen, Salaheddine Mécheri, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Mariapia Degli-Esposti, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2012) 72 (11): 2757–2767.
https://doi.org/10.1158/0008-5472.CAN-11-3379
Published: 31 May 2012
View article titled, Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells
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Includes: Supplementary data
Journal Articles

Abstract LB-138: Stimulation of natural killer cells with an anti-CD137 antibody enhances the efficacy trastuzumab, cetuximab, and rituximab in HER2-expressing breast cancer, EGFR+ head and neck cancer, and CD20+ lymphoma

Holbrook Kohrt, Roch Houot, Kipp Weiskopf, Matthew Goldstein, Peder Lund, Debra Czerwinski, John Sunwoo, Thomas Tedder, Lieping Chen, Ronald Levy
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-138.
https://doi.org/10.1158/1538-7445.AM2012-LB-138
Published: 15 April 2012
View article titled, Abstract LB-138: Stimulation of natural killer cells with an anti-CD137 antibody enhances the efficacy trastuzumab, cetuximab, and rituximab in HER2-expressing breast cancer, EGFR+ head and neck cancer, and CD20+ lymphoma
Journal Articles

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

Ke Wu, Ilona Kryczek, Lieping Chen, Weiping Zou, Theodore H. Welling
Journal: Cancer Research
Cancer Res (2009) 69 (20): 8067–8075.
https://doi.org/10.1158/0008-5472.CAN-09-0901
Published: 14 October 2009
View article titled, Kupffer Cell Suppression of CD8<sup>+</sup> T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions
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Includes: Supplementary data
Journal Articles

Tumor-Induced Immune Suppression of In vivo Effector T-Cell Priming Is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor β

Shuang Wei, Andrew B. Shreiner, Nobuhiro Takeshita, Lieping Chen, Weiping Zou, Alfred E. Chang
Journal: Cancer Research
Cancer Res (2008) 68 (13): 5432–5438.
https://doi.org/10.1158/0008-5472.CAN-07-6598
Published: 01 July 2008
View article titled, Tumor-Induced Immune Suppression of <em>In vivo</em> Effector T-Cell Priming Is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor β
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Journal Articles

Tumor-induced immune suppression of in vivo T effector cell priming is mediated by the B7-H1/PD-1 axis and TGF-β1

Shuang Wei, Andrew Shreiner, Nobuhiro Takeshita, Lieping Chen, Weiping Zou, Alfred Chang
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3794.
Published: 01 May 2008
View article titled, Tumor-induced immune suppression of in vivo T effector cell priming is mediated by the B7-H1/PD-1 axis and TGF-β1
Journal Articles

Relationship between B7-H4, Regulatory T Cells, and Patient Outcome in Human Ovarian Carcinoma

Ilona Kryczek, Shuang Wei, Gefeng Zhu, Leann Myers, Peter Mottram, Pui Cheng, Lieping Chen, George Coukos, Weiping Zou
Journal: Cancer Research
Cancer Res (2007) 67 (18): 8900–8905.
https://doi.org/10.1158/0008-5472.CAN-07-1866
Published: 17 September 2007
View article titled, Relationship between B7-H4, Regulatory T Cells, and Patient Outcome in Human Ovarian Carcinoma
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Journal Articles

Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma

Inigo Tirapu, Ainhoa Arina, Oihana Murillo, Puri Fortes, Cristiana Guiducci, Mario P. Colombo, Lieping Chen, Ignacio Melero
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1118.
Published: 15 April 2006
View article titled, Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma
Journal Articles

Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma

Iñigo Tirapu, Eduardo Huarte, Cristiana Guiducci, Ainhoa Arina, Mikel Zaratiegui, Oihana Murillo, Alvaro Gonzalez, Carmen Berasain, Pedro Berraondo, Puri Fortes, Jesús Prieto, Mario P. Colombo, Lieping Chen, Ignacio Melero
Journal: Cancer Research
Cancer Res (2006) 66 (4): 2442–2450.
https://doi.org/10.1158/0008-5472.CAN-05-1681
Published: 17 February 2006
View article titled, Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma
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Includes: Supplementary data
Journal Articles

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

Fumiya Hirano, Katsumi Kaneko, Hideto Tamura, Haidong Dong, Shengdian Wang, Masao Ichikawa, Cecilia Rietz, Dallas B. Flies, Julie S. Lau, Gefeng Zhu, Koji Tamada, Lieping Chen
Journal: Cancer Research
Cancer Res (2005) 65 (3): 1089–1096.
https://doi.org/10.1158/0008-5472.1089.65.3
Published: 10 February 2005
View article titled, Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
Open the PDF for Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity in another window
Includes: Supplementary data
Journal Articles

Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity

Suresh Radhakrishnan, Loc Tan Nguyen, Bogoljub Ciric, Dallas Flies, Virginia P. Van Keulen, Koji Tamada, Lieping Chen, Moses Rodriguez, Larry R. Pease
Journal: Cancer Research
Cancer Res (2004) 64 (14): 4965–4972.
https://doi.org/10.1158/0008-5472.CAN-03-3025
Published: 15 July 2004
View article titled, Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity
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Journal Articles

Immunotherapy of B16 melanoma with systemic treatment using a B7-DC cross-linking antibody.

Suresh Radhakrishnan, Bogoljub Ciric, Virginia P. Van Keulen, Koji Tamada, Lieping Chen, Moses Rodriguez, Larry R. Pease
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 571.
Published: 01 April 2004
View article titled, Immunotherapy of B16 melanoma with systemic treatment using a B7-DC cross-linking antibody.
Journal Articles

Expression of the B7-Related Molecule B7-H1 by Glioma Cells: A Potential Mechanism of Immune Paralysis

Sabine Wintterle, Bettina Schreiner, Meike Mitsdoerffer, Dagmar Schneider, Lieping Chen, Richard Meyermann, Michael Weller, Heinz Wiendl
Journal: Cancer Research
Cancer Res (2003) 63 (21): 7462–7467.
Published: 11 November 2003
View article titled, Expression of the B7-Related Molecule B7-H1 by Glioma Cells: <subtitle>A Potential Mechanism of Immune Paralysis</subtitle>
Open the PDF for Expression of the B7-Related Molecule B7-H1 by Glioma Cells: <subtitle>A Potential Mechanism of Immune Paralysis</subtitle> in another window