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Journal Articles

Abstract 699: Optimized dosing strategies resulting in prolonged pathway inhibition enhance dinaciclib anti-tumor activity in preclinical xenograft models.

Alwin Schuller, Robert Booher, Louise Cadzow, Minilik Angagaw, Lauren Harmonay, Xianlu Qu, Nathan Miselis, Vincenzo Pucci, Mark Ayers, Thorsten Graef, Ellie Im, Rebecca Blanchard, Brian Long, Leigh Zawel, peter strack

Cancer Res (2013) 73 (8_Supplement): 699.

https://doi.org/10.1158/1538-7445.AM2013-699

Published: 15 April 2013

View article titled, Abstract 699: Optimized dosing strategies resulting in prolonged pathway inhibition enhance dinaciclib anti-tumor activity in preclinical xenograft models.

Journal Articles

Abstract 698: MCL1 dependent cells are sensitive to the CDK inhibitor Dinaciclib.

Cancer Res (2013) 73 (8_Supplement): 698.

https://doi.org/10.1158/1538-7445.AM2013-698

Published: 15 April 2013

View article titled, Abstract 698: MCL1 dependent cells are sensitive to the CDK inhibitor Dinaciclib.

Journal Articles

Abstract 2343: A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors.

Ahmed A. Samatar, Erick J. Morris, Sharda Jha, Restaino R. Clifford, Bart Luttrerbach, Marc Pelletier, Ulrike Philippar, Lata Jayaraman, Leigh Zawel, Steve Fawell, Gary Gilliland

Cancer Res (2013) 73 (8_Supplement): 2343.

https://doi.org/10.1158/1538-7445.AM2013-2343

Published: 15 April 2013

View article titled, Abstract 2343: A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors.

Journal Articles

Abstract 3063: Mcl-1 dependency is a predictive biomarker for apoptotic induction by short-term dinaciclib (SCH 727965) treatment

Robert Booher, Heather Hirsch, Peter Strack, Leigh Zawel, Stephen Fawell

Cancer Res (2012) 72 (8_Supplement): 3063.

https://doi.org/10.1158/1538-7445.AM2012-3063

Published: 15 April 2012

View article titled, Abstract 3063: Mcl-1 dependency is a predictive biomarker for apoptotic induction by short-term dinaciclib (SCH 727965) treatment

Journal Articles

Abstract 1065: Growth factor-mediated resistance to BRAF/MEK inhibitors in BRAF mutant melanoma

Bart Lutterbach, Chris Ware, Lenora Davis, Qing Zhang, Leigh Zawel, John Reilly, Bo-Sheng Pan

Cancer Res (2012) 72 (8_Supplement): 1065.

https://doi.org/10.1158/1538-7445.AM2012-1065

Published: 15 April 2012

View article titled, Abstract 1065: Growth factor-mediated resistance to BRAF/MEK inhibitors in BRAF mutant melanoma

Journal Articles

Abstract 4931: Biomarker discovery in a large panel of cell lines shows different sample size requirement for prediction of response across a set of compounds

Michael Nebozhyn, Razvan Cristescu, Yaping Liu, Igor Feldman, Sergey Lezhnin, Theresa Zhang, Leigh Zawel, Stephen Fawell, Hongyue Dai, Jing Li, Andrey Loboda

Cancer Res (2012) 72 (8_Supplement): 4931.

https://doi.org/10.1158/1538-7445.AM2012-4931

Published: 15 April 2012

View article titled, Abstract 4931: Biomarker discovery in a large panel of cell lines shows different sample size requirement for prediction of response across a set of compounds

Journal Articles

Abstract 1868: Response biomarkers to IGF1R and mTOR inhibitor combination therapy in ovarian carcinoma

Brian B. Haines, Michael J. Wick, Kyriakos P. Papadopoulos, Anthony W. Tolcher, Jennifer G. Tammam, Marya F. Chaney, Michael Nebozhyn, Theresa Zhang, Scot W. Ebbinghaus, Jonathan D. Cheng, Leigh Zawel, Sriram Sathyanarayanan

Cancer Res (2012) 72 (8_Supplement): 1868.

https://doi.org/10.1158/1538-7445.AM2012-1868

Published: 15 April 2012

View article titled, Abstract 1868: Response biomarkers to IGF1R and mTOR inhibitor combination therapy in ovarian carcinoma

Journal Articles

Abstract LB-19: The Smac mimetic LBW242 induces apoptosis in melanoma in a TLR-3-dependent and TNFR-independent manner

Kevin T. McHenry, Elena Jacobson, Jerry Donovan, Kymberly Levine, Jingxin Zhang, David E. Fisher, Leigh Zawel, Dale Porter

Cancer Res (2011) 71 (8_Supplement): LB-19.

https://doi.org/10.1158/1538-7445.AM2011-LB-19

Published: 15 April 2011

View article titled, Abstract LB-19: The Smac mimetic LBW242 induces apoptosis in melanoma in a TLR-3-dependent and TNFR-independent manner

Journal Articles

Abstract 2775: A phase I study of LCL161, an oral IAP inhibitor, in patients with advanced cancer

Jeffrey R. Infante, E. Claire Dees, Howard A. Burris, Leigh Zawel, Jason A. Sager, Claudina Stevenson, Kathryn Clarke, Shyeilla Dhuria, Dale Porter, Suman K. Sen, Erika Zannou, Sushil Sharma, Roger B. Cohen

Cancer Res (2010) 70 (8_Supplement): 2775.

https://doi.org/10.1158/1538-7445.AM10-2775

Published: 15 April 2010

View article titled, Abstract 2775: A phase I study of LCL161, an oral IAP inhibitor, in patients with advanced cancer

Journal Articles

Mechanism of action studies using a Smac mimetic reveal positive and negative roles of inhibitor of apoptosis proteins (IAPs) in TNFα signaling

Leigh Zawel, Alex Gaither, Dale Porter, Yao Yao, Christopher Straub, Tim Ramsey, Vadim Iourgenko, Huang Alan, Robert Schlegel, Mark Labow, Stephen Fawell, William Sellers

Cancer Res (2008) 68 (9_Supplement): SY26-04.

Published: 01 May 2008

View article titled, Mechanism of action studies using a Smac mimetic reveal positive and negative roles of inhibitor of apoptosis proteins (IAPs) in TNFα signaling

Journal Articles

A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

Alex Gaither, Dale Porter, Yao Yao, Jason Borawski, Guang Yang, Jerry Donovan, David Sage, Joanna Slisz, Mary Tran, Christopher Straub, Tim Ramsey, Vadim Iourgenko, Alan Huang, Yan Chen, Robert Schlegel, Mark Labow, Stephen Fawell, William R. Sellers, Leigh Zawel

Cancer Res (2007) 67 (24): 11493–11498.

https://doi.org/10.1158/0008-5472.CAN-07-5173

Published: 18 December 2007

View article titled, A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

Includes: Supplementary data

NARROW

Abstract 699: Optimized dosing strategies resulting in prolonged pathway inhibition enhance dinaciclib anti-tumor activity in preclinical xenograft models.

Abstract 698: MCL1 dependent cells are sensitive to the CDK inhibitor Dinaciclib.

Abstract 2343: A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors.

Abstract 3063: Mcl-1 dependency is a predictive biomarker for apoptotic induction by short-term dinaciclib (SCH 727965) treatment

Abstract 1065: Growth factor-mediated resistance to BRAF/MEK inhibitors in BRAF mutant melanoma

Abstract 4931: Biomarker discovery in a large panel of cell lines shows different sample size requirement for prediction of response across a set of compounds

Abstract 1868: Response biomarkers to IGF1R and mTOR inhibitor combination therapy in ovarian carcinoma

Abstract LB-19: The Smac mimetic LBW242 induces apoptosis in melanoma in a TLR-3-dependent and TNFR-independent manner

Abstract 2775: A phase I study of LCL161, an oral IAP inhibitor, in patients with advanced cancer

Mechanism of action studies using a Smac mimetic reveal positive and negative roles of inhibitor of apoptosis proteins (IAPs) in TNFα signaling

A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

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