1-20 of 29
Lei Shi
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 1977: ACR-2316: A potentially first-in-class, potent, selective WEE1/PKMYT1 inhibitor rationally designed for superior single agent activity through synergistic disruption of cell cycle checkpoints

Caroline Wigerup, Helén Nilsson, Lei Shi, Joon Jung, Joelle Baddour-Sousounis, Ruban Cornelius, Nina Lipjankic, Uthira Muralitharan, Valentina Siino, Ignacio Arribas Diez, Zachary Best, Martina Pasetto, William Dahlberg, Shahrzad Rafiei, Portia Lombardo, Magnus E. Jakobsson, Reina Improgo, Christina Scherer, John van Duzer, David A. Proia, Kristina Masson, Peter Blume-Jensen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1977.
https://doi.org/10.1158/1538-7445.AM2024-1977
Published: 22 March 2024
View article titled, Abstract 1977: ACR-2316: A potentially first-in-class, potent, selective WEE1/PKMYT1 inhibitor rationally designed for superior single agent activity through synergistic disruption of cell cycle checkpoints
Journal Articles

Abstract 4749: Acrivon predictive precision proteomics (AP3) uncovers mechanism of resistance to ACR-368, a clinical-stage CHK1/2 inhibitor, and identifies rational combination treatment

Helén Nilsson, Lei Shi, Magnus E. Jakobsson, Joelle Baddour-Sousounis, Shahrzad Rafiei, Uthira Muralitharan, Zachary Best, Valentina Siino, Francisco J. Santana, Ignacio Arribas Diez, Kailash Singh, Portia Lombardo, William Dahlberg, Subodh Kumar, Ahmed Youssef, Reina Improgo, Corey Xu, Joon Jung, Jung-Min Lee, Ayesha Murshid, Michail Shipitsin, Jesper V. Olsen, Kristina Masson, David A. Proia, Caroline Wigerup, Peter Blume-Jensen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4749.
https://doi.org/10.1158/1538-7445.AM2024-4749
Published: 22 March 2024
View article titled, Abstract 4749: Acrivon predictive precision proteomics (AP3) uncovers mechanism of resistance to ACR-368, a clinical-stage CHK1/2 inhibitor, and identifies rational combination treatment
Journal Articles

Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC

Zhen Bian, Lei Shi, Yuan Liu, harry Stylli
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6438.
https://doi.org/10.1158/1538-7445.AM2023-6438
Published: 04 April 2023
View article titled, Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC
Journal Articles

Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination

Lei Shi, Zhen Bian, Jane Zen, Harry Stylli, Yuan Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2337.
https://doi.org/10.1158/1538-7445.AM2023-2337
Published: 04 April 2023
View article titled, Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination
Journal Articles

Abstract 3208: Bone-derived TGF-ß release is associated with cardiac dysfunction due to oxidation of SR calcium gatekeepers, Ca2+ leak and mitochondrial dysfunction

Lei Shi, Truc Kuo, Jade Martinez, Sukanya Suresh, Trupti Trivedi, Gabriel M. Pagnotti, Leah D. Guerra, Xu Cao, Theresa A. Guise
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3208.
https://doi.org/10.1158/1538-7445.AM2023-3208
Published: 04 April 2023
View article titled, Abstract 3208: Bone-derived TGF-ß release is associated with cardiac dysfunction due to oxidation of SR calcium gatekeepers, Ca<sup>2+</sup> leak and mitochondrial dysfunction
Journal Articles

Abstract 2650: Pre-clinical efficacy and toxicity profile of LM-24C5: A novel CEACAM5 x 4-1BB bispecific antibody in cancer immunotherapy

Wei Cao, Jianjian Liu, Wentao Huang, Junwei Yang, Lei Shi, Yuan Li, Te Du, Xia Qin, Da Fei, Runsheng Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2650.
https://doi.org/10.1158/1538-7445.AM2023-2650
Published: 04 April 2023
View article titled, Abstract 2650: Pre-clinical efficacy and toxicity profile of LM-24C5: A novel CEACAM5 x 4-1BB bispecific antibody in cancer immunotherapy
Journal Articles

Abstract 6298: A novel topoisomerase I inhibitor based anti-ICAM-1 antibody drug conjugate for the treatment of hematologic malignancies and solid tumors

Oi Kwan Wong, David Jackson, Lei Shi, Qi Fei, Xiaocheng Chen, Leonard Post
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6298.
https://doi.org/10.1158/1538-7445.AM2023-6298
Published: 04 April 2023
View article titled, Abstract 6298: A novel topoisomerase I inhibitor based anti-ICAM-1 antibody drug conjugate for the treatment of hematologic malignancies and solid tumors
Journal Articles

Abstract 5312: BSI-082, a fully human anti-SIRPα antibody with both high specificity and broad coverage of SIRPα variant populations

Zeyu Peng, Jinyu Liu, Wenwen Dai, Xiaodong F. Liu, Shukai Xia, Hongyan Li, Lei Shi, Hugh M. Davis, Mingjiu Chen, Mark Z. Ma
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5312.
https://doi.org/10.1158/1538-7445.AM2022-5312
Published: 15 June 2022
View article titled, Abstract 5312: BSI-082, a fully human anti-SIRPα antibody with both high specificity and broad coverage of SIRPα variant populations
Journal Articles

Epstein–Barr Virus–Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1

Junshang Ge, Jie Wang, Fang Xiong, Xianjie Jiang, Kunjie Zhu, Yian Wang, Yongzhen Mo, Zhaojian Gong, Shanshan Zhang, Yi He, Xiayu Li, Lei Shi, Can Guo, Fuyan Wang, Ming Zhou, Bo Xiang, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5074–5088.
https://doi.org/10.1158/0008-5472.CAN-20-4321
Published: 01 October 2021
View article titled, Epstein–Barr Virus–Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1
Open the PDF for Epstein–Barr Virus–Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1 in another window
Includes: Supplementary data
Journal Articles

MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression

Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R. Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Haojie Huang
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4471–4484.
https://doi.org/10.1158/0008-5472.CAN-20-4194
Published: 01 September 2021
View article titled, MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression
Open the PDF for MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression

Lei Shi, Yuqian Yan, Yundong He, Binyuan Yan, Yunqian Pan, Jacob J. Orme, Jun Zhang, Wanhai Xu, Jun Pang, Haojie Huang
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3593–3606.
https://doi.org/10.1158/0008-5472.CAN-20-3258
Published: 01 July 2021
View article titled, Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression
Open the PDF for Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation

Tiziana Monteverde, Sudhakar Sahoo, Manuela La Montagna, Peter Magee, Lei Shi, Dave Lee, Robert Sellers, Alexander R. Baker, Hui Sun Leong, Matteo Fassan, Michela Garofalo
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1719–1731.
https://doi.org/10.1158/0008-5472.CAN-20-1968
Published: 01 April 2021
View article titled, CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation
Open the PDF for CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation in another window
Includes: Supplementary data
Journal Articles

Abstract 1097: FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma

Yvonne Y. Li, James M. Cleary, Srivatsan Raghavan, Liam F. Spurr, Qibiao Wu, Lei Shi, Lauren K. Brais, Maureen Loftus, Lipika Goyal, Anuj K. Patel, Atul B. Shinagare, Thomas E. Clancy, Geoffrey Shapiro, Ethan Cerami, William R. Sellers, William C. Hahn, Matthew Meyerson, Nabeel Bardeesy, Andrew D. Cherniack, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1097.
https://doi.org/10.1158/1538-7445.AM2020-1097
Published: 15 August 2020
View article titled, Abstract 1097: FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma
Journal Articles

Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma

Meng-Ju Wu, Lei Shi, Juan Dubrot, Christine Hudson, Joshua Merritt, Ramzi Adil, Qibiao Wu, Sebastien Ronseaux, Rohini Narayanaswamy, Robert Manguso, Brandon Nicolay, Nabeel Bardeesy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2020-1810
Published: 15 August 2020
View article titled, Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma
Journal Articles

Abstract 5183: The preclinical characterization of TST001, a novel humanized anti-claudin18.2 mAb with enhanced binding affinity and anti-tumor activity

Fei Teng, Yi Gu, Hui Chai, Huanhuan Guo, Hongjun Li, Xiwen Wu, Xinlai Yao, Fei Xu, Lei Shi, Zhenzhi Yan, Xiaoli Zi, Zheng Dai, Timethy Liao, Lisa Zheng, Francis Fan, Zhen Li, Jerry Yang, Xueming Qian
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5183.
https://doi.org/10.1158/1538-7445.AM2020-5183
Published: 15 August 2020
View article titled, Abstract 5183: The preclinical characterization of TST001, a novel humanized anti-claudin18.2 mAb with enhanced binding affinity and anti-tumor activity
Journal Articles

Abstract 6056: A next-gen anti-CD73 Antibody with potential to show better efficacy and safety profile than existing approach

Xin Gan, Lei Shi, Qianqian Shan, Fei Chen, Yun He, Yiping Rong, Qiumei Du
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6056.
https://doi.org/10.1158/1538-7445.AM2020-6056
Published: 15 August 2020
View article titled, Abstract 6056: A next-gen anti-CD73 Antibody with potential to show better efficacy and safety profile than existing approach
Journal Articles

Abstract 4421: A novel long non-coding RNA competes with endogenous RNA and mediates prostate cancer progression

Xiao-Lei Shi, Yu-Tian Xiao, Fei Liu, Yue Yang, Xin-Wen Nian, Ya-Sheng Zhu, Shancheng Ren, Yinghao Sun
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4421.
https://doi.org/10.1158/1538-7445.AM2018-4421
Published: 01 July 2018
View article titled, Abstract 4421: A novel long non-coding RNA competes with endogenous RNA and mediates prostate cancer progression
Journal Articles

Abstract 4408: Development and validation of a serum miRNA biomarker panel for the detection of early stage lung cancer

Lisha Ying, Ruiyang Zou, Lingbin Du, Lei Shi, Nan Zhang, Jiaoyue Jin, Junzhou Wu, Fanrong Zhang, Kaiyan Chen, Herbert Yu, Weimin Mao, Dan Su
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4408.
https://doi.org/10.1158/1538-7445.AM2018-4408
Published: 01 July 2018
View article titled, Abstract 4408: Development and validation of a serum miRNA biomarker panel for the detection of early stage lung cancer
Journal Articles

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

Christina D. Drenberg, Alice A. Gibson, Stanley B. Pounds, Lei Shi, Dena P. Rhinehart, Lie Li, Shuiying Hu, Guoqing Du, Anne T. Nies, Matthias Schwab, Navjotsingh Pabla, William Blum, Tanja A. Gruber, Sharyn D. Baker, Alex Sparreboom
Journal: Cancer Research
Cancer Res (2017) 77 (8): 2102–2111.
https://doi.org/10.1158/0008-5472.CAN-16-2548
Published: 13 April 2017
View article titled, OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues
Open the PDF for OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues in another window
Includes: Supplementary data
Journal Articles

Abstract 5464: Host variation in OATP1B1 is associated with treatment outcome in pediatric AML

Christina D. Drenberg, Stanley Pounds, Lei Shi, Shelley Orwick, Lie Li, Shuiying Hu, Alice Gibson, Raul Ribeiro, Jeffrey Rubnitz, Alex Sparreboom, Sharyn D. Baker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5464.
https://doi.org/10.1158/1538-7445.AM2015-5464
Published: 01 August 2015
View article titled, Abstract 5464: Host variation in OATP1B1 is associated with treatment outcome in pediatric AML