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Journal Articles

Abstract 363: Exploiting Rb-deficiency: Dual inhibition of TRIP13 and Aurora A as a path to mitotic catastrophe

Free
Lacin Yapindi, Soma Ghosh, Li Shen, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 363.
https://doi.org/10.1158/1538-7445.AM2025-363
Published: 21 April 2025
View articletitled, Abstract 363: Exploiting Rb-deficiency: Dual inhibition of TRIP13 and Aurora A as a path to mitotic catastrophe
Journal Articles

Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment

Free
Soma Ghosh, Madison P. O’Hara, Tuhina Mazumdar, Lacin Yapindi, Li Shen, Jing Wang, Mitchell J. Frederick, Jagannadha K. Sastry, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3094.
https://doi.org/10.1158/1538-7445.AM2025-3094
Published: 21 April 2025
View articletitled, Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment
Journal Articles

Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer

Open Access
Tanvi H. Visal, Recep Bayraktar, Petra den Hollander, Michael A. Attathikhun, Tieling Zhou, Jing Wang, Li Shen, Corina-Elena Minciuna, Meng Chen, Elizve Barrientos-Toro, Harsh Batra, Maria Gabriela Raso, Fei Yang, Edwin R. Parra, Aysegul A. Sahin, George A. Calin, Sendurai A. Mani
Journal: Cancer Research
Cancer Res (2025) 85 (5): 894–911.
https://doi.org/10.1158/0008-5472.CAN-24-0400
Published: 03 March 2025
View articletitled, Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer
Open the PDF for Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma

Free
Nur P. Damayanti, Ricardo A. Cordova, Christopher Rupert, Ilaria Delle Fontane, Li Shen, Sabrina Orsi, Angela J. Klunk, W. Marston Linehan, Kirk A. Staschke, Peter C. Hollenhorst, David E. Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1286–1302.
https://doi.org/10.1158/0008-5472.CAN-23-1789
Published: 15 April 2024
View articletitled, TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma
Open the PDF for TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5977: A first-in-human, open-label, multi-center phase 1 study of TST003, a GREM 1 inhibitor, in subjects with locally advanced or metastatic solid tumors

Free
Ismael Rodriguez Rivera, Lin Shen, Shivaani Kummar, Minal Barve, Caroline Germa, Chuan Qi, Lei Chen, Jenny Milata, Jenny Yao, Li Shen, Xuelian Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5977.
https://doi.org/10.1158/1538-7445.AM2024-5977
Published: 22 March 2024
View articletitled, Abstract 5977: A first-in-human, open-label, multi-center phase 1 study of TST003, a GREM 1 inhibitor, in subjects with locally advanced or metastatic solid tumors
Journal Articles

Abstract 3629: Prevalence of claudin18.2 expression in gastric/gastroesophageal junction adenocarcinoma among patients in TranStar101 and TranStar102 clinical trials

Free
Li Shen, Carol Mao, Alan Lin, Ying Gu, Jenny Milata, Lijuan Zhang, Chuan Qi, Jenny Yao, Steven Yu, Changjun Yue, Lin Shen, Yelena Janjigian, Xueming Qian, Wen-I Chang, Caroline Germa
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3629.
https://doi.org/10.1158/1538-7445.AM2024-3629
Published: 22 March 2024
View articletitled, Abstract 3629: Prevalence of claudin18.2 expression in gastric/gastroesophageal junction adenocarcinoma among patients in TranStar101 and TranStar102 clinical trials
Journal Articles

Abstract 6392: Activity of HER2-and TROP2- antibody drug conjugates (ADCs) in small cell lung cancer (SCLC) models with SLFN11 as a predictive biomarker

Free
Bingnan Zhang, Ali Ibrahim, C.Allison Stewart, Lixia Diao, Qi Wang, Li Shen, Yuann xi, Alejandra Serrano, Luisa M. Solis, Wei-Lien Wang, Kavya Ramkumar, Robert J. Cardnell, Runsheng Wang, Alberto Duarte, Jing Wang, Lauren A. Byers, Carl Gay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6392.
https://doi.org/10.1158/1538-7445.AM2024-6392
Published: 22 March 2024
View articletitled, Abstract 6392: Activity of HER2-and TROP2- antibody drug conjugates (ADCs) in small cell lung cancer (SCLC) models with SLFN11 as a predictive biomarker
Journal Articles

Abstract 4525: YAP1 in relapsed pulmonary high-grade neuroendocrine carcinomas (NEC) is associated with CDKN2A loss, intact RB1, EMT and therapeutic vulnerability to MEK1 and CDK4/6 inhibition

Free
C. Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, B. Leticia Rodriguez, Benjamin B. Morris, Li Shen, Bingnan Zhang, Yan Yang, Azusa Tanimoto, Veronica Y. Novegil, Luisa M. Solis Soto, Pedro F. Simoes da Rocha, Natalie Vokes, Don L. Gibbons, Michael Frumovitz, Junya Fujimoto, Jing Wang, Bonnie Glisson, Lauren A. Byers, Carl M. Gay
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4525.
https://doi.org/10.1158/1538-7445.AM2023-4525
Published: 04 April 2023
View articletitled, Abstract 4525: YAP1 in relapsed pulmonary high-grade neuroendocrine carcinomas (NEC) is associated with CDKN2A loss, intact RB1, EMT and therapeutic vulnerability to MEK1 and CDK4/6 inhibition
Journal Articles

Abstract 3864: Targeting IL-6/STAT3 signaling in EGFR-mutant drug tolerant persister cells

Free
Sonia A. Patel, Monique Nilsson, Yan Yang, Li Shen, Jing Wang, Alissa Poteete, Xiaoxing Yu, Xiaoyang Ren, Xiuning Le, John Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3864.
https://doi.org/10.1158/1538-7445.AM2023-3864
Published: 04 April 2023
View articletitled, Abstract 3864: Targeting IL-6/STAT3 signaling in EGFR-mutant drug tolerant persister cells
Journal Articles

Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response

Free
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Ximing Tang, Sen Pathak, Maria G. Raso, Jared Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2585.
https://doi.org/10.1158/1538-7445.AM2023-2585
Published: 04 April 2023
View articletitled, Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response
Journal Articles

Abstract 6257: Developing HDAC inhibitors as immunomodulators

Free
Sean Colligan, Li Shen, Christopher Rupert, Jonathan Bard, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6257.
https://doi.org/10.1158/1538-7445.AM2023-6257
Published: 04 April 2023
View articletitled, Abstract 6257: Developing HDAC inhibitors as immunomodulators
Journal Articles

Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC

Free
Pooja A. Shah, Tuhina Mazumdar, Reid T. Powell, Li Shen, Jing Wang, Clifford C. Stephen, Mitchell J. Frederick, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2847.
https://doi.org/10.1158/1538-7445.AM2023-2847
Published: 04 April 2023
View articletitled, Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC
Journal Articles

Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer

Free
Kavya Ramkumar, C. Allison Stewart, Azusa Tanimoto, Qi Wang, Yuanxin Xi, Benjamin B. Morris, Runsheng Wang, Li Shen, Robert J. Cardnell, Jing Wang, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6206.
https://doi.org/10.1158/1538-7445.AM2023-6206
Published: 04 April 2023
View articletitled, Abstract 6206: Combined inhibition of AXL and ATR enhances replication stress, cell death and immune response in small cell lung cancer
Journal Articles

Abstract 4239: Alternate-day fasting enhances the activity of anti-androgen therapy in prostate cancer models

Free
Ricardo Cordova, May Elbanna, Angela Klunk, Christopher Rupert, Li Shen, Yanqing Wang, David Goodrich, Ron Wek, Kirk Staschke, Luigi Fontana, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4239.
https://doi.org/10.1158/1538-7445.AM2023-4239
Published: 04 April 2023
View articletitled, Abstract 4239: Alternate-day fasting enhances the activity of anti-androgen therapy in prostate cancer models
Journal Articles

Abstract 4495: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma

Free
Nur Damayanti, Sabrina Orsi, Ricardo Cordova, Christopher Rupert, Li Shen, William Marston Linehan, Kirk Staschke, Peter Hollenhorst, David Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4495.
https://doi.org/10.1158/1538-7445.AM2023-4495
Published: 04 April 2023
View articletitled, Abstract 4495: A mechanistic study of the TFE3-splicing machinery gene fusions reveals a new druggable target for translocation renal cell carcinoma
Journal Articles

Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Available to Purchase
Pooja A. Shah, Vaishnavi Sambandam, Anne M. Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M. Ahmed, Soma Ghosh, Mitchell J. Frederick, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4444–4456.
https://doi.org/10.1158/0008-5472.CAN-22-1175
Published: 02 December 2022
View articletitled, Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma
Open the PDF for Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1827: CD70 is a novel therapeutic target for EGFR mutant NSCLC with acquired, EMT-associated EGFR TKI resistance

Free
Monique B. Nilsson, Yan Yang, Sonia Patel, Simon Heeke, Xiuning Le, Thiru Aruguman, Jacqulyne Robichaux, Xiaoxing Yu, Alissa Poteete, Xiaoyang Ren, Lixia Diao, Li Shen, Qi Wang, Fahao Zhang, Leticia Campos Clemente, Luisa Solis Soto, Chunhua Shi, Hai Tran, Jason Bock, Jing Wang, Ignacio I. Wistuba, John D. Minna, John V. Heymach
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1827.
https://doi.org/10.1158/1538-7445.AM2022-1827
Published: 15 June 2022
View articletitled, Abstract 1827: CD70 is a novel therapeutic target for EGFR mutant NSCLC with acquired, EMT-associated EGFR TKI resistance
Journal Articles

Abstract 2602: Combined inhibition of AXL and ATR enhances cell death and immune response in small cell lung cancer

Free
Kavya Ramkumar, Azusa Tanimoto, C. Allison Stewart, Qi Wang, Li Shen, Robert J. Cardnell, B. Leticia Rodriguez, Don L. Gibbons, Jing Wang, Carl M. Gay, Lauren A. Byers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2602.
https://doi.org/10.1158/1538-7445.AM2022-2602
Published: 15 June 2022
View articletitled, Abstract 2602: Combined inhibition of AXL and ATR enhances cell death and immune response in small cell lung cancer
Journal Articles

Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

Free
Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Curtis R. Pickering, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1858.
https://doi.org/10.1158/1538-7445.AM2022-1858
Published: 15 June 2022
View articletitled, Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels
Journal Articles

Abstract 3125: IL-6 contributes to the suppression of T and NK cell anti-tumor activity in EGFR-mutant NSCLC

Free
Sonia Patel, Monique Nilsson, Yan Yang, Xiaoxing Yu, Fahao Zhang, Alissa Poteete, Xiaoyang Ren, Li Shen, Jing Wang, Xiuning Le, John Heymach
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3125.
https://doi.org/10.1158/1538-7445.AM2022-3125
Published: 15 June 2022
View articletitled, Abstract 3125: IL-6 contributes to the suppression of T and NK cell anti-tumor activity in EGFR-mutant NSCLC