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Leora Witkowski
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Journal Articles

SMARCA4 loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer

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Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St-Germain, Kexin Liu, Azadeh Arabzadeh, Yuxuan Qi, Yibo Xue, Leora Witkowski, Elise Graulich, Jutta Steinberger, Selim Misirlioglu, Nicklas Bassani, Racim Sansal, Amber Yasmeen, Geneviève Morin, Jingjie Guo, Anie Monast, Virginie Pilon, Alica Valachová, Kitty Pavlakis, Lili Fu, Walter H. Gotlieb, W. Glenn McCluggage, David Huntsman, Alexander J. R. Bishop, Douglas A. Levine, Morag Park, Yemin Wang, Brian Raught, William D. Foulkes, Sidong Huang
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3990
Published: 14 May 2025
View articletitled, SMARCA4 loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer
Open the PDF for SMARCA4 loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer in another window
Includes: Supplementary data
Journal Articles

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer

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Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schönberger, Dominik Schneider, Morten Hillmer, Susanne Bens, Reiner Siebert, Colin J.R. Stewart, Ziguo Zhang, William C.H. Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3499–3515.
https://doi.org/10.1158/0008-5472.CAN-21-3956
Published: 04 October 2022
View articletitled, Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
Open the PDF for Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3422: The influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary, hypercalcemic type

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Leora Witkowski, Catherine Goudie, Pilar Ramos, Anthony N. Karnezis, Talia Boshari, Patricia Pautier, Michel Longy, James A. Knost, Emmanouil Saloustros, W Glenn McCluggage, Martin Hasselblatt, William P. Hendricks, David Huntsman, Douglas A. Levine, Jeffrey Trent, William D. Foulkes
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3422.
https://doi.org/10.1158/1538-7445.AM2016-3422
Published: 15 July 2016
View articletitled, Abstract 3422: The influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary, hypercalcemic type
Journal Articles

Abstract IA03: DICER1: From ontogenesis to oncogenesis

Free
William D. Foulkes, Mona Wu, Leanne De Kock, Leora Witkowski, Nelly Sabbaghian, Evan Weber, Nancy Hamel, John R. Priest
Journal: Cancer Research
Cancer Res (2014) 74 (23_Supplement): IA03.
https://doi.org/10.1158/1538-7445.CANSUSC14-IA03
Published: 12 December 2014
View articletitled, Abstract IA03: DICER1: From ontogenesis to oncogenesis
Journal Articles

Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

Free
Leora Witkowski, Jian Carrot-Zhang, Steffen Albrecht, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Catherine Gilpin, Rachel Silva-Smith, François Plourde, Barbara Rivera, Ester Castellsagué, Mona Wu, Somayyeh Fahiminiya, Javad Nadaf, Avi Saskin, Madeleine Arseneault, Rouzan G. Karabakhtsian, Elizabeth A. Reilly, Frederick R. Ueland, Anna Margiolaki, Kitty Pavlakis, Sharon M. Castellino, Janez Lamovec, Lawrence M. Roth, Thomas M. Ulbright, Tracey Bender, Michel Longy, Andrew Berchuck, Marc Tischkowitz, Reiner Siebert, Inga Nagel, Vassilis Georgoulias, Colin J.r. Stewart, Glenn McCluggage, Jocelyne Arseneau, Blaise A. Clarke, Yasser Riazalhosseini, Martin Hasselblatt, Jacek Majewski, William D. Foulkes
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-89.
https://doi.org/10.1158/1538-7445.AM2014-LB-89
Published: 01 October 2014
View articletitled, Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type