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Journal Articles

Abstract A080: An analysis of outcomes in patients (pts) with advanced pancreatic cancer (PDAC) whose tumors harbor pathogenic BRCA1 or BRCA2 mutations based on gene mutation location

Jamie Hur, Thomas McPhaul, Dea Cunningham, Lei Zheng, Christopher J Pishvaian, Daniel Laheru, Ana De Jesus-Acosta, Dung Le, Neeha Zaidi, Nilo Azad, Ilene Browner, William R Burns, Richard Burkhart, Kelly Lafaro, Amol Narang, Jin He, Valerie Lee, Jonathan R Brody, Michael J Pishvaian
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A080.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A080
Published: 15 September 2024
View article titled, Abstract A080: An analysis of outcomes in patients (pts) with advanced pancreatic cancer (PDAC) whose tumors harbor pathogenic BRCA1 or BRCA2 mutations based on gene mutation location
Journal Articles

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma

Samantha Guinn, Benedict Kinny-Köster, Joseph A. Tandurella, Jacob T. Mitchell, Dimitrios N. Sidiropoulos, Melanie Loth, Melissa R. Lyman, Alexandra B. Pucsek, Daniel J. Zabransky, Jae W. Lee, Emma Kartalia, Mili Ramani, Toni T. Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L. Wolfgang, Jun Yu, Lei Zheng, David P. Ryan, David T. Ting, Alec Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H. Elisseeff, Laura D. Wood, Genevieve Stein-O'Brien, Luciane T. Kagohara, Elizabeth M. Jaffee, Richard A. Burkhart, Elana J. Fertig, Jacquelyn W. Zimmerman
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1517–1533.
https://doi.org/10.1158/0008-5472.CAN-23-1660
Published: 02 May 2024
View article titled, Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
Open the PDF for Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT134: Safety and immunologic impact of neoadjuvant/adjuvant GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) combined with cyclophosphamide, pembrolizumab, and macrophage-targeting CSF1R inhibitor IMC-CS4 in pancreatic adenocarcinoma

Arielle Urman, Yingjun Ding, Hao Wang, Richard A. Burkhart, Jin He, Elizabeth M. Jaffee, Amol K. Narang, Dung Le, Daniel A. Laheru, Lei Zheng, Ana De Jesus-Acosta
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT134.
https://doi.org/10.1158/1538-7445.AM2024-CT134
Published: 05 April 2024
View article titled, Abstract CT134: Safety and immunologic impact of neoadjuvant/adjuvant GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) combined with cyclophosphamide, pembrolizumab, and macrophage-targeting CSF1R inhibitor IMC-CS4 in pancreatic adenocarcinoma
Journal Articles

Abstract 1444: Modeling Twist1 overexpression in a pancreatic ductal adenocarcinoma mouse model

Muhammad Ajmal Khan, Jinhee Chang, Triet Nguyen, Danielle N. Council, Dipanwita Dutta Chowdhury, Amol Shetty, Yang Song, Aaron Chan, Christine Lam, Priyanshi Patel, Lucas Tran, Jiayu Chen, Katriana Nugent, Matthew Ballew, Ghali Lemtiri-Chlieh, Francesca A. Carrieri, Reem Malek, Hailun Wang, Noelle R. Thielman, Keyu Li, Lei Zheng, Kathleen Gabrielson, Phuoc T. Tran, Audrey Lafargue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1444.
https://doi.org/10.1158/1538-7445.AM2024-1444
Published: 22 March 2024
View article titled, Abstract 1444: Modeling <em>Twist1</em> overexpression in a pancreatic ductal adenocarcinoma mouse model
Journal Articles

Abstract 6736: Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration

Keyu Li, Junke Wang, Birginia Espinoza, Yirui Xiong, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He, Jialong Yuan, Diego Trafton, Chunhui Yuan, Michael Wichroski, Xubao Liu, Yuquan Wei, Lei Zheng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6736.
https://doi.org/10.1158/1538-7445.AM2024-6736
Published: 22 March 2024
View article titled, Abstract 6736: Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration
Journal Articles

Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders

Dimitrios N. Sidiropoulos, Sarah M. Shin, Alexander Girgis, Daniel H. Shu, Janelle Montagne, Atul Deshpande, Jeanette A. Johnson, Lucie Dequiedt, Victoria Jacobs, Aleksandra Ogurtsova, Guanglan Mo, Xuan Yuan, Genevieve Stein-O’Brien, Mark Yarchoan, Qingfeng Zhu, Ashley Kiemen, Elizabeth M. Jaffee, Lei Zheng, Won Jin Ho, Robert Anders, Elana J. Fertig, Luciane T. Kagohara
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1159.
https://doi.org/10.1158/1538-7445.AM2024-1159
Published: 22 March 2024
View article titled, Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders
Journal Articles

Abstract 2513: Distinct cancer-intrinsic mechanisms mediate nerve recruitment/outgrowth versus perineural invasion

William L. Hwang, Jennifer Su, Carina Shiau, Peter L. Wang, Jimmy A. Guo, Nicole A. Lester, Jaimie L. Barth, Hannah I. Hoffman, Prajan Divakar, Jason W. Reeves, Eric Miller, Joseph M. Beechem, Andrew J. Aguirre, Lei Zheng, David T. Ting, Mari Mino-Kenudson, Tyler Jacks
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2513.
https://doi.org/10.1158/1538-7445.AM2023-2513
Published: 04 April 2023
View article titled, Abstract 2513: Distinct cancer-intrinsic mechanisms mediate nerve recruitment/outgrowth versus perineural invasion
Journal Articles

Abstract 4168: BALB/c-CD3EDG HuGEMMTM mouse model for evaluation of CD3-targeted tumor immunotherapy

Demi Xiaojuan Liu, Kaixia Lian, Xuefei Yan, Jie Lin, Lei Zheng, Annie Xiaoyu An, Xiaoxi Xu, Ludovic Bourre, Jingjing Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4168.
https://doi.org/10.1158/1538-7445.AM2023-4168
Published: 04 April 2023
View article titled, Abstract 4168: BALB/c-CD3EDG HuGEMM<sup>TM</sup> mouse model for evaluation of CD3-targeted tumor immunotherapy
Journal Articles

Abstract 3241: Single-cell RNA and TCR sequencing of tumor infiltrating lymphocytes identifies changes in pancreatic ductal adenocarcinomas following neoadjuvant treatment with combined anti-PD-1 blocking and anti-CD137 agonist therapy

Joseph A. Tandurella, Jacob T. Mitchell, Janelle M. Montagne, Eric Christenson, Qingfeng Zhu, Ludmilla V. Danilova, Alexander V. Favorov, Won J. Ho, Luciane T. Kagohara, Melanie Loth, Su Jin Lim, Rui Zheng, Jessica Gai, Sarah Mitchell, Dimitrios N. Sidiropoulos, Wenpin Hou, Yao Xu, Hao Wang, Jacquelyn W. Zimmerman, Srinivasan Yegnasubramanian, Robert Anders, Elizabeth M. Jaffee, Lei Zheng, Elana J. Fertig
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3241.
https://doi.org/10.1158/1538-7445.AM2023-3241
Published: 04 April 2023
View article titled, Abstract 3241: Single-cell RNA and TCR sequencing of tumor infiltrating lymphocytes identifies changes in pancreatic ductal adenocarcinomas following neoadjuvant treatment with combined anti-PD-1 blocking and anti-CD137 agonist therapy
Journal Articles

Abstract 2768: Non-invasive detection of pancreatic adenocarcinoma using Ga-68 labelled epha2 targeting peptide

Ajay Kumar Sharma, Kuldeep Gupta, Akhilesh Mishra, Sophia Chen, Gabriela Lofland, Todd Armstrong, Edward Gabrielson, Lei Zheng, Elizabeth M. Jaffee, Sridhar Nimmagadda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2768.
https://doi.org/10.1158/1538-7445.AM2023-2768
Published: 04 April 2023
View article titled, Abstract 2768: Non-invasive detection of pancreatic adenocarcinoma using Ga-68 labelled epha2 targeting peptide
Journal Articles

Abstract 52: Characterization of murine intrahepatic cholangiocarcinoma homograft models for therapeutic evaluation

Jinxi Wang, Leilei Chen, Likun Zhang, Lei Zheng, Ludovic Bourre, Jingjing Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 52.
https://doi.org/10.1158/1538-7445.AM2023-52
Published: 04 April 2023
View article titled, Abstract 52: Characterization of murine intrahepatic cholangiocarcinoma homograft models for therapeutic evaluation
Journal Articles

Abstract C052: Identifying mediators of perineural invasion in pancreatic cancer using spatial transcriptomics

William L. Hwang, Jennifer Su, Jimmy A. Guo, Carina Shiau, Jaimie L. Barth, Hannah I. Hoffman, Prajan Divakar, Jason W. Reeves, Eric Miller, Grissel Cervantes-Jaramillo, William Freed-Pastor, Vanessa Funes, Jennifer Y. Wo, Theodore S. Hong, Carlos Fernandez-del Castillo, Lei Zheng, Andrew J. Aguirre, David T. Ting, Mari Mino-Kenudson, Tyler Jacks
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C052.
https://doi.org/10.1158/1538-7445.PANCA22-C052
Published: 15 November 2022
View article titled, Abstract C052: Identifying mediators of perineural invasion in pancreatic cancer using spatial transcriptomics
Journal Articles

Abstract LB099: Direct identification of MHC class I and class II epitopes for TCR-based T cell therapy for pancreatic cancer

Tengyi Zhang, Jianxin Wang, Yingkuan Shao, Pan Li, Nan Niu, Brian Herbst, Jessica Gai, Juan Fu, Pingbo Zhang, Jun Yu, Kenji Fujiwara, Lei Zheng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB099.
https://doi.org/10.1158/1538-7445.AM2022-LB099
Published: 15 June 2022
View article titled, Abstract LB099: Direct identification of MHC class I and class II epitopes for TCR-based T cell therapy for pancreatic cancer
Journal Articles

Abstract 502: In vitro characterization of antibodies targeting the SIRPα-CD47 phagocytosis checkpoint using tumor-associated macrophages from HuGEMM™ mice

Xuefei Yan, Hongjuan Zhang, Yi Liu, Yahong Zhang, Lei Zheng, Mingfa Zang, Annie Xiaoyu An, kevin Qijin Xu, Davy Ouyang, Henry Li, Yujun Huang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 502.
https://doi.org/10.1158/1538-7445.AM2021-502
Published: 01 July 2021
View article titled, Abstract 502: <em>In vitro</em> characterization of antibodies targeting the SIRPα-CD47 phagocytosis checkpoint using tumor-associated macrophages from HuGEMM™ mice
Journal Articles

Abstract 1810: Anti-human TNFR2 antagonist induces T cell proliferation and restores T cell balance to promote tumor killing in TNFR2 HuGEMM™ engrafted with MC38/OVA tumor cells

Daniel X. He, Lei Zheng, Ruilin Sun, Annie X. An, Henry Q.x. Li, Davy Xuesong Ouyang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2021-1810
Published: 01 July 2021
View article titled, Abstract 1810: Anti-human TNFR2 antagonist induces T cell proliferation and restores T cell balance to promote tumor killing in TNFR2 HuGEMM™ engrafted with MC38/OVA tumor cells
Journal Articles

Abstract 1809: In vitro and in vivo characterization of human CD3EDG triple knock-in mice (CD3EDG HuGEMM™) for CD3 bispecific antibody evaluation

Daniel X. He, Lei Zheng, Tianyi Qian, Annie X. An, Henry Q.x. Li, Davy Xuesong Ouyang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1809.
https://doi.org/10.1158/1538-7445.AM2021-1809
Published: 01 July 2021
View article titled, Abstract 1809: <em>In vitro</em> and <em>in vivo</em> characterization of human CD3EDG triple knock-in mice (CD3EDG HuGEMM™) for CD3 bispecific antibody evaluation
Journal Articles

Abstract PR-004: Systemic and intratumoral immune profiling in metastatic pancreatic cancer patients who received front-line FOLFIRINOX and were treated with combination immunotherapy with CTLA-4 blockade in the maintenance setting

Annie A. Wu, Katherine M. Bever, Won Jin Ho, Elana J. Fertig, Nan Niu, Lei Zheng, Rose M. Parkinson, Jennifer N. Durham, Beth Onners, Anna K. Ferguson, Cara Wilt, Andrew H. Ko, Andrea Wang-Gillam, Daniel A. Laheru, Robert A. Anders, Elizabeth D. Thompson, Elizabeth A. Sugar, Elizabeth M. Jaffee, Dung T. Le
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-004.
https://doi.org/10.1158/1538-7445.PANCA20-PR-004
Published: 13 November 2020
View article titled, Abstract PR-004: Systemic and intratumoral immune profiling in metastatic pancreatic cancer patients who received front-line FOLFIRINOX and were treated with combination immunotherapy with CTLA-4 blockade in the maintenance setting
Journal Articles

Abstract 1588: PEGylated recombinant human hyaluronidase, PEGPH20, significantly enhances the anti-tumor activity of the combination of focal adhesion kinase Inhibitor and anti-PD-1 antibody by targeting CXCR4-expressing myeloid cells in a murine model of PDAC

Arsen Osipov, Jianxin Wang, Shiqi Li, David Choi, Mackenzie Henderson, Jonathan Pachter, Jisook Lee, Dan Maneval, Lei Zheng, Alex Blair
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1588.
https://doi.org/10.1158/1538-7445.AM2020-1588
Published: 15 August 2020
View article titled, Abstract 1588: PEGylated recombinant human hyaluronidase, PEGPH20, significantly enhances the anti-tumor activity of the combination of focal adhesion kinase Inhibitor and anti-PD-1 antibody by targeting CXCR4-expressing myeloid cells in a murine model of PDAC
Journal Articles

Abstract 5615: Anti-human CD47 antibody Hu5F9 inhibits MC38 tumor growth in hCD47/hSIRPα double knock-in mice

Daniel Xianfei He, Chenpan Nie, Lei Zheng, Ruilin Sun, Annie Xiaoyu An, Henry Q. x. Li, Davy Xuesong Ouyang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5615.
https://doi.org/10.1158/1538-7445.AM2020-5615
Published: 15 August 2020
View article titled, Abstract 5615: Anti-human CD47 antibody Hu5F9 inhibits MC38 tumor growth in hCD47/hSIRPα double knock-in mice
Journal Articles

Abstract 5614: Combination of anti-TIGIT and anti-PD-1 antibodies enhance antitumor response in a PD-1/TIGIT double HuGEMM™ model engrafted with mouse syngeneic tumors

Daniel Xianfei He, Chenpan Nie, Lei Zheng, Ruilin Sun, Mingkun Zhang, Annie Xiaoyu An, Cunxiang Ju, Henry Q. X. Li, Davy Xuesong Ouyang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5614.
https://doi.org/10.1158/1538-7445.AM2020-5614
Published: 15 August 2020
View article titled, Abstract 5614: Combination of anti-TIGIT and anti-PD-1 antibodies enhance antitumor response in a PD-1/TIGIT double HuGEMM™ model engrafted with mouse syngeneic tumors