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Journal Articles

Abstract LB032: HH102007 is a highly selective and potent PARP1 inhibitor and trapper

Yingjie Hou, Shanyun Gao, Shujuan Jiang, Jingjing Li, Chaobo Zhang, Yanxiao Xu, Songda Yu, Lei Liu, Bing Yu, Wangyang Tu, Yixiang Zhang, Leping Li
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB032.
https://doi.org/10.1158/1538-7445.AM2024-LB032
Published: 05 April 2024
View articletitled, Abstract LB032: HH102007 is a highly selective and potent PARP1 inhibitor and trapper
Journal Articles

Abstract LB031: Discovery and Characterization of HH100937, a potent and selective SOS1 inhibitor demonstrates synergistic efficacy in combination with KRAS/MAPK therapies

Qing Xie, Dongsheng Li, Shujuan Jiang, Jie Zhu, Songda Yu, Maozhi Yang, Yalei Cai, Lei Liu, Bing Yu, Wangyang Tu, Yixiang Zhang, Leping Li
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB031.
https://doi.org/10.1158/1538-7445.AM2024-LB031
Published: 05 April 2024
View articletitled, Abstract LB031: Discovery and Characterization of HH100937, a potent and selective SOS1 inhibitor demonstrates synergistic efficacy in combination with KRAS/MAPK therapies
Journal Articles

Abstract 4754: Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer

Peichao Li, ngbing Li, Lingxiao Yang, Lei Liu, Xiaogang Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4754.
https://doi.org/10.1158/1538-7445.AM2024-4754
Published: 22 March 2024
View articletitled, Abstract 4754: Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
Journal Articles

Abstract 3429: Using metabolomics to identify biomarkers mediating the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women

Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3429.
https://doi.org/10.1158/1538-7445.AM2024-3429
Published: 22 March 2024
View articletitled, Abstract 3429: Using metabolomics to identify biomarkers mediating the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women
Journal Articles

FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma

Jiao Huang, Wai Ying Tsang, Xiao-Na Fang, Yu Zhang, Jie Luo, Lan-Qi Gong, Bai-Feng Zhang, Ching Ngar Wong, Zhi-Hong Li, Bei-Lei Liu, Jin-Lin Huang, Yu-Ma Yang, Shan Liu, Liu-Xian Ban, Yiu Hong Chan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2024) 84 (6): 855–871.
https://doi.org/10.1158/0008-5472.CAN-23-0966
Published: 15 March 2024
View articletitled, FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Open the PDF for FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1882: SCR-9171, a MUC17-targeted bispecific T cell engager molecule for gastrointestinal cancer

Guangcun Cheng, Yayuan Fu, Hua Zheng, ng Li, Xiaolei He, Xi Jiao, Shuhui Luan, Shuai Wang, Lei Jiang, Wenjing Li, Yun Zhang, Lei Liu, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1882.
https://doi.org/10.1158/1538-7445.AM2023-1882
Published: 04 April 2023
View articletitled, Abstract 1882: SCR-9171, a MUC17-targeted bispecific T cell engager molecule for gastrointestinal cancer
Journal Articles

Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile

Yingying Hu, Yayuan Fu, Lei Liu, Wenjing Li, Liting Xue, Zhiyong Yu, Yun Zhang, Meijuan Gao, Yixin Tan, Fudong Wang, Yadan Wu, Jie Li, Zhenzhen Li, Feng Zhou, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6357.
https://doi.org/10.1158/1538-7445.AM2023-6357
Published: 04 April 2023
View articletitled, Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile
Journal Articles

Abstract 1240: mSin1 regulates epithelial-mesenchymal transition

Shile Huang, Yan Luo, Lei Liu, Bing Cheng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1240.
https://doi.org/10.1158/1538-7445.AM2023-1240
Published: 04 April 2023
View articletitled, Abstract 1240: mSin1 regulates epithelial-mesenchymal transition
Journal Articles

Abstract 482: Discovery of a novel and oral CHK1 inhibitor for the treatment of solid tumors

Xin Gao, Yonggang Liao, Qi Li, Ling Yang, Chunyan Zhao, Yanfen Teng, Lei Liu, Wenyuan Qian, Xiaohong Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 482.
https://doi.org/10.1158/1538-7445.AM2023-482
Published: 04 April 2023
View articletitled, Abstract 482: Discovery of a novel and oral CHK1 inhibitor for the treatment of solid tumors
Journal Articles

Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies

Chunyan Zhao, Jianfei Wang, Aiguo Liu, Xin Gao, Yanfen Teng, Lei Liu, Yang Zhang, Xiaohong Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3451.
https://doi.org/10.1158/1538-7445.AM2023-3451
Published: 04 April 2023
View articletitled, Abstract 3451: XS-04: A first-in-class dual IRAK4/BTK inhibitor for the treatment of hematological malignancies
Journal Articles

Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors

Cuiqing Yang, Xiaohui Shao, Feng Zhou, Lei Zhou, Qi Deng, Yun Zhang, Guangcun Cheng, Yingying Hu, Huaiyuan Ma, Yadan Wu, Shuai Wang, Jie Zang, Lei Liu, Wenqing Yang, Yang Liu, Chunlei Xia, Jianzhong Hu, Ande Luo, Yayuan Fu, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6343.
https://doi.org/10.1158/1538-7445.AM2022-6343
Published: 15 June 2022
View articletitled, Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors
Journal Articles

Abstract 2406: Mechanism of mSin1 regulation of cell migration

Shile Huang, Lei Liu, Yan Luo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2406.
https://doi.org/10.1158/1538-7445.AM2022-2406
Published: 15 June 2022
View articletitled, Abstract 2406: Mechanism of mSin1 regulation of cell migration
Journal Articles

Abstract 5436: HH2853 is a selective small molecular dual inhibitor of EZH1/2 with potent anti-tumor activities

Xu-Xing Chen, Qian-Qian Shen, Zhao Zhao, Yan-Fen Fang, Jun-Yu Yang, Ying-Lei Gao, Lei Liu, Yixiang Zhang, Yi Chen, Leping Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5436.
https://doi.org/10.1158/1538-7445.AM2022-5436
Published: 15 June 2022
View articletitled, Abstract 5436: HH2853 is a selective small molecular dual inhibitor of EZH1/2 with potent anti-tumor activities
Journal Articles

Abstract 1070: SCR6106, an oral and brain penetrant SERD demonstrated anti-tumor activities in vitro and in vivo

Feng Zhou, Lei Liu, Guimei Yang, Peng Gu, Liting Xue, Wenqing Yang, Ping Chen, Renhong Tang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1070.
https://doi.org/10.1158/1538-7445.AM2021-1070
Published: 01 July 2021
View articletitled, Abstract 1070: SCR6106, an oral and brain penetrant SERD demonstrated anti-tumor activities in vitro and in vivo
Journal Articles

Abstract 4932: mTORC1 regulates FAK phosphorylation

Lin Li, Yan Luo, Lei Liu, Shile Huang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4932.
https://doi.org/10.1158/1538-7445.AM2020-4932
Published: 15 August 2020
View articletitled, Abstract 4932: mTORC1 regulates FAK phosphorylation
Journal Articles

BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail

Zhong-yi Qin, Tao Wang, Siyuan Su, Li-ting Shen, Guang-xi Zhu, Qin Liu, Liang Zhang, Ke-wei Liu, Yue Zhang, Zhi-hua Zhou, Xiao-ning Zhang, Liang-zhi Wen, Yue-liang Yao, Wen-jing Sun, Yan Guo, Kai-jun Liu, Lei Liu, Xing-wei Wang, Yan-ling Wei, Jun Wang, Hua-liang Xiao, Pengda Liu, Xiu-wu Bian, Dong-feng Chen, Bin Wang
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4869–4881.
https://doi.org/10.1158/0008-5472.CAN-19-0442
Published: 01 October 2019
View articletitled, BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail
Open the PDF for BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail in another window
Includes: Supplementary data
Journal Articles

EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer

Hai-Ting Liu, Sen Liu, Lei Liu, Ran-Ran Ma, Peng Gao
Journal: Cancer Research
Cancer Res (2018) 78 (20): 5877–5890.
https://doi.org/10.1158/0008-5472.CAN-18-1011
Published: 15 October 2018
View articletitled, EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer
Open the PDF for EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3407: A high performance target-enrichment strategy for liquid biopsy

Jilong Liu, Yan Song, Lei Liu, Meihua Tan, Han Liu, Jingjing Wang, Mingzhi Ye
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3407.
https://doi.org/10.1158/1538-7445.AM2018-3407
Published: 01 July 2018
View articletitled, Abstract 3407: A high performance target-enrichment strategy for liquid biopsy
Journal Articles

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3

Lei Liu, Yanquan Zhang, Chi Chun Wong, Jingwan Zhang, Yujuan Dong, Xiangchun Li, Wei Kang, Francis K.L. Chan, Joseph J.Y. Sung, Jun Yu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (8): 1958–1971.
https://doi.org/10.1158/0008-5472.CAN-17-2683
Published: 12 April 2018
View articletitled, RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3
Open the PDF for RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3 in another window
Includes: Supplementary data
Journal Articles

MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway

Tao Yu, Yingjun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He, Ming Yao
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5782–5794.
https://doi.org/10.1158/0008-5472.CAN-17-0671
Published: 31 October 2017
View articletitled, MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway
Open the PDF for MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway in another window
Includes: Supplementary data