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Journal Articles

Abstract 1101: Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer

Free
Shaocong Wu, Min Luo, Kenneth K. To, Jianye Zhang, Chaoyue Su, Hong Zhang, Sainan An, Fang Wang, Da Chen, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1101.
https://doi.org/10.1158/1538-7445.AM2021-1101
Published: 01 July 2021
View articletitled, Abstract 1101: Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer
Journal Articles

Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR

Free
Xiao-Lin Luo, Cheng-Cheng Deng, Xiao-Dong Su, Fang Wang, Zhen Chen, Xing-Ping Wu, Shao-Bo Liang, Ji-Hong Liu, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2018) 78 (13): 3532–3543.
https://doi.org/10.1158/0008-5472.CAN-18-0134
Published: 01 July 2018
View articletitled, Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR
Open the PDF for Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR in another window
Includes: Supplementary data
Journal Articles

Abstract 5503: Loss of MED12 induces tumor dormancy in human ovarian cancer

Free
Xiao-Lin Luo, Cheng-Cheng Deng, Ji-Hong Liu, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5503.
https://doi.org/10.1158/1538-7445.AM2018-5503
Published: 01 July 2018
View articletitled, Abstract 5503: Loss of MED12 induces tumor dormancy in human ovarian cancer
Journal Articles

Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor

Free
Pranav Gupta, Rishil Kathawala, Liuya Wei, Fang Wang, XiaoKun Wang, Brian J. Druker, Li-Wu FU, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4158.
https://doi.org/10.1158/1538-7445.AM2017-4158
Published: 01 July 2017
View articletitled, Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor
Journal Articles

Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer

Free
Xiaokun Wang, Dongjuan Qiao, Likun Chen, Liyan Huang, Meng Xu, Zhen Chen, Fang Wang, Zhesheng Chen, Musheng Zeng, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3180.
https://doi.org/10.1158/1538-7445.AM2017-3180
Published: 01 July 2017
View articletitled, Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer
Journal Articles

Abstract 3915: PBA2, a dual BCR-ABL and GSK3βkinases inhibitor, represses a wide array of Imatinib resistant cell lines in chronic myeloid leukemia

Free
Ke Yang, li-Wu Fu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3915.
https://doi.org/10.1158/1538-7445.AM2016-3915
Published: 15 July 2016
View articletitled, Abstract 3915: PBA2, a dual BCR-ABL and GSK3βkinases inhibitor, represses a wide array of Imatinib resistant cell lines in chronic myeloid leukemia
Journal Articles

Abstract 4417: Vatalanib targets ABCG2-overexpressing multidrug resistant colon cancer cells under hypoxia

Free
Kenneth K. To, Daniel C. Poon, Yuming Wei, Fang Wang, Ge Lin, Li-wu Fu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4417.
https://doi.org/10.1158/1538-7445.AM2015-4417
Published: 01 August 2015
View articletitled, Abstract 4417: Vatalanib targets ABCG2-overexpressing multidrug resistant colon cancer cells under hypoxia
Journal Articles

Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells

Free
Xiao-kun Wang, Jie-hua He, Jing-hong Xu, Sheng Ye, Fang Wang, Hui Zhang, Zhen-cong Huang, Kenneth Kin Wah To, Li-wu Fu
Journal: Cancer Research
Cancer Res (2014) 74 (16): 4431–4445.
https://doi.org/10.1158/0008-5472.CAN-13-3553
Published: 13 August 2014
View articletitled, Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Open the PDF for Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 976: CUDC-101, a hybrid molecular targeted agent, reverses multiple mechanisms of drug resistance.

Free
Kenneth K.W. To, Daniel C. Poon, XG Chen, Ge Lin, Li-wu Fu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 976.
https://doi.org/10.1158/1538-7445.AM2013-976
Published: 15 April 2013
View articletitled, Abstract 976: CUDC-101, a hybrid molecular targeted agent, reverses multiple mechanisms of drug resistance.
Journal Articles

Abstract 773: Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein

Free
Wen-jing Zhou, Fang Wang, Xu Zhang, Kenneth Kin Wah To, Hong-bing Huang, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 773.
https://doi.org/10.1158/1538-7445.AM2012-773
Published: 15 April 2012
View articletitled, Abstract 773: Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein
Journal Articles

Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2

Free
Wen Deng, Chun-Ling Dai, Xiao-qin Zhao, Shinobu Ohnuma, Yong-ju Liang, Zhi-Jie Xiao, Mu-Sheng Zeng, Suresh V. Ambudkar, Li-wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5614.
https://doi.org/10.1158/1538-7445.AM2012-5614
Published: 15 April 2012
View articletitled, Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2
Journal Articles

Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer

Free
Zhi Shi, Amit K. Tiwari, Atish S. Patel, Li-Wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3735–3738.
https://doi.org/10.1158/0008-5472.CAN-11-0375
Published: 31 May 2011
View articletitled, Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer
Open the PDF for Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer in another window
Journal Articles

Abstract 1740: Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents

Free
Jay P. Patel, Ye-Hong Kuang, Kamlesh Sodani, Chun-Pu Wu, Li-Qiu Liao, Amit K. Tiwari, Chun-ling Dai, Xiang Chen, Li-Wu Fu, Suresh V. Ambudkar, Vijaya L. Korlipara, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2011-1740
Published: 15 April 2011
View articletitled, Abstract 1740: Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents
Journal Articles

Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil

Free
Amit K. Tiwari, Zhi Shi, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xing-xiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1739.
https://doi.org/10.1158/1538-7445.AM2011-1739
Published: 15 April 2011
View articletitled, Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil
Journal Articles

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

Free
Zhi Shi, Amit K. Tiwari, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xingxiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-Wu Fu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3029–3041.
https://doi.org/10.1158/0008-5472.CAN-10-3820
Published: 13 April 2011
View articletitled, Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance
Open the PDF for Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance in another window
Includes: Supplementary data
Journal Articles

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

Free
Yan-jun Mi, Yong-ju Liang, Hong-bing Huang, Hong-yun Zhao, Chung-Pu Wu, Fang Wang, Li-yang Tao, Chuan-zhao Zhang, Chun-Ling Dai, Amit K. Tiwari, Xiao-xu Ma, Kenneth Kin Wah To, Suresh V. Ambudkar, Zhe-Sheng Chen, Li-wu Fu
Journal: Cancer Research
Cancer Res (2010) 70 (20): 7981–7991.
https://doi.org/10.1158/0008-5472.CAN-10-0111
Published: 13 October 2010
View articletitled, Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters
Open the PDF for Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters in another window
Includes: Supplementary data
Journal Articles

Abstract 1533: Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity

Free
Dai Chun-ling, Yong-ju Liang, Yan-sheng Wang, Amit K Tiwari, Yan-yan Yan, Fang Wang, Zhe-sheng Chen, Xiu-zhen Tong, Li-wu Fu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1533.
https://doi.org/10.1158/1538-7445.AM10-1533
Published: 15 April 2010
View articletitled, Abstract 1533: Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity
Journal Articles

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Free
Chun-ling Dai, Amit K. Tiwari, Chung-Pu Wu, Xiao-dong Su, Si-Rong Wang, Dong-geng Liu, Charles R. Ashby, Jr., Yan Huang, Robert W. Robey, Yong-ju Liang, Li-ming Chen, Cheng-Jun Shi, Suresh V. Ambudkar, Zhe-Sheng Chen, Li-wu Fu
Journal: Cancer Research
Cancer Res (2008) 68 (19): 7905–7914.
https://doi.org/10.1158/0008-5472.CAN-08-0499
Published: 30 September 2008
View articletitled, Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2
Open the PDF for Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2 in another window
Includes: Supplementary data
Journal Articles

Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

Free
Zhi Shi, Xing-Xiang Peng, In-Wha Kim, Suneet Shukla, Qiu-Sheng Si, Robert W. Robey, Susan E. Bates, Tong Shen, Charles R. Ashby, Jr., Li-Wu Fu, Suresh V. Ambudkar, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2007) 67 (22): 11012–11020.
https://doi.org/10.1158/0008-5472.CAN-07-2686
Published: 15 November 2007
View articletitled, Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance
Open the PDF for Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance in another window
Journal Articles

Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein-mediated multidrug mesistance in cancer cells

Free
Zhi Shi, Sandeep Jain, In-Wha Kim, Xing-Xiang Peng, Ioana Abraham, Li-Wu Fu, Diaa Youssef, Khalid El Sayed, Suresh Ambudkar, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2288.
Published: 01 May 2007
View articletitled, Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein-mediated multidrug mesistance in cancer cells