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Journal Articles

Abstract 1101: Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer

Shaocong Wu, Min Luo, Kenneth K. To, Jianye Zhang, Chaoyue Su, Hong Zhang, Sainan An, Fang Wang, Da Chen, Li-Wu Fu

Cancer Res (2021) 81 (13_Supplement): 1101.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1101

Published: 01 July 2021

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Journal Articles

Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR

Xiao-Lin Luo, Cheng-Cheng Deng, Xiao-Dong Su, Fang Wang, Zhen Chen, Xing-Ping Wu, Shao-Bo Liang, Ji-Hong Liu, Li-Wu Fu

Cancer Res (2018) 78 (13): 3532–3543.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-0134

Published: 01 July 2018

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Includes: Supplementary data

Journal Articles

Abstract 5503: Loss of MED12 induces tumor dormancy in human ovarian cancer

Xiao-Lin Luo, Cheng-Cheng Deng, Ji-Hong Liu, Li-Wu Fu

Cancer Res (2018) 78 (13_Supplement): 5503.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5503

Published: 01 July 2018

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Journal Articles

Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor

Pranav Gupta, Rishil Kathawala, Liuya Wei, Fang Wang, XiaoKun Wang, Brian J. Druker, Li-Wu FU, Zhe-Sheng Chen

Cancer Res (2017) 77 (13_Supplement): 4158.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4158

Published: 01 July 2017

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Journal Articles

Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer

Xiaokun Wang, Dongjuan Qiao, Likun Chen, Liyan Huang, Meng Xu, Zhen Chen, Fang Wang, Zhesheng Chen, Musheng Zeng, Li-Wu Fu

Cancer Res (2017) 77 (13_Supplement): 3180.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3180

Published: 01 July 2017

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Journal Articles

Abstract 3915: PBA2, a dual BCR-ABL and GSK3βkinases inhibitor, represses a wide array of Imatinib resistant cell lines in chronic myeloid leukemia

Ke Yang, li-Wu Fu

Cancer Res (2016) 76 (14_Supplement): 3915.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3915

Published: 15 July 2016

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Journal Articles

Abstract 4417: Vatalanib targets ABCG2-overexpressing multidrug resistant colon cancer cells under hypoxia

Kenneth K. To, Daniel C. Poon, Yuming Wei, Fang Wang, Ge Lin, Li-wu Fu

Cancer Res (2015) 75 (15_Supplement): 4417.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4417

Published: 01 August 2015

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Journal Articles

Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells

Xiao-kun Wang, Jie-hua He, Jing-hong Xu, Sheng Ye, Fang Wang, Hui Zhang, Zhen-cong Huang, Kenneth Kin Wah To, Li-wu Fu

Cancer Res (2014) 74 (16): 4431–4445.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-3553

Published: 13 August 2014

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Includes: Supplementary data

Journal Articles

Abstract 976: CUDC-101, a hybrid molecular targeted agent, reverses multiple mechanisms of drug resistance.

Kenneth K.W. To, Daniel C. Poon, XG Chen, Ge Lin, Li-wu Fu

Cancer Res (2013) 73 (8_Supplement): 976.

DOI: https://doi.org/10.1158/1538-7445.AM2013-976

Published: 15 April 2013

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Journal Articles

Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2

Wen Deng, Chun-Ling Dai, Xiao-qin Zhao, Shinobu Ohnuma, Yong-ju Liang, Zhi-Jie Xiao, Mu-Sheng Zeng, Suresh V. Ambudkar, Li-wu Fu, Zhe-Sheng Chen

Cancer Res (2012) 72 (8_Supplement): 5614.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5614

Published: 15 April 2012

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Journal Articles

Abstract 773: Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein

Wen-jing Zhou, Fang Wang, Xu Zhang, Kenneth Kin Wah To, Hong-bing Huang, Li-Wu Fu

Cancer Res (2012) 72 (8_Supplement): 773.

DOI: https://doi.org/10.1158/1538-7445.AM2012-773

Published: 15 April 2012

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Journal Articles

Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer

Zhi Shi, Amit K. Tiwari, Atish S. Patel, Li-Wu Fu, Zhe-Sheng Chen

Cancer Res (2011) 71 (11): 3735–3738.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-0375

Published: 31 May 2011

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Journal Articles

Abstract 1740: Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents

Jay P. Patel, Ye-Hong Kuang, Kamlesh Sodani, Chun-Pu Wu, Li-Qiu Liao, Amit K. Tiwari, Chun-ling Dai, Xiang Chen, Li-Wu Fu, Suresh V. Ambudkar, Vijaya L. Korlipara, Zhe-Sheng Chen

Cancer Res (2011) 71 (8_Supplement): 1740.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1740

Published: 15 April 2011

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Journal Articles

Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil

Amit K. Tiwari, Zhi Shi, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xing-xiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-wu Fu, Zhe-Sheng Chen

Cancer Res (2011) 71 (8_Supplement): 1739.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1739

Published: 15 April 2011

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Journal Articles

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

Zhi Shi, Amit K. Tiwari, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xingxiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-Wu Fu, Zhe-Sheng Chen

Cancer Res (2011) 71 (8): 3029–3041.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-3820

Published: 13 April 2011

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Includes: Supplementary data

Journal Articles

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

Yan-jun Mi, Yong-ju Liang, Hong-bing Huang, Hong-yun Zhao, Chung-Pu Wu, Fang Wang, Li-yang Tao, Chuan-zhao Zhang, Chun-Ling Dai, Amit K. Tiwari, Xiao-xu Ma, Kenneth Kin Wah To, Suresh V. Ambudkar, Zhe-Sheng Chen, Li-wu Fu

Cancer Res (2010) 70 (20): 7981–7991.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-0111

Published: 13 October 2010

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Includes: Supplementary data

Journal Articles

Abstract 1533: Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity

Dai Chun-ling, Yong-ju Liang, Yan-sheng Wang, Amit K Tiwari, Yan-yan Yan, Fang Wang, Zhe-sheng Chen, Xiu-zhen Tong, Li-wu Fu

Cancer Res (2010) 70 (8_Supplement): 1533.

DOI: https://doi.org/10.1158/1538-7445.AM10-1533

Published: 15 April 2010

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Journal Articles

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Chun-ling Dai, Amit K. Tiwari, Chung-Pu Wu, Xiao-dong Su, Si-Rong Wang, Dong-geng Liu, Charles R. Ashby, Jr., Yan Huang, Robert W. Robey, Yong-ju Liang, Li-ming Chen, Cheng-Jun Shi, Suresh V. Ambudkar, Zhe-Sheng Chen, Li-wu Fu

Cancer Res (2008) 68 (19): 7905–7914.

DOI: https://doi.org/10.1158/0008-5472.CAN-08-0499

Published: 30 September 2008

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Includes: Supplementary data

Journal Articles

Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

Zhi Shi, Xing-Xiang Peng, In-Wha Kim, Suneet Shukla, Qiu-Sheng Si, Robert W. Robey, Susan E. Bates, Tong Shen, Charles R. Ashby, Jr., Li-Wu Fu, Suresh V. Ambudkar, Zhe-Sheng Chen

Cancer Res (2007) 67 (22): 11012–11020.

DOI: https://doi.org/10.1158/0008-5472.CAN-07-2686

Published: 15 November 2007

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Journal Articles

Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein-mediated multidrug mesistance in cancer cells

Zhi Shi, Sandeep Jain, In-Wha Kim, Xing-Xiang Peng, Ioana Abraham, Li-Wu Fu, Diaa Youssef, Khalid El Sayed, Suresh Ambudkar, Zhe-Sheng Chen

Cancer Res (2007) 67 (9_Supplement): 2288.

Published: 01 May 2007

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NARROW

Abstract 1101: Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer

Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR

Abstract 5503: Loss of MED12 induces tumor dormancy in human ovarian cancer

Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor

Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer

Abstract 3915: PBA2, a dual BCR-ABL and GSK3βkinases inhibitor, represses a wide array of Imatinib resistant cell lines in chronic myeloid leukemia

Abstract 4417: Vatalanib targets ABCG2-overexpressing multidrug resistant colon cancer cells under hypoxia

Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells

Abstract 976: CUDC-101, a hybrid molecular targeted agent, reverses multiple mechanisms of drug resistance.

Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2

Abstract 773: Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein

Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer

Abstract 1740: Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents

Abstract 1739: Reversal of ABCB1- and ABCG2-mediated drug resistance by sildenafil

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

Abstract 1533: Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein-mediated multidrug mesistance in cancer cells

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