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Leif W. Ellisen
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Journal Articles

Abstract 5248: CDK4/6 inhibition (CDK4/6i) is effective in the real-world setting for hormone receptor-positive metastatic breast cancer (HR+ MBC) with ESR1 mutations and fusions

Jamie O. Brett, Caroline M. Weipert, Lauren L. Ritterhouse, Nicole Zhang, Junhua Yu, Lianne Y. Ryan, Laura M. Spring, Miguel N. Rivera, Jochen K. Lennerz, Dora Dias-Santagata, Leif W. Ellisen, Aditya Bardia, Seth A. Wander
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5248.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5248
Published: 15 June 2022
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Journal Articles

Abstract P5-13-21: Relationship between circulating tumor DNA and response to neoadjuvant niraparib in HER2-negative, BRCA-mutated breast cancer

Ming Shan, Laura Spring, Minetta C Liu, Erika Hamilton, Hanna Irie, Cesar A Santa-Maria, Steven J Isakoff, James Reeves, Leif W Ellisen, Lee P Lim, Kavita Garg, Caterina Bertucci, Bin Feng, Hailei Zhang, Kaiming Sun, Julie R Graham, Erin Hofstatter, Hyo Han
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-21.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-13-21
Published: 15 February 2022
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Journal Articles

Abstract OT2-24-03: Phase II study of a PARP inhibitor in metastatic breast cancer with somaticBRCA1/2mutations identified by cell-free DNA: Genotyping based clinical trial

Neelima Vidula, Erica Blouch, Erin Basile, Nathan Royce Ruffle-Deignan, Nora Horick, Senthil Damodaran, Alvaro Moreno Aspitia, Manali Bhave, Ami Shah, Minetta C. Liu, Joseph Sparano, Harry Ostrer, Hope Rugo, Leif W. Ellisen, Aditya Bardia
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT2-24-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT2-24-03
Published: 15 February 2022
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Journal Articles

Abstract P1-18-22: AKT inhibition in combination with endocrine therapy and a CDK4/6 inhibitor (CDK4/6i) in patients with hormone receptor positive (HR+)/HER2 negative metastatic breast cancer (MBC) and prior CDK4/6i exposure: A translational investigation

Seth A. Wander, Douglas S. Micalizzi, Taronish Dubash, Dejan Juric, Laura M. Spring, Neelima Vidula, Jennifer Keenan, Maureen Beeler, Elene Viscosi, Dante Che, Elizabeth L. Fisher, Rachel A. Hepp, Beverly Moy, Steven J. Isakoff, Leif W. Ellisen, Jeffrey G. Supko, Shyamala Maheswaran, Daniel A. Haber, Aditya Bardia
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-18-22.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-18-22
Published: 15 February 2022
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Journal Articles

Abstract P3-09-11: Clinical characteristics associated withBRCA1/2mutations identified on routine tumor tissue genotyping in metastatic breast cancer

Neelima Vidula, Erica Blouch, Alexander Farahani, Hetal Marble, Andrzej Niemierko, Kathleen Hesler, Elyssa Denault, Dejan Juric, Leif W. Ellisen, Beverly Moy, Steven Isakoff, Jochen Lennerz, Aditya Bardia
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-11.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-11
Published: 15 February 2022
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Journal Articles

Abstract P3-23-02: Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer receiving CDK 4/6 inhibitors

Elyssa Denault, Erika Nakajima, Vivek Naranbhai, Alejandro Balazs, Lindsey Mortensen, Elizabeth Niehoff, Caroline Barabell, Jennifer A. Hutchinson, Seth A. Wander, Aron S. Rosenstock, Leif W. Ellisen, Beverly Moy, Steven J. Isakoff, Justin F. Gainor, A. John Iafrate, Aditya Bardia, Laura M. Spring
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-23-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-23-02
Published: 15 February 2022
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Journal Articles

Abstract PS17-02: Molecular alterations in the androgen receptor and associated clinical outcomes in hormone receptor-positive/HER2- metastatic breast cancer

Charles Dai, Andrzej Niemierko, Neelima Vidula, Laura M Spring, Seth A Wander, Arielle J Medford, Katherine A Hesler, Giuliana Malvarosa, Jeffrey Peppercorn, Dejan Juric, Steven J Isakoff, Beverly Moy, Leif W Ellisen, Aditya Bardia
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-02
Published: 15 February 2021
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Journal Articles

Abstract OT-03-06: Phase 2 study of response-guided neoadjuvant sacituzumab govitecan (IMMU-132) in patients with localized triple-negative breast cancer (NeoSTAR)

Laura M. Spring, Sara M. Tolaney, Neelam Desai, Amy Comander, Therese Mulvey, Ian E. Krop, Eric P. Winer, Elizabeth A. Mittendorf, Leif W. Ellisen, Aditya Bardia
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-03-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-03-06
Published: 15 February 2021
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Journal Articles

Abstract OT-30-02: Phase II study of talazoparib, a PARP inhibitor, in somatic BRCA1/2 mutant metastatic breast cancer

Neelima Vidula, Nora Horick, Erin Basile, Erica Blouch, Leif W. Ellisen, Hope S. Rugo, Aditya Bardia
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-30-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-OT-30-02
Published: 15 February 2021
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Journal Articles

Abstract PS18-19: Comparison of metastatic genomic profile in patients ≤45 years and patients >45 years with triple-negative breast cancer

Neelima Vidula, Andrzej Niemierko, Katherine Hesler, Steven Isakoff, Dejan Juric, Jennifer Shin, Laura Spring, Jeffrey Peppercorn, Jerry Younger, Irene Kuter, Beverly Moy, Leif W. Ellisen, Aditya Bardia
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS18-19.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS18-19
Published: 15 February 2021
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Journal Articles

Abstract 1903: PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ká inhibitors in breast cancer

Carlotta Costa, Ye Wang, Amy Ly, Yasuyuki Hosono, Ellen Murchie, Charlotte S. Walmsley, Tiffany Huynh, Christopher Healy, Rachel Peterson, Shogo Yanase, Charles T. Jakubik, Laura E. Henderson, Leah J. Damon, Daria Timonina, Ioannis Sanidas, Christopher J. Pinto, Mari Mino-Kenudson, James Stone, Nicholas J. Dyson, Leif W. Ellisen, Aditya Bardia, Hiromichi Ebi, Cyril H. Benes, Jeffrey A. Engelman, Dejan Juric
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1903.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1903
Published: 15 August 2020
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Journal Articles

Abstract OT2-08-01: A phase 1b trial to evaluate safety and anti-tumor activity of the AKT inhibitor, ipatasertib, in combination with endocrine therapy with/without CDK 4/6 inhibitor for patients with hormone receptor positive (HR+)/HER2 negative metastatic breast cancer (MBC) (TAKTIC)

Seth A. Wander, Dejan Juric, Laura M. Spring, Neelima Vidula, Maureen Beeler, Karleen Habin, Elene Viscosi, Lauren Scarpetti, Elizabeth Tripp, Rachel Hepp, Beverly Moy, Steven J. Isakoff, Leif W. Ellisen, Aditya Bardia
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT2-08-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-OT2-08-01
Published: 15 February 2020
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Journal Articles

Abstract P3-09-15: A phase 1b study of PVX-410 (PVX) vaccine plus durvalumab (DUR) as adjuvant therapy in HLA-A2+ early stage triple negative breast cancer (eTNBC) to assess safety and immune response

Steven J Isakoff, Sylvia Adams, Hatem H Soliman, Nadine Tung, William T Barry, Jiani Hu, Lorenzo Trippa, Rachel Deering, Joanne Parker, Hannah Park, Elena F Brachtel, Leif W Ellisen, Mariano Severgnini, Doris Peterkin, Sara M Tolaney
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-09-15.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P3-09-15
Published: 15 February 2020
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Journal Articles

Abstract P3-11-03: Pilot neoadjuvant study of niraparib in HER2-negative, BRCA-mutated resectable breast cancer

Hyo Han, Minetta C Liu, Erika Hamilton, Hanna Irie, Cesar A Santa-Maria, James Reeves, Andre Liem, Adrianna Milillo Naraine, Julie Nangia, David Page, Meghan Duncan, Ming Shan, Yongqiang Tang, Julie R Graham, Leif W Ellisen, Steven Isakoff, Laura Spring
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-11-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P3-11-03
Published: 15 February 2020
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Journal Articles

Abstract P6-10-08: AKT1 alterations following exposure to endocrine-based therapy in patients with hormone-receptor positive (HR+) metastatic breast cancer (MBC): Clinical and functional implications

Seth Wander, Pingping Mao, Maxwell Lloyd, Kailey Kowalski, Gabriela N. Johnson, Giuliana Malvarosa, Beverly Moy, Leif W. Ellisen, John Iafrate, Nikhil Wagle, Aditya Bardia
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-10-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P6-10-08
Published: 15 February 2020
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Journal Articles

Abstract P2-21-01: Feasibility of a multidisciplinary diagnostic breast research biopsy project

Kassidy Beyerlin, Christine Edmonds, Siang Boon Koh, Veerle Bossuyt, Annie Ma, Rachel Jimenez, Michelle Specht, Barbara L Smith, Brian Dontchos, Dennis Sgroi, Steven J Isakoff, Constance Lehman, Leif W Ellisen, Laura M Spring
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-21-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-21-01
Published: 15 February 2020
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Journal Articles

Abstract 2727: The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

Kirsten Kubler, Rosa Karlic, Nicholas J. Haradhvala, Kyungsik Ha, Jaegil Kim, Maja Kuzman, Wei Jiao, Sitanshu Gakkhar, Kent W. Mouw, Lior Z. Braunstein, Olivier Elemento, Andrew V. Biankin, Ilse Rooman, Mendy Miller, Christopher D. Nogiec, Edward Curry, Mari Mino-Kenudson, Leif W. Ellisen, Robert Brown, Alexander Gusev, Cristian Tomasetti, Hong-Gee Kim, Hwajin Lee, Kristian Vlahovicek, Charles Sawyers, Katherine A. Hoadley, Edwin Cuppen, Amnon Koren, Peter F. Arndt, David N. Louis, Lincoln Stein, William D. Foulkes, Paz Polak, Gad Getz
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2727.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2727
Published: 01 July 2019
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Journal Articles

Abstract 4992: Sirt6 loss increases stemness and defense against oxidative stress in tumor-propagating cells, promoting tumor growth and maintenance in squamous cell carcinoma

Jee-Eun Choi, Carlos Sebastian, Caroline Lewis, Murat Cetinbas, Gregory Wojtkiewicz, Ruslan Sadreyev, Leif W. Ellisen, Salvador Aznar-Benitah, Raul Mostoslavsky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4992.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4992
Published: 01 July 2018
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Journal Articles

Abstract 4828: Recapitulating mammary ductal carcinoma microenvironment in vitro using sacrificial bioprinting

Y. Shrike Zhang, Margaux Duchamp, Leif W. Ellisen, Marsha Moses, Ali Khademhosseini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4828.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4828
Published: 01 July 2017
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Journal Articles

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis

Lidia Rodriguez Calleja, Camille Jacques, François Lamoureux, Marc Baud'huin, Marta Tellez Gabriel, Thibaut Quillard, Debashish Sahay, Pierre Perrot, Jerome Amiaud, Celine Charrier, Regis Brion, Fernando Lecanda, Franck Verrecchia, Dominique Heymann, Leif W. Ellisen, Benjamin Ory
Journal: Cancer Research
Cancer Res (2016) 76 (11): 3236–3251.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2317
Published: 31 May 2016
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Includes: Supplementary data