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Journal Articles

Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers

Arany Soosainathan, Marjan Iravani, Rania El-Botty, John Alexander, Laura Sourd, Ludivine Morisset, Pierre Painsec, Rebecca Orha, Joanna Nikitorowicz-Buniak, Sunil Pancholi, Syed Haider, Mitch Dowsett, Elisabetta Marangoni, Lesley-Ann Martin, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0650
Published: 06 October 2023
View article titled, Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers
Open the PDF for Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers in another window
Includes: Supplementary data
Journal Articles

Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping

Carsten Denkert, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Erik S. Knudsen, Seock-Ah Im, Angela DeMichele, Agnieszka Witkiewicz, Laura Van ’t Veer, Sung-Bae Kim, Harry D. Bear, Nicole McCarthy, Karen Gelmon, Frederik Marmé, José Ángel García-Sáenz, Nicholas Turner, Federico Rojo, Martin Filipits, Lesley-Ann Martin, Peter A. Fasching, Christian Schem, Catherine M. Kelly, Toralf Reimer, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Yuan Liu, Karsten Weber, Sivaramakrishna Rachakonda, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): HER2-06.
https://doi.org/10.1158/1538-7445.SABCS22-HER2-06
Published: 01 March 2023
View article titled, Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping
Journal Articles

Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial

Erik S. Knudsen, Sivaramakrishna Rachakonda, Frederik Marmé, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Wolfgang D. Schmitt, Sung-Bae Kim, Harry D. Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Nicole McCarthy, Bruno V. Sinn, Karen Gelmon, José Ángel García-Sáenz, Catherine M. Kelly, Toralf Reimer, Nicholas Turner, Federico Rojo, Martin Filipits, Peter A. Fasching, Christian Schem, Lesley-Ann Martin, Yuan Liu, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Jenny Furlanetto, Karsten Weber, Carsten Denkert, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD17-06.
https://doi.org/10.1158/1538-7445.SABCS22-PD17-06
Published: 01 March 2023
View article titled, Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial
Journal Articles

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Barrie Peck, Philip Bland, Ioanna Mavrommati, Gareth Muirhead, Hannah Cottom, Patty T. Wai, Sarah L. Maguire, Holly E. Barker, Eamonn Morrison, Divya Kriplani, Lu Yu, Amy Gibson, Giulia Falgari, Keith Brennan, Gillian Farnie, Richard Buus, Rebecca Marlow, Daniela Novo, Eleanor Knight, Naomi Guppy, Daniela Kolarevic, Snezana Susnjar, Natasa Medic Milijic, Kalnisha Naidoo, Patrycja Gazinska, Ioannis Roxanis, Sunil Pancholi, Lesley-Ann Martin, Erle M. Holgersen, Maggie C.U. Cheang, Farzana Noor, Sophie Postel-Vinay, Gerard Quinn, Simon McDade, Lukas Krasny, Paul Huang, Frances Daley, Fredrik Wallberg, Jyoti S. Choudhary, Syed Haider, Andrew N. Tutt, Rachael Natrajan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 847–859.
https://doi.org/10.1158/0008-5472.CAN-20-1822
Published: 15 February 2021
View article titled, 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Open the PDF for 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 925: PDX models of ER+ endocrine-resistant metastatic breast cancer identify Polo-like kinase 1 (PLK1) as a therapeutic target

Elodie Montaudon, Joanna Nikitorowicz-Buniak, Laura Sourd, Rania El Botty, Ahmed Dahmani, Léa Huguet, Ludivine Morriset, Pierre Painsec, Fariba Nemati, Sophie Vacher, Sophie Chateau-Joubert, Sunil Pancholi, Camilla Rega, Ricardo Ribas, André Nicolas, Didier Meseure, Anne Salomon, Zakia Tariq, Keltouma Driouch, Florence Coussy, Guillaume Dutertre, Paul Cottu, Ivan Bièche, Lesley-Ann Martin, Elisabetta Marangoni
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 925.
https://doi.org/10.1158/1538-7445.AM2019-925
Published: 01 July 2019
View article titled, Abstract 925: PDX models of ER+ endocrine-resistant metastatic breast cancer identify Polo-like kinase 1 (PLK1) as a therapeutic target
Journal Articles

Abstract 2986: E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer

Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N. Pemberton, Jessica Frankum, Fei Fei Song, Rumana Rafiq, Asha Konde, Malini Menon, James Campbell, Aditi Gulati, Rahul Kumar, Stephen J. Pettitt, Mark D. Gurden, Marta Llorca Cardenosa, Irene Chong, Patrycja Gazinska, Fredrik Wallberg, Elinor J. Sawyer, Lesley-Ann Martin, Mitch Dowsett, Spiros Linardopoulos, Colm Ryan, Patrick W. Derksen, Jos Jonkers, Andrew N.J. Tutt, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2986.
https://doi.org/10.1158/1538-7445.AM2018-2986
Published: 01 July 2018
View article titled, Abstract 2986: E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
Journal Articles

Abstract 4950: MPS1 as a novel target in endocrine- and palbociclib-resistant estrogen receptor positive breast cancer

Joanna Nikitorowicz-Buniak, Sunil Pancholi, Nikiana Simigdala, Ricardo Ribas, Spiros Linardopoulos, Mitch Dowsett, Stephen Johnston, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4950.
https://doi.org/10.1158/1538-7445.AM2018-4950
Published: 01 July 2018
View article titled, Abstract 4950: MPS1 as a novel target in endocrine- and palbociclib-resistant estrogen receptor positive breast cancer
Journal Articles

Abstract 4157: Co-blockade of mTORC1, ERBB and estrogen receptor signalling pathways in endocrine resistance breast cancer: Combating tumor plasticity

Ricardo Ribas, Sunil Pancholi, Stephanie K. Guest, Aradhana Rani, Joanna Nikitorowicz-Buniak, Nikiana Simigdala, Allan Thornhill, Richard E. Cutler, Jr., Alshad S. Lalani, Francesca Avogadri-Connors, Mitch Dowsett, Stephen R. Johnston, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4157.
https://doi.org/10.1158/1538-7445.AM2017-4157
Published: 01 July 2017
View article titled, Abstract 4157: Co-blockade of mTORC1, ERBB and estrogen receptor signalling pathways in endocrine resistance breast cancer: Combating tumor plasticity
Journal Articles

Abstract 4160: Impact of oral selective estrogen receptor degrader RAD1901 in preclinical models of endocrine sensitive/resistant breast cancer

Sunil Pancholi, Joanna Nikitorowicz-Buniak, Ricardo Ribas, Nikiana Simigdala, Fiona Garner, Teeru Bihani, Stephen R. Johnston, Mitch Dowsett, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4160.
https://doi.org/10.1158/1538-7445.AM2017-4160
Published: 01 July 2017
View article titled, Abstract 4160: Impact of oral selective estrogen receptor degrader RAD1901 in preclinical models of endocrine sensitive/resistant breast cancer
Journal Articles

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

Maria Teresa Herrera-Abreu, Marta Palafox, Uzma Asghar, Martín A. Rivas, Rosalind J. Cutts, Isaac Garcia-Murillas, Alex Pearson, Marta Guzman, Olga Rodriguez, Judit Grueso, Meritxell Bellet, Javier Cortés, Richard Elliott, Sunil Pancholi, Christopher J. Lord, José Baselga, Mitch Dowsett, Lesley-Ann Martin, Nicholas C. Turner, Violeta Serra
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2301–2313.
https://doi.org/10.1158/0008-5472.CAN-15-0728
Published: 14 April 2016
View article titled, Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer
Open the PDF for Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer in another window
Includes: Supplementary data
Journal Articles

miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors

Marina Bacci, Elisa Giannoni, Antony Fearns, Ricardo Ribas, Qiong Gao, Maria Letizia Taddei, Gianfranco Pintus, Mitch Dowsett, Clare M. Isacke, Lesley-Ann Martin, Paola Chiarugi, Andrea Morandi
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1615–1626.
https://doi.org/10.1158/0008-5472.CAN-15-2038
Published: 14 March 2016
View article titled, miR-155 Drives Metabolic Reprogramming of ER<sup>+</sup> Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors
Open the PDF for miR-155 Drives Metabolic Reprogramming of ER<sup>+</sup> Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 926: ESR1 mutations evolve during the treatment of metastatic breast cancer, and detection in ctDNA predicts sensitivity to subsequent hormone therapy

Gaia Schiavon, Sarah Hrebien, Isaac Garcia-Murillas, Alex Pearson, Noelia Tarazona, Elena Lopez-Knowles, Ricardo Ribas, Ashutosh Nerurkar, Peter Osin, Lesley-Ann Martin, Mitch Dowsett, Ian E. Smith, Nicholas C. Turner
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 926.
https://doi.org/10.1158/1538-7445.AM2015-926
Published: 01 August 2015
View article titled, Abstract 926: ESR1 mutations evolve during the treatment of metastatic breast cancer, and detection in ctDNA predicts sensitivity to subsequent hormone therapy
Journal Articles

Abstract S1-04: Exome sequencing of post-menopausal ER+ breast cancer (BC) treated pre-surgically with aromatase inhibitors (AIs) in the POETIC trial (CRUK/07/015)

Pascal Gellert, Corrinne V Segal, Qiong Gao, Tiandao Li, Christopher A Miller, Elaine Mardis, Lesley-Ann Martin, Christopher Holcombe, Anthony Skene, Judith Bliss, John Robertson, Ian Smith, Mitch Dowsett, POETIC Trial Management Group and Trialists
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): S1-04.
https://doi.org/10.1158/1538-7445.SABCS14-S1-04
Published: 01 May 2015
View article titled, Abstract S1-04: Exome sequencing of post-menopausal ER+ breast cancer (BC) treated pre-surgically with aromatase inhibitors (AIs) in the POETIC trial (CRUK/07/015)
Journal Articles

Abstract P3-05-04: AKT antagonist AZD5363 targets estrogen receptor (ER) function in endocrine resistant breast cancer (BC) and synergises with fulvestrant in vivo

Lesley-Ann Martin, Stephanie K Guest, Sunil Pancholi, Ricardo Ribas, Qiong Gao, Nikiana Simigdala, Aradhana Rani, Barry Davies, Stephen Johnston, Mitch Dowsett
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P3-05-04.
https://doi.org/10.1158/1538-7445.SABCS14-P3-05-04
Published: 01 May 2015
View article titled, Abstract P3-05-04: AKT antagonist AZD5363 targets estrogen receptor (ER) function in endocrine resistant breast cancer (BC) and synergises with fulvestrant in vivo
Journal Articles

GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors

Andrea Morandi, Lesley-Ann Martin, Qiong Gao, Sunil Pancholi, Alan Mackay, David Robertson, Marketa Zvelebil, Mitch Dowsett, Ivan Plaza-Menacho, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3783–3795.
https://doi.org/10.1158/0008-5472.CAN-12-4265
Published: 13 June 2013
View article titled, GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Open the PDF for GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 4761: Glial cell derived neurotrophic factor (GDNF)-RET signaling as a target in aromatase inhibitor resistant ER-positive breast cancers.

Andrea Morandi, Lesley-Ann Martin, Qiong Gao, Alan Mackay, David Robertson, Marketa Zvelebil, Mitch Dowsett, Ivan Plaza-Menacho, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4761.
https://doi.org/10.1158/1538-7445.AM2013-4761
Published: 15 April 2013
View article titled, Abstract 4761: Glial cell derived neurotrophic factor (GDNF)-RET signaling as a target in aromatase inhibitor resistant ER-positive breast cancers.
Journal Articles

Abstract 4598: Temporal changes of gene expression in breast cancer cells during adaptation to estrogen deprivation highlight the clinical potential for targeting kinase pathways

Zara Ghazoui, Marion T. Weigel, Helen Anderson, Anita Dunbier, Mitch Dowsett, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4598.
https://doi.org/10.1158/1538-7445.AM10-4598
Published: 15 April 2010
View article titled, Abstract 4598: Temporal changes of gene expression in breast cancer cells during adaptation to estrogen deprivation highlight the clinical potential for targeting kinase pathways
Journal Articles

Abstract 2920: Experimental and clinical studies reveal the PDGF/Abl pathway as a novel therapeutic target in endocrine-resistant breast cancer

Marion T. Weigel, Zara Ghazoui, Anne E. Lykkesfeldt, Helen Anderson, Anita Dunbier, Christoph Mundhenke, Mitch Dowsett, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2920.
https://doi.org/10.1158/1538-7445.AM10-2920
Published: 15 April 2010
View article titled, Abstract 2920: Experimental and clinical studies reveal the PDGF/Abl pathway as a novel therapeutic target in endocrine-resistant breast cancer
Journal Articles

Abstract 2916: Novel genes closely adjacent to and coexpressed with ESR1 affect proliferation in ER+ve breast tumors

Anita Dunbier, Helen Anderson, Zara Ghazoui, Sunil Pancholi, Kally Sidhu, Alexandra Leary, Lesley-Ann Martin, Mitch Dowsett
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2916.
https://doi.org/10.1158/1538-7445.AM10-2916
Published: 15 April 2010
View article titled, Abstract 2916: Novel genes closely adjacent to and coexpressed with ESR1 affect proliferation in ER+ve breast tumors
Journal Articles

The Vascular Endothelial Growth Factor Receptor Inhibitor PTK787/ZK222584 Inhibits Aromatase

Susana Banerjee, Marketa Zvelebil, Pascal Furet, Ursula Mueller-Vieira, Dean B. Evans, Mitch Dowsett, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4716–4723.
https://doi.org/10.1158/0008-5472.CAN-08-4711
Published: 01 June 2009
View article titled, The Vascular Endothelial Growth Factor Receptor Inhibitor PTK787/ZK222584 Inhibits Aromatase
Open the PDF for The Vascular Endothelial Growth Factor Receptor Inhibitor PTK787/ZK222584 Inhibits Aromatase in another window
Includes: Supplementary data