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Journal Articles

Hypoxia-Induced Senescent Fibroblasts Secrete IGF1 to Promote Cancer Stemness in Esophageal Squamous Cell Carcinoma

Available to Purchase
Zhengjie Ou, Liang Zhu, Xinjie Chen, Tianyuan Liu, Guoyu Cheng, Rucheng Liu, Shaosen Zhang, Wen Tan, Dongxin Lin, Chen Wu
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1064–1081.
https://doi.org/10.1158/0008-5472.CAN-24-1185
Published: 14 March 2025
View articletitled, Hypoxia-Induced Senescent Fibroblasts Secrete IGF1 to Promote Cancer Stemness in Esophageal Squamous Cell Carcinoma
Open the PDF for Hypoxia-Induced Senescent Fibroblasts Secrete IGF1 to Promote Cancer Stemness in Esophageal Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma

Open Access
Yan Sun, Liang Zhu, Pian Liu, Huan Zhang, Feng Guo, Xin Jin
Journal: Cancer Research
Cancer Res (2023) 83 (12): 2034–2051.
https://doi.org/10.1158/0008-5472.CAN-22-3105
Published: 15 June 2023
View articletitled, ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma
Open the PDF for ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 563: Preclinical development of YL202, a novel HER3-targeting antibody-drug conjugate (ADC) with novel DNA topoisomerase I inhibitor for treatment of solid tumors

Free
Jian Xu, Qing Zong, Liang Zhu, Qigang Liu, Sasha Stann, Jiaqiang Cai
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 563.
https://doi.org/10.1158/1538-7445.AM2023-563
Published: 04 April 2023
View articletitled, Abstract 563: Preclinical development of YL202, a novel HER3-targeting antibody-drug conjugate (ADC) with novel DNA topoisomerase I inhibitor for treatment of solid tumors
Journal Articles

Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma

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Ming-Yu Luo, Ye Zhou, Wei-Ming Gu, Cheng Wang, Ning-Xiang Shen, Jiang-Kai Dong, Hui-Min Lei, Ya-Bin Tang, Qian Liang, Jing-Hua Zou, Lu Xu, Pengfei Ma, Guanglei Zhuang, Ling Bi, Ling Xu, Liang Zhu, Hong-Zhuan Chen, Ying Shen
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3516–3531.
https://doi.org/10.1158/0008-5472.CAN-21-4074
Published: 04 October 2022
View articletitled, Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma
Open the PDF for Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2928: Evaluating Cks1-Skp2 interface as an effective therapeutic target for RB1-deficient metastatic castration-resistant prostate cancer (mCRPC)

Free
Yingjiao Xue, Liang Zhu, Hongling Zhao, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2928.
https://doi.org/10.1158/1538-7445.AM2021-2928
Published: 01 July 2021
View articletitled, Abstract 2928: Evaluating Cks1-Skp2 interface as an effective therapeutic target for RB1-deficient metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 1060: Genetic and pharmacologic inhibition of Skp2, an E3 ubiquitin ligase and RB1-target, has antitumor activity in RB1-deficient human and mouse small cell lung cancer (SCLC)

Free
Hongling Zhao, Vineeth Sukrithan, Niloy Iqbal, Cari Nicholas, Yingjiao Xue, Joseph Locker, Juntao Zou, Liang Zhu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1060.
https://doi.org/10.1158/1538-7445.AM2020-1060
Published: 15 August 2020
View articletitled, Abstract 1060: Genetic and pharmacologic inhibition of Skp2, an E3 ubiquitin ligase and RB1-target, has antitumor activity in RB1-deficient human and mouse small cell lung cancer (SCLC)
Journal Articles

Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer

Available to Purchase
Hongling Zhao, Niloy J. Iqbal, Vineeth Sukrithan, Cari Nicholas, Yingjiao Xue, Cindy Yu, Joseph Locker, Juntao Zou, Edward L. Schwartz, Liang Zhu
Journal: Cancer Research
Cancer Res (2020) 80 (11): 2355–2367.
https://doi.org/10.1158/0008-5472.CAN-19-2400
Published: 02 June 2020
View articletitled, Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer
Open the PDF for Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2078: CK-101 (RX518), a mutant-selective inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC

Free
Xiangping Qian, Yong-Liang Zhu, Edward Cullen, Robert M. Niecestro, James F. Oliviero
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2078.
https://doi.org/10.1158/1538-7445.AM2017-2078
Published: 01 July 2017
View articletitled, Abstract 2078: CK-101 (RX518), a mutant-selective inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
Journal Articles

Abstract 518: Synergistic effects of dual inhibition of YAP1 and TAZ in non-small cell lung cancer cells

Free
Elaine Shum, Huijie Liu, Liang Zhu, Roman Perez-Soler, Balazs Halmos, Haiying Cheng
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 518.
https://doi.org/10.1158/1538-7445.AM2017-518
Published: 01 July 2017
View articletitled, Abstract 518: Synergistic effects of dual inhibition of YAP1 and TAZ in non-small cell lung cancer cells
Journal Articles

Abstract 4788: Discovery of potent and selective inhibitors of ERK1/2 with a unique mechanism of action

Free
Yongqi Deng, Ahmed Samatar, Gerald Shipps, Alan Cooper, Brian Long, Donnar Carr, Li Xiao, Alan Hruza, Tong Wang, Liang Zhu, Yang Nan, Mehul Patel, Kiran Muppalla, Hugh Zhu, Babu Sobhana Boga, Xiaolei Gao
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4788.
https://doi.org/10.1158/1538-7445.AM2016-4788
Published: 15 July 2016
View articletitled, Abstract 4788: Discovery of potent and selective inhibitors of ERK1/2 with a unique mechanism of action
Journal Articles

Abstract 2168: Molecular pathway analysis of esophageal squamous cell differentiation versus carcinoma formation

Free
Wusheng Yan, Liang Zhu, Joanna Shih, Jaime Rodriguez-Canales, Jason Hipp, Audrey Player, Nan Hu, Alisa M. Goldstein, Philip R. Taylor, Michael R. Emmert-Buck, Heidi S. Erickson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2168.
https://doi.org/10.1158/1538-7445.AM10-2168
Published: 15 April 2010
View articletitled, Abstract 2168: Molecular pathway analysis of esophageal squamous cell differentiation versus carcinoma formation
Journal Articles

Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein

Free
Xintao Wang, Haiyun Deng, Indranil Basu, Liang Zhu
Journal: Cancer Research
Cancer Res (2004) 64 (4): 1377–1385.
https://doi.org/10.1158/0008-5472.CAN-03-2428
Published: 18 February 2004
View articletitled, Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein
Open the PDF for Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein in another window