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Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery

Cancer Res (2018) 78 (3): 817–829.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-1467

Published: 31 January 2018

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Includes: Supplementary data

Journal Articles

Structural Basis for Induction of Peripheral Neuropathy by Microtubule-Targeting Cancer Drugs

Jennifer A. Smith, Barbara S. Slusher, Krystyna M. Wozniak, Mohamed H. Farah, Gregoriy Smiyun, Leslie Wilson, Stuart Feinstein, Mary Ann Jordan

Cancer Res (2016) 76 (17): 5115–5123.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-3116

Published: 31 August 2016

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Journal Articles

Abstract 1666: Increased sensitivity of βIII tubulin-containing microtubules to cabazitaxel compared with docetaxel: A possible role of βIII tubulin in specifying good efficacy of cabazitaxel for docetaxel-resistant tumors

Leslie Wilson, Olga Azarenko, Gregoriy Smiyun, Herbert Miller, Mary Ann Jordan

Cancer Res (2015) 75 (15_Supplement): 1666.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1666

Published: 01 August 2015

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Journal Articles

Abstract 5294: Inhibition of mitochondrial transport in neuronal cells by microtubule-targeting drugs eribulin, ixabepilone, paclitaxel, and vincristine

Jennifer A. Smith, Gregoriy Smiyun, Leslie Wilson, Stuart Feinstein, Mary Ann Jordan

Cancer Res (2014) 74 (19_Supplement): 5294.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5294

Published: 01 October 2014

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Journal Articles

Abstract 5503: Microtubule-targeting agents induce differential myelinated axon degeneration in a mouse model of peripheral neuropathy

Brett M. Cook, Sarah J. Benbow, Krystyna M. Wozniak, Barbara S. Slusher, Bruce A. Littlefield, Leslie Wilson, Stuart C. Feinstein, Mary Ann Jordan

Cancer Res (2014) 74 (19_Supplement): 5503.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5503

Published: 01 October 2014

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Journal Articles

Abstract 5464: Distinct effects of eribulin on axonal microtubule composition and modifications relative to paclitaxel, vincristine and ixabepilone in preclinical models: correlations with lower levels of eribulin-induced peripheral neuropathy

Sarah J. Benbow, Brett M. Cook, Krystyna M. Wozniak, Barbara S. Slusher, Bruce A. Littlefield, Leslie Wilson, Stuart C. Feinstein, Mary A. Jordan

Cancer Res (2014) 74 (19_Supplement): 5464.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5464

Published: 01 October 2014

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Journal Articles

Abstract 772: Effects of natural products on proliferation of human breast cancer cells induced by estrogen or PhIP, a heterocyclic amine compound derived from cooked meat

Choong Jae Lee, Mi Nam Lee, Hyun Jae Lee, Su Yel Lee, Jeong Ho Seok, Mary Ann Jordan, Leslie Wilson

Cancer Res (2010) 70 (8_Supplement): 772.

DOI: https://doi.org/10.1158/1538-7445.AM10-772

Published: 15 April 2010

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Journal Articles

Abstract #2701: Effects of paeoniflorin, baicalein, hesperidin and oleanolic acid on human breast and prostate cancer cells

Choong Jae Lee, Mary Ann Jordan, Leslie Wilson, Su Yel Lee, Mi Nam Lee

Cancer Res (2009) 69 (9_Supplement): 2701.

Published: 01 May 2009

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Journal Articles

Eribulin (E7389) binds to 13 saturable sites at microtubule ends to inhibit microtubule dynamics

Jennifer Smith, Leslie Wilson, Xiaojie Zhu, Bryan Lewis, Bruce Littlefield, Mary Ann Jordan

Cancer Res (2008) 68 (9_Supplement): 1408.

Published: 01 May 2008

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Journal Articles

Maytansine derivatives and metabolites of antibody-maytansinoid conjugates inhibit microtubule polymerization and strongly suppress microtubule dynamics

Manu Lopus, Emin Oroudjev, Leslie Wilson, Sharon Wilhelm, Wayne Widdison, Ravi Chari, Mary Ann Jordan

Cancer Res (2008) 68 (9_Supplement): 1406.

Published: 01 May 2008

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Journal Articles

Carbendazim inhibits cell proliferation and arrests mitosis by binding to tubulin and suppressing microtubule dynamic instability

Mythili Yenjerla, Corey Cox, Mary Jordan, Leslie Wilson

Cancer Res (2008) 68 (9_Supplement): 1407.

Published: 01 May 2008

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Journal Articles

Antibody-maytansinoid conjugates affect microtubule morphology and suppress microtubule dynamics in live cells

Emin Oroudjev, Manu Lopus, Leslie Wilson, Charlene Audette, Carmela Provenzano, Hans Erickson, Yelena Kovtun, Ravi Chari, Mary Ann Jordan

Cancer Res (2008) 68 (9_Supplement): 1403.

Published: 01 May 2008

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Journal Articles

OMN54, a multifunctional multitargeted (MFMT) agent with potent effects on the inflammatory process associated with cancer initiation and progression

Judy Mikovits, Lena Gerwick, Emin Oroudjev, Longkuan Xiang, Yuzhuo Wang, Leslie Wilson, Mary Jordan, William Gerwick

Cancer Res (2008) 68 (9_Supplement): 5403.

Published: 01 May 2008

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Journal Articles

Mechanism of Action of the Microtubule-Targeted Antimitotic Depsipeptide Tasidotin (Formerly ILX651) and Its Major Metabolite Tasidotin C-Carboxylate

Anasuya Ray, Tatiana Okouneva, Tapas Manna, Herbert P. Miller, Steven Schmid, Larry Arthaud, Richard Luduena, Mary Ann Jordan, Leslie Wilson

Cancer Res (2007) 67 (8): 3767–3776.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-3065

Published: 17 April 2007

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Journal Articles

Effects of stably altered stathmin expression on microtubule dynamic instability in breast cancer cells

Chitose Nakao, Elizabeth Alli, William N. Hait, Leslie Wilson, Mary Ann Jordan

Cancer Res (2006) 66 (8_Supplement): 756.

Published: 15 April 2006

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Journal Articles

βIII tubulin confers paclitaxel resistance by reducing paclitaxel’s effects on microtubule dynamics

Kathryn V. L. Kamath, Leslie Wilson, Fernando Cabral, Mary Ann Jordan

Cancer Res (2005) 65 (9_Supplement): 775.

Published: 01 May 2005

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Journal Articles

NPI-2358, a novel tumor vascular disrupting agent

Benjamin Nicholson, Jamie Bishop, Yoshio Hayashi, Mary Ann Jordan, Leslie Wilson, Yoshiaki Kiso, Per Borgström, Michael A. Palladino, Saskia T. C. Neuteboom, G. Kenneth Lloyd

Cancer Res (2005) 65 (9_Supplement): 808.

Published: 01 May 2005

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Journal Articles

Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells

Stéphane Honore, Kathy Kamath, Diane Braguer, Susan Band Horwitz, Leslie Wilson, Claudette Briand, Mary Ann Jordan

Cancer Res (2004) 64 (14): 4957–4964.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-0693

Published: 15 July 2004

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Includes: Supplementary data

Journal Articles

2-Methoxyestradiol arrests mitosis by a mechanism independent of microtubule dynamics.

Kathy Kamath, Tatiana Okouneva, Gary Larson, Dulal Panda, Leslie Wilson, Mary Ann Jordan

Cancer Res (2004) 64 (7_Supplement): 884–885.

Published: 01 April 2004

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Journal Articles

E7389 and ER-076349, synthetic halichondrin B analogs, suppress centromere dynamics in concert with mitotic block

Tatiana Okouneva, Leslie Wilson, Bruce A. Littlefield, Mary Ann Jordan

Cancer Res (2004) 64 (7_Supplement): 1255.

Published: 01 April 2004

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NARROW

Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery

Structural Basis for Induction of Peripheral Neuropathy by Microtubule-Targeting Cancer Drugs

Abstract 1666: Increased sensitivity of βIII tubulin-containing microtubules to cabazitaxel compared with docetaxel: A possible role of βIII tubulin in specifying good efficacy of cabazitaxel for docetaxel-resistant tumors

Abstract 5294: Inhibition of mitochondrial transport in neuronal cells by microtubule-targeting drugs eribulin, ixabepilone, paclitaxel, and vincristine

Abstract 5503: Microtubule-targeting agents induce differential myelinated axon degeneration in a mouse model of peripheral neuropathy

Abstract 5464: Distinct effects of eribulin on axonal microtubule composition and modifications relative to paclitaxel, vincristine and ixabepilone in preclinical models: correlations with lower levels of eribulin-induced peripheral neuropathy

Abstract 772: Effects of natural products on proliferation of human breast cancer cells induced by estrogen or PhIP, a heterocyclic amine compound derived from cooked meat

Abstract #2701: Effects of paeoniflorin, baicalein, hesperidin and oleanolic acid on human breast and prostate cancer cells

Eribulin (E7389) binds to 13 saturable sites at microtubule ends to inhibit microtubule dynamics

Maytansine derivatives and metabolites of antibody-maytansinoid conjugates inhibit microtubule polymerization and strongly suppress microtubule dynamics

Carbendazim inhibits cell proliferation and arrests mitosis by binding to tubulin and suppressing microtubule dynamic instability

Antibody-maytansinoid conjugates affect microtubule morphology and suppress microtubule dynamics in live cells

OMN54, a multifunctional multitargeted (MFMT) agent with potent effects on the inflammatory process associated with cancer initiation and progression

Mechanism of Action of the Microtubule-Targeted Antimitotic Depsipeptide Tasidotin (Formerly ILX651) and Its Major Metabolite Tasidotin C-Carboxylate

Effects of stably altered stathmin expression on microtubule dynamic instability in breast cancer cells

βIII tubulin confers paclitaxel resistance by reducing paclitaxel’s effects on microtubule dynamics

NPI-2358, a novel tumor vascular disrupting agent

Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells

2-Methoxyestradiol arrests mitosis by a mechanism independent of microtubule dynamics.

E7389 and ER-076349, synthetic halichondrin B analogs, suppress centromere dynamics in concert with mitotic block

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