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Journal Articles

Abstract LB566: Class 1 HDAC inhibition induces antitumor immunity by NF-kB-mediated enhanced metabolic fitness and generation of unique effector function enriched memory CD8 T cell subtype

Nour Shobaki, Pankaj Gaur, Rahul Nadre, Vivek Verma, Peter Ordentlich, Lei Wang, Nazli Jafarzadeh, Wael Traboulsi, Mikayel Mkrtichyan, Seema Gupta, Samir N. Khleif

Cancer Res (2022) 82 (12_Supplement): LB566.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB566

Published: 15 June 2022

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Journal Articles

Abstract 3112: Metabolic hallmarks of rare renal cell carcinoma patient-derived xenograft models

Manuel Ozambela, Alberto Pieretti, Graciela M. Nogueras Gonzalez, Tapati Maity, Lei Wang, Carolyn De La Cerda, Breanna Alonzo, Luis Segarra, Angelita Alaniz, Priya Rao, Nizar Tannir, Jose A. Karam, Christopher G. Wood, Pavlos Msaouel, Niki M. Zacharias

Cancer Res (2022) 82 (12_Supplement): 3112.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3112

Published: 15 June 2022

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Journal Articles

Abstract 1405: Novel ADC platform delivers promising in vivo activity and safety

Haidong Liu, Wenke Qi, Lei Wang, Guobao Wang, Xinyue Chen, Julia Gavrilyuk, Tae Han, Baiteng Zhao, Xiao Shang

Cancer Res (2022) 82 (12_Supplement): 1405.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1405

Published: 15 June 2022

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Journal Articles

Abstract 1085: PRO1184, a novel folate receptor alpha-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse carcinoma models

Baiteng Zhao, Lei Wang, Haidong Liu, Suping Huang, Xiao Shang, Tae Han

Cancer Res (2022) 82 (12_Supplement): 1085.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1085

Published: 15 June 2022

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Journal Articles

Abstract 1758: The preclinical pharmacology of PRO1102, a novel exatecan-based HER2-directed antibody-drug conjugate with robust anti-tumor activity

Lei Wang, Haidong Liu, Xiao Shang, Tae H. Han, Baiteng Zhao

Cancer Res (2022) 82 (12_Supplement): 1758.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1758

Published: 15 June 2022

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Journal Articles

Abstract 1759: PRO1160, a novel CD70-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse models of renal cell carcinoma and non-Hodgkin lymphoma

Lei Wang, Haidong Liu, Xiao Shang, Tae Han, Baiteng Zhao

Cancer Res (2022) 82 (12_Supplement): 1759.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1759

Published: 15 June 2022

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Journal Articles

Abstract P1-18-33: Real-world outcomes with palbociclib, abemaciclib and ribociclib; experience of a tertiary oncology centre in the United Kingdom

Lei Wang, Muhammad Ibrahim, Anthony Neal

Cancer Res (2022) 82 (4_Supplement): P1-18-33.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-18-33

Published: 15 February 2022

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Journal Articles

Abstract 498: ZL-1201, a differentiated CD47 therapeutic antibody with improved hematological safety profile

Bing Wan, Xu Fang, Shou Li, Wenhua Shi, Holly Li, David Bellovin, Lei Wang, Yusong Zhu, Yuan Lin, Shali Qi, Sophia Yin, Frank Tao, Lishan Kang, Omar Kabbarah, Haiying Zhou, Petter Veiby, James Yan, Karl Hsu

Cancer Res (2021) 81 (13_Supplement): 498.

DOI: https://doi.org/10.1158/1538-7445.AM2021-498

Published: 01 July 2021

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Journal Articles

PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis

Lilia Gheghiani, Lei Wang, Youwei Zhang, Xavier T.R. Moore, Jinglei Zhang, Steven C. Smith, Yijun Tian, Liang Wang, Kristi Turner, Colleen K. Jackson-Cook, Nitai D. Mukhopadhyay, Zheng Fu

Cancer Res (2021) 81 (5): 1293–1307.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-1377

Published: 01 March 2021

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Includes: Multimedia, Supplementary data

Journal Articles

Combinatorial Normalization of Liver-Derived Cytokine Pathways Alleviates Hepatic Tumor-Associated Cachexia in Zebrafish

Fei Fei, Shaoyang Sun, Qiang Li, Zhou Pei, Lei Wang, Ranran Zhang, Feihong Luo, Min Yu, Xu Wang

Cancer Res (2021) 81 (4): 873–884.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2818

Published: 15 February 2021

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Includes: Supplementary data

Journal Articles

Abstract PS17-45: Metastatic tissues display organ specific immune infiltration archetypes; lessons from a rapid autopsy tissue collection study

Colt Egelston, Weihua Guo, Eliza R. Bacon, Kena Ihle, Diana Simons, Christian Avalos, JIayi Tan, Jian Ye, Lei Wang, Minhui Lim, James R. Waisman, Peter P Lee

Cancer Res (2021) 81 (4_Supplement): PS17-45.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-45

Published: 15 February 2021

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Journal Articles

Abstract 1689: Intranodal self-correlation analysis reveals differences in gene-to-gene interactions between lymph nodes draining cold vs. hot triple-negative breast tumors

Weihua Guo, Minhui Lim, Jiayi Tan, Lei Wang, Ting-fang He, Shawn Solomon, Colt A. Egelston, Diana L. Simons, Daniel Schmolze, James Waisman, Peter P. Lee

Cancer Res (2020) 80 (16_Supplement): 1689.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1689

Published: 15 August 2020

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Journal Articles

Abstract 4394: Utilizing pharmacokinetics and toxicity data in the translational drug interaction knowledgebase to bridge the phase I cancer drug combination studies

Lei Wang, Shijun Zhang, Lai Wei, Dwight H. Owen, Lang Li

Cancer Res (2020) 80 (16_Supplement): 4394.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4394

Published: 15 August 2020

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Journal Articles

Abstract 4400: Translational drug interaction database (TDID): A knowledgebase for drug interactions

Shijun Zhang, Heng-Yi Wu, Rohith Vanam, chien-WeiChiang, Lei Wang, Lang Li

Cancer Res (2020) 80 (16_Supplement): 4400.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4400

Published: 15 August 2020

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Journal Articles

Abstract 789: Development and validation of a capture based NGS assay that enables the detection of Epstein Barr virus from gastric cancer patients' tumor tissues

Yajie Hu, Bo Yang, Lei Wang, Shiyi Liu, Lei Liang, Jie Wang, Fugen Li, Yu Sun

Cancer Res (2020) 80 (16_Supplement): 789.

DOI: https://doi.org/10.1158/1538-7445.AM2020-789

Published: 15 August 2020

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Journal Articles

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Ying Zhang, Stefan Pusch, James Innes, Kastytis Sidlauskas, Matthew Ellis, Joanne Lau, Tedani El-Hassan, Natasha Aley, Francesca Launchbury, Angela Richard-Loendt, Jasper deBoer, Sheng Chen, Lei Wang, Andreas von Deimling, Ningning Li, Sebastian Brandner

Cancer Res (2019) 79 (19): 4994–5007.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-0054

Published: 01 October 2019

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Includes: Supplementary data

Journal Articles

Abstract CT041: Identification of gene signatures associated with response in a Phase II trial of entinostat (ENT) plus pembrolizumab (PEMBRO) in non-small cell lung cancer (NSCLC) patients whose disease has progressed on or after anti-PD-(L)1 therapy

Peter Ordentlich, Lei Wang, David Tamang, Amy H. Sullivan, Sally E. Church, Dan Rozelle, Michael L. Meyers, Suresh S. Ramalingam, Matthew D. Hellmann

Cancer Res (2019) 79 (13_Supplement): CT041.

DOI: https://doi.org/10.1158/1538-7445.AM2019-CT041

Published: 01 July 2019

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Journal Articles

Abstract 148: Analysis of the tumor microenvironment in seven cancer types by single-cell RNA-seq

Michael Dean, Guibo Li, Jianhua Jin, Yong Hou, Kui Wu, Shida Zhu, Hanlin Zhou, Ruqian Lv, Feng Lin, Si Liu, Shichen Dong, Lei Wang, Cuijuan Zhang, Yi Zhao

Cancer Res (2019) 79 (13_Supplement): 148.

DOI: https://doi.org/10.1158/1538-7445.AM2019-148

Published: 01 July 2019

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Journal Articles

Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma

Teruki Yanagi, Masashi Watanabe, Hiroo Hata, Shinya Kitamura, Keisuke Imafuku, Hiroko Yanagi, Akihiro Homma, Lei Wang, Hidehisa Takahashi, Hiroshi Shimizu, Shigetsugu Hatakeyama

Cancer Res (2018) 78 (24): 6795–6806.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-1495

Published: 13 December 2018

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Includes: Supplementary data

Journal Articles

Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong, Xu Wang

Cancer Res (2018) 78 (19): 5548–5560.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-3964

Published: 01 October 2018

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Includes: Supplementary data

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NARROW

Abstract LB566: Class 1 HDAC inhibition induces antitumor immunity by NF-kB-mediated enhanced metabolic fitness and generation of unique effector function enriched memory CD8 T cell subtype

Abstract 3112: Metabolic hallmarks of rare renal cell carcinoma patient-derived xenograft models

Abstract 1405: Novel ADC platform delivers promising in vivo activity and safety

Abstract 1085: PRO1184, a novel folate receptor alpha-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse carcinoma models

Abstract 1758: The preclinical pharmacology of PRO1102, a novel exatecan-based HER2-directed antibody-drug conjugate with robust anti-tumor activity

Abstract 1759: PRO1160, a novel CD70-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse models of renal cell carcinoma and non-Hodgkin lymphoma

Abstract P1-18-33: Real-world outcomes with palbociclib, abemaciclib and ribociclib; experience of a tertiary oncology centre in the United Kingdom

Abstract 498: ZL-1201, a differentiated CD47 therapeutic antibody with improved hematological safety profile

PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis

Combinatorial Normalization of Liver-Derived Cytokine Pathways Alleviates Hepatic Tumor-Associated Cachexia in Zebrafish

Abstract PS17-45: Metastatic tissues display organ specific immune infiltration archetypes; lessons from a rapid autopsy tissue collection study

Abstract 1689: Intranodal self-correlation analysis reveals differences in gene-to-gene interactions between lymph nodes draining cold vs. hot triple-negative breast tumors

Abstract 4394: Utilizing pharmacokinetics and toxicity data in the translational drug interaction knowledgebase to bridge the phase I cancer drug combination studies

Abstract 4400: Translational drug interaction database (TDID): A knowledgebase for drug interactions

Abstract 789: Development and validation of a capture based NGS assay that enables the detection of Epstein Barr virus from gastric cancer patients' tumor tissues

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Abstract CT041: Identification of gene signatures associated with response in a Phase II trial of entinostat (ENT) plus pembrolizumab (PEMBRO) in non-small cell lung cancer (NSCLC) patients whose disease has progressed on or after anti-PD-(L)1 therapy

Abstract 148: Analysis of the tumor microenvironment in seven cancer types by single-cell RNA-seq

Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma

Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult

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