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Journal Articles

Abstract 7544: Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo

Haitao Wang, Ruihong Wang, Frank Villa-Hernandez, Vivek Shukla, Lyuba Varticovski, Songjoon Baek, Frank Echtenkamp, Sudheer Kumar Gara, Mary R. Zhang, Stephanie Shiffka, Razi Raziuddin, Leonard M. Neckers, W. Marston Linehan, Gordon L. Hager, Shamus R. Carr, Chuong D. Hoang, Haobin Chen, David S. Schrump

Cancer Res (2024) 84 (6_Supplement): 7544.

https://doi.org/10.1158/1538-7445.AM2024-7544

Published: 22 March 2024

View article titled, Abstract 7544: Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo

Journal Articles

Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized¹³C MRI

Nobu Oshima, Ryo Ishida, Shun Kishimoto, Jeffrey R. Brender, Tomoaki Okada, Kazuataka Obama, Yoshiharu Sakai, Murali C. Krishna, Leonard M. Neckers

Cancer Res (2020) 80 (16_Supplement): 2783.

https://doi.org/10.1158/1538-7445.AM2020-2783

Published: 15 August 2020

View article titled, Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized13C MRI

Journal Articles

Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Cancer Res (2020) 80 (14_Supplement): PR08.

https://doi.org/10.1158/1538-7445.PEDCA19-PR08

Published: 15 July 2020

View article titled, Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Journal Articles

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Cancer Res (2019) 79 (19): 5060–5073.

https://doi.org/10.1158/0008-5472.CAN-19-0217

Published: 01 October 2019

View article titled, Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Includes: Supplementary data

Journal Articles

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Michael A. Moses, Yeong Sang Kim, Genesis M. Rivera-Marquez, Nobu Oshima, Matthew J. Watson, Kristin E. Beebe, Catherine Wells, Sunmin Lee, Abbey D. Zuehlke, Hao Shao, William E. Bingman, III, Vineet Kumar, Sanjay V. Malhotra, Nancy L. Weigel, Jason E. Gestwicki, Jane B. Trepel, Leonard M. Neckers

Cancer Res (2018) 78 (14): 4022–4035.

https://doi.org/10.1158/0008-5472.CAN-17-3728

Published: 15 July 2018

View article titled, Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Includes: Supplementary data

Journal Articles

Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized ¹³C magnetic resonance imaging

Nobu Oshima, Shun Kishimoto, Kristin Beebe, Dan Crooks, Michael Moses, Kazutoshi Yamamoto, Jeffry R. Brender, Anastasia Sowers, Ganesha Rai, Daniel Urban, Goria Benavides, Giuseppe Squadrito, Victor Darley-Usmar, Matthew Hall, James B. Mitchell, Murali C. Krishna, Leonard M. Neckers

Cancer Res (2018) 78 (13_Supplement): 4104.

https://doi.org/10.1158/1538-7445.AM2018-4104

Published: 01 July 2018

View article titled, Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized 13C magnetic resonance imaging

Journal Articles

Abstract 2852: Monitoring the impact on metabolic flux in vivo of a newly developed LDH inhibitor using hyperpolarized 13C magnetic resonance spectroscopic imaging

Nobu Oshima, Shun Kishimoto, Kristin Beebe, Keita Saito, Kazutoshi Yamamoto, Jeffery Brender, Anastasia Sowers, Ganesha Rai, Bryan T. Mott, David J. Maloney, James B. Mitchell, Murali K. Cherukuri, Leonard M. Neckers

Cancer Res (2017) 77 (13_Supplement): 2852.

https://doi.org/10.1158/1538-7445.AM2017-2852

Published: 01 July 2017

View article titled, Abstract 2852: Monitoring the impact on metabolic flux in vivo of a newly developed LDH inhibitor using hyperpolarized 13C magnetic resonance spectroscopic imaging

Journal Articles

Abstract 1005: Mitochondrial inhibition decreases the malignant phenotype of esophageal adenocarcinoma cells through the induction of autophagy

Deborah R. Depew, Paul L. Feingold, Kate Brown, Yuan Xu, Mahadev Rao, Michael Moses, Leonard M. Neckers, David S. Schrump, R Taylor Ripley.

Cancer Res (2016) 76 (14_Supplement): 1005.

https://doi.org/10.1158/1538-7445.AM2016-1005

Published: 15 July 2016

View article titled, Abstract 1005: Mitochondrial inhibition decreases the malignant phenotype of esophageal adenocarcinoma cells through the induction of autophagy

Journal Articles

Abstract 3796: Synergistic effect of targeted combination therapy in bladder cancer model using HSP90 inhibitors

Raju Chelluri, Piyush K. Agarwal, Leonard M. Neckers, Armine K. Smith

Cancer Res (2015) 75 (15_Supplement): 3796.

https://doi.org/10.1158/1538-7445.AM2015-3796

Published: 01 August 2015

View article titled, Abstract 3796: Synergistic effect of targeted combination therapy in bladder cancer model using HSP90 inhibitors

Journal Articles

Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2⁺ Tumor Cell Recognition by Specific CD8⁺ T Cells

Mayumi Kawabe, Maja Mandic, Jennifer L. Taylor, Cecilia A. Vasquez, Amy K. Wesa, Leonard M. Neckers, Walter J. Storkus

Cancer Res (2009) 69 (17): 6995–7003.

https://doi.org/10.1158/0008-5472.CAN-08-4511

Published: 31 August 2009

View article titled, Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells

Includes: Supplementary data

Journal Articles

Expression of the Insulin-Like Growth Factor I Receptor and Urokinase Plasminogen Activator in Breast Cancer Is Associated with Poor Survival: Potential for Intervention with 17-Allylamino Geldanamycin

Torsten O. Nielsen, Heather N. Andrews, Maggie Cheang, Jill E. Kucab, Forrest D. Hsu, Joseph Ragaz, C. Blake Gilks, Nikita Makretsov, Chris D. Bajdik, Christy Brookes, Leonard M. Neckers, Valentina Evdokimova, David G. Huntsman, Sandra E. Dunn

Cancer Res (2004) 64 (1): 286–291.

https://doi.org/10.1158/0008-5472.CAN-03-1242

Published: 16 January 2004

View article titled, Expression of the Insulin-Like Growth Factor I Receptor and Urokinase Plasminogen Activator in Breast Cancer Is Associated with Poor Survival: <subtitle>Potential for Intervention with 17-Allylamino Geldanamycin</subtitle>

Journal Articles

Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

Kheem S. Bisht, C. Matthew Bradbury, David Mattson, Aradhana Kaushal, Anastasia Sowers, Stephanie Markovina, Karen L. Ortiz, Leah K. Sieck, Jennifer S. Isaacs, Martin W. Brechbiel, James B. Mitchell, Leonard M. Neckers, David Gius

Cancer Res (2003) 63 (24): 8984–8995.

Published: 24 December 2003

View article titled, Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

Includes: Supplementary data

Journal Articles

Geldanamycin Abrogates ErbB2 Association with Proteasome-resistant β-Catenin in Melanoma Cells, Increases β-Catenin-E-Cadherin Association, and Decreases β-Catenin-sensitive Transcription

Paolo Bonvini, Won G. An, Angelo Rosolen, Phongmai Nguyen, Jane Trepel, Antonio Garcia de Herreros, Mireia Dunach, Leonard M. Neckers

Cancer Res (2001) 61 (4): 1671–1677.

Published: 02 February 2001

View article titled, Geldanamycin Abrogates ErbB2 Association with Proteasome-resistant β-Catenin in Melanoma Cells, Increases β-Catenin-E-Cadherin Association, and Decreases β-Catenin-sensitive Transcription

Journal Articles

KF25706, a Novel Oxime Derivative of Radicicol, Exhibits in Vivo Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules

Shiro Soga, Leonard M. Neckers, Theodor W. Schulte, Yukimasa Shiotsu, Kazuhito Akasaka, Hiroaki Narumi, Tsutomu Agatsuma, Yoji Ikuina, Chikara Murakata, Tatsuya Tamaoki, Shiro Akinaga

Cancer Res (1999) 59 (12): 2931–2938.

Published: 15 June 1999

View article titled, KF25706, a Novel Oxime Derivative of Radicicol, Exhibits in Vivo Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules

Journal Articles

Taxol-induced Apoptosis and Phosphorylation of Bcl-2 Protein Involves c-Raf-1 and Represents a Novel c-Raf-1 Signal Transduction Pathway

Mikhail V. Blagosklonny, Theodor Schulte, Phuongmai Nguyen, Jane Trepel, Leonard M. Neckers

Cancer Res (1996) 56 (8): 1851–1854.

Published: 01 April 1996

View article titled, Taxol-induced Apoptosis and Phosphorylation of Bcl-2 Protein Involves c-Raf-1 and Represents a Novel c-Raf-1 Signal Transduction Pathway

Journal Articles

Antisense Inhibition of Single Copy N-myc Expression Results in Decreased Cell Growth without Reduction of c-myc Protein in a Neuroepithelioma Cell Line

Angelo Rosolen, Luke Whitesell, Naohiko Ikegaki, Roger H. Kennett, Leonard M. Neckers

Cancer Res (1990) 50 (19): 6316–6322.

Published: 01 October 1990

View article titled, Antisense Inhibition of Single Copy N-myc Expression Results in Decreased Cell Growth without Reduction of c-myc Protein in a Neuroepithelioma Cell Line

NARROW

Abstract 7544: Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo

Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized¹³C MRI

Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized ¹³C magnetic resonance imaging

Abstract 2852: Monitoring the impact on metabolic flux in vivo of a newly developed LDH inhibitor using hyperpolarized 13C magnetic resonance spectroscopic imaging

Abstract 1005: Mitochondrial inhibition decreases the malignant phenotype of esophageal adenocarcinoma cells through the induction of autophagy

Abstract 3796: Synergistic effect of targeted combination therapy in bladder cancer model using HSP90 inhibitors

Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2⁺ Tumor Cell Recognition by Specific CD8⁺ T Cells

Expression of the Insulin-Like Growth Factor I Receptor and Urokinase Plasminogen Activator in Breast Cancer Is Associated with Poor Survival: Potential for Intervention with 17-Allylamino Geldanamycin

Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

Geldanamycin Abrogates ErbB2 Association with Proteasome-resistant β-Catenin in Melanoma Cells, Increases β-Catenin-E-Cadherin Association, and Decreases β-Catenin-sensitive Transcription

KF25706, a Novel Oxime Derivative of Radicicol, Exhibits in Vivo Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules

Taxol-induced Apoptosis and Phosphorylation of Bcl-2 Protein Involves c-Raf-1 and Represents a Novel c-Raf-1 Signal Transduction Pathway

Antisense Inhibition of Single Copy N-myc Expression Results in Decreased Cell Growth without Reduction of c-myc Protein in a Neuroepithelioma Cell Line

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