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Leonard D. Shultz
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Journal Articles

Abstract 6354: A new tumor-bearing humanized mouse model to evaluate the efficacy of bispecific T cell engager and monoclonal checkpoint antibodies

Li-Chin Yao, Danying Cai, Destanie Rose, Guoxiang Yang, Mingshan Cheng, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, James G. Keck
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6354.
https://doi.org/10.1158/1538-7445.AM2023-6354
Published: 04 April 2023
View articletitled, Abstract 6354: A new tumor-bearing humanized mouse model to evaluate the efficacy of bispecific T cell engager and monoclonal checkpoint antibodies
Journal Articles

Abstract 2875: Development of a new tumor-bearing humanized mouse model to evaluate the efficacy and toxicity of bispecific T cell engagers

Guoxiang Yang, Li-Chin Yao, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Danying Cai, MIngshan Cheng, James G. Keck
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2875.
https://doi.org/10.1158/1538-7445.AM2022-2875
Published: 15 June 2022
View articletitled, Abstract 2875: Development of a new tumor-bearing humanized mouse model to evaluate the efficacy and toxicity of bispecific T cell engagers
Journal Articles

Abstract 1640: Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L

Li-Chin Yao, Shantashri Vaidya, Pali Kaur, James G. Keck, Leonard D. Shultz, Dale L. Greiner, MIchael A. Brehm
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1640.
https://doi.org/10.1158/1538-7445.AM2022-1640
Published: 15 June 2022
View articletitled, Abstract 1640: Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L
Journal Articles

Abstract 2049: A novel, rapid, sensitive, and reproducible in vivo platform to assess efficacy and toxicity of bispecific antibodies

Jiwon Yang, Jing Jiao, Kyle Draheim, Danying Cai, Michael A. Brehm, Leonard D. Shultz, Dale L. Greiner, Mingshan Cheng, James G. Keck
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2049.
https://doi.org/10.1158/1538-7445.AM2022-2049
Published: 15 June 2022
View articletitled, Abstract 2049: A novel, rapid, sensitive, and reproducible in vivo platform to assess efficacy and toxicity of bispecific antibodies
Journal Articles

Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology

Li-Chin Yao, Mingshan Cheng, Danying Cai, Leonard D. Shultz, James G. Keck
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3320.
https://doi.org/10.1158/1538-7445.AM2020-3320
Published: 15 August 2020
View articletitled, Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology
Journal Articles

Abstract 5619: PBMC humanized NSG-(KbDb)null (IA)null mouse model to evaluate immune-oncology drug efficacy

Li-Chin Yao, Mingshan Cheng, Leonard D. Shultz, James G. Keck
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5619.
https://doi.org/10.1158/1538-7445.AM2020-5619
Published: 15 August 2020
View articletitled, Abstract 5619: PBMC humanized NSG-(KbDb)null (IA)null mouse model to evaluate immune-oncology drug efficacy
Journal Articles

Abstract 5632: PBMC-humanized mouse model for the assessment of cytokine release syndrome caused by checkpoint and bispecific immunotherapy

Danying Cai, Jing Jiao, Chunting Ye, Hongyuan Yang, Mingshan Cheng, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, James G. Keck
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5632.
https://doi.org/10.1158/1538-7445.AM2020-5632
Published: 15 August 2020
View articletitled, Abstract 5632: PBMC-humanized mouse model for the assessment of cytokine release syndrome caused by checkpoint and bispecific immunotherapy
Journal Articles

Abstract 1070: Evaluation of human NK cell responses to PDX tumors in humanized NOD-scid IL2rgnull (NSG) mice expressing human IL15

Ken-Edwin Aryee, Lisa Burzenski, Dale L. Greiner, Giles F. Whalen, Li-Chin Yao, Leonard D. Shultz, James G. Keck, Michael A. Brehm
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1070.
https://doi.org/10.1158/1538-7445.AM2019-1070
Published: 01 July 2019
View articletitled, Abstract 1070: Evaluation of human NK cell responses to PDX tumors in humanized NOD-scid IL2rgnull (NSG) mice expressing human IL15
Journal Articles

Abstract 5674: Transgenic expression of human IL15 in NOD-scid IL2rgnull (NSG) mice enhances the development and survival of functional human NK cells

Ken-Edwin Aryee, Lisa Burzenski, Dale L. Greiner, Raymond M. Welsh, Leonard D. Shultz, James G. Keck, Michael A. Brehm
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5674.
https://doi.org/10.1158/1538-7445.AM2018-5674
Published: 01 July 2018
View articletitled, Abstract 5674: Transgenic expression of human IL15 in NOD-scid IL2rgnull (NSG) mice enhances the development and survival of functional human NK cells
Journal Articles

Abstract 5665: NOD-scid IL2rgnull (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC

Michael A. Brehm, Michael Wiles, Laurie Kenney, Ben Low, Roland M. Tisch, Lisa Burzenski, James G. Keck, Dale L. Greiner, Leonard D. Shultz
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5665.
https://doi.org/10.1158/1538-7445.AM2018-5665
Published: 01 July 2018
View articletitled, Abstract 5665: NOD-scid IL2rgnull (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMC
Journal Articles

Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process

Gatien Moriceau, Benjamin Ory, Laura Mitrofan, Chiara Riganti, Frédéric Blanchard, Régis Brion, Céline Charrier, Séverine Battaglia, Paul Pilet, Marc G. Denis, Leonard D. Shultz, Jukka Mönkkönen, Françoise Rédini, Dominique Heymann
Journal: Cancer Research
Cancer Res (2010) 70 (24): 10329–10339.
https://doi.org/10.1158/0008-5472.CAN-10-0578
Published: 14 December 2010
View articletitled, Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process
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Includes: Supplementary data
Journal Articles

Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

Molly A. Harris, Hyuna Yang, Benjamin E. Low, Joydeep Mukherje, Abhijit Guha, Roderick T. Bronson, Leonard D. Shultz, Mark A. Israel, Kyuson Yun
Journal: Cancer Research
Cancer Res (2008) 68 (24): 10051–10059.
https://doi.org/10.1158/0008-5472.CAN-08-0786
Published: 15 December 2008
View articletitled, Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
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Includes: Supplementary data
Journal Articles

Granulosa Cell Tumorigenesis in Genetically Hypogonadal-immunodeficient Mice Grafted with Ovaries from Tumor-susceptible Donors

Wesley G. Beamer, Kathryn L. Shultz, Barbara J. Tennent, Leonard D. Shultz
Journal: Cancer Research
Cancer Res (1993) 53 (16): 3741–3746.
Published: 01 August 1993
View articletitled, Granulosa Cell Tumorigenesis in Genetically Hypogonadal-immunodeficient Mice Grafted with Ovaries from Tumor-susceptible Donors
Open the PDF for Granulosa Cell Tumorigenesis in Genetically Hypogonadal-immunodeficient Mice Grafted with Ovaries from Tumor-susceptible Donors in another window
Journal Articles

Gene for Ovarian Granulosa Cell Tumor Susceptibility, Gct, in SWXJ Recombinant Inbred Strains of Mice Revealed by Dehydroepiandrosterone

Wesley G. Beamer, Barbara J. Tennent, Kathryn L. Shultz, Joseph H. Nadeau, Leonard D. Shultz, Loren C. Skow
Journal: Cancer Research
Cancer Res (1988) 48 (18): 5092–5095.
Published: 01 September 1988
View articletitled, Gene for Ovarian Granulosa Cell Tumor Susceptibility, Gct, in SWXJ Recombinant Inbred Strains of Mice Revealed by Dehydroepiandrosterone
Open the PDF for Gene for Ovarian Granulosa Cell Tumor Susceptibility, Gct, in SWXJ Recombinant Inbred Strains of Mice Revealed by Dehydroepiandrosterone in another window
Journal Articles

Effect of DNA-damaging Agents on Isolated Spleen Cells and Lung Fibroblasts from the Mouse Mutant “Wasted,” a Putative Animal Model for Ataxia-Telangiectasia

Tadashi Inoue, Katsuhiro Aikawa, Hideo Tezuka, Tsuneo Kada, Leonard D. Shultz
Journal: Cancer Research
Cancer Res (1986) 46 (8): 3979–3982.
Published: 01 August 1986
View articletitled, Effect of DNA-damaging Agents on Isolated Spleen Cells and Lung Fibroblasts from the Mouse Mutant “Wasted,” a Putative Animal Model for Ataxia-Telangiectasia
Open the PDF for Effect of DNA-damaging Agents on Isolated Spleen Cells and Lung Fibroblasts from the Mouse Mutant “Wasted,” a Putative Animal Model for Ataxia-Telangiectasia in another window