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Journal Articles

Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression

Open Access
Kun Wang, Jingzhuo Li, Hai Zhang, Hongyan Ma, Hong-Yong Cui, Huai-Qiang Ju, Jing Zhang, Qing-zhi Ma, Ming Zhao, Qing-mei Zeng, Jie Zou, Xiu-Xuan Sun, Gang Nan, Meirui Qian, Lin Jing, Yiming Li, Cai-feng Xiong, Qiu-zi Yang, Hao Wang, Jian-Li Jiang, Zhi-Nan Chen, Liang Chen, Wan Huang
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3525
Published: 14 May 2025
View articletitled, Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression
Open the PDF for Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract LB233: Targeting ENO1 to tilt the immunometabolic balance in the tumor microenvironment of KRAS-mutated colorectal cancer to improve therapeutic efficacy

Free
Maisie Huang, Hsin-Yu Chang, Ta-Tung Yuan, K.S. Clifford Chao, William Tzu-Liang Chen, Tao-Wei Ke, Ji-An Liang, Wei-Ze Hong, Kevin Chih-Yang Huang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB233.
https://doi.org/10.1158/1538-7445.AM2025-LB233
Published: 25 April 2025
View articletitled, Abstract LB233: Targeting ENO1 to tilt the immunometabolic balance in the tumor microenvironment of KRAS-mutated colorectal cancer to improve therapeutic efficacy
Journal Articles

Abstract CT126: Aumolertinib as adjuvant therapy in patients with stage II-IIIB EGFR-mutated NSCLC after complete tumor resection: A randomized, double-blind, placebo-controlled, phase 3 trial (ARTS)

Free
Ying Cheng, Xiqin Zhang, Lin Wu, Wenxiang Wang, Wenqun Xing, Chunling Liu, Caigang Liu, Kai Chen, Jianhua Shi, Peng Zhang, Shidong Xu, Xiaodong Zhang, Xiaorong Dong, Haohui Fang, Xinmin Yu, Yang Gao, Gaofeng Li, Liang Chen, Huiyuan Gong, Renhua Guo, Zhenyuan Gao, Yinghua Ji, Lunxu Liu, Xianling Liu, Hui Tian, Fei Xiong, Xin Zhao, Lejie Cao, Qing Geng, Hongxu Liu, Jixian Liu, Li Yang, Zhenfa Zhang, Di Ge, Xingya Li, Minghui Wang, Yan Xu, Zhi Xu, Jun Chen, Zhaoxia Dai, Jian Hu, Juan Li, Shujun Li, Min Ye, Aimin Zang, Chanjuan Xie, Zhenzhong Su, Zhenmin Chen, Shaonan Fan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT126.
https://doi.org/10.1158/1538-7445.AM2025-CT126
Published: 25 April 2025
View articletitled, Abstract CT126: Aumolertinib as adjuvant therapy in patients with stage II-IIIB EGFR-mutated NSCLC after complete tumor resection: A randomized, double-blind, placebo-controlled, phase 3 trial (ARTS)
Journal Articles

Abstract 6284: Multimoics reveal aberrant pathways and regulation of castration resistant and metastatic prostate cancer

Free
Aaron M. Horning, Chia-Nung Hung, Brandon Liebermann, Chih-Wei Chou, Che-Kuang Lin, Yao Vickie Wang, Victor X. Jin, Michael A. Liss, Chiou-Miin Wang, Chun- Lin, Meizhen Chen, Tim H-M Huang, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6284.
https://doi.org/10.1158/1538-7445.AM2024-6284
Published: 22 March 2024
View articletitled, Abstract 6284: Multimoics reveal aberrant pathways and regulation of castration resistant and metastatic prostate cancer
Journal Articles

Abstract A030: Fusion between macrophages and cancer cells up-regulates signal regulatory protein pathway and contributes to malignant progression of pancreatic cancer after radiation

Free
Hui Ju Ch'ang, Yi-Chih Tsai, Ting Wei Li, Rui-Jun Liu, Tze-Sing Huang, Sse-Pei Wan, Su-Liang Chen, Shih-Sheng Jiang
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A030.
https://doi.org/10.1158/1538-7445.PANCA2023-A030
Published: 16 January 2024
View articletitled, Abstract A030: Fusion between macrophages and cancer cells up-regulates signal regulatory protein pathway and contributes to malignant progression of pancreatic cancer after radiation
Journal Articles

Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Free
Hong Wu, Xuefeng Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang, Chuan Xu
Journal: Cancer Research
Cancer Res (2023) 83 (18): 3131–3144.
https://doi.org/10.1158/0008-5472.CAN-22-2593
Published: 15 September 2023
View articletitled, Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma
Open the PDF for Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort

Open Access
Yanhong Liu, Jennifer R. Kramer, Vlad C. Sandulache, Robert Yu, Guojun Li, Liang Chen, Zenab I. Yusuf, Yunling Shi, Saiju Pyarajan, Spyros Tsavachidis, Li Jiao, Michelle L. Mierzwa, Elizabeth Chiao, Yvonne M. Mowery, Andrew Shuman, Sanjay Shete, Andrew G. Sikora, Donna L. White
Journal: Cancer Research
Cancer Res (2023) 83 (3): 386–397.
https://doi.org/10.1158/0008-5472.CAN-22-1641
Published: 03 February 2023
View articletitled, Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort
Open the PDF for Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort in another window
Includes: Supplementary data
Journal Articles

Abstract 1623: AXL-STAT3 targeting of lung tumor microenvironments

Free
Josephine Amalia Taverna, Chia-Nung Hung, Meizhen Chen, Joel Michalek, Chun-Liang Chen, Nameer Kirma, Chih-Wei Chou, Xi Tan, Chiou-Miin Wang, Zhang Zhao, Duy Nguyen, Daniel DeArmond, Tim Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1623.
https://doi.org/10.1158/1538-7445.AM2022-1623
Published: 15 June 2022
View articletitled, Abstract 1623: AXL-STAT3 targeting of lung tumor microenvironments
Journal Articles

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Free
Pawel A. Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin, Chia-Nung Hung, Devalingam Mahalingam, Nameer B. Kirma, Chun-Liang Chen, Josephine A. Taverna, Michael A. Liss, Ian M. Thompson, Tim H.-M. Huang, Maria E. Gaczynska
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4110–4123.
https://doi.org/10.1158/0008-5472.CAN-20-3595
Published: 01 August 2021
View articletitled, Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer
Open the PDF for Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2001: Krupple like factor 10 modulates stem cell phenotype of pancreatic adenocarcinoma via transcriptional regulation of Notch signal pathway

Free
Yi-Chih Tsai, Su-Liang Chen, Shu-Ling Peng, Kuang-Hung Cheng, Shih-Sheng Jiang, Shuang-En Chuang, Ch'ang Hui-Ju
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2001.
https://doi.org/10.1158/1538-7445.AM2021-2001
Published: 01 July 2021
View articletitled, Abstract 2001: Krupple like factor 10 modulates stem cell phenotype of pancreatic adenocarcinoma via transcriptional regulation of Notch signal pathway
Journal Articles

Abstract 870: Immunogenetic determinants of head and neck cancer in Veterans in the Million Veteran Program cohort

Free
Yanhong Liu, Jennifer R. Kramer, Liang Chen, Zenab I. Yusuf, Vlad Sandulache, Li Jiao, Elizabeth Y. Chiao, Andrew G. Sikora, Donna L. White
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 870.
https://doi.org/10.1158/1538-7445.AM2021-870
Published: 01 July 2021
View articletitled, Abstract 870: Immunogenetic determinants of head and neck cancer in Veterans in the Million Veteran Program cohort
Journal Articles

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Available to Purchase
Josephine A. Taverna, Chia-Nung Hung, Daniel T. DeArmond, Meizhen Chen, Chun-Lin Lin, Pawel A. Osmulski, Maria E. Gaczynska, Chiou-Miin Wang, Nicholas D. Lucio, Chih-Wei Chou, Chun-Liang Chen, Alia Nazarullah, Shellye R. Lampkin, Lianqun Qiu, David J. Bearss, Steven Warner, Clifford J. Whatcott, Lars Mouritsen, Mark Wade, Steven Weitman, Ruben A. Mesa, Nameer B. Kirma, Wei-Ting Chao, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1551–1563.
https://doi.org/10.1158/0008-5472.CAN-19-3183
Published: 02 April 2020
View articletitled, Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
Open the PDF for Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C11: Linoleic acid elevates sirtuin 6 expression and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like factor 10

Free
Hui-Ju Ch'ang, Yi-Chih Tsai, Su-Liang Chen, Vincent H.S. Chang
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C11.
https://doi.org/10.1158/1538-7445.PANCA19-C11
Published: 13 December 2019
View articletitled, Abstract C11: Linoleic acid elevates sirtuin 6 expression and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like factor 10
Journal Articles

Correction: ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis

Free
Yun-Xin Lu, Huai-Qiang Ju, Ze-Xian Liu, Dong-Liang Chen, Yun Wang, Qi Zhao, Qi-Nian Wu, Zhao-lei Zeng, Hai-Bo Qiu, Pei-Shan Hu, Zhi-Qiang Wang, Dong-Sheng Zhang, Feng Wang, Rui-Hua Xu
Journal: Cancer Research
Cancer Res (2019) 79 (14): 3789.
https://doi.org/10.1158/0008-5472.CAN-19-1611
Published: 15 July 2019
View articletitled, Correction: ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis
Open the PDF for Correction: ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis in another window
Journal Articles

Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells

Free
Chun-Lin Lin, Tan Xi, Chia-Nung Hung, Pawel A. Osmulski, Chih-Wei Chou, Meizhen Chen, Chiou-Miin Wang, Kohzoh Mitsuya, Nameer Kirma, Maria E. Gaczynska, Chun-Liang Chen, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2766.
https://doi.org/10.1158/1538-7445.AM2019-2766
Published: 01 July 2019
View articletitled, Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells
Journal Articles

Abstract 173: Upregulated EPHB2 and SRC pathways modulate spatial EGFR dynamics and malignant phenotypes and predict poor prognosis in prostate cancer

Free
Yen-Liang Liu, Aaron M. Horning, Che-Kuang Lin, Brandon Lieberman, Chia-Nung Hung, Chih-Wei Chou, Chiou-Miin Wang, Michael A. Liss, Mirae Kim, Rohan Vasisht, Evan P. Perillo, Katherine Blocher, Hannah Horng, Xi Tian, Chun-Lin Lin, Andrew K. Dunn, Tim H.-M. Huang, Hsin-Chih Yeh, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 173.
https://doi.org/10.1158/1538-7445.AM2019-173
Published: 01 July 2019
View articletitled, Abstract 173: Upregulated EPHB2 and SRC pathways modulate spatial EGFR dynamics and malignant phenotypes and predict poor prognosis in prostate cancer
Journal Articles

Abstract 3460: MPRIP-ALK,a novel ALK rearrangement that responds to ALK inhibitor in non-small-cell lung cancer

Free
Wenfeng Fang, Jiadi Gan, Feng Lu, Yangyang Deng, Liang Chen, Yunpeng Yang, Li Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3460.
https://doi.org/10.1158/1538-7445.AM2019-3460
Published: 01 July 2019
View articletitled, Abstract 3460: MPRIP-ALK,a novel ALK rearrangement that responds to ALK inhibitor in non-small-cell lung cancer
Journal Articles

Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer

Free
Srikanth R. Polusani, Yi-Wen Huang, Guangcun Huang, Chun-Wei Chen, Chiou-Miin Wang, Li-Ling Lin, Pawel Osmulski, Nicholas D. Lucio, Lu Liu, Ya-Ting Hsu, Yufan Zhou, Chun-Lin Lin, Irene Aguilera-Barrantes, Philip T. Valente, Edward R. Kost, Chun-Liang Chen, Eun Yong Shim, Sang Eun Lee, Jianhua Ruan, Maria E. Gaczynska, Pearlly Yan, Paul J. Goodfellow, David G. Mutch, Victor X. Jin, Bruce J. Nicholson, Tim H.-M. Huang, Nameer B. Kirma
Journal: Cancer Research
Cancer Res (2019) 79 (1): 196–208.
https://doi.org/10.1158/0008-5472.CAN-18-1615
Published: 02 January 2019
View articletitled, Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer
Open the PDF for Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3402: Castration resistance transcriptome in prostate cancer revealed by single-cell RNA-seq

Free
Aaron M. Horning, Che-Kuang Lin, Yao Wang, Brandon Lieberman, Devalingam Mahalingam, Ming Gao, Pei Wang, Chiou-Miin Wang, Zhijie Liu, Jianhua Ruan, Michael A. Liss, Victor X. Jin, Tim H-M Huang, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3402.
https://doi.org/10.1158/1538-7445.AM2018-3402
Published: 01 July 2018
View articletitled, Abstract 3402: Castration resistance transcriptome in prostate cancer revealed by single-cell RNA-seq
Journal Articles

Abstract 4946: The association between antihypertensive medication, sRAGE, and risk of pancreatic cancer: Results from the Women's Health Initiative Study

Free
Zhensheng Wang, Donna White, Liang Chen, Peter Richardson, Hashem B. El-Serag, Li Jiao
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4946.
https://doi.org/10.1158/1538-7445.AM2018-4946
Published: 01 July 2018
View articletitled, Abstract 4946: The association between antihypertensive medication, sRAGE, and risk of pancreatic cancer: Results from the Women's Health Initiative Study