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Lenka Besse
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Journal Articles

Abstract 3079: Uncovering novel molecular mechanisms of PI resistance in multiple myeloma through multi-omics analysis

Free
Seungbin Han, Chien-Yun Lee, Lenka Besse, Umair Munawar, Shilpa Kurian, Andrej Besse, Ann-Sohpie Hainold, Silvia Nerreter, Cornelia Vogt, Johanna Thurner, Nina Rein, Max Köppel, Xiang Zhou, Larissa Haertle, Christoph Driessen, Hermann Einsele, Leo Rasche, Ondrej Slaby, Johannes Waldschmidt, Bernhard Küster, Klaus Martin Kortüm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3079.
https://doi.org/10.1158/1538-7445.AM2025-3079
Published: 21 April 2025
View articletitled, Abstract 3079: Uncovering novel molecular mechanisms of PI resistance in multiple myeloma through multi-omics analysis
Journal Articles

Abstract 4430: Combination of IGF1R/InsR and proteasome inhibition shows strong antitumor activity in proteasome inhibitor resistant multiple myeloma

Free
Andrej Besse, Tiberiu Totu, Marianne Kraus, Max Mendez Lopez, Jana Veprkova, Ondrej Slaby, Marija Buljan, Leo Rasche, K. Martin Kortum, Christoph Driessen, Lenka Besse
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4430.
https://doi.org/10.1158/1538-7445.AM2025-4430
Published: 21 April 2025
View articletitled, Abstract 4430: Combination of IGF1R/InsR and proteasome inhibition shows strong antitumor activity in proteasome inhibitor resistant multiple myeloma
Journal Articles

Abstract 2974: Bortezomib resistant multiple myeloma shows a specific dependency on Ecm29 in vitro and in vivo

Free
Andrej Besse, Lenka Besse, Sara C. Stolze, Marianne Kraus, Ondrej Slaby, Hirofumi Nakagami, Christoph Driessen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2974.
https://doi.org/10.1158/1538-7445.AM2025-2974
Published: 21 April 2025
View articletitled, Abstract 2974: Bortezomib resistant multiple myeloma shows a specific dependency on Ecm29 in vitro and in vivo
Journal Articles

Abstract 7191: Targeting IGF1R/INSR pathway with approved ALK inhibitors inhibits AKT signaling and overcomes proteasome inhibitor resistance in multiple myeloma

Free
Andrej Besse, Tiberiu Totu, Marianne Kraus, Anthonius P. Janssen, Jana Veprkova, Max Mendez Lopez, Ondrej Slaby, Marija Buljan, Mario van der Stelt, Christoph Driessen, Lenka Besse
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7191.
https://doi.org/10.1158/1538-7445.AM2024-7191
Published: 22 March 2024
View articletitled, Abstract 7191: Targeting IGF1R/INSR pathway with approved ALK inhibitors inhibits AKT signaling and overcomes proteasome inhibitor resistance in multiple myeloma
Journal Articles

Abstract 2851: ALK-inhibitors as a novel potential therapy for proteasome inhibitor-resistant multiple myeloma

Free
Lenka Besse, Andrej Besse, Marianne Kraus, Matej Jasik, Ondrej Slaby, Christoph Driessen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2851.
https://doi.org/10.1158/1538-7445.AM2023-2851
Published: 04 April 2023
View articletitled, Abstract 2851: ALK-inhibitors as a novel potential therapy for proteasome inhibitor-resistant multiple myeloma
Journal Articles

Abstract 3298: Propagation competence of a self-antigen-targeting arenavirus vector based cancer therapy determines antitumor efficacy in mouse melanoma

Free
Mette-Triin Purde, Fabienne Hartmann, Jovana Cupovic, Sarah Schmidt, David Bomze, Felix Stemeseder, Alexander Lercher, Lenka Besse, Fiamma Berner, Thomas Tüting, Andreas Bergthaler, Andrea Schietinger, Stefan Kochanek, Burkhard Ludewig, Klaus K. Orlinger, Tobias Bald, Sandra S. Ring, Lukas Flatz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3298.
https://doi.org/10.1158/1538-7445.AM2022-3298
Published: 15 June 2022
View articletitled, Abstract 3298: Propagation competence of a self-antigen-targeting arenavirus vector based cancer therapy determines antitumor efficacy in mouse melanoma
Journal Articles

Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma

Open Access
Lenka Besse, Andrej Besse, Sara C. Stolze, Amin Sobh, Esther A. Zaal, Alwin J. van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J. Thomas Hannich, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Christopher D. Vulpe, Herman S. Overkleeft, Christoph Driessen
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4581–4593.
https://doi.org/10.1158/0008-5472.CAN-20-3323
Published: 01 September 2021
View articletitled, Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
Open the PDF for Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1243: Inside of multiple mechanism of adaption towards the proteasome inhibitors in multiple myeloma

Free
Andrej Besse, Lenka Besse, Marianne Kraus, Jurgen Bader, Mario Novkovic, Fedor Kryukov, Pavel Nemec, Tobias Silzle, Christoph Driessen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1243.
https://doi.org/10.1158/1538-7445.AM2016-1243
Published: 15 July 2016
View articletitled, Abstract 1243: Inside of multiple mechanism of adaption towards the proteasome inhibitors in multiple myeloma