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Leonard A. Zwelling
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Journal Articles

Adenovirus-mediated Human Topoisomerase IIα Gene Transfer Increases the Sensitivity of Etoposide-resistant Human Breast Cancer Cells

Zhichao Zhou, Leonard A. Zwelling, Yasuhiko Kawakami, Taeha An, Kunihisa Kobayashi, Cynthia Herzog, Eugenie S. Kleinerman
Journal: Cancer Research
Cancer Res (1999) 59 (18): 4618–4624.
Published: 15 September 1999
View article titled, Adenovirus-mediated Human <em>Topoisomerase IIα</em> Gene Transfer Increases the Sensitivity of Etoposide-resistant Human Breast Cancer Cells
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Journal Articles

Absence of Topoisomerase IIβ in an Amsacrine-resistant Human Leukemia Cell Line with Mutant Topoisomerase IIα

Cynthia E. Herzog, Katherine A. Holmes, Laura M. Tuschong, Ram Ganapathi, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1998) 58 (23): 5298–5300.
Published: 01 December 1998
View article titled, Absence of Topoisomerase IIβ in an Amsacrine-resistant Human Leukemia Cell Line with Mutant Topoisomerase IIα
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Journal Articles

Single-Strand Conformational Polymorphism Analysis of the Mr 170,000 Isozyme of DNA Topoisomerase II in Human Tumor Cells

Mary K. Danks, Michael R. Warmoth, Ellen Friche, Bernd Granzen, Barbara Y. Bugg, W. Graydon Harker, Leonard A. Zwelling, Bernard W. Futscher, D. Parker Suttle, William T. Beck
Journal: Cancer Research
Cancer Res (1993) 53 (6): 1373–1379.
Published: 01 March 1993
View article titled, Single-Strand Conformational Polymorphism Analysis of the <em>M</em><sub>r</sub> 170,000 Isozyme of DNA Topoisomerase II in Human Tumor Cells
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Journal Articles

Relative Activity of Structural Analogues of Amsacrine against Human Leukemia Cell Lines Containing Amsacrine-sensitive or -resistant Forms of Topoisomerase II: Use of Computer Simulations in New Drug Development

Leonard A. Zwelling, Michael J. Mitchell, Patricia Satitpunwaycha, Janice Mayes, Elizabeth Altschuler, Michael Hinds, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1992) 52 (1): 209–217.
Published: 01 January 1992
View article titled, Relative Activity of Structural Analogues of Amsacrine against Human Leukemia Cell Lines Containing Amsacrine-sensitive or -resistant Forms of Topoisomerase II: Use of Computer Simulations in New Drug Development
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Journal Articles

N-(5,5-Diacetoxypentyl)doxorubicin: A Novel Anthracycline Producing DNA Interstrand Cross-Linking and Rapid Endonucleolytic Cleavage in Human Leukemia Cells

Leonard A. Zwelling, Elizabeth Altschuler, Abdallah Cherif, David Farquhar
Journal: Cancer Research
Cancer Res (1991) 51 (24): 6704–6707.
Published: 01 December 1991
View article titled, <em>N</em>-(5,5-Diacetoxypentyl)doxorubicin: A Novel Anthracycline Producing DNA Interstrand Cross-Linking and Rapid Endonucleolytic Cleavage in Human Leukemia Cells
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Journal Articles

Identification of a Point Mutation in the Topoisomerase II Gene from a Human Leukemia Cell Line Containing an Amsacrine-resistant Form of Topoisomerase II

Michael Hinds, Karl Deisseroth, Janice Mayes, Elizabeth Altschuler, Ruud Jansen, Fred D. Ledley, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1991) 51 (17): 4729–4731.
Published: 01 September 1991
View article titled, Identification of a Point Mutation in the Topoisomerase II Gene from a Human Leukemia Cell Line Containing an Amsacrine-resistant Form of Topoisomerase II
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Journal Articles

Phorbol Ester Effects on Topoisomerase II Activity and Gene Expression in HL-60 Human Leukemia Cells with Different Proclivities toward Monocytoid Differentiation

Leonard A. Zwelling, Michael Hinds, Diana Chan, Elizabeth Altschuler, Janice Mayes, Theodore F. Zipf
Journal: Cancer Research
Cancer Res (1990) 50 (22): 7116–7122.
Published: 01 November 1990
View article titled, Phorbol Ester Effects on Topoisomerase II Activity and Gene Expression in HL-60 Human Leukemia Cells with Different Proclivities toward Monocytoid Differentiation
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Journal Articles

Enhancement of Murine Tumor Cell Sensitivity to Adriamycin by Presentation of the Drug in Phosphatidylcholine-Phosphatidylserine Liposomes

Dominic Fan, Corazon D. Bucana, Catherine A. O'Brian, Leonard A. Zwelling, Christopher Seid, Isaiah J. Fidler
Journal: Cancer Research
Cancer Res (1990) 50 (12): 3619–3626.
Published: 01 June 1990
View article titled, Enhancement of Murine Tumor Cell Sensitivity to Adriamycin by Presentation of the Drug in Phosphatidylcholine-Phosphatidylserine Liposomes
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Journal Articles

Liblomycin-mediated DNA Cleavage in Human Head and Neck Squamous Carcinoma Cells and Purified DNA

Karsten Wassermann, Leonard A. Zwelling, J. William Lown, John A. Hartley, Kiyohiro Nishikawa, Juan-Ru Lin, Robert A. Newman
Journal: Cancer Research
Cancer Res (1990) 50 (6): 1732–1737.
Published: 01 March 1990
View article titled, Liblomycin-mediated DNA Cleavage in Human Head and Neck Squamous Carcinoma Cells and Purified DNA
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Journal Articles

Modulation of 4′-(9-Acridinylamino)methanesulfon-m-anisidide-induced, Topoisomerase II-mediated DNA Cleavage by Gossypol

Ramesh C. Adlakha, Cheryl L. Ashorn, Diana Chan, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1989) 49 (8): 2052–2058.
Published: 01 April 1989
View article titled, Modulation of 4′-(9-Acridinylamino)methanesulfon-<em>m</em>-anisidide-induced, Topoisomerase II-mediated DNA Cleavage by Gossypol
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Journal Articles

Effect of Retinoic Acid on DNA Cleavage and Cytotoxicity of Topoisomerase II-reactive Drugs in a Human Head and Neck Squamous Carcinoma Cell Line

Hoon-Kyo Kim, Leonard A. Zwelling, Peter G. Sacks, Waun Ki Hong, Diana Chan, Lynn Silberman, Bonnie S. Glisson
Journal: Cancer Research
Cancer Res (1989) 49 (5): 1197–1201.
Published: 01 March 1989
View article titled, Effect of Retinoic Acid on DNA Cleavage and Cytotoxicity of Topoisomerase II-reactive Drugs in a Human Head and Neck Squamous Carcinoma Cell Line
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Journal Articles

Effect of Phorbol Ester Treatment on Drug-induced, Topoisomerase II-mediated DNA Cleavage in Human Leukemia Cells

Leonard A. Zwelling, Diana Chan, Michael Hinds, Janice Mayes, Lynn E. Silberman, Mark Blick
Journal: Cancer Research
Cancer Res (1988) 48 (23): 6625–6633.
Published: 01 December 1988
View article titled, Effect of Phorbol Ester Treatment on Drug-induced, Topoisomerase II-mediated DNA Cleavage in Human Leukemia Cells
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Journal Articles

Effect of Polyamine Depletion by α-Difluoromethylornithine or (2R,5R)-6-Heptyne-2,5-diamine on Drug-induced Topoisomerase II-mediated DNA Cleavage and Cytotoxicity in Human and Murine Leukemia Cells

Milorad Bakic, Diana Chan, Emil J Freireich, Laurence J. Marton, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1987) 47 (24_Part_1): 6437–6443.
Published: 15 December 1987
View article titled, Effect of Polyamine Depletion by α-Difluoromethylornithine or (2R,5R)-6-Heptyne-2,5-diamine on Drug-induced Topoisomerase II-mediated DNA Cleavage and Cytotoxicity in Human and Murine Leukemia Cells
Open the PDF for Effect of Polyamine Depletion by α-Difluoromethylornithine or (2R,5R)-6-Heptyne-2,5-diamine on Drug-induced Topoisomerase II-mediated DNA Cleavage and Cytotoxicity in Human and Murine Leukemia Cells in another window
Journal Articles

In Vitro Toxicity and DNA Cleaving Capacity of Benzisoquinolinedione (Nafidimide; NSC 308847) in Human Leukemia

Borje S. Andersson, Miloslav Beran, Milorad Bakic, Lynn E. Silberman, Robert A. Newman, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1987) 47 (4): 1040–1044.
Published: 01 February 1987
View article titled, <em>In Vitro</em> Toxicity and DNA Cleaving Capacity of Benzisoquinolinedione (Nafidimide; NSC 308847) in Human Leukemia
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Journal Articles

Effect of Cell Proliferation and Chromatin Conformation on Intercalator-induced, Protein-associated DNA Cleavage in Human Brain Tumor Cells and Human Fibroblasts

Leonard A. Zwelling, Elihu Estey, Lynn Silberman, Sharon Doyle, Walter Hittelman
Journal: Cancer Research
Cancer Res (1987) 47 (1): 251–257.
Published: 01 January 1987
View article titled, Effect of Cell Proliferation and Chromatin Conformation on Intercalator-induced, Protein-associated DNA Cleavage in Human Brain Tumor Cells and Human Fibroblasts
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Journal Articles

Effects of 3′-Deamino-3′-(3-cyano-4-morpholinyl)doxorubicin and Doxorubicin on the Survival, DNA Integrity, and Nucleolar Morphology of Human Leukemia Cells in Vitro

Karsten Wassermann, Leonard A. Zwelling, Ted D. Mullins, Lynn E. Silberman, Borje S. Andersson, Milorad Bakic, Edward M. Acton, Robert A. Newman
Journal: Cancer Research
Cancer Res (1986) 46 (8): 4041–4046.
Published: 01 August 1986
View article titled, Effects of 3′-Deamino-3′-(3-cyano-4-morpholinyl)doxorubicin and Doxorubicin on the Survival, DNA Integrity, and Nucleolar Morphology of Human Leukemia Cells <em>in Vitro</em>
Open the PDF for Effects of 3′-Deamino-3′-(3-cyano-4-morpholinyl)doxorubicin and Doxorubicin on the Survival, DNA Integrity, and Nucleolar Morphology of Human Leukemia Cells <em>in Vitro</em> in another window
Journal Articles

Reduced Formation of Protein-associated DNA Strand Breaks in Chinese Hamster Cells Resistant to Topoisomerase II Inhibitors

Yves Pommier, Ronald E. Schwartz, Leonard A. Zwelling, Donna Kerrigan, Michael R. Mattern, Jean Y. Charcosset, Alain Jacquemin-Sablon, Kurt W. Kohn
Journal: Cancer Research
Cancer Res (1986) 46 (2): 611–616.
Published: 01 February 1986
View article titled, Reduced Formation of Protein-associated DNA Strand Breaks in Chinese Hamster Cells Resistant to Topoisomerase II Inhibitors
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Journal Articles

Correlations between Intercalator-induced DNA Strand Breaks and Sister Chromatid Exchanges, Mutations, and Cytotoxicity in Chinese Hamster Cells

Yves Pommier, Leonard A. Zwelling, Chien-Song Kao-Shan, Jacqueline Whang-Peng, Matthews O. Bradley
Journal: Cancer Research
Cancer Res (1985) 45 (7): 3143–3149.
Published: 01 July 1985
View article titled, Correlations between Intercalator-induced DNA Strand Breaks and Sister Chromatid Exchanges, Mutations, and Cytotoxicity in Chinese Hamster Cells
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Journal Articles

Effect of Difluoromethylornithine, an Inhibitor of Polyamine Biosynthesis, on the Topoisomerase II-mediated DNA Scission Produced by 4′-(9-Acridinylamino)methanesulfon-m-anisidide in L1210 Murine Leukemia Cells

Leonard A. Zwelling, Donna Kerrigan, Laurence J. Marton
Journal: Cancer Research
Cancer Res (1985) 45 (3): 1122–1126.
Published: 01 March 1985
View article titled, Effect of Difluoromethylornithine, an Inhibitor of Polyamine Biosynthesis, on the Topoisomerase II-mediated DNA Scission Produced by 4′-(9-Acridinylamino)methanesulfon-<em>m</em>-anisidide in L1210 Murine Leukemia Cells
Open the PDF for Effect of Difluoromethylornithine, an Inhibitor of Polyamine Biosynthesis, on the Topoisomerase II-mediated DNA Scission Produced by 4′-(9-Acridinylamino)methanesulfon-<em>m</em>-anisidide in L1210 Murine Leukemia Cells in another window
Journal Articles

Enhancement of the DNA Breakage and Cytotoxic Effects of Intercalating Agents by Treatment with Sublethal Doses of 1-β-d-Arabinofuranosylcytosine or Hydroxyurea in L1210 Cells

Jon Minford, Donna Kerrigan, Margaret Nichols, Stanley Shackney, Leonard A. Zwelling
Journal: Cancer Research
Cancer Res (1984) 44 (12_Part_1): 5583–5593.
Published: 01 December 1984
View article titled, Enhancement of the DNA Breakage and Cytotoxic Effects of Intercalating Agents by Treatment with Sublethal Doses of 1-β-<sc>d</sc>-Arabinofuranosylcytosine or Hydroxyurea in L1210 Cells
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