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Leroy F. Liu
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Journal Articles

Abstract 3438: Oncogenes-induced interferon-beta: modulation of tranformation phenotypes through interferon-ISG15 autocrine signaling

Free
Yu-Chen Tsai, Sidney Pestka, Lu-Hai Wang, Loren W. Runnels, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3438.
https://doi.org/10.1158/1538-7445.AM2011-3438
Published: 15 April 2011
View articletitled, Abstract 3438: Oncogenes-induced interferon-beta: modulation of tranformation phenotypes through interferon-ISG15 autocrine signaling
Journal Articles

Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane

Free
Yi Lisa Lyu, John E. Kerrigan, Chao-Po Lin, Anna M. Azarova, Yuan-Chin Tsai, Yi Ban, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2007) 67 (18): 8839–8846.
https://doi.org/10.1158/0008-5472.CAN-07-1649
Published: 17 September 2007
View articletitled, Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
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Journal Articles

A novel role of topoisomerase III in cell cycle checkpoint and tumorigenesis

Free
Jia-Rong Fan, Mei-Yi Hsieh, Han-Wen Chang, Hsiang-Chin Chen, Tang-Long Shen, Shu-Chun Teng, Leroy F. Liu, Tsai-Kun Li
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-68.
Published: 01 May 2007
View articletitled, A novel role of topoisomerase III in cell cycle checkpoint and tumorigenesis
Journal Articles

G-Quadruplexes Induce Apoptosis in Tumor Cells

Free
Haiyan Qi, Chao-Po Lin, Xuan Fu, Laurence M. Wood, Angela A. Liu, Yuan-Chin Tsai, Yongjie Chen, Christopher M. Barbieri, Daniel S. Pilch, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2006) 66 (24): 11808–11816.
https://doi.org/10.1158/0008-5472.CAN-06-1225
Published: 18 December 2006
View articletitled, G-Quadruplexes Induce Apoptosis in Tumor Cells
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Includes: Supplementary data
Journal Articles

Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia

Free
Eszter S. Hars, Yi Lisa Lyu, Chao-Po Lin, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2006) 66 (18): 8975–8979.
https://doi.org/10.1158/0008-5472.CAN-06-1724
Published: 18 September 2006
View articletitled, Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia
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Journal Articles

Antitumor therapeutic effects of new gene-targeted alkylating agents, 9-anilinoacridines bearing an alkylating N-mustard residue on the acridine chromophore

Free
Tsann-Long Su, Ting-Chao Chou, Yi-Wen Lin, Xiuguo Zhang, Leroy F. Liu, Ching-Huang Chen, Valeriy A. Bacherikov, Tsong-Jen Tsai
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 129.
Published: 15 April 2006
View articletitled, Antitumor therapeutic effects of new gene-targeted alkylating agents, 9-anilinoacridines bearing an alkylating N-mustard residue on the acridine chromophore
Journal Articles

Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway

Free
Shyamal D. Desai, Arthur L. Haas, Laurence M. Wood, Yu-Chen Tsai, Sidney Pestka, Eric H. Rubin, Ahamed Saleem, Alam Nur-E-Kamal, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2006) 66 (2): 921–928.
https://doi.org/10.1158/0008-5472.CAN-05-1123
Published: 19 January 2006
View articletitled, Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway
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Journal Articles

Autophagy is required for normal mitochondrial turnover and functions

Free
Yong Zhang, Xuan Fu, Weihong Xu, Leroy F. Liu, Shengkan Jin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 635.
Published: 01 May 2005
View articletitled, Autophagy is required for normal mitochondrial turnover and functions
Journal Articles

Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug

Free
Tsai-Kun Li, Peter J. Houghton, Shyamal D. Desai, Parima Daroui, Angela A. Liu, Eszter S. Hars, Alexander L. Ruchelman, Edmond J. LaVoie, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8400–8407.
Published: 16 December 2003
View articletitled, Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug
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Journal Articles

Ubiquitin/26S Proteasome-mediated Degradation of Topoisomerase I As a Resistance Mechanism to Camptothecin in Tumor Cells

Free
Shyamal D. Desai, Tsai-Kun Li, Alexandra Rodriguez-Bauman, Eric H. Rubin, Leroy F. Liu
Journal: Cancer Research
Cancer Res (2001) 61 (15): 5926–5932.
Published: 01 August 2001
View articletitled, Ubiquitin/26S Proteasome-mediated Degradation of Topoisomerase I As a Resistance Mechanism to Camptothecin in Tumor Cells
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Journal Articles

Induction of DNA Topoisomerase II-mediated DNA Cleavage by β-Lapachone and Related Naphthoquinones

Free
Benjamin Frydman, Laurence J. Marton, Jerry S. Sun, Karen Neder, Donald T. Witiak, Angela A. Liu, Hui-Min Wang, Yong Mao, Hong-Yan Wu, Marilyn M. Sanders, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1997) 57 (4): 620–627.
Published: 01 February 1997
View articletitled, Induction of DNA Topoisomerase II-mediated DNA Cleavage by β-Lapachone and Related Naphthoquinones
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Journal Articles

Identification of Topoisomerase I as the Cytotoxic Target of the Protoberberine Alkaloid Coralyne

Free
Barbara Gatto, Marilyn M. Sanders, Chiang Yu, Hong-Yan Wu, Darshan Makhey, Edmond J. LaVoie, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1996) 56 (12): 2795–2800.
Published: 01 June 1996
View articletitled, Identification of Topoisomerase I as the Cytotoxic Target of the Protoberberine Alkaloid Coralyne
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Journal Articles

Interaction between Replication Forks and Topoisomerase I-DNA Cleavable Complexes: Studies in a Cell-free SV40 DNA Replication System

Free
Yeou-Ping Tsao, Alicia Russo, Gill Nyamuswa, Robert Silber, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1993) 53 (24): 5908–5914.
Published: 01 December 1993
View articletitled, Interaction between Replication Forks and Topoisomerase I-DNA Cleavable Complexes: Studies in a Cell-free SV40 DNA Replication System
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Journal Articles

A New Mammalian DNA Topoisomerase I Poison Hoechst 33342: Cytotoxicity and Drug Resistance in Human Cell Cultures

Free
Allan Y. Chen, Chiang Yu, Annette Bodley, Lynn F. Peng, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1993) 53 (6): 1332–1337.
Published: 01 March 1993
View articletitled, A New Mammalian DNA Topoisomerase I Poison Hoechst 33342: Cytotoxicity and Drug Resistance in Human Cell Cultures
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Journal Articles

The Involvement of Active DNA Synthesis in Camptothecin-induced G2 Arrest: Altered Regulation of p34cdc2/Cyclin B

Free
Yeou-Ping Tsao, Peter D'Arpa, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1992) 52 (7): 1823–1829.
Published: 01 April 1992
View articletitled, The Involvement of Active DNA Synthesis in Camptothecin-induced G2 Arrest: Altered Regulation of p34cdc2/Cyclin B
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Journal Articles

Camptothecin Overcomes MDR1-mediated Resistance in Human KB Carcinoma Cells

Free
Allan Y. Chen, Chiang Yu, Milan Potmesil, Monroe E. Wall, Mansukh C. Wani, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1991) 51 (22): 6039–6044.
Published: 01 November 1991
View articletitled, Camptothecin Overcomes MDR1-mediated Resistance in Human KB Carcinoma Cells
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Journal Articles

Topoisomerase II Levels during Granulocytic Maturation in Vitro and in Vivo

Free
Scott H. Kaufmann, Sharon J. McLaughlin, Michael B. Kastan, Leroy F. Liu, Judith E. Karp, Philip J. Burke
Journal: Cancer Research
Cancer Res (1991) 51 (13): 3534–3543.
Published: 01 July 1991
View articletitled, Topoisomerase II Levels during Granulocytic Maturation in Vitro and in Vivo
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Journal Articles

Elevated Expression of DNA Topoisomerase II in Camptothecin-resistant Human Tumor Cell Lines

Free
Yoshikazu Sugimoto, Satomi Tsukahara, Tomoko Oh-hara, Leroy F. Liu, Takashi Tsuruo
Journal: Cancer Research
Cancer Res (1990) 50 (24): 7962–7965.
Published: 01 December 1990
View articletitled, Elevated Expression of DNA Topoisomerase II in Camptothecin-resistant Human Tumor Cell Lines
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Journal Articles

Involvement of Nucleic Acid Synthesis in Cell Killing Mechanisms of Topoisomerase Poisons

Free
Peter D'Arpa, Christopher Beardmore, Leroy F. Liu
Journal: Cancer Research
Cancer Res (1990) 50 (21): 6919–6924.
Published: 01 November 1990
View articletitled, Involvement of Nucleic Acid Synthesis in Cell Killing Mechanisms of Topoisomerase Poisons
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Journal Articles

Establishment of a Camptothecin Analogue (CPT-11)-resistant Cell Line of Human Non-Small Cell Lung Cancer: Characterization and Mechanism of Resistance

Free
Fumihiko Kanzawa, Yoshikazu Sugimoto, Koichi Minato, Kazuo Kasahara, Masami Bungo, Kazuhiko Nakagawa, Yasuhiro Fujiwara, Leroy F. Liu, Nagahiro Saijo
Journal: Cancer Research
Cancer Res (1990) 50 (18): 5919–5924.
Published: 01 September 1990
View articletitled, Establishment of a Camptothecin Analogue (CPT-11)-resistant Cell Line of Human Non-Small Cell Lung Cancer: Characterization and Mechanism of Resistance
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