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Leng Han
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Journal Articles

Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer

Available to Purchase
Chenyang Zhang, Yan-Yan Chen, Shuyu Chen, Yunzhe Wang, Yifan Yuan, Xiwen Yang, Wei Hu, Bo Chen, Zengxin Qi, Jason T. Huse, Yun Liu, Bo Wen, Xiuping Liu, Leng Han, Yuxiang Wang, Zhao Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8): 1530–1543.
https://doi.org/10.1158/0008-5472.CAN-24-2289
Published: 15 April 2025
View articletitled, Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer
Open the PDF for Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer in another window
Includes: Supplementary data
Journal Articles

Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer

Available to Purchase
Chenyang Zhang, Yan-Yan Chen, Shuyu Chen, Yunzhe Wang, Yifan Yuan, Xiwen Yang, Wei Hu, Bo Chen, Zengxin Qi, Jason T. Huse, Yun Liu, Bo Wen, Xiuping Liu, Leng Han, Yuxiang Wang, Zhao Zhang
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2289
Published: 04 February 2025
View articletitled, Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer
Open the PDF for Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer in another window
Includes: Supplementary data
Journal Articles

The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers

Available to Purchase
Chengxuan Chen, Yuan Liu, Qiang Li, Zhao Zhang, Mei Luo, Yaoming Liu, Leng Han
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3673–3680.
https://doi.org/10.1158/0008-5472.CAN-23-0758
Published: 15 November 2023
View articletitled, The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers
Open the PDF for The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract P4-08-23: ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

Free
Chengheng Liao, Wentong Fang, Rachel Shi, Jeremy Simon, Travis Ptacek, Giada Zurlo, Youqiong Ye, Leng Han, Cheng Fan, Lei Bao, Christopher Llynard Ortiz, Hong-Rui Lin, Ujjawal Manocha, Weibo Luo, Yan Peng, William Y Kim, Lee-Wei Yang, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-23.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-23
Published: 01 March 2023
View articletitled, Abstract P4-08-23: ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer
Journal Articles

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy

Available to Purchase
Gaoyang Wang, Zuozhong Xie, Juan Su, Meishan Chen, Yanhua Du, Qian Gao, Guanxiong Zhang, Hailun Zhang, Xiang Chen, Hong Liu, Leng Han, Youqiong Ye
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3474–3485.
https://doi.org/10.1158/0008-5472.CAN-22-1417
Published: 04 October 2022
View articletitled, Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy
Open the PDF for Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 4082: Expression of chimeric antigen receptor therapy targets in subpopulations detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity

Free
Ying Jing, Yuan Liu, Qiang Li, Leng Han
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4082.
https://doi.org/10.1158/1538-7445.AM2022-4082
Published: 15 June 2022
View articletitled, Abstract 4082: Expression of chimeric antigen receptor therapy targets in subpopulations detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity
Journal Articles

RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1

Open Access
Zhen Liu, Youqiong Ye, Yizhe Liu, Yanfang Liu, Huifang Chen, Mengting Shen, Zhen Wang, Shenglin Huang, Leng Han, Zhiao Chen, Xianghuo He
Journal: Cancer Research
Cancer Res (2022) 82 (10): 1937–1952.
https://doi.org/10.1158/0008-5472.CAN-21-3038
Published: 16 May 2022
View articletitled, RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1
Open the PDF for RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1 in another window
Includes: Supplementary data
Journal Articles

Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers

Available to Purchase
Zhao Zhang, Mei Luo, Qiang Li, Yuan Liu, Charles Lussier, Jian Zhang, Youqiong Ye, An-Yuan Guo, Leng Han
Journal: Cancer Research
Cancer Res (2022) 82 (5): 785–790.
https://doi.org/10.1158/0008-5472.CAN-21-2058
Published: 03 March 2022
View articletitled, Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers
Open the PDF for Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers in another window
Includes: Supplementary data
Journal Articles

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Available to Purchase
Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya'an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4054–4065.
https://doi.org/10.1158/0008-5472.CAN-20-3792
Published: 01 August 2021
View articletitled, Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Open the PDF for Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors

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Bin Yang, Xi Li, Yu Fu, Ensong Guo, Youqiong Ye, Fuxia Li, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Jia Huang, Tianyu Qin, Leng Han, Guang Peng, Gordon B. Mills, Chaoyang Sun, Gang Chen
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2714–2729.
https://doi.org/10.1158/0008-5472.CAN-20-2370
Published: 15 May 2021
View articletitled, MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
Open the PDF for MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors in another window
Includes: Supplementary data
Journal Articles

Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer

Free
Zhen Xing, Yanyan Zhang, Ke Liang, Liang Yan, Yu Xiang, Chunlai Li, Qingsong Hu, Feng Jin, Vasanta Putluri, Nagireddy Putluri, Cristian Coarfa, Arun Sreekumar, Peter K. Park, Tina K. Nguyen, Shouyu Wang, Jianwei Zhou, Yan Zhou, Jeffrey R. Marks, David H. Hawke, Mien-Chie Hung, Liuqing Yang, Leng Han, Haoqiang Ying, Chunru Lin
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4524–4532.
https://doi.org/10.1158/0008-5472.CAN-17-0385
Published: 14 August 2018
View articletitled, Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 3279: Comprehensive analysis of small nucleolar RNAs across in human cancers

Free
Jing Gong, Yajuan Li, Chunjie Liu, Yu Xiang, An-yuan Guo, Chunru Lin, Leng Han
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3279.
https://doi.org/10.1158/1538-7445.AM2018-3279
Published: 01 July 2018
View articletitled, Abstract 3279: Comprehensive analysis of small nucleolar RNAs across in human cancers
Journal Articles

Abstract 1412: Comprehensive characterization of clock genes in human cancers

Free
Youqiong Ye, Yu Xiang, Joseph Takahashi, Gordon Mills, Seung-Hee Yoo, Leng Han
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1412.
https://doi.org/10.1158/1538-7445.AM2018-1412
Published: 01 July 2018
View articletitled, Abstract 1412: Comprehensive characterization of clock genes in human cancers
Journal Articles

TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer

Free
Jun Li, Leng Han, Paul Roebuck, Lixia Diao, Lingxiang Liu, Yuan Yuan, John N. Weinstein, Han Liang
Journal: Cancer Research
Cancer Res (2015) 75 (18): 3728–3737.
https://doi.org/10.1158/0008-5472.CAN-15-0273
Published: 14 September 2015
View articletitled, TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer
Open the PDF for TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer in another window
Includes: Supplementary data