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Lianglin Zhang
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Journal Articles

Abstract 2336: Assessment of mechanisms of action (MOAs) of the Fc-engineered integrin α5β1 targeting antibody PF-04605412 in human integrin α5 knock-in mice.

Lianglin Zhang, Jeffrey L. Stock, Mark W. Elliott, Enhong Chen, Thao Nguyen, Anthony Wong, Craig B. Davis, James G. Christensen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2336.
https://doi.org/10.1158/1538-7445.AM2013-2336
Published: 15 April 2013
View article titled, Abstract 2336: Assessment of mechanisms of action (MOAs) of the Fc-engineered integrin α5β1 targeting antibody PF-04605412 in human integrin α5 knock-in mice.
Journal Articles

Abstract 3270: Combination strategy to circumvent the acquired resistance to VEGF receptor tyrosine kinase inhibitor in M24met melanoma in mice

Lianglin Zhang, Maruja E. Lira, Keith A. Ching, Enhong Chen, Tina Lu, James G. Christensen, Dana D. Hu-Lowe
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3270.
https://doi.org/10.1158/1538-7445.AM2011-3270
Published: 15 April 2011
View article titled, Abstract 3270: Combination strategy to circumvent the acquired resistance to VEGF receptor tyrosine kinase inhibitor in M24met melanoma in mice
Journal Articles

Targeting Activin Receptor-Like Kinase 1 Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies

Dana D. Hu-Lowe, Enhong Chen, Lianglin Zhang, Katherine D. Watson, Patrizia Mancuso, Patrick Lappin, Grant Wickman, Jeffrey H. Chen, Jianying Wang, Xin Jiang, Karin Amundson, Ronald Simon, Andreas Erbersdobler, Simon Bergqvist, Zheng Feng, Terri A. Swanson, Brett H. Simmons, John Lippincott, Gerald F. Casperson, Wendy J. Levin, Corrado Gallo Stampino, David R. Shalinsky, Katherine W. Ferrara, Walter Fiedler, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2011) 71 (4): 1362–1373.
https://doi.org/10.1158/0008-5472.CAN-10-1451
Published: 14 February 2011
View article titled, Targeting Activin Receptor-Like Kinase 1 Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies
Open the PDF for Targeting Activin Receptor-Like Kinase 1 Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies in another window
Includes: Supplementary data
Journal Articles

Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin α5β1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity

Gang Li, Lianglin Zhang, Enhong Chen, Jianying Wang, Xin Jiang, Jeffrey H. Chen, Grant Wickman, Karin Amundson, Simon Bergqvist, James Zobel, Dana Buckman, Sangita M. Baxi, Steven L. Bender, Gerald F. Casperson, Dana D. Hu-Lowe
Journal: Cancer Research
Cancer Res (2010) 70 (24): 10243–10254.
https://doi.org/10.1158/0008-5472.CAN-10-1996
Published: 14 December 2010
View article titled, Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin α5β1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity
Open the PDF for Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin α5β1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity in another window
Includes: Supplementary data
Journal Articles

Abstract 3811: Robust anti-tumor activity through targeting integrin α5β1 and eliciting ADCC with a dual functional monoclonal antibody PF-04605412

Dana D. Hu-Lowe, Gary Li, Enhong Chen, Jianying Wang, Lianglin Zhang, Jeffrey H. Chen, Karin Amundson, Zobel James, Eugenia Kraynov, Leslie Sharp, Grant Wickman, Xin Jiang, Steve Bender, Gerald Casperson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3811.
https://doi.org/10.1158/1538-7445.AM10-3811
Published: 15 April 2010
View article titled, Abstract 3811: Robust anti-tumor activity through targeting integrin α5β1 and eliciting ADCC with a dual functional monoclonal antibody PF-04605412
Journal Articles

Abstract #144: Impact of dosing schedule and dosing sequence on anti-tumor efficacy of combination therapy with the antiangiogenic agent (AA) axitinib (AG-013736) in xenograft tumor models of human pancreatic carcinoma and non-small cell lung cancer (NSCLC)

Dana Hu-Lowe, Adam Mathias, Chassidy Hall, Enhong Chen, Lianglin Zhang, Robert Mullin, Beth Hollister, Jamie Christensen
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 144.
Published: 01 May 2009
View article titled, Abstract #144: Impact of dosing schedule and dosing sequence on anti-tumor efficacy of combination therapy with the antiangiogenic agent (AA) axitinib (AG-013736) in xenograft tumor models of human pancreatic carcinoma and non-small cell lung cancer (NSCLC)
Journal Articles

Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma

Valentina Fogal, Lianglin Zhang, Stan Krajewski, Erkki Ruoslahti
Journal: Cancer Research
Cancer Res (2008) 68 (17): 7210–7218.
https://doi.org/10.1158/0008-5472.CAN-07-6752
Published: 28 August 2008
View article titled, Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma
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Includes: Supplementary data
Journal Articles

Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance

Lianglin Zhang, Jonathan A.F. Hannay, Juehui Liu, Parimal Das, Maocheng Zhan, Theresa Nguyen, Daniel J. Hicklin, Dihua Yu, Raphael E. Pollock, Dina Lev
Journal: Cancer Research
Cancer Res (2006) 66 (17): 8770–8778.
https://doi.org/10.1158/0008-5472.CAN-06-1217
Published: 01 September 2006
View article titled, Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance
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Journal Articles

Lymphatic Zip Codes in Premalignant Lesions and Tumors

Lianglin Zhang, Enrico Giraudo, Jason A. Hoffman, Douglas Hanahan, Erkki Ruoslahti
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5696–5706.
https://doi.org/10.1158/0008-5472.CAN-05-3876
Published: 01 June 2006
View article titled, Lymphatic Zip Codes in Premalignant Lesions and Tumors
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Includes: Supplementary data
Journal Articles

Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis

Lianglin Zhang, Dihua Yu, Daniel J. Hicklin, Jonathan A. F. Hannay, Lee M. Ellis, Raphael E. Pollock
Journal: Cancer Research
Cancer Res (2002) 62 (7): 2034–2042.
Published: 01 April 2002
View article titled, Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis
Open the PDF for Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis in another window
Journal Articles

Up-Regulation of Vascular Endothelial Growth Factor in Breast Cancer Cells by the Heregulin-β1-activated p38 Signaling Pathway Enhances Endothelial Cell Migration

Shunbin Xiong, Rebecca Grijalva, Lianglin Zhang, Nina T. Nguyen, Peter W. Pisters, Raphael E. Pollock, Dihua Yu
Journal: Cancer Research
Cancer Res (2001) 61 (4): 1727–1732.
Published: 02 February 2001
View article titled, Up-Regulation of Vascular Endothelial Growth Factor in Breast Cancer Cells by the Heregulin-β1-activated p38 Signaling Pathway Enhances Endothelial Cell Migration
Open the PDF for Up-Regulation of Vascular Endothelial Growth Factor in Breast Cancer Cells by the Heregulin-β1-activated p38 Signaling Pathway Enhances Endothelial Cell Migration in another window
Journal Articles

Wild-Type p53 Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression

Lianglin Zhang, Dihua Yu, Mei Hu, Shunbin Xiong, Aiqing Lang, Lee M. Ellis, Raphael E. Pollock
Journal: Cancer Research
Cancer Res (2000) 60 (13): 3655–3661.
Published: 01 July 2000
View article titled, Wild-Type <em>p53</em> Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression
Open the PDF for Wild-Type <em>p53</em> Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression in another window