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Journal Articles

Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression

Yani Pan, Yue Zhou, Yonghua Shen, Lei Xu, Hongwen Liu, Nannan Zhang, Tianlu Huang, Kui Meng, Yu Liu, Lishan Wang, Ge Bai, Qi Chen, Yun Zhu, Xiaoping Zou, Siliang Wang, Zhangding Wang, Lei Wang
Journal: Cancer Research
Cancer Res (2024)
https://doi.org/10.1158/0008-5472.CAN-24-0088
Published: 20 August 2024
View article titled, Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Open the PDF for Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract LB425: A tumor microenvironment-targeting CD98-directed ADC confers robust anti-tumor activity in multiple cancers with favorable pharmacokinetics and safety profiles in preclinical models

Fang Yang, Lei Wang, Xinxin Tian, Xuan Qiu, Jianhe Chen, Wenke Qi, Guangyu Li, Haidong Liu, Juan Liu, Suping Huang, Bin Ye, Qilin Wu, Baiteng Zhao, Wenhui Li, Jianhua Sui, Zhu Chen
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB425.
https://doi.org/10.1158/1538-7445.AM2024-LB425
Published: 05 April 2024
View article titled, Abstract LB425: A tumor microenvironment-targeting CD98-directed ADC confers robust anti-tumor activity in multiple cancers with favorable pharmacokinetics and safety profiles in preclinical models
Journal Articles

Abstract 6652: Advanced glioblastoma immunotherapy: Attenuated herpes oncolytic virus armed with anti-PD-1 antibody and IL-12

Lei Wang, Xusha Zhou, Xiaoqing Chen, Yuanyuan Liu, Yanxin Zheng, Runbin Yan, Yonghong Liu, Jing Zhao, Grace Guoying Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6652.
https://doi.org/10.1158/1538-7445.AM2024-6652
Published: 22 March 2024
View article titled, Abstract 6652: Advanced glioblastoma immunotherapy: Attenuated herpes oncolytic virus armed with anti-PD-1 antibody and IL-12
Journal Articles

Abstract 6014: PLK1-dependent phosphorylation of PRMT5 promotes DNA damage response in prostate cancer

Jia Peng, Yanquan Zhang, Jianlin Wang, Qianjin Li, Daheng He, Xinyi Wang, Xiongjian Rao, Meng Wu, Pingli Mo, Lei Wang, Sai Wu, Ruixin Wang, Jinghui Liu, Mansoureh Nouri, Izumi Tadahide, Xiaoqi Liu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6014.
https://doi.org/10.1158/1538-7445.AM2024-6014
Published: 22 March 2024
View article titled, Abstract 6014: PLK1-dependent phosphorylation of PRMT5 promotes DNA damage response in prostate cancer
Journal Articles

Abstract 6580: A Novel EGFR x cMET bispecific ADC PRO1286 demonstrated broad antitumor activity and promising tolerability in preclinical models

Yang Xiao, Haiyu Huang, Jianhe Yin, Xuan Qiu, Lei Wang, Haidong Liu, Baiteng Zhao, Zhu Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6580.
https://doi.org/10.1158/1538-7445.AM2024-6580
Published: 22 March 2024
View article titled, Abstract 6580: A Novel EGFR x cMET bispecific ADC PRO1286 demonstrated broad antitumor activity and promising tolerability in preclinical models
Journal Articles

Abstract 2050: Preclinical characterization of PRO1106, a novel and promising SLITRK6-directed sesutecan ADC

Wanwan Shen, Haotian Lu, Yang Xiao, Xuan Qiu, Haidong Liu, Lei Wang, Zhu Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2050.
https://doi.org/10.1158/1538-7445.AM2024-2050
Published: 22 March 2024
View article titled, Abstract 2050: Preclinical characterization of PRO1106, a novel and promising SLITRK6-directed sesutecan ADC
Journal Articles

Abstract 1571: Upregulation of phosphoglyceric acid mutase (PGAM)-1 is related to lymph node metastasis in gastric cancer

Helei Wang, Zhicheng Liu, Lei Wang, Zitian Wang, Christina Jamieson, Nicholas A. Cacalano
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1571.
https://doi.org/10.1158/1538-7445.AM2024-1571
Published: 22 March 2024
View article titled, Abstract 1571: Upregulation of phosphoglyceric acid mutase (PGAM)-1 is related to lymph node metastasis in gastric cancer
Journal Articles

Abstract 2469: PROTAC mediated NR4A1 degradation as a novel strategy for cancer immunotherapy

Lei Wang, Yufeng Xiao, Yuewan Luo, Rohan Master, Jiao Mo, Myung-Chul Kim, Yi Liu, Chandra Maharjan, Urvi Patel, Xiangming Li, Donald Shaffer, Guertin Kevin, Haoyang Zhuang, Emily Moser, Keiran Smalley, Daohong Zhou, Guangrong Zheng, Weizhou Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2469.
https://doi.org/10.1158/1538-7445.AM2024-2469
Published: 22 March 2024
View article titled, Abstract 2469: PROTAC mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
Journal Articles

Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy

Yifan Liu, Hongying Wang, Xinyu Zhao, Jiashen Zhang, Zhiling Zhao, Xia Lian, Juan Zhang, Feng Kong, Tao Hu, Ting Wang, Xiaohua Li, Lei Wang, Dapeng Wang, Chunling Li, Huiwen Luan, Xiaoli Liu, Chunyan Wang, Yun Jiang, Xiaomin Li, Fangmin Li, Shuhao Ji, Yaopeng Wang, Zunling Li
Journal: Cancer Research
Cancer Res (2023) 83 (20): 3385–3399.
https://doi.org/10.1158/0008-5472.CAN-22-3115
Published: 13 October 2023
View article titled, Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
Open the PDF for Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy in another window
Includes: Supplementary data
Journal Articles

AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis

Zicheng Sun, Qiwei Jiang, Bing Gao, Xiaomei Zhang, Lang Bu, Lei Wang, Ying Lin, Wei Xie, Jie Li, Jianping Guo
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1264–1279.
https://doi.org/10.1158/0008-5472.CAN-22-3407
Published: 14 April 2023
View article titled, AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis
Open the PDF for AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract CT076: Randomized, global, phase 3 study of tislelizumab plus chemotherapy versus chemotherapy as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-306): China subgroup analysis

Yongqian Shu, Yueyin Pan, Ping Lu, Yi Jiang, Jingdong Zhang, Xiaohong Wu, Yuanhu Yao, Lin Shen, Yi Ba, Zhiyong He, Yuxian Bai, Jianhua Chen, Guohua Yu, Yanyan Peng, Hongqian Wu, Lei Wang, Liyun Li, Jianming Xu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT076.
https://doi.org/10.1158/1538-7445.AM2023-CT076
Published: 14 April 2023
View article titled, Abstract CT076: Randomized, global, phase 3 study of tislelizumab plus chemotherapy versus chemotherapy as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (RATIONALE-306): China subgroup analysis
Journal Articles

Abstract 6573: Drug Combo: A unique resource for efficient phase 1 trial design with manually curated MTD and DLT

Lei Wang, Shijun Zhang, Lai Wei, Yuxi Zhu, Dwight Owen, Lang Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6573.
https://doi.org/10.1158/1538-7445.AM2023-6573
Published: 04 April 2023
View article titled, Abstract 6573: Drug Combo: A unique resource for efficient phase 1 trial design with manually curated MTD and DLT
Journal Articles

Abstract 571: Angiopoietin-like 4 as a potential therapeutic target for clear cell renal carcinoma

Zeng Jin, Umasankar De, Lei Wang, Jeremy Kleberg, Weizhou Zhang, Ryan Kolb
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 571.
https://doi.org/10.1158/1538-7445.AM2023-571
Published: 04 April 2023
View article titled, Abstract 571: Angiopoietin-like 4 as a potential therapeutic target for clear cell renal carcinoma
Journal Articles

Abstract 2923: JAB-X1800: A potent immunostimulatory antibody-drug conjugate (iADC) targeting CD73

Yang Ye, Guiqun Yang, Hongling Wang, Xin Sun, Yanping Wang, Fashun Yan, Lei Wang, Wei Long
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2923.
https://doi.org/10.1158/1538-7445.AM2023-2923
Published: 04 April 2023
View article titled, Abstract 2923: JAB-X1800: A potent immunostimulatory antibody-drug conjugate (iADC) targeting CD73
Journal Articles

Abstract 2637: Novel folate receptor alpha-directed antibody-drug conjugate PRO1184 demonstrates broad antitumor activity with a promising safety profile in preclinical models

Lei Wang, Haidong Liu, Chang Zhou, Tae Han, Baiteng Zhao, Zhu Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2637.
https://doi.org/10.1158/1538-7445.AM2023-2637
Published: 04 April 2023
View article titled, Abstract 2637: Novel folate receptor alpha-directed antibody-drug conjugate PRO1184 demonstrates broad antitumor activity with a promising safety profile in preclinical models
Journal Articles

Abstract 4451: Developing a PROTAC-based NR4A1 degrader for melanoma cancer therapy

Rohan Master, Yuewan Luo, Yufeng Xiao, Daohong Zhou, Lei Wang, Guangrong Zheng, Weizhou Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4451.
https://doi.org/10.1158/1538-7445.AM2023-4451
Published: 04 April 2023
View article titled, Abstract 4451: Developing a PROTAC-based NR4A1 degrader for melanoma cancer therapy
Journal Articles

Abstract 2326: Proteolysis-targeting chimera against NR4A1 for cancer immunotherapy

Lei Wang, Yufeng Xiao, Rohan P. Master, Zeng Jin, Urvi M. Patel, Yuewan Luo, Daohong Zhou, Guangrong Zheng, Weizhou Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2326.
https://doi.org/10.1158/1538-7445.AM2023-2326
Published: 04 April 2023
View article titled, Abstract 2326: Proteolysis-targeting chimera against NR4A1 for cancer immunotherapy
Journal Articles

Abstract 5347: Selective targeting deacetylase 3 (HDAC3) and HDAC8 by PROTACs

Yufeng Xiao, Seth Hale, Nikee Awasthee, Xuan Zhang, Yi Liu, Zhiguang Huo, Dongwen Lyu, Lei Wang, Weizhou Zhang, Megan Mosteiro, Daiqing Liao, Guangrong Zheng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5347.
https://doi.org/10.1158/1538-7445.AM2023-5347
Published: 04 April 2023
View article titled, Abstract 5347: Selective targeting deacetylase 3 (HDAC3) and HDAC8 by PROTACs
Journal Articles

Abstract 961: HER2-low expression in patients with advanced or metastatic solid tumors

Burak Uzunparmak, Cara Haymaker, Gabriela Raso, Chen Zhu, Serena Masciari, Lei Wang, Bryce Kirby, Heather Lin, Aysegul Gorur, Ann-Marie Cimo, Amber Kennon, Qingqing Ding, Andrea Palmieri, Gabriele Elizabeth Urschel, Ying Yuan, Guoxin Feng, Yasmeen Rizvi, Aisha Hussain, Vivek Subbiah, Timothy Anthony Yap, Jordi Rodon-Ahnert, Sarina Anne Piha-Paul, David S. Hong, Funda Meric-Bernstam, Ecaterina E. Dumbrava
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 961.
https://doi.org/10.1158/1538-7445.AM2023-961
Published: 04 April 2023
View article titled, Abstract 961: HER2-low expression in patients with advanced or metastatic solid tumors
Journal Articles

Abstract P3-07-25: Efficacy and safety of neoadjuvant pertuzumab biosimilar TQB2440, trastuzumab and docetaxel in HR negative, HER2 positive breast cancer: a single-arm trial

Jiang Wu, Jing Yu, Yuqing Yang, Xinxin Wen, Jixin Yang, Hongliang Wei, Xiaolong Xu, Yike Li, Liu Yang, Dongdong Xu, Lei Wang, Yijia Wang, Wen Ma, Nanlin Li
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-07-25.
https://doi.org/10.1158/1538-7445.SABCS22-P3-07-25
Published: 01 March 2023
View article titled, Abstract P3-07-25: Efficacy and safety of neoadjuvant pertuzumab biosimilar TQB2440, trastuzumab and docetaxel in HR negative, HER2 positive breast cancer: a single-arm trial