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Leisha A. Emens
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Journal Articles

Abstract OT1-12-02: Trial in progress: Phase 2, open-label study to evaluate the safety and efficacy of praluzatamab ravtansine in metastatic HER2 non-amplified breast cancer as monotherapy and combination with pacmilimab

Kathy Miller, Leisha A. Emens, Sara M. Tolaney, Sara A. Hurvitz, Erika Hamilton, Virginia Paton, Alison Hannah, Valentina Boni
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT1-12-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT1-12-02
Published: 15 February 2022
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Journal Articles

Abstract GS2-10: Nimbus: A phase 2 trial of nivolumab plus ipilimumab for patients with hypermutated her2-negative metastatic breast cancer (MBC)

Romualdo Barroso-Sousa, Tianyu Li, Sangeetha Reddy, Leisha A. Emens, Beth Overmoyer, Paulina Lange, Molly K Dilullo, Victoria Attaya, Jeffrey Kimmel, Eric P. Winer, Elizabeth A. Mittendorf, Nabihah Tayob, Sara M. Tolaney
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS2-10.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS2-10
Published: 15 February 2022
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Journal Articles

Abstract CT218: Phase 1/2 study of a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), BDC-1001, alone and in combination with pembrolizumab (pembro) in patients (pts) with HER2-expressing advanced solid tumors

Manish R. Sharma, Richard D. Carvajal, Daniel Catenacci, Leisha A. Emens, Glenn J. Hanna, Dejan Juric, Yoon-Koo Kang, Jeeyun Lee, Keun-Wook Lee, Bob T. Li, Kathleen Moore, Mark D. Pegram, Paula R. Pohlmann, Drew Rasco, Alexander Spira, Arielle L. Heeke, Ding Wang, Lawrence Garbo, Sudhir Manda, Jasgit Sachdev, Shelley E. Ackerman, Heidi LeBlanc, David Dornan, Marcin Kowanetz, Michael N. Alonso, Amreen Husain, Edith A. Perez, Ecaterina Ileana Dumbrava
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT218.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT218
Published: 01 July 2021
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Journal Articles

Abstract OT-13-09: Translational breast cancer research consortium 044 trial: Randomized phase 2 study of pembrolizumab and carboplatin versus carboplatin alone for chest wall recurrence of breast cancer

Neelima Vidula, Rita Nanda, Kathy Miller, Paula Pohlmann, Vandana Abramson, Leisha A. Emens, Ben H. Park, Minetta C. Liu, Andrei Goga, Hope S. Rugo
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-13-09.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-13-09
Published: 15 February 2021
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Journal Articles

Abstract OT-32-01: A phase 2, open-label study of bintrafusp alfa monotherapy in patients with HMGA2-expressing triple-negative breast cancer

Leisha A Emens, Margaret E. Gatti-Mays, Joyce O’Shaughnessy, Luc Dirix, Giovanni Faggioni, Andrea Fontana, Jerome Martin-Babau, Christoph Helwig, Alice Huang, Riham Iadevaia, Laureen S Ojalvo
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-32-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-32-01
Published: 15 February 2021
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Journal Articles

Abstract OT-03-02: Phase 1/2 study of a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), BDC-1001, as a single agent and in combination with an immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors

Ecaterina Ileana Dumbrava, Manish R. Sharma, Richard D. Carvajal, Daniel Catenacci, Leisha A. Emens, Shirish M. Gadgeel, Glenn J. Hanna, Dejan Juric, Yoon-Koo Kang, Jeeyun Lee, Keun-Wook Lee, Bob T. Li, Kathleen Moore, Mark D. Pegram, Paula R. Pohlmann, Drew Rasco, Alexander Spira, Antoinette R. Tan, Shelley E. Ackerman, Heidi LeBlanc, David Dornan, Marcin Kowanetz, Michael N. Alonso, Edith A. Perez
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-03-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-03-02
Published: 15 February 2021
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Journal Articles

Abstract OT-03-08: A Phase 2, open-label study to evaluate the safety and efficacy of the probody therapeutic (Pb-Tx) CX-2009 in metastatic HR-Positive/HER2-negative breast cancer (mHR+/HER2− BC) and of CX-2009 as monotherapy and in combination therapy with CX-072 in metastatic triple-negative breast cancer (TNBC)

Kathy D. Miller, Leisha A. Emens, Sara Tolaney, Sara A. Hurvitz, Erika Hamilton, Virginia Paton, Alison Hannah, Valentina Boni
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-03-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-03-08
Published: 15 February 2021
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Journal Articles

Abstract PS1-10: Outcomes after sentinel lymph node biopsy and radiation therapy in women over 70 years old with ER+, HER2-, clinically node negative breast cancer

Priscilla F McAuliffe, Neil M Carleton, Jian Zou, Yusi Fang, Stephen E Koscumb, Osama Shah, Fangyuan Chen, Sushil Beriwal, Emilia J Diego, Adam M Brufsky, Steffi Oesterreich, Steve D Shapiro, Robert Ferris, Leisha A Emens, George Tseng, Oscar C Marroquin, Adrian V Lee
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS1-10.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS1-10
Published: 15 February 2021
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Journal Articles

Abstract PD1-05: Atezolizumab in combination with trastuzumab emtansine or with trastuzumab and pertuzumab in patients with HER2-positive breast cancer and atezolizumab with doxorubicin and cyclophosphamide in HER2-negative breast cancer: Safety and biomarker outcomes from a multi-cohort Phase Ib study

Erika Paige Hamilton, Virginia Kaklamani, Carla Falkson, Gregory A Vidal, Patrick J Ward, Monika Patre, Stephen Y Chui, Jacob Rotmensch, Kushagra Gupta, Luciana Molinero, Yijin Li, Leisha A Emens
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD1-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD1-05
Published: 15 February 2020
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Journal Articles

Abstract PD1-07: Exploratory analytical harmonization of PD-L1 immunohistochemistry assays in advanced triple-negative breast cancer: A retrospective substudy of IMpassion130

Hope Rugo, Sherene Loi, Sylvia Adams, Peter Schmid, Andreas Schneeweiss, Carlos H Barrios, Hiroji Iwata, Véronique Diéras, Eric P Winer, Mark M Kockx, Dieter Peeters, Stephen Y Chui, Jennifer C Lin, Anh Nguyen Duc, Guiseppe Viale, Luciana Molinero, Leisha A Emens
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD1-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD1-07
Published: 15 February 2020
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Journal Articles

Abstract P2-16-26: Mixed invasive ductal and lobular carcinoma (IDC/L) behaves similarly to invasive lobular carcinoma (ILC) with regard to neoadjuvant chemotherapy response and metastatic dissemination

Azadeh Nasrazadani, Jennifer M Atkinson, Yujia Li, Priscilla F McAuliffe, Rachel C Jankowitz, Leisha A Emens, George C Tseng, Adrian V Lee, Norman Wolmark, Steffi Oesterreich, Peter C Lucas
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-16-26.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-16-26
Published: 15 February 2020
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Journal Articles

Abstract CT001: Biomarkers of systemic inflammation associated to reduced clinical activity of atezolizumab monotherapy in patients with metastatic triple negative breast cancer

Yijin Li, Marcella Fassò, Leisha A. Emens, Luciana Molinero
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT001.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT001
Published: 01 July 2019
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Journal Articles

Abstract 3748: Development of anti-human mesothelin chimeric antigen receptor (CAR) messenger RNA (mRNA) transfected peripheral blood mononuclear cells (CARMA) for the treatment of mesothelin-expressing cancers

Chien-Fu Hung, Xuequn Xu, Linhong Li, Ying Ma, Qiu Jin, Angelia Viley, Cornell Allen, Pachai Natarajan, Rama Shivakumar, Madhusudan V. Peshwa, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3748.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3748
Published: 01 July 2017
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Journal Articles

Abstract 2986: Atezolizumab in metastatic TNBC (mTNBC): Long-term clinical outcomes and biomarker analyses

Peter Schmid, Cristina Cruz, Fadi S. Braiteh, Joseph Paul Eder, Sara Tolaney, Irene Kuter, Rita Nanda, Cathie Chung, Philippe Cassier, Jean-Pierre Delord, Michael Gordon, Yijin Li, Bo Liu, Carol O’Hear, Marcella Fasso, Luciana Molinero, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2986.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2986
Published: 01 July 2017
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Journal Articles

Abstract 2993: STING signaling in breast tumor microenvironment modulates immune checkpoint blockade efficacy in the neu-N mouse model of breast cancer

Jeremy B. Foote, Marlene Kok, James M. Leatherman, Todd D. Armstrong, Bridget Marcinkowski, David B. Kanne, Elizabeth M. Jaffee, Thomas W. Dubensky, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2993.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2993
Published: 01 July 2017
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Journal Articles

Abstract 3991: Profiling the immune tumor microenvironment in primary and recurrent epithelial ovarian cancer

Laureen S. Ojalvo, Elizabeth D. Thompson, Tian-Li Wang, Alan K. Meeker, Ie-Ming Shih, Amanda N. Fader, Ashley Cimino-Mathews, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3991.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3991
Published: 01 July 2017
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Journal Articles

Abstract 2859: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer (TNBC)

Leisha A. Emens, Fadi S. Braiteh, Philippe Cassier, Jean-Pierre Delord, Joseph Paul Eder, Marcella Fasso, Yuanyuan Xiao, Yan Wang, Luciana Molinero, Daniel S. Chen, Ian Krop
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2859.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2859
Published: 01 August 2015
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Journal Articles

Abstract PD1-6: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer

Leisha A Emens, Fadi S Braiteh, Philippe Cassier, Jean-Pierre DeLord, Joseph Paul Eder, Xiaodong Shen, Yuanyuan Xiao, Yan Wang, Priti S Hegde, Daniel S Chen, Ian Krop
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): PD1-6.
DOI: https://doi.org/10.1158/1538-7445.SABCS14-PD1-6
Published: 01 May 2015
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Journal Articles

Abstract 4749: Cyclophosphamide induces dose dependent apoptosis of CD4+FoxP3+ regulatory T cells relative to CD4+FoxP3- effector T cells in breast cancer patients.

Gang Chen, James M. Leatherman, Melek Erdinc Sunay, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4749.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4749
Published: 15 April 2013
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Journal Articles

Abstract 3985: Sorafenib modulates macrophages to promote T helper type 1 immunity.

Melek M. Sunay, James M. Leatherman, Gang Chen, Leisha A. Emens
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3985.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3985
Published: 15 April 2013
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