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Journal Articles

Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer

Ganfei Xu, Rui Huang, Reziya Wumaier, Jiacheng Lyu, Minjing Huang, Yaya Zhang, Qingjian Chen, Wenting Liu, Mengyu Tao, Junjian Li, Zhonghua Tao, Bo Yu, Erxiang Xu, Lingfeng Wang, Guoying Yu, Olivier Gires, Lei Zhou, Wei Zhu, Chen Ding, Hongxia Wang
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3267–3285.
https://doi.org/10.1158/0008-5472.CAN-23-3998
Published: 01 October 2024
View article titled, Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer
Open the PDF for Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB271: Synergistic anti-tumor efficacy in olaparib-sensitive and -resistant models via simultaneously inhibition of USP1 and PARP

Shuqun Yang, Zhengtao Li, Lei Zhou, Feng Zhou, Xiaokang Qin, Liting Xue, Piaopiao Xu, Jianxing Tang, Wendy Wang, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB271.
https://doi.org/10.1158/1538-7445.AM2024-LB271
Published: 05 April 2024
View article titled, Abstract LB271: Synergistic anti-tumor efficacy in olaparib-sensitive and -resistant models via simultaneously inhibition of USP1 and PARP
Journal Articles

Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors

Feng Zhou, Lei Zhou, Ruina Wang, Liting Xue, Xiaokang Qin, Zhengtao Li, Jian Yu, Renhong Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5946.
https://doi.org/10.1158/1538-7445.AM2024-5946
Published: 22 March 2024
View article titled, Abstract 5946: ZM-412, a potent and selective KIF18A inhibitor with robust efficacy as monotherapy in CIN-positive tumors and in combination with MMAE-conjugated ADC in CIN-negative tumors
Journal Articles

Abstract 5447: Microtubule-associated protein MAP2 promotes drug resistance and cancer stemness in hepatocellular carcinoma through integrin dysregulation

Ut Kei Lou, Ka-Hei Lam, Huajian Yu, Jia Jian Loh, Ki-Fong Man, Lei Zhou, Yuan Gao, Tin-Lok Wong, Cheng-Han Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5447.
https://doi.org/10.1158/1538-7445.AM2024-5447
Published: 22 March 2024
View article titled, Abstract 5447: Microtubule-associated protein MAP2 promotes drug resistance and cancer stemness in hepatocellular carcinoma through integrin dysregulation
Journal Articles

N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression

Xinyue Zhang, Tianhong Su, Yifan Wu, Yuhong Cai, Lina Wang, Cong Liang, Lei Zhou, Shiyan Wang, Xiao-Xing Li, Sui Peng, Ming Kuang, Jun Yu, Lixia Xu
Journal: Cancer Research
Cancer Res (2024) 84 (6): 827–840.
https://doi.org/10.1158/0008-5472.CAN-23-1916
Published: 15 March 2024
View article titled, <em>N<sup>6</sup></em>-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Open the PDF for <em>N<sup>6</sup></em>-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression in another window
Includes: Supplementary data
Journal Articles

Abstract 1755: ADAR1-mediated RNA editing of SCD1 links lipid metabolism to gastric cancer drug resistance and self-renewal

Jia Jian Loh, Tin Lok Wong, Shixun Lu, Helen HN Yan, Hoi Cheong Siu, Ren Xi, Dessy Chan, Max JF Kam, Lei Zhou, Man Tong, John A. Copland, Leilei Chen, Jingping Yun, Suet Yi Leung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1755.
https://doi.org/10.1158/1538-7445.AM2023-1755
Published: 04 April 2023
View article titled, Abstract 1755: ADAR1-mediated RNA editing of SCD1 links lipid metabolism to gastric cancer drug resistance and self-renewal
Journal Articles

Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma

Ki-Fong Man, Lei Zhou, Ying-Tung Lam, Jun Yu, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5799.
https://doi.org/10.1158/1538-7445.AM2023-5799
Published: 04 April 2023
View article titled, Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma
Journal Articles

Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling

Huajian Yu, Lei Zhou, Jane Ho-Chun Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor WS Ma, Yanyan Wang, Xiang Zhang, Terence K Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2023-2433
Published: 04 April 2023
View article titled, Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling
Journal Articles

Abstract 6201: Identification of SP-002, a highly selective USP1 inhibitor effectively inhibits HRD tumor growth and displays low hematotoxicity risk

Feng Zhou, Zhengtao Li, Lei Zhou, Wei Zhu, Jiyan Zhang, Wenqing Yang, Liting Xue, Xiaokang Qin, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6201.
https://doi.org/10.1158/1538-7445.AM2023-6201
Published: 04 April 2023
View article titled, Abstract 6201: Identification of SP-002, a highly selective USP1 inhibitor effectively inhibits HRD tumor growth and displays low hematotoxicity risk
Journal Articles

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie Ma, Terence Kin Wah Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3102–3115.
https://doi.org/10.1158/0008-5472.CAN-21-2934
Published: 02 September 2022
View article titled, Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma
Open the PDF for Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors

Cuiqing Yang, Xiaohui Shao, Feng Zhou, Lei Zhou, Qi Deng, Yun Zhang, Guangcun Cheng, Yingying Hu, Huaiyuan Ma, Yadan Wu, Shuai Wang, Jie Zang, Lei Liu, Wenqing Yang, Yang Liu, Chunlei Xia, Jianzhong Hu, Ande Luo, Yayuan Fu, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6343.
https://doi.org/10.1158/1538-7445.AM2022-6343
Published: 15 June 2022
View article titled, Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors
Journal Articles

ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Cuicui Liu, Jiankun Qiang, Qiaodan Deng, Jie Xia, Lu Deng, Lei Zhou, Dong Wang, Xueyan He, Ying Liu, Botao Zhao, Jinhui Lv, Zuoren Yu, Qun-Ying Lei, Zhi-Ming Shao, Xiao-Yong Zhang, Lixing Zhang, Suling Liu
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5919–5934.
https://doi.org/10.1158/0008-5472.CAN-21-1337
Published: 01 December 2021
View article titled, ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression
Open the PDF for ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Jia-Jian Loh, Tsz-Wai Li, Lei Zhou, Tin-Lok Wong, Xue Liu, Victor W.S. Ma, Chung-Mau Lo, Kwan Man, Terence K. Lee, Wen Ning, Man Tong, Stephanie Ma
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5692–5705.
https://doi.org/10.1158/0008-5472.CAN-20-4226
Published: 15 November 2021
View article titled, FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness
Open the PDF for FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 6045: Interferon signaling induces NAD(H) consumption via PARP9/10/14 and sensitizes pancreatic cancer cells to NAMPT inhibition

Alexandra M. Moore, Lei Zhou, Shili Xu, Timothy R. Donahue
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6045.
https://doi.org/10.1158/1538-7445.AM2020-6045
Published: 15 August 2020
View article titled, Abstract 6045: Interferon signaling induces NAD(H) consumption via PARP9/10/14 and sensitizes pancreatic cancer cells to NAMPT inhibition
Journal Articles

Abstract 554: Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression

Stephanie S Kim, JING CUI, Shili Xu, Soumya Poddar, Thuc M. Le, Luyi Li, Nanping Wu, Alexandra Moore, Lei Zhou, Alice Yu, Amanda M. Dann, Irmina A. Elliott, Evan R. Abt, Woosuk Kim, David W. Dawson, Caius G. Radu, Timothy R. Donahue
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 554.
https://doi.org/10.1158/1538-7445.AM2020-554
Published: 15 August 2020
View article titled, Abstract 554: Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
Journal Articles

Abstract CT247: A phase 1/2 study of GB1275, a first-in-class CD11b modulator, as monotherapy and with an anti-PD-1 antibody in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Andrea Wang-Gillam, Drew W. Rasco, Wungki Park, Eileen O'Reilly, Wells Messersmith, David G. DeNardo, Vineet Gupta, Lei Zhou, Anna Galkin, Debbie Slee, Laura L. Carter, David Nickle, Rebecca Tran, Jack Li, Beatrice Ferguson, Marya F. Chaney, Luisa Salter-Cid, Jakob Dupont, Johanna C. Bendell
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT247.
https://doi.org/10.1158/1538-7445.AM2020-CT247
Published: 15 August 2020
View article titled, Abstract CT247: A phase 1/2 study of GB1275, a first-in-class CD11b modulator, as monotherapy and with an anti-PD-1 antibody in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)
Journal Articles

Abstract 4264: Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion

Shili Xu, Irmina A. Elliott, Amanda M. Dann, Stephanie S. Kim, Evan R. Abe, Woosuk Kim, Soumya Poddar, Alexandra Moore, Lei Zhou, Jennifer L. Williams, Joseph R. Capri, Razmik Ghukasyan, Cynthia Matsumura, D. Andrew Tucker, Wesley R. Armstrong, Anthony E. Cabebe, Nanping Wu, Luyi Li, Thuc M. Le, Caius G. Radu, Timothy R. Donahue
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4264.
https://doi.org/10.1158/1538-7445.AM2019-4264
Published: 01 July 2019
View article titled, Abstract 4264: Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion
Journal Articles

Abstract 5367: Elucidating the factors determining P53 binding and transcriptomic response to DNA damage

Varsha Sundaresan, Ying Li, Benedetto DiCiaccio, Victor T. Lin, Adrian A. Acuna Higaki, Nicole F. Pelletier, Jessica T. Cheung, Lei Zhou
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5367.
https://doi.org/10.1158/1538-7445.AM2018-5367
Published: 01 July 2018
View article titled, Abstract 5367: Elucidating the factors determining P53 binding and transcriptomic response to DNA damage
Journal Articles

Abstract 4496: Myofibroblast-secreted follistatin-like 1 promotes hepatocellular carcinoma formation and metastasis

Natalie Tsz Wai Li, Man Tong, Lei Zhou, Wen Ning, Chung-Mau Lo, Kwan Man, Terence Kin-Wah Lee, Stephanie Kwai-Yee Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4496.
https://doi.org/10.1158/1538-7445.AM2018-4496
Published: 01 July 2018
View article titled, Abstract 4496: Myofibroblast-secreted follistatin-like 1 promotes hepatocellular carcinoma formation and metastasis
Journal Articles

Abstract 901: Antibody-mediated blockade of annexin A3 (ANXA3) synergistically enhances the efficacy of sorafenib and regorafenib for hepatocellular carcinoma

Man Tong, Noelia Che, Lei Zhou, Phillis W. Kau, Steve T. Luk, Xin Chen, Jin Ding, Terence K. Lee, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 901.
https://doi.org/10.1158/1538-7445.AM2018-901
Published: 01 July 2018
View article titled, Abstract 901: Antibody-mediated blockade of annexin A3 (ANXA3) synergistically enhances the efficacy of sorafenib and regorafenib for hepatocellular carcinoma