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Journal Articles

Abstract 638: Discovery of HX016-7, a novel PD-L1 x VEGF BsAb, as a new candidate treatment of solid tumors

Hang Ke, Tao Yang, Feiyu Peng, Jialing Li, Cen Chen, Stephen Xiong, Lei Zhang, Faming Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 638.
https://doi.org/10.1158/1538-7445.AM2025-638
Published: 21 April 2025
View articletitled, Abstract 638: Discovery of HX016-7, a novel PD-L1 x VEGF BsAb, as a new candidate treatment of solid tumors
Journal Articles

Abstract 3236: Analytical validation of a tumor-agnostic DNA methylation-based assay for minimal residual disease detection in lung cancer

Bo Yang, Yuan Sun, Lei Wang, Peiru Liu, Simei Qiu, Lei Chen, Fujun Qiu, Yalan Jin, Shuailai Wu, Yu Xu, Lei Zhang, Zhihong Zhang, Kezhong Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3236.
https://doi.org/10.1158/1538-7445.AM2025-3236
Published: 21 April 2025
View articletitled, Abstract 3236: Analytical validation of a tumor-agnostic DNA methylation-based assay for minimal residual disease detection in lung cancer
Journal Articles

Abstract 6026: HX016-9, a novel PD1xVEGF BsAb, as a new candidate treatment of solid tumors

Hang Ke, Tao Yang, Feiyu Peng, Jialing Li, Cen Chen, Lei Zhang, Stephen Xiong, Faming Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6026.
https://doi.org/10.1158/1538-7445.AM2025-6026
Published: 21 April 2025
View articletitled, Abstract 6026: HX016-9, a novel PD1xVEGF BsAb, as a new candidate treatment of solid tumors
Journal Articles

Abstract 5501: An integrated end-to-end platform facilitating the evaluation of next generation KRAS inhibitors

Di Zhan, Lingling Huang, Lei Zhang, Ting Ma, Yuzhou Xu, Yinfei Yin, Zichun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5501.
https://doi.org/10.1158/1538-7445.AM2025-5501
Published: 21 April 2025
View articletitled, Abstract 5501: An integrated end-to-end platform facilitating the evaluation of next generation KRAS inhibitors
Journal Articles

Abstract 6076: Non-clinical pharmacology of HX044, a novel FIC CTLA4xCD47 bi-specific antibody

Hang Ke, Tao Yang, Feiyu Peng, Jialing Li, Cen Chen, Lingxin Xiong, Ruiling Sun, Lei Zhang, Faming Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6076.
https://doi.org/10.1158/1538-7445.AM2025-6076
Published: 21 April 2025
View articletitled, Abstract 6076: Non-clinical pharmacology of HX044, a novel FIC CTLA4xCD47 bi-specific antibody
Journal Articles

Abstract 6022: YH006: a next-generation CTLA-4×OX40 Treg antagonist, demonstrates superior tumor-infiltrating Treg-depletion efficacy and favorable manufacturability

Sarah Chan, Baihong Liu, Bahetiyaer Huwatibieke, Jing Zhang, Yang Chen, Minjuan Meng, Wenchao Zheng, Lei Zhang, Yi Yang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6022.
https://doi.org/10.1158/1538-7445.AM2025-6022
Published: 21 April 2025
View articletitled, Abstract 6022: YH006: a next-generation CTLA-4×OX40 Treg antagonist, demonstrates superior tumor-infiltrating Treg-depletion efficacy and favorable manufacturability
Journal Articles

Abstract 4788: Discovery of HX035, an OX40-bi-epitope bi-specific antibody (BsAb), for the treatment of inflammatory/autoimmune diseases

Hang Ke, Tao Yang, Feiyu Peng, Jialing Li, Cen Chen, Peixuan Song, Lei Zhang, Faming Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4788.
https://doi.org/10.1158/1538-7445.AM2025-4788
Published: 21 April 2025
View articletitled, Abstract 4788: Discovery of HX035, an OX40-bi-epitope bi-specific antibody (BsAb), for the treatment of inflammatory/autoimmune diseases
Journal Articles

Abstract 3134: Preclinical anti-glioblastoma pharmacology of HX301, a novel CSF-1R inhibitor

Tao Yang, Hang Ke, Jessie Wang, Steven Xiong, Lei Zhang, Faming Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3134.
https://doi.org/10.1158/1538-7445.AM2025-3134
Published: 21 April 2025
View articletitled, Abstract 3134: Preclinical anti-glioblastoma pharmacology of HX301, a novel CSF-1R inhibitor
Journal Articles

Abstract 3018: Discovery of SIGX1094R, a novel FAK inhibitor simultaneously blocking FAK and SRC signaling

Haisheng Zhang, Shu Zhuo, Lei Zhang, Lin Li, Wanfen Peng, Fengtao Jiang, Yufang Chen, Lin Lin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3018.
https://doi.org/10.1158/1538-7445.AM2025-3018
Published: 21 April 2025
View articletitled, Abstract 3018: Discovery of SIGX1094R, a novel FAK inhibitor simultaneously blocking FAK and SRC signaling
Journal Articles

Abstract 985: An effective cfDNA methylation-based assay in discriminating primary liver cancer from cirrhosis or chronic hepatitis virus infection: marker discovery, phase I pilot, and phase II clinical validation

Yang Tian, Yanan Wang, Mingxin Pan, Lei Zhang, Qiancheng You, Bingsi Li, Shangli Cai, Feng Shen, Guoyue Lv
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 985.
https://doi.org/10.1158/1538-7445.AM2024-985
Published: 22 March 2024
View articletitled, Abstract 985: An effective cfDNA methylation-based assay in discriminating primary liver cancer from cirrhosis or chronic hepatitis virus infection: marker discovery, phase I pilot, and phase II clinical validation
Journal Articles

Abstract 1808: Discovery of highly selective novel MTA-cooperative PRMT5 inhibitors for the treatment of cancers

Wen-Lian Wu, Taishan Hu, Zhilin Deng, Honghai Li, Quanrong Shen, Lei Zhang, Xiaochu Ma, Peihua Sun, Cindy Cheng, Fang Liu, Xin Chen, Ye Hua, Bryan Huang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1808.
https://doi.org/10.1158/1538-7445.AM2024-1808
Published: 22 March 2024
View articletitled, Abstract 1808: Discovery of highly selective novel MTA-cooperative PRMT5 inhibitors for the treatment of cancers
Journal Articles

The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response

Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1834–1850.
https://doi.org/10.1158/0008-5472.CAN-22-2485
Published: 02 June 2023
View articletitled, The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response
Open the PDF for The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response in another window
Includes: Supplementary data
Journal Articles

Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors

Jonathan A. Terrett, Demetrios Kalaitzidis, Mary-Lee Dequeant, Sushant Karnik, Mohammed Ghonime, Changan Guo, Robert Chain, Heidi Heath, Nivedita Jaishankar, Rachel Yuen, Davis Settipane, Zinkal Padalia, Lauren Zakas, Meghna Kuppuraju, Paul Tetteh, Chandirasegaran Massilamany, Brigid McEwan, Glenn Leary, Henia Dar, Daniel Ferulo, Melanie Allen, Kimberley Tipton, Laura Serwer, Thao Nguyen, Melanie Butler-Gauthier, Parin Sripakdeevong, Shashwat D. Nagar, Yin Tang, Hemangi Chaudhari, Nicole Flanagan, Elaine Huang, Shashwant Phuyal, Elizabeth Koch, Andrew Dunn, Erisa Sula, Jacob Waldman, Cristian Loaiza, Maria Lei Zhang, Erin Thorstensen, Keith Steiger, Katie Schum, Kayla Urbaez, Mark Benton, Anna Ma, Sarah Cohen, Annie Weaver, Christopher Finch, Phuong Khanh Morrow
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): ND02.
https://doi.org/10.1158/1538-7445.AM2023-ND02
Published: 29 May 2023
View articletitled, Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors
Journal Articles

Abstract 5665: HX301 (ON1232580) a novel kinase inhibitor with potent activity against CSF1R and FLT3, shows strong anti-AML activity in defined preclinical models

Xiaoyu An, Henry Li, Linda Xue, Jinping Liu, Lingxin Xiong, Hang Ke, Cen Chen, Bing Gao, Jia Zheng, Zhengzheng Bao, Sheng Guo, Lei Zhang, Faming Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5665.
https://doi.org/10.1158/1538-7445.AM2023-5665
Published: 04 April 2023
View articletitled, Abstract 5665: HX301 (ON1232580) a novel kinase inhibitor with potent activity against CSF1R and FLT3, shows strong anti-AML activity in defined preclinical models
Journal Articles

Abstract 429: Efficacy of JSI-1187 or VIC-1911 in combination with KRAS G12C inhibitors for the treatment of KRAS G12C-mutated non-small cell lung cancer and colorectal cancer

Lei Zhang, Ao Li, Shanzhong Jian, Chengyi Du, Wan Zhu, Yue Tao, Meiwei Wang, Wen Xu, Wenshan Hao, Linda Paradiso, Thomas Myers, Keizo Koya, Jintao Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 429.
https://doi.org/10.1158/1538-7445.AM2023-429
Published: 04 April 2023
View articletitled, Abstract 429: Efficacy of JSI-1187 or VIC-1911 in combination with KRAS G12C inhibitors for the treatment of KRAS G12C-mutated non-small cell lung cancer and colorectal cancer
Journal Articles

Abstract 2980: HX009, a first-in-class PD1xCD47 BsAb, demonstrated anti-AML activity in PDX models

Xiaoyu An, Jinping Liu, Hang Ke, Lingxin Xiong, Xiaolong Tu, Lei Zhang, Faming Zhang, Henry Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2980.
https://doi.org/10.1158/1538-7445.AM2023-2980
Published: 04 April 2023
View articletitled, Abstract 2980: HX009, a first-in-class PD1xCD47 BsAb, demonstrated anti-AML activity in PDX models
Journal Articles

Abstract 6345: Non-clinical pharmacology of HX009, a novel FIC PD1xCD47 BsAb

Faming Zhang, Hang Ke, Feiyu Peng, Cen Chen, Lei Zhang, Henry Qixiang Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6345.
https://doi.org/10.1158/1538-7445.AM2023-6345
Published: 04 April 2023
View articletitled, Abstract 6345: Non-clinical pharmacology of HX009, a novel FIC PD1xCD47 BsAb
Journal Articles

Ancient Human Endogenous Retroviruses Contribute to Genetic Evolution and Regulate Cancer Cell Type–Specific Gene Expression

Mingyue Chen, Lei Jia, Xiaofeng Zheng, Mingshu Han, Lin Li, Lei Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3457–3473.
https://doi.org/10.1158/0008-5472.CAN-22-0290
Published: 04 October 2022
View articletitled, Ancient Human Endogenous Retroviruses Contribute to Genetic Evolution and Regulate Cancer Cell Type–Specific Gene Expression
Open the PDF for Ancient Human Endogenous Retroviruses Contribute to Genetic Evolution and Regulate Cancer Cell Type–Specific Gene Expression in another window
Includes: Supplementary data
Journal Articles

Abstract 2130: Uncovering the spatial landscape of tumor-immune interactions using latent spaces from spatial transcriptomics

Atul Deshpande, Melanie Loth, Dimitrios Sidiropoulos, QingFeng Zhu, Genevieve Stein-O'Brien, NIkhil Rao, Cedric Uytingco, Stephen Williams, Cesar Santa-Maria, Daniele M. Gilkes, Lei Zhang, Elizabeth Jaffee, Robert Anders, Ludmila Danilova, Luciane T. Kagohara, Elana J. Fertig
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2130.
https://doi.org/10.1158/1538-7445.AM2022-2130
Published: 15 June 2022
View articletitled, Abstract 2130: Uncovering the spatial landscape of tumor-immune interactions using latent spaces from spatial transcriptomics
Journal Articles

Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer

Kumaravel Mohankumar, Gus Wright, Subhashree Kumaravel, Rupesh Shrestha, Lei Zhang, Maen Abdelrahim, Robert S. Chapkin, Stephen Safe
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 236.
https://doi.org/10.1158/1538-7445.AM2022-236
Published: 15 June 2022
View articletitled, Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer