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Levi A. Garraway
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Journal Articles

Editor’s Note: PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

Martin L. Sos, Mirjam Koker, Barbara A. Weir, Stefanie Heynck, Rosalia Rabinovsky, Thomas Zander, Jens M. Seeger, Jonathan Weiss, Florian Fischer, Peter Frommolt, Kathrin Michel, Martin Peifer, Craig Mermel, Luc Girard, Michael Peyton, Adi F. Gazdar, John D. Minna, Levi A. Garraway, Hamid Kashkar, William Pao, Matthew Meyerson, Roman K. Thomas
Journal: Cancer Research
Cancer Res (2025) 85 (5): 1003.
https://doi.org/10.1158/0008-5472.CAN-24-5044
Published: 03 March 2025
View articletitled, Editor’s Note: PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
Open the PDF for Editor’s Note: PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR in another window
Journal Articles

Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade

Parin Shah, Michael Cuoco, Mei-Ju Su, Johannes Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rozenblatt-Rosen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev, Livnat Jerby-Arnon
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR01.
https://doi.org/10.1158/1538-7445.MEL2019-PR01
Published: 02 October 2020
View articletitled, Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade
Journal Articles

Abstract NG13: Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A. Shukla, Dominick Bosse, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, Frank Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary B. Clish, Toni K. Choueiri, Marios Giannakis
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG13.
https://doi.org/10.1158/1538-7445.AM2020-NG13
Published: 15 August 2020
View articletitled, Abstract NG13: Metabolomic adaptations and correlates of survival to immune checkpoint blockade
Journal Articles

Abstract PD2-09: The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in patients with hormone receptor-positive (HR+)/HER2- metastatic breast cancer (MBC)

Seth A. Wander, Ofir Cohen, Xueqian Gong, Gabriela N. Johnson, Jorge Buendia-Buendia, Maxwell Lloyd, Dewey Kim, Flora Luo, Pingping Mao, Karla Helvie, Kailey Kowalski, Utthara Nayar, Stephen Parsons, Ricardo Martinez, Lacey Litchfield, Xiang Ye, Chun Ping Yu, Valerie Jansen, Levi A. Garraway, Eric P. Winer, Sara M. Tolaney, Nancy U. Lin, Sean Buchanan, Nikhil Wagle
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD2-09.
https://doi.org/10.1158/1538-7445.SABCS19-PD2-09
Published: 15 February 2020
View articletitled, Abstract PD2-09: The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in patients with hormone receptor-positive (HR+)/HER2- metastatic breast cancer (MBC)
Journal Articles

Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem

Benjamin Izar, Livnat Jerby-Arnon, Itay Tirosh, Parin Shah, Michael C. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes C. Melms, Rachel Leeson, Abhay Kanodia, Jia-Ren Lin, Genevieve M. Boland, Gao Zhang, F. Stephen Hodi, Peter K. Sorger, Kai W. Wucherpfennig, Eli M. Van Allen, Dirk Schadendorf, Orit Rozenblatt-Rosen, Levi A. Garraway, Asaf Rotem, Charles H. Yoon, Aviv Regev
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY45-04.
https://doi.org/10.1158/1538-7445.AM2019-SY45-04
Published: 01 July 2019
View articletitled, Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem
Journal Articles

Abstract SY05-03: Dissecting genomic correlates of response and resistance to chemotherapy in bladder cancer through clinical computational oncology

David Liu, Philip Abbosh, Daniel Keliher, Brendan Reardon, Diana Miao, Kent Mouw, Amaro Weiner-Taylor, Stephanie Wankowicz, Garam Han, Min-Yuen Teo, Catharine Cipolla, Jaegil Kim, Gopa Iyer, Hikmat Al-Ahmadie, Essel Dulaimi, David Y.T. Chen, R. Katherine Alpaugh, Jean Hoffman-Censits, Levi A. Garraway, Gad Getz, Scott L. Carter, Joaquim Bellmunt, Elizabeth Plimack, Jonathan E. Rosenberg, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY05-03.
https://doi.org/10.1158/1538-7445.AM2019-SY05-03
Published: 01 July 2019
View articletitled, Abstract SY05-03: Dissecting genomic correlates of response and resistance to chemotherapy in bladder cancer through clinical computational oncology
Journal Articles

A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma

Tikvah K. Hayes, Flora Luo, Ofir Cohen, Amy B. Goodale, Yenarae Lee, Sasha Pantel, Mukta Bagul, Federica Piccioni, David E. Root, Levi A. Garraway, Matthew Meyerson, Cory M. Johannessen
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2352–2366.
https://doi.org/10.1158/0008-5472.CAN-18-2711
Published: 01 May 2019
View articletitled, A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma
Open the PDF for A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3254: Dissecting genomic determinants of response to platinum-based chemotherapy in advanced NSCLC and colorectal cancer

Shirley S. Mo, David Liu, Stacy W. Gray, Steven Joffe, Nikhil Wagle, Judy Garber, Levi A. Garraway, Lynette Sholl, Pasi A. Janne, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3254.
https://doi.org/10.1158/1538-7445.AM2018-3254
Published: 01 July 2018
View articletitled, Abstract 3254: Dissecting genomic determinants of response to platinum-based chemotherapy in advanced NSCLC and colorectal cancer
Journal Articles

Abstract 5647: Intron retention as a novel source of tumor neoantigens associated with response to checkpoint inhibitor therapy

Alicia C. Smart, Claire Margolis, Diana Miao, David Liu, Jihye Park, Meng Xiao He, Brendan Reardon, Stephanie Mullane, Bastian Schilling, Levi A. Garraway, Dirk Schadendorf, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5647.
https://doi.org/10.1158/1538-7445.AM2017-5647
Published: 01 July 2017
View articletitled, Abstract 5647: Intron retention as a novel source of tumor neoantigens associated with response to checkpoint inhibitor therapy
Journal Articles

Abstract 3566: The long tail of significantly mutated genes in prostate cancer

Joshua Armenia, Stephanie Mullane, Jianjiong Gao, Debyani Chakravarty, Ritika Kundra, Franklin Huang, Celine Han, Dan Robinson, Levi A. Garraway, Peter Nelson, Mark Rubin, Mary-Ellen Taplin, Wassim Abida, Charles L. Sawyers, Arul M. Chinnaiyan, Philip W. Kantoff, Johann S. Bono, Nikolaus Schultz, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3566.
https://doi.org/10.1158/1538-7445.AM2017-3566
Published: 01 July 2017
View articletitled, Abstract 3566: The long tail of significantly mutated genes in prostate cancer
Journal Articles

Abstract 3036: Real-time genomic characterization of metastatic pancreatic cancer to enable precision medicine

Andrew J. Aguirre, Scott Carter, Nicholas Camarda, Arezou Ghazani, Jonathan Nowak, Annacarolina Da Silva, Lauren Brais, Dorisanne Ragon, Devin McCabe, Lori Marini, Kristin Anderka, Karla Helvie, Nelly Oliver, Ana Babic, Paul Shyn, Douglas Rubinson, Anuj Patel, James Cleary, Nadine McCleary, Matthew Kulke, Thomas Clancy, Leona Doyle, Jason Hornick, Christine Ardito-Abraham, Ruth Yu, Michael Downes, Ronald Evans, Richard A. Moffitt, Jen Jen Yeh, William C. Hahn, Charles Fuchs, Robert Mayer, Nikhil Wagle, David Tuveson, Levi A. Garraway, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3036.
https://doi.org/10.1158/1538-7445.AM2017-3036
Published: 01 July 2017
View articletitled, Abstract 3036: Real-time genomic characterization of metastatic pancreatic cancer to enable precision medicine
Journal Articles

Abstract 5561: Single-cell analysis reveals an adaptive, transiently heritable, slowly-dividing, drug-resistant state inhibitable by drug combinations

Mohammad Fallahi-Sichani, Verena Becker, Benjamin Izar, Gregory J. Baker, Jia-Ren Lin, Sarah A. Boswell, Levi A. Garraway, Peter K. Sorger
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5561.
https://doi.org/10.1158/1538-7445.AM2017-5561
Published: 01 July 2017
View articletitled, Abstract 5561: Single-cell analysis reveals an adaptive, transiently heritable, slowly-dividing, drug-resistant state inhibitable by drug combinations
Journal Articles

Abstract PR01: Fusobacterium nucleatum and mutational landscape of colorectal cancer in whole-exome sequencing analysis

Reiko Nishihara, Andrew T. Chan, Jasmine Xinmeng Mu, Marios Giannakis, Kosuke Mima, Zhi Rong Qian, Susan Bullman, Aleksandar D. Kostic, Curtis Huttenhower, Wendy Garrett, Edward L. Giovannucci, Matthew Meyerson, Levi A. Garraway, Charles S. Fuchs, Shuji Ogino
Journal: Cancer Research
Cancer Res (2017) 77 (3_Supplement): PR01.
https://doi.org/10.1158/1538-7445.CRC16-PR01
Published: 31 January 2017
View articletitled, Abstract PR01: Fusobacterium nucleatum and mutational landscape of colorectal cancer in whole-exome sequencing analysis
Journal Articles

Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer

Andrew J. Aguirre, Wei Shao, Han Xu, Barbara Weir, Francisca Vazquez, Robin Meyers, Cheng-Zhong Zhang, Mihir Doshi, Glenn S. Cowley, Theodore Ewachiw, Zeshaan Rasheed, Todd R. Golub, Kimberly Stegmaier, Charles W. Roberts, Levi A. Garraway, Matthew Meyerson, Aviad Tsherniak, David E. Root, Peter J. Espenshade, William C. Hahn
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): PR05.
https://doi.org/10.1158/1538-7445.PANCA16-PR05
Published: 14 December 2016
View articletitled, Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer
Journal Articles

High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells

Thomas Horn, Stéphane Ferretti, Nicolas Ebel, Angela Tam, Samuel Ho, Fred Harbinski, Ali Farsidjani, Matthew Zubrowski, William R. Sellers, Robert Schlegel, Dale Porter, Erick Morris, Jens Wuerthner, Sébastien Jeay, Joel Greshock, Ensar Halilovic, Levi A. Garraway, Giordano Caponigro, Joseph Lehár
Journal: Cancer Research
Cancer Res (2016) 76 (23): 6950–6963.
https://doi.org/10.1158/0008-5472.CAN-15-3425
Published: 30 November 2016
View articletitled, High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
Open the PDF for High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1806: TRIM24 is an oncogenic transcriptional activator in prostate cancer

Anna C. Groner, Laura Cato, Jonas de Tribolet-Hardy, Tiziano Bernasocchi, Qing Zhong, Christian Fankhauser, Christine Fritz, Cédric Poyet, Ulrich Wagner, Levi A. Garraway, Peter J. Wild, Jean-Philippe Theurillat, Myles Brown
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1806.
https://doi.org/10.1158/1538-7445.AM2016-1806
Published: 15 July 2016
View articletitled, Abstract 1806: TRIM24 is an oncogenic transcriptional activator in prostate cancer
Journal Articles

Abstract 1311: High order drug combinations are required to effectively kill colorectal cancer cells

Thomas Horn, Stephane Ferretti, Nicolas Ebel, Angela Tam, Samuel Ho, Fred Harbinski, Ali Farsidjani, Matt Zubrowski, William R. Sellers, Robert Schlegel, Dale Porter, Erick Morris, Jens Wuerthner, Sebastien Jeay, Joel Greshock, Ensar Halilovic, Levi A. Garraway, Giordano Caponigro, Joseph Lehar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1311.
https://doi.org/10.1158/1538-7445.AM2016-1311
Published: 15 July 2016
View articletitled, Abstract 1311: High order drug combinations are required to effectively kill colorectal cancer cells
Journal Articles

Abstract 600: Melanoma and ovarian cancer cells tested for drug sensitivity using anchorage-independent growth

Asaf Rotem, Benjamin Izar, Levi A. Garraway
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 600.
https://doi.org/10.1158/1538-7445.AM2016-600
Published: 15 July 2016
View articletitled, Abstract 600: Melanoma and ovarian cancer cells tested for drug sensitivity using anchorage-independent growth
Journal Articles

Abstract 95: Somatic mutations and copy number variations in cancer-associated genes in 695 ovarian cancer patients

Elizabeth H. Stover, Brooke Howitt, Neal I. Lindeman, Levi A. Garraway, Ursula A. Matulonis
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 95.
https://doi.org/10.1158/1538-7445.AM2016-95
Published: 15 July 2016
View articletitled, Abstract 95: Somatic mutations and copy number variations in cancer-associated genes in 695 ovarian cancer patients
Journal Articles

Abstract 3576: Broad analysis of recurrent somatic mutations in cancer reveals a common novel non-coding mutation in the promoter of PMS2 associated with greatly increased tumor mutation load

Zachary R. Chalmers, Franklin W. Huang, Laurie M. Gay, Siraj M. Ali, Roman Yelensky, Juliann Chmielecki, Jeffery S. Ross, Vincent A. Miller, Philip J. Stephens, Levi A. Garraway, Garrett M. Frampton
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3576.
https://doi.org/10.1158/1538-7445.AM2016-3576
Published: 15 July 2016
View articletitled, Abstract 3576: Broad analysis of recurrent somatic mutations in cancer reveals a common novel non-coding mutation in the promoter of PMS2 associated with greatly increased tumor mutation load