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Journal Articles

Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression

Yani Pan, Yue Zhou, Yonghua Shen, Lei Xu, Hongwen Liu, Nannan Zhang, Tianlu Huang, Kui Meng, Yu Liu, Lishan Wang, Ge Bai, Qi Chen, Yun Zhu, Xiaoping Zou, Siliang Wang, Zhangding Wang, Lei Wang
Journal: Cancer Research
Cancer Res (2024) 84 (22): 3803–3817.
https://doi.org/10.1158/0008-5472.CAN-24-0088
Published: 15 November 2024
View article titled, Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Open the PDF for Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract PR-004: Targeting EPHB2/ABL1 restores anti-tumor immunity in a preclinical model of ependymoma

Taylor P. Uccello, Jun Ren, Zohreh Amoozgar, Yuhui Zhao, Pin-Ji Lei, William W. Ho, Sylvie Roberge, Peigen Huang, Dan G. Duda, Lei Xu, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): PR-004.
https://doi.org/10.1158/1538-7445.BRAIN23-PR-004
Published: 04 March 2024
View article titled, Abstract PR-004: Targeting EPHB2/ABL1 restores anti-tumor immunity in a preclinical model of ependymoma
Journal Articles

Abstract A104: Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity

Yao Sun, Zhenzhen Yin, Limeng Wu, Changli Yue, Sonu Subudhi, Pinji Lei, Alona Muzikansky, Bo R. Rueda, Lei Xu
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): A104.
https://doi.org/10.1158/1538-7445.OVARIAN23-A104
Published: 04 March 2024
View article titled, Abstract A104: Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity
Journal Articles

Abstract CT253: Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with nectin-4 associated advanced malignancies

Thomas R. Evans, Afshin Dowlati, Juanita S. Lopez, Mohammed M. Milhem, Jordi Rodón Ahnert, Alexander Spira, Richard D. Carvajal, Matthew Zibelman, Sebastien J. Hazard, Amy Dickson, Lei Xu, Heather Cohen, Justin Bader, Kristen Hurov, Rajiv Sharma, Dominic Smethurst, Kyriakos P. Papadopoulos
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT253.
https://doi.org/10.1158/1538-7445.AM2023-CT253
Published: 14 April 2023
View article titled, Abstract CT253: Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with nectin-4 associated advanced malignancies
Journal Articles

Abstract 2343: Targeting EPHB2/ABL1 restores anti-tumor immunity in a preclinical model of ependymoma

Jun Ren, Zohreh Amoozgar, Yuhui Zhao, Pinji Lei, William W. Ho, Sylvie Robergea, Peigen Huang, Dan G. Duda, Lei Xu, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2343.
https://doi.org/10.1158/1538-7445.AM2023-2343
Published: 04 April 2023
View article titled, Abstract 2343: Targeting EPHB2/ABL1 restores anti-tumor immunity in a preclinical model of ependymoma
Journal Articles

Abstract LB-261: Association between tumor mutational burden (TMB) assessed by whole-exome sequencing (WES) and outcomes of pembrolizumab (pembro) monotherapy

Razvan Cristescu, Deepti Aurora-Garg, Andrew Albright, Lei Xu, Xiao Qiao Liu, Andrey Loboda, Lixin Lang, Fan Jin, Alexandra Snyder, Jared Lunceford
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-261.
https://doi.org/10.1158/1538-7445.AM2020-LB-261
Published: 15 August 2020
View article titled, Abstract LB-261: Association between tumor mutational burden (TMB) assessed by whole-exome sequencing (WES) and outcomes of pembrolizumab (pembro) monotherapy
Journal Articles

Abstract CT073: Pembrolizumab after two or more lines of prior therapy in patients with advanced small-cell lung cancer (SCLC): Results from the KEYNOTE-028 and KEYNOTE-158 studies

Hyun Cheol Chung, Sarina A. Piha-Paul, Jose Lopez-Martin, Jan H.M. Schellens, Steven Kao, Wilson H. Miller, Jr., Jean-Pierre Delord, Bo Gao, David Planchard, Maya Gottfried, Alona Zer, Shadia I. Jalal, Nicolas Penel, Janice M. Mehnert, Ignacio Matos, Jaafar Bennouna, Dong-Wan Kim, Lei Xu, Suba Krishnan, Kevin Norwood, Patrick A. Ott
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT073.
https://doi.org/10.1158/1538-7445.AM2019-CT073
Published: 01 July 2019
View article titled, Abstract CT073: Pembrolizumab after two or more lines of prior therapy in patients with advanced small-cell lung cancer (SCLC): Results from the KEYNOTE-028 and KEYNOTE-158 studies
Journal Articles

Abstract 2580: Investigation of plasma exosomal miRNA as a biomarker and its potential function in prostate cancer castration resistant development

Tianyu Guo, Yang Wang, Xueying Mao, Lei Xu, Jacek Marzec, Edwina Burke, Glenda Scandura, Elzbieta Stankiewicz, Caitlin R. Davies, John Hines, Greg Shaw, Jonathan Shamash, Daniel Berney, Prabhakar Rajan, Karen Tipples, Alistair Grey, Yong-jie Lu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2580.
https://doi.org/10.1158/1538-7445.AM2019-2580
Published: 01 July 2019
View article titled, Abstract 2580: Investigation of plasma exosomal miRNA as a biomarker and its potential function in prostate cancer castration resistant development
Journal Articles

Abstract 341: The role of telomere protective protein TPP1 in hepatocellular carcinoma

Jiang Zou, Ru Sun, Jingruo Xia, Dan Xiao, Chang Liu, Hebin Liao, Lei Xu, Qiang Ma, Yan Cai, Jingdong Li, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 341.
https://doi.org/10.1158/1538-7445.AM2018-341
Published: 01 July 2018
View article titled, Abstract 341: The role of telomere protective protein TPP1 in hepatocellular carcinoma
Journal Articles

Abstract 3951: NVP-BEZ235 decreases mutant p53 and affects miR-23a-24a-27a to inhibit metastasis in breast cancer cells

Jiajing Cai, Jingruo Xia, Dan Xiao, Chang Liu, Hebin Liao, Lei Xu, Dongsheng Wang, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3951.
https://doi.org/10.1158/1538-7445.AM2018-3951
Published: 01 July 2018
View article titled, Abstract 3951: NVP-BEZ235 decreases mutant p53 and affects miR-23a-24a-27a to inhibit metastasis in breast cancer cells
Journal Articles

Abstract 2577: Expression of P53/PTEN/c-Myc in peripheral blood leukocytes from patients with breast cancer and its clinical significance

Guangcheng Huang, Qiang Ma, Jiang Zou, Ru Sun, Lihua Yao, Lei Xu, Dongsheng Wang, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2577.
https://doi.org/10.1158/1538-7445.AM2017-2577
Published: 01 July 2017
View article titled, Abstract 2577: Expression of P53/PTEN/c-Myc in peripheral blood leukocytes from patients with breast cancer and its clinical significance
Journal Articles

Abstract 5745: Study on telomere shelterin component TPP1 in esophageal squamous cell carcinoma

Lihua Yao, Jiang Zou, Ru Sun, Jiajing Cai, Guangcheng Huang, Qiang Ma, Lei Xu, Mayong Fu, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5745.
https://doi.org/10.1158/1538-7445.AM2017-5745
Published: 01 July 2017
View article titled, Abstract 5745: Study on telomere shelterin component TPP1 in esophageal squamous cell carcinoma
Journal Articles

Abstract B59: Mathematical Model of Oxygen Transport in Tuberculosis Granulomas

Meenal Datta, Laura Via, Wei Chen, James Baish, Lei Xu, Clfton Barry, Rakesh Jain
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): B59.
https://doi.org/10.1158/1538-7445.EPSO16-B59
Published: 16 January 2017
View article titled, Abstract B59: Mathematical Model of Oxygen Transport in Tuberculosis Granulomas
Journal Articles

Abstract C32: The function of GPR56 in metastasis formation of melanoma

Nancy Corson, Liquan Yang, Lei Xu
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): C32.
https://doi.org/10.1158/1538-7445.TME16-C32
Published: 28 July 2016
View article titled, Abstract C32: The function of GPR56 in metastasis formation of melanoma
Journal Articles

Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloepper, Lars Riedemann, Zohreh Amoozgar, Giorgio Seano, Katharina H. Susek, Veronica Yu, Nisha Dalvie, Robin L. Amelung, Meenal Datta, Jonathan W. Song, Vasileios Askoxylakis, Jennie W. Taylor, Christine Lu-Emerson, Ana Batista, Nathaniel D. Kirkpatrick, Keehoon Jung, Matija Snuderl, Alona Muzikansky, Kay G. Stubenrauch, Oliver Krieter, Hiroaki Wakimoto, Lei Xu, Lance L. Munn, Dan G. Duda, Dai Fukumura, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-347.
https://doi.org/10.1158/1538-7445.AM2016-LB-347
Published: 15 July 2016
View article titled, Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
Journal Articles

Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Zohreh Amoozgar, Teresa E. Peterson, Nathaniel D. Kirkpatrick, Yuhui Huang, Christian T. Farrar, Koen A. Marijt, Jonas Kloepper, Meenal Datta, Giorgio Seano, Keehoon Jung, Walid S. Kamoun, Trupti Vardam, Matija Snuderl, Jermaine Goveia, Sampurna Chatterjee, Ana Batista, Alona Muzikansky, Ching Ching Leow, Lei Xu, Tracy T. Batchelor, Dan G. Duda, Dai Fukumura, Jain K. Jain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-346.
https://doi.org/10.1158/1538-7445.AM2016-LB-346
Published: 15 July 2016
View article titled, Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
Journal Articles

Abstract 3541: Targeting autophagy to enhance paclitaxel sensitivity in esophageal carcinoma

Jiajing Cai, Yan Cai, Qiang Ma, Jiang Zou, Binfeng He, Fan Chang, Lei Xu, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3541.
https://doi.org/10.1158/1538-7445.AM2016-3541
Published: 15 July 2016
View article titled, Abstract 3541: Targeting autophagy to enhance paclitaxel sensitivity in esophageal carcinoma
Journal Articles

Abstract 1678: DRAM1 regulates EMT of lung cancer A549 cells via SQSTM1/p62 in vitro

Binfeng He, Jiajing Cai, Guangcheng Huang, Fan Chang, Lei Xu, Dongsheng Wang, Yibin Deng, Xiaolan Guo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1678.
https://doi.org/10.1158/1538-7445.AM2016-1678
Published: 15 July 2016
View article titled, Abstract 1678: DRAM1 regulates EMT of lung cancer A549 cells via SQSTM1/p62 in vitro
Journal Articles

Abstract 1614: Identification of FBXL4 as a bone metastasis-associated gene in prostate cancer

Elzbieta Stankiewicz, Xueying Mao, D Chas Mangham, Lei Xu, Gabrielle Fisher, Bernard North, Henrik Moller, Peter Scardino, Jack Cuzick, Dan Berney, Yong-Jie Lu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1614.
https://doi.org/10.1158/1538-7445.AM2016-1614
Published: 15 July 2016
View article titled, Abstract 1614: Identification of FBXL4 as a bone metastasis-associated gene in prostate cancer
Journal Articles

Abstract A36: Function of GPR56 in metastasis dormancy of melanoma

Nancy Corson, Michelle Warren, Lei Xu
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): A36.
https://doi.org/10.1158/1538-7445.TUMMET15-A36
Published: 26 May 2016
View article titled, Abstract A36: Function of GPR56 in metastasis dormancy of melanoma