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Lewis C. Cantley
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Journal Articles

Abstract A072: Decoding human kinome specificities through a computational data-driven approach and unveiling kinase activity in pancreatic ductal adenocarcinoma

Li Cai, Jared L Johnson, Chen Peng, Tomer M Yaron, Lewis C Cantley, Ronald A DePinho
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A072.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A072
Published: 15 September 2024
View article titled, Abstract A072: Decoding human kinome specificities through a computational data-driven approach and unveiling kinase activity in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 3955: A proteogenomic study of high-grade glioma among adolescents and young adults

Nicole Tignor, Mateusz P. Koptyra, Shrabanti Chowdhury, Weiping Ma, Jo Lynne Rokita, Marina Gritsenko, Xiaoyu Song, Giacomo B. Marino, Eden Z. Deng, Francesca Petralia, Azra Krek, Dmitry Rykunov, Felipe da Veiga Leprevost, Noshad Hosseini, Komal S. Rathi, Yingwei Hu, Simona Migliozzi, Tomer Yaron, Weijia Fu, Bo Zhang, Yuankun Zhu, Miguel A. Brown, Jeffrey R. Whiteaker, Clinical Proteomics Tumor Analysis Consortium (CPTAC), Children’s Brain Tumor Network (CBTN), Mehdi Mesri, Ana I. Robles, Karin Rodland, Lewis C. Cantley, Antonio Iavarone, Kenneth Aldape, Marcin Cieślik, Alexey I. Nesvizhskii, Joseph E. Ippolito, Joshua B. Rubin, Amanda G. Paulovich, Hui Zhang, Avi Ma'ayan, Tao Liu, Phillip B. Storm, Adam C. Resnick, Brian R. Rood, Pei Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3955.
https://doi.org/10.1158/1538-7445.AM2024-3955
Published: 22 March 2024
View article titled, Abstract 3955: A proteogenomic study of high-grade glioma among adolescents and young adults
Journal Articles

Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism

Meri Rogava, Tyler Joseph Aprati, Wei-Yu Chen, Johannes Melms, Clemens Hug, Amit Dipak Amin, Bryan Ngo, Michae l Lee, Patricia Ho, Yiping Wang, Stephen Tang, Ethan Earlie, Sean Chen, Thomas Tüting, Martin Röcken, Thomas K. Eigentler, Samuel F. Bakhoum, Andrei Molotkov, Akiva Mintz, Dirk Schadendorf, Lewis C. Cantley, Peter K. Sorger, Ashley Laughney, David Liu, Benjamin Izar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3514.
https://doi.org/10.1158/1538-7445.AM2023-3514
Published: 04 April 2023
View article titled, Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism
Journal Articles

Abstract 3487: An atlas of substrate specificities for the human tyrosine kinome

Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, Michael B. Yaffe, Benjamin E. Turk, Emily M. Huntsman, Peter V. Hornbeck
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3487.
https://doi.org/10.1158/1538-7445.AM2023-3487
Published: 04 April 2023
View article titled, Abstract 3487: An atlas of substrate specificities for the human tyrosine kinome
Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3861–3867.
https://doi.org/10.1158/0008-5472.CAN-22-2453
Published: 02 November 2022
View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission
Open the PDF for The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission in another window
Journal Articles

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Shawn M. Davidson, Daniel R. Schmidt, Julia E. Heyman, James P. O'Brien, Amy C. Liu, William J. Israelsen, Talya L. Dayton, Raghav Sehgal, Roderick T. Bronson, Elizaveta Freinkman, Howard H. Mak, Giuseppe Nicolò Fanelli, Scott Malstrom, Gary Bellinger, Arkaitz Carracedo, Pier Paolo Pandolfi, Kevin D. Courtney, Abhishek Jha, Ronald A. DePinho, James W. Horner, Craig J. Thomas, Lewis C. Cantley, Massimo Loda, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2403–2416.
https://doi.org/10.1158/0008-5472.CAN-21-2352
Published: 05 July 2022
View article titled, Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Open the PDF for Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 162: Identification of novel targets of Serine/arginine-rich protein-specific kinase 2

Kripa Shobana Ganesh, Bethany Schaffer, Gina Lee, Jared Johnson, Tomer M. Yaron, Noah Dephoure, Lewis C. Cantley, John Blenis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 162.
https://doi.org/10.1158/1538-7445.AM2022-162
Published: 15 June 2022
View article titled, Abstract 162: Identification of novel targets of Serine/arginine-rich protein-specific kinase 2
Journal Articles

Abstract 981: A genetic-metabolic axis of metastatic liver organotropism

Meri Rogava, Johannes C. Melms, Stephanie Davis, Clemens Hug, Bryan Ngo, Michael J. Lee, Patricia Ho, Amit Dipak Amin, Yiping Wang, Sean Chen, William Ge, David Liu, Thomas Tüting, Martin Röcken, Thomas K. Eigentler, Samuel F. Bakhoum, Andrei Molotkov, Akiva Mintz, Lewis C. Cantley, Peter K. Sorger, Benjamin Izar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 981.
https://doi.org/10.1158/1538-7445.AM2022-981
Published: 15 June 2022
View article titled, Abstract 981: A genetic-metabolic axis of metastatic liver organotropism
Journal Articles

Abstract 794: Pan-cancer proteogenomic analysis reveals functional mechanisms underlying DNA repair deficiencies

Yo Akiyama, Yifat Geffen, Shankara Anand, Tomer Yaron, Jared L. Johnson, Emily Huntsman, David Heiman, Chet Birger, Karl Clauser, Özgün Babur, Mendy Miller, Karsten Krug, D R Mani, Lewis C. Cantley, Steven A. Carr, PanCancer Oncogenic Drivers and Pathways Group, Clinical Proteomic Tumor Analysis Consortium (CPTAC), Francois Aguet, Li Ding, Gad Getz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 794.
https://doi.org/10.1158/1538-7445.AM2022-794
Published: 15 June 2022
View article titled, Abstract 794: Pan-cancer proteogenomic analysis reveals functional mechanisms underlying DNA repair deficiencies
Journal Articles

Abstract 16: Patterns and regulation of post translational modifications in cancer

Yifat Geffen, Shankara Anand, Yo Akiyama, Tommer M. Yaron, Alexander Kerelsky, Jared L. Johnson, Karsten Krug, David Heiman, Shankha Satpathy, Karl Clauser, Michael Gillette, D. R. Mani, Chet Birger, Steven Carr, Lewis C. Cantley, Francois Aguet, Gad Getz, Oncogenic Drivers and Pathways Group, Clinical Proteomic Tumor Analysis Consortium (CPTAC)
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 16.
https://doi.org/10.1158/1538-7445.AM2021-16
Published: 01 July 2021
View article titled, Abstract 16: Patterns and regulation of post translational modifications in cancer
Journal Articles

Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Neil Vasan, Pedram Razavi, Jared L. Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Frauke Schimmoller, Timothy R. Wilson, Lori S. Friedman, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG16.
https://doi.org/10.1158/1538-7445.AM2020-NG16
Published: 15 August 2020
View article titled, Abstract NG16: Double <em>PIK3CA</em> mutations in <em>cis</em> increase oncogenicity and sensitivity to PI3Kα inhibitors
Journal Articles

Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition

Bryan Ngo, Eugenie Kim, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Ferraro, Diane Kang, Jing Ni, Roger Liang, Ariana Plasger, Edward R. Kastenhuber, Roozbeh Eskandari, Sarah Bacha, Roshan Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Edouard Mullarky, Matija Snuderl, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Matthew G. Vander Heiden, Matthias Mann, Lewis C. Cantley, Michael E. Pacold
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5712.
https://doi.org/10.1158/1538-7445.AM2020-5712
Published: 15 August 2020
View article titled, Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition
Journal Articles

Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer

Neil Vasan, Pedram Razavi, Jared L Johnson, Hong Shao, Timothy Wilson, Frauke Schimmoller, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L Smith, Robert Sebra, Lori Friedman, Lewis C Cantley, Maurizio Scaltriti, José Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-03-01.
https://doi.org/10.1158/1538-7445.SABCS19-P3-03-01
Published: 15 February 2020
View article titled, Abstract P3-03-01: Double <em>PIK3CA</em> mutations in <em>cis</em> drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

Abstract 3917: Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer

Neil Vasan, Pedram Razavi, Jared Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3917.
https://doi.org/10.1158/1538-7445.AM2019-3917
Published: 01 July 2019
View article titled, Abstract 3917: Double <em>PIK3CA</em> mutations in <em>cis</em> enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response

Samuel F. Bakhoum, Bryon Ngo, Ashley L. Bakhoum, Julie-Ann Cavallo, Charles J. Murphy, Peter Ly, Pragya Shah, Roshan K. Sriram, Thomas B.k. Watkins, Neil K. Taunk, Mercedes Duran, Chantal Pauli, Christine Shaw, Kalyani Chadalavada, Vinagolu K. Rajasekhar, Giulio Genovese, Subramanian Venkatesan, Nicolai J. Birkbak, Nicholas McGranahan, Mark Lundquist, Quincy LaPlant, John H. Healey, Olivier Elemento, Christine H. Chung, Nancy Y. Lee, Marcin Imielinski, Gouri Nanjangud, Dana Pe'er, Don W. Cleveland, Simon N. Powell, Jan Lammerding, Charles Swanton, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): NG03.
https://doi.org/10.1158/1538-7445.AM2018-NG03
Published: 01 July 2018
View article titled, Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response
Journal Articles

Abstract 1772: PIK3CA C2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors

Sarah Croessmann, Jonathan Sheehan, Gregory Sliwoski, Nalin Leelatian, Jie He, Rebecca Nagy, Justin M. Balko, Ingrid A. Mayer, Richard B. Lanman, Vincent Miller, Lewis C. Cantley, Jonathan M. Irish, Jens Meiler, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1772.
https://doi.org/10.1158/1538-7445.AM2017-1772
Published: 01 July 2017
View article titled, Abstract 1772: <em>PIK3CA</em> C2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors
Journal Articles

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Christine Chio, John M. Asara, John D. Minna, David A. Tuveson, Ralph J. DeBerardinis, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B04.
https://doi.org/10.1158/1538-7445.PANCA16-B04
Published: 14 December 2016
View article titled, Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract SY12-01: PI 3-kinase and cancer metabolism

Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): SY12-01.
https://doi.org/10.1158/1538-7445.AM2016-SY12-01
Published: 15 July 2016
View article titled, Abstract SY12-01: PI 3-kinase and cancer metabolism
Journal Articles

Abstract 3858: Feasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models

Hui Liu, Charles Murphy, Florian Karreth, Kangkang Yang, Gerburg Wulf, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3858.
https://doi.org/10.1158/1538-7445.AM2016-3858
Published: 15 July 2016
View article titled, Abstract 3858: Feasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models
Journal Articles

Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer

Carlos E. Stahlhut, Alexandra J. Ambrico, Kaitlin E. Watrud, Hyejin Cho, Lily Wang, Jun Qi, Lewis C. Cantley, James Bradner, Lloyd Trotman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4165.
https://doi.org/10.1158/1538-7445.AM2016-4165
Published: 15 July 2016
View article titled, Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer